Thermal Characteristics Of Tumors
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Thermal Characteristics Of Tumors
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Author : Rakesh K. Jain
language : en
Publisher:
Release Date : 1980
Thermal Characteristics Of Tumors written by Rakesh K. Jain and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1980 with Medical categories.
Study Of Dosimetric And Thermal Properties Of A Newly Developed Thermo Brachytherapy Seed For Treatment Of Solid Tumors
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Author : Bhoj R. Gautam
language : en
Publisher:
Release Date : 2013
Study Of Dosimetric And Thermal Properties Of A Newly Developed Thermo Brachytherapy Seed For Treatment Of Solid Tumors written by Bhoj R. Gautam and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with Cancer categories.
Studies on the curative effects of hyperthermia and radiation therapy on treatment of cancer show strong evidence of synergistic enhancement when both radiation and hyperthermia treatment modalities are applied simultaneously. A variety of tissue heating approaches developed to date still fail to overcome essential limitations such as inadequate temperature control, temperature non-uniformity, and prolonged time delay between hyperthermia and radiation treatments. We propose a new self-regulating Thermo-brachytherapy (TB) seed, which serves as a source of both radiation and heat for concurrent administration of brachytherapy and hyperthermia. The proposed seed is based on the BEST seed model 2301, where the tungsten marker core and the air gap are replaced with ferromagnetic material. The ferromagnetic core produces heat when subjected to an alternating electromagnetic (EM) field and effectively shuts off after reaching the Curie temperature (TC) of the ferromagnetic material, thus establishing temperature self-regulation. The seed has a ferromagnetic Ni-Cu alloy core having a Curie transition at a temperature of 52 O C. This study summarizes the design and development of the self regulating ferromagnetic core TB seed for the concurrent hyperthermia and brachytherapy treatments. An experimental study of the magnetic properties of the Ni1-xCux (0.28= x =0.3) alloys, and the simulation studies of radiation and thermal distribution properties of the seed have been performed. A preliminary experiment for the ferromagnetic induction heating of Ni-Cu needles has been carried out to ensure the practical feasibility of the induction heating. Radiation dose characterizing parameters (dose rate constant and other TG-43 factors) were calculated using the Monte Carlo method. For the thermal characteristics, we studied a model consisting of single or multiple seeds placed in the central region of a cylindrical phantom using a finite-element analysis method, with and without considering the effect of the blood perfusion. The experimental study of the Ni-Cu alloys shows that heat treatment has a strong influence on the magnetic properties of the Ni-Cu alloy. The TC of the Ni1-xCux alloy decreases drastically with an increase in copper composition in the alloy. The study of the thermal expansion properties of the seed materials in the range of 37 O C to 60 O C shows negligible change in dimension due to the change of the temperature during the treatment. Imaging studies using CT and plane X-ray radiographs on the other hand, demonstrated that the new seed preserves the radiographic properties of the standard BEST seed model 2301 and is realistic for clinical use. The modification of the internal structure of the seed slightly changes dose rate and other TG-43 factors characterizing radiation distribution. The thermal modeling results show that the temperature of the seed surface rises rapidly and stays constant around TC) of the ferromagnetic material. The amount of heat produced by the ferromagnetic core is sufficient to raise the temperature of the surrounding phantom to the therapeutic range. The volume of the phantom reaching the therapeutic temperature range increases with the increase in frequency or magnetic field strength. An isothermal distribution closely matching the radiation isodose distribution can be achieved within a target volume by tuning the frequency and intensity of the alternating magnetic field. The effect of heat loss due to the blood perfusion in a living tissue can be compensated by adjusting the magnetic field parameter. The results of the preliminary induction heating experiment conducted in a ham slice (implanted with ferromagnetic needles) demonstrated practical feasibility of induction heating and thermal self regulating property of the ferromagnetic Ni-Cu alloy. Modeling studies of the radiation and thermal properties of the TB seed show that the therapeutic implementation of the concurrent hyperthermia and brachytherapy treatment of the tumor is feasible. The seed has the capability of addressing some of the limitations of conventional hyperthermia treatment techniques, and has several advantages. The proposed seed model has high potential in the implementation of concurrent brachytherapy and hyperthermia treatments.
Identification Of The Thermal Growth Characteristics Of Coagulated Tumor Tissue In Laser Induced Thermotherapy
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Author : Dietmar Hömberg
language : en
Publisher:
Release Date : 2011
Identification Of The Thermal Growth Characteristics Of Coagulated Tumor Tissue In Laser Induced Thermotherapy written by Dietmar Hömberg and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with categories.
Diagnosis And Treatment Of Cancer Using Thermal Therapies
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Author : Citlalli J. Trujillo Romero
language : en
Publisher: CRC Press
Release Date : 2023-10-06
Diagnosis And Treatment Of Cancer Using Thermal Therapies written by Citlalli J. Trujillo Romero and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-10-06 with Medical categories.
New research is being conducted in the diagnosis and new treatments of cancer that has high efficacy and are minimally invasiveness. Artificial intelligence, bioimpedance, thermal images and nanomaterials have been used to provide early diagnosis. New treatments based on the generation of microwaves, radiofrequency, or ultrasound have been proposed in the last couple of decades. Although thermotherapies have been shown to be efficient, for them to be considered as a primary treatment, they must overcome some hurdles. One of the main challenges is to ensure applicators that point the electromagnetic or the mechanical waves at a tumor, don't affect the surrounding healthy tissues. In some cases, nanoparticles have also been designed to achieve better focus. The design of new applicators can be made by computational models based on methods such as the finite element. However, to efficiently predict the applicator’s performance, it is important that dielectric, thermal, and acoustic properties (tissue characterization) are included in the models. Not only healthy tissue, but also tumors must be characterized. Patient specific treatment planning, which consists of a 3D patient model based on medical images, can be developed to implement a safety treatment. Moreover, tissue properties as well as the applicator must be defined. Parameters such as temperature increase, and heat pattern must be evaluated to ensure patient safety and treatment success.
Brain And Human Body Modeling 2020
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Author : Sergey N. Makarov
language : en
Publisher: Springer Nature
Release Date : 2021
Brain And Human Body Modeling 2020 written by Sergey N. Makarov and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021 with Biomedical engineering categories.
The 41st Annual International Conference of the IEEE EMBS, took place between July 23 and 27, 2019, in Berlin, Germany. The focus was on "Biomedical engineering ranging from wellness to intensive care." This conference provided an opportunity for researchers from academia and industry to discuss a variety of topics relevant to EMBS and hosted the 4th Annual Invited Session on Computational Human Models. At this session, a bevy of research related to the development of human phantoms was presented, together with a substantial variety of practical applications explored through simulation.
Hyperthermia In Cancer Treatment
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Author :
language : en
Publisher:
Release Date : 1986
Hyperthermia In Cancer Treatment written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1986 with Cancer categories.
Biological Basis Of Oncologic Thermotherapy
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Author : Michel Gautherie
language : en
Publisher:
Release Date : 1990
Biological Basis Of Oncologic Thermotherapy written by Michel Gautherie and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990 with Cancer categories.
Studies on the effects of hyperthermia have aroused great interest in recent years. On the one hand, it has been demonstrated. that hyperthermia may be a useful treatment modality for tumors, in combination with ionizing radia tion or cytotoxic drugs. On the other hand, it is of great scientific interest to study the effects of increased temperature on biological systems. Although hyperthermia has been used in the treatment of cancer for cen turies, its therapeutic success was doubtful. However, since it has been shown that radiation-induced cell killirtg can be remarkably enhanced by hyperthermia, many investigations have been performed with cells in vitro, tumors in situ, and normal tissues. From these studies it has been concluded that many biological phenomena and their characteristics which are found in tumors may be conducive to the use of hyperthermia in cancer therapy. Many researchers are studying the cell-killing mechanisms of heat and fac tors that modify cell thermosensitivity. A very fascinating biological phenomenon is the general observation that living cells can enhance their thermoresistance within hours of heat treatment. The development of such thermotolerance is apparently a universal process, and its mechanism is of general scientific interest. Metabolic and physiological processes are changed during and after hyperthermic treatment. These changes exert a strong feedback on the thermo sensitivity of cells and tissues, and also in fluence the heating characteristics of tissues, especially in tumors.
Advances In Mechanical Engineering
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Author : B. B. Biswal
language : en
Publisher: Springer Nature
Release Date : 2020-01-16
Advances In Mechanical Engineering written by B. B. Biswal and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-16 with Technology & Engineering categories.
This book comprises select proceedings of the International Conference on Recent Innovations and Developments in Mechanical Engineering (IC-RIDME 2018). The book contains peer reviewed articles covering thematic areas such as fluid mechanics, renewable energy, materials and manufacturing, thermal engineering, vibration and acoustics, experimental aerodynamics, turbo machinery, and robotics and mechatronics. Algorithms and methodologies of real-time problems are described in this book. The contents of this book will be useful for both academics and industry professionals.
Thermal Modeling And Analysis Of Radiofrequency Abaltion Technique In Prostate Cancer Treatment
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Author : Bikash Vaidya
language : en
Publisher:
Release Date : 2005
Thermal Modeling And Analysis Of Radiofrequency Abaltion Technique In Prostate Cancer Treatment written by Bikash Vaidya and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with categories.
[Author's abstract] Accurate prediction of temperature distribution in the prostate undergoing thermally based treatment for prostate cancer is crucial for successful cancer cell necrosis simultaneously minimizing thermal damage to healthy prostate tissue. A two dimensional transverse cross section of the prostate was modeled using preprocessor software Gambit 2.0 (Fluent Inc.) and simulated using software Fluent 6.0 (Fluent Inc.), a commercial finite volume method software. The prostate geometry was modeled with a radiofrequency probe at the center of the cancerous tumor tissue and the healthy prostate tissue surrounding the tumor. Two different locations of cancerous tumor tissue within the prostate were modeled. Analyses were carried out with tumor tissue located at the center of the prostate and tumor tissue located 12.5 mm from the center of the prostate. The presence and location of a 1 mm in diameter blood vessel on the tumor ablation were analyzed. The outer surface of the prostate gland was assumed to remain at basal temperature. The effect of blood perfusion was modeled using Penne's Perfusion term. Literature research revealed that most of the thermal analyses were performed for benign prostate hyperplasia in which the tissue properties were assumed to be normal prostate tissue. Since the thermo physical properties of the tumor were different from normal healthy tissue, the properties of cancerous prostate tissue were assumed using the ratio obtained for normal and tumor tissues of the lungs. Investigations were also conducted on the effect on tumor ablation due to inclusion of thermo physical properties of dense cancerous tumor tissues, the effect of variable thermal conductivities of the tissue materials, the effect of blood perfusion during normal perfusion, vasodilation and vasoconstriction, and the effect of cancerous tumor size. A transient bio heat equation was solved to predict the temperature distribution in the tissue and the ablation time required for successful necrosis of cancerous tumor cells. The inclusion of thermo physical properties of cancerous tumor tissues had a significant impact on temperature distribution and ablation time to kill the tumor tissue. The cancerous tumor tissues were more heat sensitive than normal healthy tissue resulting in shorter time for ablation. The variable thermal conductivities had no significant effect on temperature distribution and also on the time required for successful tumor cell necrosis. With the increase in tumor size, blood perfusion played a significant role in determining the thermal damage to the tissue. The presence of blood vessel at the tumor surface had the potential to cause incomplete destruction of tumor cells. A comprehensive development of the present model will enable clinicians to precisely calculate the power and the ablation duration prior using these tumor and other patient characteristics.
Computational Methodologies For Electrical And Electronics Engineers
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Author : Singh, Rajiv
language : en
Publisher: IGI Global
Release Date : 2021-03-18
Computational Methodologies For Electrical And Electronics Engineers written by Singh, Rajiv and has been published by IGI Global this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-18 with Technology & Engineering categories.
Artificial intelligence has been applied to many areas of science and technology, including the power and energy sector. Renewable energy in particular has experienced the tremendous positive impact of these developments. With the recent evolution of smart energy technologies, engineers and scientists working in this sector need an exhaustive source of current knowledge to effectively cater to the energy needs of citizens of developing countries. Computational Methodologies for Electrical and Electronics Engineers is a collection of innovative research that provides a complete insight and overview of the application of intelligent computational techniques in power and energy. Featuring research on a wide range of topics such as artificial neural networks, smart grids, and soft computing, this book is ideally designed for programmers, engineers, technicians, ecologists, entrepreneurs, researchers, academicians, and students.