Towards New Therapies For Parkinson S Disease

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Towards New Therapies For Parkinson S Disease

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Author : David Finkelstein
language : en
Publisher: BoD – Books on Demand
Release Date : 2011-11-02

Towards New Therapies For Parkinson S Disease written by David Finkelstein and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-11-02 with Medical categories.

Parkinson's disease (PD) is characterised clinically by various non-motor and progressive motor symptoms, pathologically by loss of dopamine producing cells and intraneuronal cytoplasmic inclusions composed primarily of ?-synuclein. By the time a patient first presents with symptoms of Parkinson's disease at the clinic, a significant proportion of the cells in the substantia nigra have already been destroyed. This degeneration progresses despite the current therapies until the cell loss is so great that the quality of normal life is compromised. The dopamine precursor levodopa is the most valuable drug currently available for the treatment of PD. However for most PD patients, the optimal clinical benefit from levodopa decreases around five to six years of treatment. The aim of the chapters of this book is to work towards an understanding in the mechanisms of degeneration and to develop disease modifying therapies.

Towards New Therapies For Parkinson S Disease

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Author : David Finkelstein
language : en
Publisher: IntechOpen
Release Date : 2011-11-02

Towards New Therapies For Parkinson S Disease written by David Finkelstein and has been published by IntechOpen this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-11-02 with Medical categories.

Parkinson's disease (PD) is characterised clinically by various non-motor and progressive motor symptoms, pathologically by loss of dopamine producing cells and intraneuronal cytoplasmic inclusions composed primarily of ?-synuclein. By the time a patient first presents with symptoms of Parkinson's disease at the clinic, a significant proportion of the cells in the substantia nigra have already been destroyed. This degeneration progresses despite the current therapies until the cell loss is so great that the quality of normal life is compromised. The dopamine precursor levodopa is the most valuable drug currently available for the treatment of PD. However for most PD patients, the optimal clinical benefit from levodopa decreases around five to six years of treatment. The aim of the chapters of this book is to work towards an understanding in the mechanisms of degeneration and to develop disease modifying therapies.

The New Parkinson S Disease Treatment Book

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Author : J. Eric Ahlskog, ,
language : en
Publisher: Oxford University Press, USA
Release Date : 2015

The New Parkinson S Disease Treatment Book written by J. Eric Ahlskog, , and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with Health & Fitness categories.

2015 marks the ten-year anniversary since the First Edition of The Parkinson's Disease Treatment Book was published. This completely updated Second Edition represents a major revision with even more directed treatment guidelines, updated discussions relating to the possible cause(s), and assessments of the current and future role of surgical and innovative strategies.

The New Parkinson S Treatment

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Author : Melissa McConaghy
language : en
Publisher: Simon and Schuster
Release Date : 2019-03-23

The New Parkinson S Treatment written by Melissa McConaghy and has been published by Simon and Schuster this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-03-23 with Health & Fitness categories.

This revised edition of The New Parkinson’s Treatment: Exercise is Medicine is a must read if you, or someone you know, has been diagnosed with Parkinson’s. Exercise cannot be underestimated for its role in slowing Parkinson’s down. This book introduces the seven key concepts to help you get the most out of your exercise program, as well as easy strategies and hints to keep you motivated. Based on cutting-edge research and tested extensively by Australian physiotherapists, this exercise program has been designed to bring out your inner warrior – your PD Warrior! The PD Warrior Philosophy is that exercise, education, community and a life-long commitment to fighting the symptoms of Parkinson’s can help you develop a greater state of physical, mental and social wellbeing. Neurologists and other health professionals are referring to PD Warrior as a game-changer and, since its launch in Australia in 2012, it has grown exponentially, with extremely successful outcomes and widespread popularity. PD Warrior is not a cure, it’s your chance to take control. So start now – you have nothing to lose and everything to gain.

10 Breakthrough Therapies For Parkinson S Disease

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Author : Michael Okun
language : en
Publisher: Books4patients
Release Date : 2015-08-21

10 Breakthrough Therapies For Parkinson S Disease written by Michael Okun and has been published by Books4patients this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-08-21 with categories.

Michael S. Okun, M.D. is internationally celebrated as both a neurologist and a leading researcher. He has often been referred to as, "the voice of the Parkinson's disease patient." He was honored at the White House in 2015 as a Champion of Change for Parkinson's disease. He has an international following on the National Parkinson Foundation's Ask the Doctor web-forum and he is a Professor of Neurology at the University of Florida Health Center for Movement Disorders and Neurorestoration. His many books and internet blog posts are brimming with up-to date and extremely practical information. This book is the sequel to his runaway bestseller, Parkinson's Treatment: 10 Secrets to a Happier Life, which was translated into over 20 languages. Dr. Okun is well known for infusing his readers with positivity and optimism. In his latest book he reveals the breakthroughs in Parkinson's disease that will pave the road to meaningful progress. In this book he reviews all of the recent breakthrough ideas and therapies in Parkinson's disease, and he reviews the knowledge gained which is extending far beyond a single drug or stem cell. He paints the broader and more exciting picture and reviews the portfolio of breakthroughs spanning drug, cell, vaccine, device, genetics, care, and behavior. He believes that patients and families with personal investments in Parkinson's disease should be informed and updated about all of these potential breakthrough therapies. This book informs, educates, and will inspire Parkinson's disease patients, family members, as well as health care professionals and scientists. As Dr. Okun points out, we will journey toward better treatments -- and one day a cure.

Restorative Therapies In Parkinson S Disease

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Author : Patrik Brundin
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-08-31

Restorative Therapies In Parkinson S Disease written by Patrik Brundin and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-08-31 with Medical categories.

In this exciting and timely book new approaches to repairing the parkinsonian brain are described by leading experts. Never in history has there been greater hope that novel experimental therapies can support significant restoration of brain function. This book gives an overview of the current state-of-the-art research for brain repair, what the challenges are and an indication of what research can provide for the next generation of people with Parkinson’s disease. The comprehensive chapters are geared to an audience of neuroscientists, neurologists, neurosurgeons and anyone interested in how findings in the research laboratory can effectively be transferred to the clinic.

Rethinking Parkinson S Disease

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Author : John C Coleman
language : en
Publisher: Hybrid Publishers
Release Date : 2020-10-08

Rethinking Parkinson S Disease written by John C Coleman and has been published by Hybrid Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-10-08 with Health & Fitness categories.

John Coleman was diagnosed with Parkinson's disease while studying to be a naturopath, and banished all the frustrating symptoms of this cruel condition from his body ... naturally! His new book equips those diagnosed with the knowledge needed to reverse their Parkinson's disease symptoms and even recover, using completely natural means. Rethinking Parkinson's Disease traces known pathways leading to a diagnosis of Parkinson's disease, together with strategies to reverse each pathway. It includes the best evidence from Western allopathic medicine and complementary/alternative medicine in discovering how and why people with Parkinson's develop symptoms, the diagnostic process, standard treatments and prognoses offered by expert practitioners, and ongoing research. The book presents strategies that have been shown, clinically or in research, to improve the health of people with Parkinson's, with the possibility of reversing symptoms. A major section of this work details strategies to create wellness, many available to patients at little or no cost. There are sections on symptom control, complementary medical treatments and therapies to avoid. The book is aimed primarily at people with Parkinson's, families and supporters, and may be used as a self-help book, including advice on building a team of supportive practitioners. There are also suggestions and advice for both Western allopathic medicine and complementary/alternative medicine practitioners to enhance their care of patients with a Parkinson's disease diagnosis, so it may be used as a handbook for practitioners wishing to move away from the standard conservative view of Parkinson's disease as an "incurable" disease.

2018 Update Of Road To Recovery From Parkinsons Disease

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Author : Robert Rodgers
language : en
Publisher: Createspace Independent Publishing Platform
Release Date : 2018-07-30

2018 Update Of Road To Recovery From Parkinsons Disease written by Robert Rodgers and has been published by Createspace Independent Publishing Platform this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-07-30 with Parkinson's disease categories.

2018 has been a life changer for many persons diagnosed with Parkinson's disease. I am hearing many encouraging reports from peoplewho have found how to get relief from their symptoms. This is a truly exciting development from previous years. I have described and summarized each of the ways that have been helping persons diagnosed with Parkinson's in a 98 page book titled:2018 Update to Road to Recovery from Parkinsons Disease.This 2018 Update covers a series of promising, new options for recovery that I have documented over the previous year in my interviews on Parkinsons Recovery Radio. Many promising possibilities - some recently discovered or invented over the past year - are helping more and more people reverse their Parkinson's symptoms. The 2018 Update covers the following:* Light Therapy* High Dose Thiamine* Pulsed Electromagnetic Field Therapy (PEMF)* Sleep Therapies* Ketone Esters* CBD Oils* MacrobioticsThere * Amino Acid TherapyThere is no overlap between the content of Road to Recovery from Parkinsons (released in 2017) and this 2018 update.

Living Well With Parkinson S

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Author : Glenna Wotton Atwood
language : en
Publisher: Turner Publishing Company
Release Date : 2007-08-03

Living Well With Parkinson S written by Glenna Wotton Atwood and has been published by Turner Publishing Company this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-08-03 with Health & Fitness categories.

The long-awaited update to the definitive guide to successfully living with Parkinson's disease Known for its upbeat, informative, and inspirational guidance, Living Well with Parkinson's includes a wealth of up-to-date medical information for Parkinson's sufferers, who number over 1 million in the U.S. alone. Combined with the author's poignant personal account of her own struggles with the disease, this new edition features coverage of pallidotomy (a new surgical technique), the dramatic implications of recent genetic research, and new drugs and therapies. The book also includes tips on dealing with social services and elder law, maintaining a positive attitude, handling issues with spouses and children, and finding support groups. Glenna Wotton Atwood, a former home economics teacher from Maine, lived with Parkinson's for over two decades until her death in 1998. Lila Green Hunnewell (Rockaway, NJ) is a freelance writer and editor. Roxanne Moore Saucier (Bangor, ME) is a journalist with the Bangor Daily News.

Levodopa Pharmacokinetics From Stomach To Brain

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Author : Maria Nord
language : sv
Publisher: Linköping University Electronic Press
Release Date : 2019-01-07

Levodopa Pharmacokinetics From Stomach To Brain written by Maria Nord and has been published by Linköping University Electronic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-01-07 with categories.

Parkinson’s disease (PD) is one of the most common neurodegenerative disorders and it is caused by a loss of dopamine (DA) producing neurons in the basal ganglia in the brain. The PD patient suffers from motor symptoms such as tremor, bradykinesia and rigidity and treatment with levodopa (LD), the precursor of DA, has positive effects on these symptoms. Several factors affect the availability of orally given LD. Gastric emptying (GE) is one factor and it has been shown to be delayed in PD patients resulting in impaired levodopa uptake. Different enzymes metabolize LD on its way from the gut to the brain resulting in less LD available in the brain and more side effects from the metabolites. By adding dopa decarboxylase inhibitors (carbidopa or benserazide) or COMT-inhibitors (e.g. entacapone) the bioavailability of LD increases significantly and more LD can pass the blood-brain-barrier and be converted to DA in the brain. It has been considered of importance to avoid high levodopa peaks in the brain because this seems to induce changes in postsynaptic dopaminergic neurons causing disabling motor complications in PD patients. More continuously given LD, e.g. duodenal or intravenous (IV) infusions, has been shown to improve these motor complications. Deep brain stimulation of the subthalamic nucleus (STN DBS) has also been proven to improve motor complications and to make it possible to reduce the LD dosage in PD patients. In this doctoral thesis the main purpose is to study the pharmacokinetics of LD in patients with PD and motor complications; in blood and subcutaneous tissue and study the effect of GE and PD stage on LD uptake and the effect of continuously given LD (CDS) on LD uptake and GE; in blood and cerebrospinal fluid (CSF) when adding the peripheral enzyme inhibitors entacapone and carbidopa to LD infusion IV; in brain during STN DBSand during oral or IV LD treatment. To conclude, LD uptake is more favorable in PD patients with less severe disease and GE is delayed in PD patients. No obvious relation between LD uptake and GE or between GE and PD stage is seen and CDS decreases the LD levels. Entacapone increases the maximal concentration of LD in blood and CSF. This is more evident with additional carbidopa and important to consider in avoiding high LD peaks in brain during PD treatment. LD in brain increases during both oral and IV LD treatment and the DA levels follows LD well indicating that PD patients still have capacity to metabolize LD to DA despite probable pronounced nigral degeneration. STN DBS seems to increase putaminal DA levels and together with IV LD treatment also increases LD in brain possibly explaining why it is possible to decrease LD medication after STN DBS surgery. Parkinsons sjukdom (PS) är en av de vanligaste s.k. neurodegenerativasjukdomarna och orsakas av förlust av dopamin(DA)producerande nervceller i hjärnan. Detta orsakar motoriska symptom såsom skakningar, stelhet och förlångsammade rörelser. Levodopa (LD) är ett ämne, som kan omvandlas till DA i hjärnan och ge symptomlindring och det är oftast förstahandsval vid behandling av patienter med PS. Flera faktorer påverkar tillgängligheten av LD, bl.a. den hastighet som magsäcken tömmer sig med och denna verkar förlångsammad hos personer med PS vilket ger sämre tillgänglighet av LD i blodet och därmed i hjärnan. LD bryts även ner i hög grad av olika enzym ute i kroppen vilket leder till mindre mängd LD som hamnar i hjärnan och till fler nedbrytningsprodukter som orsakar biverkningar. Tillägg av enzymhämmare leder till ökad mängd LD som kan nå hjärnan och omvandlas till DA. Det anses viktigt att undvika höga toppar av LD i hjärnan då dessa verkar bidra till utvecklandet av besvärliga motoriska komplikationer hos patienter med PS. Om LD ges mer kontinuerligt, exempelvis som en kontinuerlig infusion in i tarmen eller i blodet, så minskar dessa motoriska komplikationer. Inopererande av stimulatorer i vissa delar av hjärnan (DBS) har också visat sig minska dessa motoriska komplikationer och även resultera i att man kan minska LD-dosen. Huvudsyftet med den här avhandlingen är att studera LD hos patienter med PS; i blod och fettvävnad då LD ges i tablettform och se om det finns något samband med LD-upptag och hastigheten på magsäckstömningen (MT) och om kontinuerligt given LD påverkar LD-upptaget eller MT; i blod och i ryggmärgsvätska då enzymhämmarna entakapon och karbidopa tillsätts LD; i hjärna vid behandling med DBS och då LD ges både som tablett och som infusion i blodet. Sammanfattningsvis kan vi se att LD-upptaget är mer gynnsamt hos patienter med PS i tidigare skede av sjukdomens komplikationsfas. MT är förlångsammad hos patienter med PS och det är inget tydligt samband mellan LD-upptag och MT eller mellan MT och sjukdomsgrad. Kontinuerligt given LD minskar LDnivåerna. Enzymhämmaren entakapon ökar den maximala koncentrationen av LD i blod och ryggmärgsvätska och effekten är mer tydlig vid tillägg av karbidopa vilket är viktigt att ta i beaktande vid behandling av PS för att undvika höga toppar av LD i hjärnan. LD ökar i hjärnan då man behandlar med LD i tablettform och som infusion i blodet och DA-nivåerna i hjärnan följer LD väl vilket visar på att patienter med PS fortfarande kan omvandla LD till DA trots trolig uttalad brist av de DA-producerande nervcellerna i hjärnan. DBS verkar öka DA i vissa områden i hjärnan och tillsammans med LD-infusion i blodet verkar det även öka LD i hjärnan och det kan förklara varför man kan sänka LDdosen efter DBS-operation.