Vascular Smooth Muscle
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Mechanisms Of Vascular Disease
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Author : Robert Fitridge
language : en
Publisher: University of Adelaide Press
Release Date : 2011
Mechanisms Of Vascular Disease written by Robert Fitridge and has been published by University of Adelaide Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Medical categories.
New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.
Vascular Smooth Muscle Structure And Function In Health And Disease
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Author : Chi-ming Hai
language : en
Publisher: World Scientific
Release Date : 2016-10-12
Vascular Smooth Muscle Structure And Function In Health And Disease written by Chi-ming Hai and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-10-12 with Science categories.
This book presents key concepts in the structure and function of vascular smooth muscle cells in health and disease. Supplemental reading may be drawn from the extensive references listed at the end of each chapter. Vascular smooth muscle cell is the major cell type in blood vessels. Dysfunction of vascular smooth muscle cells is an important cause of vascular diseases, for example, atherosclerosis, hypertension, and circulatory shock. Vascular smooth muscle cells are phenotypically plastic, capable of switching between two major phenotypes — contractile/differentiated phenotype and invasive/proliferative phenotype in response to environmental clues. Chapter 1 introduces the major areas of research presented in this monograph. Chapters 2 to 4 address the structure and function of the contractile/differentiated phenotype of vascular smooth muscle cell. Chapters 5 and 6 address the developmental basis of vascular smooth muscle cell phenotype and structure and function of podosomes (invasive organelles) in the invasive/proliferative phenotype of vascular smooth muscle cell. Chapters 7 to 9 address the role of vascular smooth muscle cell dysfunction in vascular diseases — atherosclerosis, hypertension, and circulatory shock.
The Vascular Smooth Muscle Cell
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Author :
language : en
Publisher: Elsevier
Release Date : 1995-10-24
The Vascular Smooth Muscle Cell written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995-10-24 with Science categories.
In the last several years, the development of reagents that recognize smooth muscle-specific proteins has enabled researchers to identify smooth muscle cells (SMC) in tissue undergoing both differentiation and repair. These developments have led to increased research on SMC. The latest volume in the Biology of the Extracellular Matrix Series takes a current and all-encompassing look at this growing area of research. Devoted entirely to the subject of SMC, the book covers a diversity of topics-from SMC architecture and contractility to differentiation and gene expression in development. It also examines the proliferation and replication of SMC and its role in pharmacology and vascular disease. A must for cell, developmental, and molecular biologists, this book also will appeal to cardiologists, pathologists, and biomedical researchers interested in smooth muscle cells. Presents a molecular, genetic, and developmental perspective of the vas smooth muscle cell Overview sections highlight key points of chapters, including the clinical relevance of the research and expectations for future study Appeals to both the basic biologist and to the biomedical researcher of vascular disease
Vascular Smooth Muscle Culture
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Author : Julie H. Campbell
language : en
Publisher: Springer
Release Date : 1987-05-31
Vascular Smooth Muscle Culture written by Julie H. Campbell and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1987-05-31 with Medical categories.
Ionic Actions On Vascular Smooth Muscle
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Author : E. Betz
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Ionic Actions On Vascular Smooth Muscle written by E. Betz and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
This book contains the contributions and discussions of the second symposium on vascular smooth muscles held in Ttibingen in February, 1976. It provides an up-to-date review of the role of ions in the trans mission of signals from the perivascular space to the contractile ele ments of the smooth muscle cells. The various aspects are mainly discussed from a functional point of view and only few contributions concern the morphologic variations of cells .during varying ion activity. Special emphasis was placed on the significance of ion variations in the cerebral tissue and their rela tion to metabolic and nervous control of the brain vessels. It could be seen in this symposium that new techniques enabled the in vestigators to make considerable progress in the understanding of the actions and the interactions of ions on the membranes and on the inter nal structures of the smooth muscle cells if one compares the findings with the results of the previous symposium held in Ttibingen in 1972. It became evident that the insight into ionic actions enables the de velopment of powerful tools to be utilized in future therapy of dis turbances of local blood flow regulation. The participants of the symposium render thanks to the Dr. Thiemann GmbH in Ltinen, which supported the symposium and this publication in a generous way. Finally it is a pleasure of the Editor to thank the members of the Physiological Institute of Ttibingen for their encouragement in the ar rangement of the meeting.
Vascular Smooth Muscle
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Author : Chi-Ming Hai
language : en
Publisher:
Release Date : 2016
Vascular Smooth Muscle written by Chi-Ming Hai and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with Vascular smooth muscle categories.
Vascular Smooth Muscle Metabolic Ionic And Contractile Mechanisms
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Author : M.F. III Crass
language : en
Publisher: Elsevier
Release Date : 2012-12-02
Vascular Smooth Muscle Metabolic Ionic And Contractile Mechanisms written by M.F. III Crass and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Medical categories.
Vascular Smooth Muscle: Metabolic, Ionic, and Contractile Mechanisms addresses the vascular smooth muscle function by describing plasma lipoprotein structure, synthesis, and transport in relation to the concepts of altered vascular smooth muscle lipid metabolism leading to the genesis of atherosclerotic disease. This book is organized into six chapters and begins with an introduction to the complexities of energy metabolism and how metabolic events can be correlated with a simultaneous quantitative assessment of smooth muscle mechanics and the contractile machinery at the molecular level. The next two chapters offer the reader a view of smooth muscle membrane properties in terms of the distribution, transport, and metabolic control of electrolytes and specific aspects of ion conductance and electrical activity. This text also explains how smooth muscle cells regulate their contractile activity through regulation of calcium ion fluxes and the interaction, at the molecular level, of calcium ions with regulatory proteins associated with the contractile apparatus. Reference is made to the relation of possible anomalies in cellular or subcellular smooth muscle metabolic and/or ionic events to the bases of certain types of vascular disease. A chapter that examines the events leading to vascular pathology in the form of atherogenesis concludes the book. This book is intended for researchers and clinicians engaged in the study of smooth muscle and related areas.
Vascular Smooth Muscle In Culture
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Author :
language : en
Publisher:
Release Date : 1987
Vascular Smooth Muscle In Culture written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1987 with Cultures (Biology) categories.
Vascular Smooth Muscle Cell Fate And Vascular Remodeling Mechanisms Therapeutic Targets And Drugs Volume I
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Author : Ping Song
language : en
Publisher: Frontiers Media SA
Release Date : 2022-09-26
Vascular Smooth Muscle Cell Fate And Vascular Remodeling Mechanisms Therapeutic Targets And Drugs Volume I written by Ping Song and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-09-26 with Science categories.
Regulation Of Vascular Smooth Muscle Function
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Author : Raouf A. Khalil
language : en
Publisher: Biota Publishing
Release Date : 2010-05-01
Regulation Of Vascular Smooth Muscle Function written by Raouf A. Khalil and has been published by Biota Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-05-01 with Medical categories.
Vascular smooth muscle (VSM) constitutes most of the tunica media in blood vessels and plays an important role in the control of vascular tone. Ca2+ is a major regulator of VSM contraction and is strictly regulated by an intricate system of Ca2+ mobilization and Ca2+ homeostatic mechanisms. The interaction of a physiological agonist with its plasma membrane receptor stimulates the hydrolysis of membrane phospholipids and increases the generation of inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). IP3 stimulates Ca2+ release from the intracellular stores in the sarcoplasmic reticulum. Agonists also stimulate Ca2+ influx from the extracellular space via voltage-gated, receptor-operated, and store-operated channels. Ca2+ homeostatic mechanisms tend to decrease the intracellular free Ca2+ concentration ([Ca2+]i) by activating Ca2+ extrusion via the plasmalemmal Ca2+ pump and the Na+/Ca2+ exchanger and the uptake of excess Ca2+ by the sarcoplasmic reticulum and possibly the mitochondria. A threshold increase in [Ca2+]i activates Ca2+-dependent myosin light chain (MLC) phosphorylation, stimulates actin–myosin interaction, and initiates VSM contraction. The agonist-induced maintained increase in DAG also activates specific protein kinase C (PKC) isoforms, which in turn cause phosphorylation of cytoplasmic substrates that increase the contractile myofilaments force sensitivity to Ca2+ and thereby enhance VSM contraction. Agonists could also activate Rho kinase (ROCK), leading to inhibition of MLC phosphatase and further enhancement of the myofilaments force sensitivity to Ca2+. The combined increases in [Ca2+]i, PKC and ROCK activity cause significant vasoconstriction and could also stimulate VSM hypertrophy and hyperplasia. The protracted and progressive activation of these processes could lead to pathological vascular remodeling and vascular disease.