Transcription Factor Ap 2 Regulatory Signatures In Breast Cancer

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Transcription Factor Ap 2 Regulatory Signatures In Breast Cancer

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Author :
language : en
Publisher:
Release Date : 2007

Transcription Factor Ap 2 Regulatory Signatures In Breast Cancer written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with categories.

Regulation Of Transcription Factor Ap 2 Expression In Breast Cancer Cells

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Author : Mark Daniel Hasleton
language : en
Publisher:
Release Date : 2001

Regulation Of Transcription Factor Ap 2 Expression In Breast Cancer Cells written by Mark Daniel Hasleton and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with categories.

Breast Cancer

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Author : Phuc Van Pham
language : en
Publisher: BoD – Books on Demand
Release Date : 2017-04-05

Breast Cancer written by Phuc Van Pham and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-04-05 with Medical categories.

Breast Cancer - From Biology to Medicine thoroughly examines breast cancer from basic definitions, to cellular and molecular biology, to diagnosis and treatment. This book also has some additional focus on preclinical and clinical results in diagnosis and treatment of breast cancer. The book begins with introduction on epidemiology and pathophysiology of breast cancer in Section 1. In Section 2, the subsequent chapters introduce molecular and cellular biology of breast cancer with some particular signaling pathways, the gene expression, as well as the gene methylation and genomic imprinting, especially the existence of breast cancer stem cells. In Section 3, some new diagnostic methods and updated therapies from surgery, chemotherapy, hormone therapy, immunotherapy, radiotherapy, and some complementary therapies are discussed. This book provides a succinct yet comprehensive overview of breast cancer for advanced students, graduate students, and researchers as well as those working with breast cancer in a clinical setting.

Transgenic Analysis Of The Role Of Transcription Factor Ap 2 In Breast Development And Breast Cancer

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Author :
language : en
Publisher:
Release Date : 1997

Transgenic Analysis Of The Role Of Transcription Factor Ap 2 In Breast Development And Breast Cancer written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with categories.

One of the most alterations in human breast cancer is the overexpression of the c-erbB-2 protooncogene that has been shown to occur in 25-30% of human breast tumors. Recently this increased expression has been shown to correlate with the presence of the transcription factor AP-2. We have begun to determine the role of AP-2 both in normal mammary gland development and in breast cancer.

Targeting The Ap 1 Transcription Factor For The Treatment Of Breast Cancer

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Author :
language : en
Publisher:
Release Date : 2004

Targeting The Ap 1 Transcription Factor For The Treatment Of Breast Cancer written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with categories.

The AP-1 transcription factor is a central component of many signal transduction pathways. We have shown that blocking AP-1 by over-expressing a dominant negative form of cJun (cjun-DN, Tam67) inhibits breast cancer cell growth. We hypothesize that inhibition of AP-1 blocks the cell cycle, suppression of AP-1 in vivo inhibits the development of breast tumors, the cjun-DN protein binds and inactivates important growth regulatory proteins present in breast cancer cells, these proteins include Jun and Fos family members as well as coactivators that bind cJun. In the present study, we demonstrated that TAM67 inhibits breast cancer growth both in vitro and in vivo. We determined the mechanism by which AP-1 blockade inhibits breast cancer growth. Our studies suggested that TAM67 inhibits breast cancer growth predominantly by inducing CDK inhibitors?such as P27), suppressing G1 cyclins expression and reducing CDKs activity, thus inducing a cell cycle block. We also showed that TAM67 binds all Jun and Fos family members, and it inhibits breast cancer cell also by interacting with cFos and preventing the recruitment of co-activators.

Regulation Of Cancer Immune Checkpoints

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Author :
language : en
Publisher:
Release Date : 2020

Regulation Of Cancer Immune Checkpoints written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with Cancer categories.

This book systematically reviews the most important findings on cancer immune checkpoints, sharing essential insights into this rapidly evolving yet largely unexplored research topic. The past decade has seen major advances in cancer immune checkpoint therapy, which has demonstrated impressive clinical benefits. The family of checkpoints for mediating cancer immune evasion now includes CTLA-4, PD-1/PD-L1, CD27/CD70, FGL-1/LAG-3, Siglec-15, VISTA (PD-1L)/VSIG3, CD47/SIRPA, APOE/LILRB4, TIGIT, and many others. Despite these strides, most patients do not show lasting remission, and some cancers have been completely resistant to the therapy. The potentially lethal adverse effects of checkpoint blockade represent another major challenge, the mechanisms of which remain poorly understood. Compared to the cancer signaling pathways, such as p53 and Ras, mechanistic studies on immune checkpoint pathways are still in their infancy. To improve the responses to checkpoint blockade therapy and limit the adverse effects, it is essential to understand the molecular regulation of checkpoint molecules in both malignant and healthy cells/tissues. This book begins with an introduction to immune checkpoint therapy and its challenges, and subsequently describes the regulation of checkpoints at different levels. In closing, it discusses recent therapeutic developments based on mechanistic findings, and outlines goals for future translational studies. The book offers a valuable resource for researchers in the cancer immunotherapy field, helping to form a roadmap for checkpoint regulation and develop safer and more effective immunotherapies.

Gene Expression And Regulation In Mammalian Cells Transcription Toward The Establishment Of Novel Therapeutics

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Author :
language : en
Publisher:
Release Date : 19??

Gene Expression And Regulation In Mammalian Cells Transcription Toward The Establishment Of Novel Therapeutics written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 19?? with categories.

Biology Of The Mammary Gland

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Author : John A. Mol
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-04-11

Biology Of The Mammary Gland written by John A. Mol and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-04-11 with Science categories.

Proceedings of the European Cooperation in the Field of Scientific and Technical Research (COST 825) Symposium on Mammary Gland Biology, held September 16-18, 1999, in Tours, France. It is difficult to overstate the evolutionary and functional significance of mammary tissue in biology. Substantial progress has been made by researchers in various disciplines, particularly over the last fifteen years, towards realizing the potential of this tissue to yield powerful experimental models for morphogenesis and tissue development; for cellular differentiation; for the biosynthesis and secretion of proteins, lipids, small molecules and inorganic salts; and for the coordination and regulation of these processes. More recently, the possibility of exploiting the secretory epithelial cells of mammary tissue as `cell factories' has become a reality and the recombinant production by lactating animals of an increasing number of proteins, valuable both in the pharmaceutical and `nutraceutical' fields, is in progress or under development. Also in this sphere of agricultural production, genetic as well as nutritional technologies are under investigation and exploitation to optimize milk composition for various end-uses - for instance in food process and manufacture. The possibilities of deriving health benefit from the bioactive properties of some of the minor constituents of milk are emerging to counter the highly-publicized negative health impact of excessive consumption of saturated animal fats. In human nutrition and medicine, the mammary gland is both a source of nutrition to the neonate and a potential health threat to the adult female - breast cancer remains the major single cause of female mortality in most developed countries. This volume provides a unique glimpse into our understanding, at the cutting edge of a variety of disciplines, of this versatile and extraordinary tissue, at the birth of the twenty-first century.

A Handbook Of Transcription Factors

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Author : Timothy R. Hughes
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-05-10

A Handbook Of Transcription Factors written by Timothy R. Hughes and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-05-10 with Medical categories.

Transcription factors are the molecules that the cell uses to interpret the genome: they possess sequence-specific DNA-binding activity, and either directly or indirectly influence the transcription of genes. In aggregate, transcription factors control gene expression and genome organization, and play a pivotal role in many aspects of physiology and evolution. This book provides a reference for major aspects of transcription factor function, encompassing a general catalogue of known transcription factor classes, origins and evolution of specific transcription factor types, methods for studying transcription factor binding sites in vitro, in vivo, and in silico, and mechanisms of interaction with chromatin and RNA polymerase.

Mutant P53 And Mdm2 In Cancer

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Author : Swati Palit Deb
language : en
Publisher: Springer
Release Date : 2016-09-10

Mutant P53 And Mdm2 In Cancer written by Swati Palit Deb and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-09-10 with Medical categories.

This book provides the readers with an overview of research on p53, which has been shown to play a role in numerous crucial biological pathways in normal and cancer cells. Leading scientist in the field, who have all made direct contributions to the understanding of the molecular events underpinning p53 function, have been invited to contribute the various chapters, which discuss the current knowledge of the signaling cascades that are activated by mutations in p53 and overexpression of MDM2, frequently found in human cancer and are major causes of oncogenesis. This book features chapters on the molecular basis of oncogenesis induced by gain of function mutation of p53, signaling pathways induced by MDM2 overexpression, control of mutant or wild-type p53 function by MDM2 and MDMX, p53 mutation in hereditary cancer and structural aspects that activate mutant p53 which can be targeted by drug therapy. This book should be useful for scientists at all levels.