Tuc Tuc Vai Praia
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Tuc Tuc Vai Praia
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Author : Luciane Maria Micheletti Tonon
language : pt-BR
Publisher: Independently Published
Release Date : 2019-01-15
Tuc Tuc Vai Praia written by Luciane Maria Micheletti Tonon and has been published by Independently Published this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-01-15 with Juvenile Fiction categories.
Livro para a primeira infância. Conta a história de uma pequena gaivota chamada Tuc Tuc e sua aventura na praia. É também uma homenagem a todas as mães que precisam trabalhar fora e deixar seus pequenos em casa.
Translational Medicine
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Author : Joy A. Cavagnaro
language : en
Publisher: CRC Press
Release Date : 2021-11-26
Translational Medicine written by Joy A. Cavagnaro and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-26 with Medical categories.
Translational Medicine: Optimizing Preclinical Safety Evaluation of Biopharmaceuticals provides scientists responsible for the translation of novel biopharmaceuticals into clinical trials with a better understanding of how to navigate the obstacles that keep innovative medical research discoveries from becoming new therapies or even making it to clinical trials. The book includes sections on protein-based therapeutics, modified proteins, oligonucleotide-based therapies, monoclonal antibodies, antibody–drug conjugates, gene and cell-based therapies, gene-modified cell-based therapies, combination products, and therapeutic vaccines. Best practices are defined for efficient discovery research to facilitate a science-based, efficient, and predictive preclinical development program to ensure clinical efficacy and safety. Key Features: Defines best practices for leveraging of discovery research to facilitate a development program Includes general principles, animal models, biomarkers, preclinical toxicology testing paradigms, and practical applications Discusses rare diseases Discusses "What-Why-When-How" highlighting different considerations based upon product attributes. Includes special considerations for rare diseases About the Editors Joy A. Cavagnaro is an internationally recognized expert in preclinical development and regulatory strategy with an emphasis on genetic medicines.. Her 40-year career spans academia, government (FDA), and the CRO and biotech industries. She was awarded the 2019 Arnold J Lehman Award from the Society of Toxicology for introducing the concept of science-based, case-by-case approach to preclinical safety evaluation, which became the foundation of ICH S6. She currently serves on scientific advisory boards for advocacy groups and companies and consults and lectures in the area of preclinical development of novel therapies. Mary Ellen Cosenza is a regulatory toxicology consultant with over 30 years of senior leadership experience in the biopharmaceutical industry in the U.S., Europe, and emerging markets. She has held leadership position in both the American College of Toxicology (ACT) and the International Union of Toxicology (IUTOX) and is also an adjunct assistant professor at the University of Southern California where she teaches graduate-level courses in toxicology and regulation of biologics.
Stations Of The Sun
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Author : Ronald Hutton
language : en
Publisher: OUP Oxford
Release Date : 2001-02-15
Stations Of The Sun written by Ronald Hutton and has been published by OUP Oxford this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-02-15 with Social Science categories.
Comprehensive and engaging, this colourful study covers the whole sweep of ritual history from the earliest written records to the present day. From May Day revels and Midsummer fires, to Harvest Home and Hallowe'en, to the twelve days of Christmas, Ronald Hutton takes us on a fascinating journey through the ritual year in Britain. He challenges many common assumptions about the customs of the past, and debunks many myths surrounding festivals of the present, to illuminate the history of the calendar year we live by today.
Preclinical Safety Evaluation Of Biopharmaceuticals
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Author : Joy A. Cavagnaro
language : en
Publisher: John Wiley & Sons
Release Date : 2013-03-07
Preclinical Safety Evaluation Of Biopharmaceuticals written by Joy A. Cavagnaro and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-07 with Medical categories.
"The goal is to provide a comprehensive reference book for the preclinicaldiscovery and development scientist whose responsibilities span target identification, lead candidate selection, pharmacokinetics, pharmacology, and toxicology, and for regulatory scientists whose responsibilities include the evaluation of novel therapies." —From the Afterword by Anthony D. Dayan Proper preclinical safety evaluation can improve the predictive value, lessen the time and cost of launching new biopharmaceuticals, and speed potentially lifesaving drugs to market. This guide covers topics ranging from lead candidate selection to establishing proof of concept and toxicity testing to the selection of the first human doses. With chapters contributed by experts in their specific areas, Preclinical Safety Evaluation of Biopharmaceuticals: A Science-Based Approach to Facilitating Clinical Trials: Includes an overview of biopharmaceuticals with information on regulation and methods of production Discusses the principles of ICH S6 and their implementation in the U.S., Europe, and Japan Covers current practices in preclinical development and includes a comparison of safety assessments for small molecules with those for biopharmaceuticals Addresses all aspects of the preclinical evaluation process, including: the selection of relevant species; safety/toxicity endpoints; specific considerations based upon class; and practical considerations in the design, implementation, and analysis of biopharmaceuticals Covers transitioning from preclinical development to clinical trials This is a hands-on, straightforward reference for professionals involved in preclinical drug development, including scientists, toxicologists, project managers, consultants, and regulatory personnel.
Toxicological Survey Of African Medicinal Plants
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Author : Victor Kuete
language : en
Publisher: Elsevier
Release Date : 2014-05-30
Toxicological Survey Of African Medicinal Plants written by Victor Kuete and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-05-30 with Medical categories.
Toxicological Survey of African Medicinal Plants provides a detailed overview of toxicological studies relating to traditionally used medicinal plants in Africa, with special emphasis on the methodologies and tools used for data collection and interpretation. The book considers the physical parameters of these plants and their effect upon various areas of the body and human health, including chapters dedicated to genotoxicity, hepatotoxicity, nephrotoxicity, cardiotoxicity, neurotoxicity, and specific organs and systems.Following this discussion of the effects of medicinal plants is a critical review of the guidelines and methods in use for toxicological research as well as the state of toxicology studies in Africa. With up-to-date research provided by a team of experts, Toxicological Survey of African Medicinal Plants is an invaluable resource for researchers and students involved in pharmacology, toxicology, phytochemistry, medicine, pharmacognosy, and pharmaceutical biology. Offers a critical review of the methods used in toxicological survey of medicinal plants Provides up-to-date toxicological data on African medicinal plants and families Serves as a resource tool for students and scientists in the various areas of toxicology
Duke S Handbook Of Medicinal Plants Of The Bible
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Author : James A. Duke
language : en
Publisher: CRC Press
Release Date : 2007-12-26
Duke S Handbook Of Medicinal Plants Of The Bible written by James A. Duke and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-12-26 with Health & Fitness categories.
Readers have come to depend on Jim Duke's comprehensive handbooks for their ease of use and artful presentation of scientific information. Following the successful format of his other CRC handbooks, Duke's Handbook of Medicinal Plants of the Bible contains 150 herbs listed alphabetically and by scientific name. Each entry provides illustrations of the plant, synonyms, notes, common names, activities, indications, dosages, downsides and interactions, natural history, and extracts. It includes Biblical quotes as well as comments on points of interest.
Design
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Author : Bernhard E. Bürdek
language : de
Publisher: Birkhäuser
Release Date : 2015-08-31
Design written by Bernhard E. Bürdek and has been published by Birkhäuser this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-08-31 with Architecture categories.
For students of design, professional product designers, and anyone interested in design equally indispensable: the fully revised and updated edition of the reference work on product design. The book traces the history of product design and its current developments, and presents the most important principles of design theory and methodology, looking in particular at the communicative function of products and highlighting aspects such as corporate and service design, design management, strategic design, interface/interaction design and human design.. From the content: Design and history: The Bauhaus; The Ulm School of Design; The Example of Braun; The Art of Design Design and Globalization Design and Methodology: Epistemological Methods in Design Design and Theory: Aspects of the Disciplinary Design Theory Design and its Context: From Corporate Design to Service Design Product Language and Product Semiotics Architecture and Design Design and Society Design and Technological Progress
Phytomedicine
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Author : Rouf Ahmad Bhat
language : en
Publisher: Academic Press
Release Date : 2021-02-20
Phytomedicine written by Rouf Ahmad Bhat and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-02-20 with Science categories.
Phytomedicine: A Treasure of Pharmacologically Active Products from Plants aims to present updated knowledge of plant-based medicines in terms of their research and development, production, and utilization, from the viewpoint of sustainability and by using the latest technologies. The book explores different phytometabolites on a mass scale, coupled with the efficacy, performance and applicability on target organisms to treat curable and fatal diseases. Readers will find a coherent package of phytotherapeutic information regarding inclusive assortment of research based, scientific amplitude of metabolites from the plant world encompassing various action plans. Information is presented sequentially regarding phytochemistry, biological activity and the serviceable aspects of bioactive compounds. The book also addresses various advancements and achievements of novel drugs from plants using molecular and enzymatic activities, and various technological tools in an ecofriendly fashion. Discusses phytotherapeutic properties for a wide range of medical conditions, including anti-pyretic, anti-infective, anti-malarial, Anti-AIDS, anti-diabetic, anti-cancerous, immune-modulatory applications Includes a discussion of synergistic effects of formulations and antagonistic drug interactions Addresses advancements and achievements of novel plant-based drugs using molecular, enzymatic activities and various technological tools in an eco-friendly fashion
Africa Since 1935
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Author : Unesco. International Scientific Committee for the Drafting of a General History of Africa
language : en
Publisher: Univ of California Press
Release Date : 1999
Africa Since 1935 written by Unesco. International Scientific Committee for the Drafting of a General History of Africa and has been published by Univ of California Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with History categories.
The hardcover edition of volume 8 was published in 1994. This paperback edition is the eighth and final volume to be published in the UNESCO General History of Africa. Volume 8 examines the period from 1935 to the present, and details the role of African states in the Second World War and the rise of postwar Africa. This is one of the most important books in the entire series, and as such, it is an unabridged paperback.
Wildlife Conservation In Africa
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Author : S.S. Ajayi
language : en
Publisher: Academic Press
Release Date : 2019-06-15
Wildlife Conservation In Africa written by S.S. Ajayi and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-06-15 with Nature categories.
Wildlife Conservation in Africa: A Scientific Approach presents comprehensive management strategies for the consumptive and non-consumptive utilization of wildlife across Sub-Saharan Africa. It describes African economies that are currently dependent on wildlife resources and prescribes strategies for conserving biodiversity in both forests and animals in ecosystems across the continent. The book covers the history and current status of how Africa's culture, traditions, healthcare and food sources are woven intricately around the local wildlife and resources. It is a necessary resource for researchers and practitioners in wildlife and ecological conservation, but is also useful for administrators and managers of protected areas. Written by the world's leading expert on African wildlife conservation Uses over 45 years of research and knowledge on the topic Provides a detailed categorization of conservation areas across Sub-Saharan Africa Covers both in-situ and ex-situ conservation methods for wildlife