Use Of Magnetic Resonance Imaging In Drug Delivery To The Gastrointestinal Tract
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Use Of Magnetic Resonance Imaging In Drug Delivery To The Gastrointestinal Tract
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Author : Bridget O'Mahony
language : en
Publisher:
Release Date : 1998
Use Of Magnetic Resonance Imaging In Drug Delivery To The Gastrointestinal Tract written by Bridget O'Mahony and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with categories.
Magnetic Resonance Imaging For Drug Delivery
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Author : Brett Zain Fite
language : en
Publisher:
Release Date : 2013
Magnetic Resonance Imaging For Drug Delivery written by Brett Zain Fite and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with categories.
Magnetic resonance imaging (MRI) is a versatile imaging modality that can be a powerful tool for developing and improving drug delivery strategies. High field ([greater than or equal to]7T), small bore MR systems are increasingly available for preclinical research, and high field human systems are becoming available as well, thus promising easier translation of high field MR techniques to human medicine. The increased signal to noise at high field can be allocated to improving spatial resolution, which allows for earlier detection of both primary and metastatic neoplasias. Moreover, resolving smaller lesions also permits us to more fully characterize the development process of disease, such as the progression of permeability of metastatic brain lesions, which is an important consideration when choosing an appropriate therapeutic course. In addition to the general benefit of higher signal to noise at higher field, some methods, such as MR thermometry (via the proton resonance frequency shift), and more generally, any imaging method that attempts to resolve differences in resonance frequency/chemical shift, also benefit from the increased spectral separation, in absolute terms, at higher field strengths. Here, we examine MRI methods for improving drug delivery strategies including using real time MR thermometry in a closed loop with an MR compatible focused ultrasound system to provide a consistent acoustic dose in vivo. Further, we examine the use of paramagnetic micelles as a way to track the disposition of these small drug delivery vehicles, comparing peptide targeted to untargeted versions. We then extend our examination to the detection and characterization of small brain metastases followed by the imaging the vascular volume both for registration with PET images and estimation of the arterial input function as a step in pharmacokinetic modeling of vascular permeability. Finally, we examine displacement imaging techniques and successfully program and implement displacement imaging sequences for two purposes: adaptive focusing of an ultrasound beam without heating, and obtaining the shear modulus for evaluating tissue stiffness.
Handbook Of Neuro Oncology Neuroimaging
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Author : Herbert B. Newton
language : en
Publisher: Academic Press
Release Date : 2022-08-21
Handbook Of Neuro Oncology Neuroimaging written by Herbert B. Newton and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-08-21 with Medical categories.
With treatment approaches and the field of neuro-oncology neuroimaging changing rapidly, this third edition of the Handbook of Neuro-Oncology Neuroimaging is very relevant to those in the field, providing a single-source, comprehensive, reference handbook of the most up-to-date clinical and technical information regarding the application of neuroimaging techniques to brain tumor and neuro-oncology patients. This new volume will have updates on all of the material from the second edition, and in addition features several new important chapters covering diverse topics such as imaging for the use of Laser Interstitial Thermal Therapy, advanced imaging techniques in radiation therapy, therapeutic treatment fields, response assessment in clinical trials, surgical planning of neoplastic disease of the spine, and more. Sections first overview neuro-oncological disorders before delving into the physics and basic science of neuroimaging and great focus on CT and MRI. The book then focuses on advances in the neuroimaging of brain tumors and neuroimaging of specific tumor types. There is also discussion of neuroimaging of other neuro-oncological syndromes. This book will serve as a resource of background information to neuroimaging researchers and basic scientists with an interest in brain tumors and neuro-oncology. Summarizes translational research on brain imaging for brain tumors Discusses limitations of neuroimaging for diagnosis and treatment Presents advanced imaging technologies, including CT, MRI, and PET Contains new coverage on Laser Interstitial Thermal Therapy, radiation therapy, clinical trials, and more
Nanobiomedicine
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Author : Shailendra K. Saxena
language : en
Publisher: Springer Nature
Release Date : 2020-02-03
Nanobiomedicine written by Shailendra K. Saxena and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-02-03 with Medical categories.
This book provides a comprehensive overview of the recent trends in various Nanotechnology-based therapeutics and challenges associated with its development. Nanobiotechnology is an interdisciplinary research that has wide applications in the various fields of biomedical research. The book discusses the various facets of the application of Nanotechnology in drug delivery, clinical diagnostics, Nanomedicine and treatment of infectious and chronic diseases. The book also highlights the recent advancements on important devices and applications that are based on Nanotechnology in medicine and brief the regulatory and ethical issues related to nanomedical devices. It also reviews the toxicological profile of various nanomaterials and emphasizes the need for safe nanomaterials for clinical use. Finally, the book discusses the recent developments of potential commercial applications of Nanotechnology.
Oral Drug Absorption
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Author : Jennifer B. Dressman
language : en
Publisher: CRC Press
Release Date : 2016-04-19
Oral Drug Absorption written by Jennifer B. Dressman and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-19 with Medical categories.
Oral Drug Absorption, Second Edition thoroughly examines the special equipment and methods used to test whether drugs are released adequately when administered orally. The contributors discuss methods for accurately establishing and validating in vitro/in vivo correlations for both MR and IR formulations, as well as alternative approaches for MR an
Fluorine Magnetic Resonance Imaging
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Author : Ulrich Flogel
language : en
Publisher: CRC Press
Release Date : 2016-10-26
Fluorine Magnetic Resonance Imaging written by Ulrich Flogel and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-10-26 with Medical categories.
Over the past decade, fluorine (19F) magnetic resonance imaging (MRI) has garnered significant scientific interest in the biomedical research community owing to the unique properties of fluorinated materials and the 19F nucleus. Fluorine has an intrinsically sensitive nucleus for MRI. There is negligible endogenous 19F in the body and thus there is no background signal. Fluorine-containing compounds are ideal tracer labels for a wide variety of MRI applications. Moreover, the chemical shift and nuclear relaxation rate can be made responsive to physiology via creative molecular design. This book is an interdisciplinary compendium that details cutting-edge science and medical research in the emerging field of 19F MRI. Edited by Ulrich Flögel and Eric Ahrens, two prominent MRI researchers, this book will appeal to investigators involved in MRI, biomedicine, immunology, pharmacology, probe chemistry, and imaging physics.
Drug Delivery Approaches
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Author : Bret Berner
language : en
Publisher: John Wiley & Sons
Release Date : 2021-08-04
Drug Delivery Approaches written by Bret Berner and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-08-04 with Medical categories.
Explore this comprehensive discussion of the application of physiologically- and physicochemical-based models to guide drug delivery edited by leading experts in the field Drug Delivery Approaches: Perspectives from Pharmacokinetics and Pharmacodynamics delivers a thorough discussion of drug delivery options to achieve target profiles and approaches as defined by physical and pharmacokinetic models. The book offers an overview of drug absorption and physiological models, chapters on oral delivery routes with a focus on both PBPK and multiple dosage form options. It also provides an explanation of the pharmacokinetics of the formulation of drugs delivered by systemic transdermal routes. The distinguished editors have included practical and accessible resources that address the biological and delivery approaches to pulmonary and mucosal delivery of drugs. Emergency care settings are also described, with explorations of the relationship between parenteral infusion profiles and PK/PD. The future of drug delivery is addressed via discussions of virtual experiments to elucidate mechanisms and approaches to drug delivery and personalized medicine. Readers will also benefit from the inclusion of: A thorough introduction to the utility of mathematical models in drug development and delivery An exploration of the techniques and applications of physiologically based models to drug delivery Discussions of oral delivery and pharmacokinetic models and oral site-directed delivery A review of integrated transdermal delivery and pharmacokinetics in development An examination of virtual experiment methods for integrating pharmacokinetic, pharmacodynamic, and drug delivery mechanisms Alternative endpoints to pharmacokinetics for topical delivery Perfect for researchers, industrial scientists, graduate students, and postdoctoral students in the area of pharmaceutical science and engineering, Drug Delivery Approaches: Perspectives from Pharmacokinetics and Pharmacodynamics will also earn a place in the libraries of formulators, pharmacokineticists, and clinical pharmacologists.
Fundamentals And Industrial Applications Of Magnetic Nanoparticles
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Author : Chaudhery Mustansar Hussain
language : en
Publisher: Woodhead Publishing
Release Date : 2022-03-30
Fundamentals And Industrial Applications Of Magnetic Nanoparticles written by Chaudhery Mustansar Hussain and has been published by Woodhead Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-03-30 with Technology & Engineering categories.
Fundamentals and Industrial Applications of Magnetic Nanomaterials highlights industrial applications of magnetic nanoparticles, reviews their rapidly emerging applications, and discusses future research directions. The book emphasizes the structure-property-functionality of magnetic nanoparticles for the most relevant industry applications. After reviewing the fundamentals, industry applications in the biomedical, pharma, environmental, cosmetics and energy industries are explored. Cross-cutting barriers to commercialization are then discussed, along with legal, health and safety implications. Finally, opportunities for enabling a more sustainable future are covered. This book is suitable for researchers and practitioners in academia and industry in materials science and engineering, chemistry and chemical engineering. Reveals fundamental concepts of magnetic nanoparticles for modern industries and perspectives Establishes routes for the utilization of magnetic nanoparticles in commercial-scale manufacturing Discusses opportunities for magnetic nanoparticles to help enable sustainable applications
Magnetic Particle Imaging
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Author : Tobias Knopp
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-05-04
Magnetic Particle Imaging written by Tobias Knopp and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-05-04 with Medical categories.
This volume provides a comprehensive overview of recent developments in magnetic particle imaging (MPI), a novel imaging modality. Using various static and oscillating magnetic fields, and tracer materials made from iron oxide nanoparticles, MPI can perform background-free measurements of the particles’ local concentration. The method exploits the nonlinear remagnetization behavior of the particles and has the potential to surpass current methods for the detection of iron oxide in terms of sensitivity and spatiotemporal resolution. Starting from an introduction to the technology, the topics addressed include setting up an imaging device, assessment of image quality, development of new MPI tracer materials, and the first preclinical results. This is the first book to be published on magnetic particle imaging, and it will be an invaluable source of information for everyone with an interest in this exciting new modality.
Structure Activity Relationship Studies In Drug Development By Nmr Spectroscopy
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Author : Atta-ur- Rahman
language : en
Publisher: Bentham Science Publishers
Release Date : 2011
Structure Activity Relationship Studies In Drug Development By Nmr Spectroscopy written by Atta-ur- Rahman and has been published by Bentham Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Science categories.
"NMR (Nuclear Magnetic Resonance) Spectroscopy has found significant applications in drug discovery based on its capacity to map molecular interactions at the atomic level. Chemical shifts, cross relaxation, and exchange of protons are among the NMR parame"