Valproate

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Valproate

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Author : Wolfgang Löscher
language : en
Publisher: Birkhäuser
Release Date : 2012-12-06

Valproate written by Wolfgang Löscher and has been published by Birkhäuser this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.

Since the fortuitous discovery of its anticonvulsant activIty in 1962, valproate has established itself worldwide as a major antiepileptic drug against several types of epileptic seizures. Clinical experience with valpro ate has continued to grow in recent years, including use of valproate for diseases other than epilepsy, for example in bipolar disorders and migraine. In this volume on valproate emphasis is placed on the scientific back ground leading to the discovery of val pro ate, its subsequent pharmacologi cal and toxicological characterization, and its clinical development into one of the most widely and successfully used anti epileptic drugs, a real mile stone in drug therapy. The current state of knowledge of valproate will be reviewed by experts in the field, including new hypotheses about its mecha nisms of action, its metabolism into pharmacologically active metabolites, its unique distribution characteristics, its unwanted hepatotoxic and terato genic adverse effects and its various clinical uses. Furthermore, the wide variety of available pharmaceutical formulations of valproate, including novel controlled-release formulations, will be outlined. The monograph is aimed at a broad readership, particularly neurologists, psychiatrists and basic scientists working in the field of epilepsy research. Because the monograph also deals with structure-activity relationships of valproate as well as of its metabolites and analogs, the book should also serve for rese archers working in medicinal chemistry, particularly in the pharmaceutical industry.

Valproic Acid

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Author : National Institute of Neurological and Communicative Disorders and Stroke. Neurological Disorders Program
language : en
Publisher:
Release Date : 1978

Valproic Acid written by National Institute of Neurological and Communicative Disorders and Stroke. Neurological Disorders Program and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1978 with Anticonvulsants categories.

"This bibliography is published to aid in the dissemination of information about valproic acid, to advance the treatment of persons with seizures, and to stimulated research in antiepileptic drug therapy." 734 references to worldwide journal articles and monographic literature available as of Oct. 1, 1978. Classified arrangement. Subject (keyword), author indexes.

The Place Of Sodium Valproate In The Treatment Of Epilepsy

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Author : M. J. Parsonage
language : en
Publisher: Royal Society of Medicine Press
Release Date : 1980

The Place Of Sodium Valproate In The Treatment Of Epilepsy written by M. J. Parsonage and has been published by Royal Society of Medicine Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1980 with Medical categories.

Valproate

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Author : Günter Krämer
language : en
Publisher:
Release Date : 2010

Valproate written by Günter Krämer and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with categories.

Valproate Sodium Second Edition

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Author : G. J. Blokdijk
language : en
Publisher: Createspace Independent Publishing Platform
Release Date : 2018-01-19

Valproate Sodium Second Edition written by G. J. Blokdijk and has been published by Createspace Independent Publishing Platform this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-01-19 with categories.

How much am I likely to spend on Valproate Sodium prescription drugs? How much do I need to really understand about the interactions of my Valproate Sodium prescription drugs? What is the safest way to dispose of unused prescription Valproate Sodium medication? When should I be on Valproate Sodium medication? Is Valproate Sodium compatible with my current prescribed medication? Always talk to your doctor about Valproate Sodium, your condition and your treatment. But what exactly to ask your doctor to make sure you are both covering everything you need to know about Valproate Sodium? 'Valproate Sodium; Second Edition' presents readers with a whole new set of 588 pivotal questions to discuss your situation with your healthcare provider, consider your options, and help you make decisions that are right for you. 'Valproate Sodium; Second Edition' poses questions that Valproate Sodium medication users didn't even know they needed to ask. With lots of room to note down your doctor's answers and an extensive index, this book is a must-have for anyone who has, or is about to have, Valproate Sodium prescription medication, and indispensable for healthcare providers who want to make sure they are able to answer every question.

Fourth International Symposium On Sodium Valproate And Epilepsy

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Author : David Chadwick
language : en
Publisher:
Release Date : 1989

Fourth International Symposium On Sodium Valproate And Epilepsy written by David Chadwick and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1989 with Medical categories.

Valproic Acid

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Author : Alexis Boucher
language : en
Publisher: Nova Science Publishers
Release Date : 2013

Valproic Acid written by Alexis Boucher and has been published by Nova Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with Valproic acid categories.

Valproic acid (VPA) is a short chain fatty acid which has been used medicinally to treat conditions as far reaching as epilepsy, Bipolar disorder, migraines, and cancer. In this book, the authors research the pharmacology, mechanisms of action and clinical implications of valproic acid. Topics discussed include novel applications of the anticonvulsant drug valproic acid in cancer therapeutics; VPA treatment for epilepsy; use of fish models in fetal valproate syndrome studies; prenatal valproic acid exposure correlating with the occurrence of autism; and using 3D spheroids to determine the acute and chronic lethal thresholds of valproic acid.

Pharmacokinetics And Metabolism Of The Antiepileptic Drug Sodium Valproate Depakine Epilim

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Author : Tom B. Vree
language : en
Publisher:
Release Date : 1977

Pharmacokinetics And Metabolism Of The Antiepileptic Drug Sodium Valproate Depakine Epilim written by Tom B. Vree and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1977 with Anticonvulsants categories.

Sodium Valproate

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Author : Bhagya Manoj Sattigeri
language : en
Publisher: LAP Lambert Academic Publishing
Release Date : 2012-06

Sodium Valproate written by Bhagya Manoj Sattigeri and has been published by LAP Lambert Academic Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-06 with categories.

Histological, electrophysiological and behavioral studies suggest a regulatory role of GABA on the DAergic neurons. Behavioral studies in animals have demonstrated that drugs which influence the activity of central GABAergic systems modulate the intensity of behaviors dependent on the functional status of nigrostriatal and mesolimbic DAergic systems. Sodium valproate, enhances theGABAergic neurotransmission by acting through different mechanisms. Our study demonstrates that at higher doses valproate also enhances the central 5HTergic neurotransmission by releasing 5HT. Histological studies demonstrate an anatomical connection between the central ascending serotonergic pathway and nigrostriatal dopaminergic pathway. Drugs known to influence the activity of central GABAergic systems have been reported to modulate the intensity of behaviors dependent on the functioning of the nigrostriatal DAergic systems and mesolimbic DAergic systems. Hence sodium valproate was investigated for its interaction and influence on DAergic and 5HTergic systems with the help of behavioral models in animals with the hope of its use in specific psychiatric disorders.

Idiosyncratic Reactions To Valproate

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Author : Rene H. Levy
language : en
Publisher:
Release Date : 1991-01-01

Idiosyncratic Reactions To Valproate written by Rene H. Levy and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991-01-01 with categories.