Update On Stevens Johnson Syndrome

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Update On Stevens Johnson Syndrome

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Author : Jodhbir Mehta
language : en
Publisher: Frontiers Media SA
Release Date : 2022-02-10

Update On Stevens Johnson Syndrome written by Jodhbir Mehta and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-10 with Medical categories.

Updates In Sjs Ten Collaboration Innovation And Community

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Author : Madeline E. Marks
language : en
Publisher:
Release Date : 2023

Updates In Sjs Ten Collaboration Innovation And Community written by Madeline E. Marks and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023 with categories.

Abstract: Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis (SJS/TEN) is a predominantly drug-induced disease, with a mortality rate of 15-20%, that engages the expertise of multiple disciplines: dermatology, allergy, immunology, clinical pharmacology, burn surgery, ophthalmology, urogynecology, and psychiatry. SJS/TEN has an incidence of 1-5/million persons per year in the United States, with even higher rates globally. One of the challenges of SJS/TEN has been developing the research infrastructure and coordination to answer questions capable of transforming clinical care and leading to improved patient outcomes. SJS/TEN 2021, the third research meeting of its kind, was held as a virtual meeting on August 28-29, 2021. The meeting brought together 428 international scientists, in addition to a community of 140 SJS/TEN survivors and family members. The goal of the meeting was to brainstorm strategies to support the continued growth of an international SJS/TEN research network, bridging science and the community. The community workshop section of the meeting focused on eight primary themes: mental health, eye care, SJS/TEN in children, non-drug induced SJS/TEN, long-term health complications, new advances in mechanisms and basic science, managing long-term scarring, considerations for skin of color, and COVID-19 vaccines. The meeting featured several important updates and identified areas of unmet research and clinical need that will be highlighted in this white paper

Stevens Johnson Syndrome Past Present And Future Directions

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Author : Hajirah Saeed
language : en
Publisher: Frontiers Media SA
Release Date :

Stevens Johnson Syndrome Past Present And Future Directions written by Hajirah Saeed and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on with Medical categories.

Inpatient Dermatology

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Author : Misha Rosenbach
language : en
Publisher: Springer
Release Date : 2018-11-03

Inpatient Dermatology written by Misha Rosenbach and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-11-03 with Medical categories.

​​​ Inpatient Dermatology is a concise and portable resource that synthesizes the most essential material to help physicians with recognition, differential diagnosis, work-up, and treatment of dermatologic issues in the hospitalized patient. Complete with hundreds of clinical and pathologic images, this volume is both an inpatient dermatology atlas and a practical guide to day-one, initial work-up, and management plan for common and rare skin diseases that occur in the inpatient setting. Each chapter is a bulleted, easy-to-read reference that focuses on one specific inpatient dermatologic condition, with carefully curated clinical photographs and corresponding histopathologic images to aid readers in developing clinical-pathologic correlation for the dermatologic diseases encountered in the hospital. Before each subsection the editors share diagnostic pearls, explaining their approach to these challenging conditions. This book is structured to be useful to physicians, residents, and medical students. It spans dermatology, emergency medicine, internal medicine, infectious disease, and rheumatology. Inpatient Dermatology is the go-to guide for hospital-based skin diseases, making even the most complex inpatient dermatologic issues approachable and understandable for any clinician.

Adverse Cutaneous Drug Eruptions

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Author : Lars E. French
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2012

Adverse Cutaneous Drug Eruptions written by Lars E. French and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Medical categories.

An indispensable tool for understanding, diagnosing and managing this common clinical problem The skin is one of the most frequently involved organs in adverse drug reactions. Occurring with an incidence of 1-5% for certain types of drugs, cutaneous drug eruptions are mostly benign in nature, and comprise the maculopapular type of eruption and urticaria. However, about one third of them require hospital treatment, leading to a considerable burden for the health care system. In this book, a selected group of experts provide an up-to-date, condensed and clinically relevant overview of the field of cutaneous drug eruptions, ranging from epidemiology and genetic predisposition to available therapeutic measures, including rapid drug desensitization. Reflecting the great progress made in recent years in this field, this publication will be a useful tool for a better understanding, diagnosis and management of cutaneous drug eruptions, not only for general physicians, dermatologists and clinical allergologists, but also for nurses and scientists.

Stevens Johnson Syndrome New Insights For The Healthcare Professional 2011 Edition

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Author :
language : en
Publisher: ScholarlyEditions
Release Date : 2012-01-09

Stevens Johnson Syndrome New Insights For The Healthcare Professional 2011 Edition written by and has been published by ScholarlyEditions this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-09 with Medical categories.

Stevens-Johnson Syndrome: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Stevens-Johnson Syndrome in a compact format. The editors have built Stevens-Johnson Syndrome: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Stevens-Johnson Syndrome in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Stevens-Johnson Syndrome: New Insights for the Healthcare Professional: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Stevens Johnson Syndrome And Toxic Epidermal Necrolysis

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Author : Tran Thi Huyen
language : en
Publisher:
Release Date : 2018

Stevens Johnson Syndrome And Toxic Epidermal Necrolysis written by Tran Thi Huyen and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with Electronic books categories.

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe cutaneous adverse drug reactions (SCARs). The most common causative drugs of SJS/TEN are allopurinol, carbamazepine, abacavir, phenytoin, and lamotrigine. SJS/TEN are categorized based on the percentage of epidermal detachment area: (i) SJS: less than 10%, (ii) TEN: greater than 30%, (iii) and overlapping SJS/TEN: 10,Äì30%. The pathogenesis of SJS/TEN is not fully understood, but some immunological and genetic factors are believed to be involved. There is a strong association between some specific HLA haplotypes and drug-induced SJS/TEN, for example, HLA-B*15:02 and carbamazepine-, HLA-B*58:01 and allopurinol. CD8+ cytotoxic T cells and natural killer (NK) cells play an important role in the pathogenesis of SJS/TEN, and upon the activation, they produce cytokines, chemokines, and cytotoxic proteins, that cause extensive keratinocytes apoptosis. Systemic corticosteroid and cyclosporine are still used as the first line in the treatment of SJS/TEN, in combination with care support.

Investigation Into The Mechanisms Of Stevens Johnson Syndrome And Toxic Epidermal Necrolysis

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Author : G. B. Nwikue
language : en
Publisher:
Release Date : 2019

Investigation Into The Mechanisms Of Stevens Johnson Syndrome And Toxic Epidermal Necrolysis written by G. B. Nwikue and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with categories.

Advances In Diagnosis And Management Of Cutaneous Adverse Drug Reactions

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Author : Neil H. Shear
language : en
Publisher: Springer
Release Date : 2018-10-19

Advances In Diagnosis And Management Of Cutaneous Adverse Drug Reactions written by Neil H. Shear and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-10-19 with Medical categories.

This resource guides prescribers, pharmacists, and regulators with an update on the recent expansion of basic and clinical knowledge that forms a framework for understanding cutaneous reactions. This understanding will lead, in turn, to better outcomes and decisions in treatment and management, both in the clinic and in the life cycle of drug development. The skin is a common target for adverse drug events and even mild rashes can be part of life-threatening syndromes. Patients and practitioners often face important decisions about therapy after a drug eruption, including treatment, cross-reactivity with future pharmaceuticals, genetic considerations and dealing with long-term sequelae after a reaction. An international team of experts and leaders in the field share their story and insights into the scientific details and relevant clinical context.

Stevens Johnson Syndrome And Toxic Epidermal Necrolysis A Single Center Review

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Author : Rita Passos Meireles
language : en
Publisher:
Release Date : 2017

Stevens Johnson Syndrome And Toxic Epidermal Necrolysis A Single Center Review written by Rita Passos Meireles and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with categories.

Objectives: Stevens Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) and their overlap (SJS/TEN) are severe acute mucocutaneous diseases, triggered manly by a newly administered drug, life threatening and rare, which still lack a definite treatment method. Our aim was to describe the clinical aspects and etiologic factors of SJS, SJS/TEN and TEN in order to evaluate treatment responses and different outcomes in mortality regarding the therapeutic options.Materials and Methods: This is a retrospective study of patients with the diagnosis described above, who were admitted to our center between 2000 and 2016 in order to characterize their clinical evaluation, treatment and mortality. Detached BSA% was used to categorize the disorder. Logistic regression was used to identify predictive variables of mortality.Results: The final diagnosis was 16 patients with SJS, 35 patients with TEN and 06 patients with SJS/TEN, with ages comprised between 15 and 91 years old, mainly females. The majority of patients with SJS were treated in the Dermatology Department and the majority of patients with TEN were treated in our Burn Center Unit. The most commonly reported causative agent was allopurinol. Oral erosion was the most reported mucosal erosion and ocular involvement was reported in 47% of patients.There was no statistical difference in mortality between patients treated with corticosteroids or intravenous immunoglobulin and plasmapheresis.ConclusionsAlthough the majority of patients with SJS can be treated outside an intensive care unit like our Burn Center Unit, TEN remains a challenging life-threatening disease and many questions regarding best treatment strategies are still without an answer. In the mean time we can state that the discontinuation of the suspected drug, wound care and early supportive therapies contribute to lowering the mortality rates.