Viagem Solit Ria Nova Edi O


Viagem Solit Ria Nova Edi O
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Translational Medicine


Translational Medicine
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Author : Joy A. Cavagnaro
language : en
Publisher: CRC Press
Release Date : 2021-11-26

Translational Medicine written by Joy A. Cavagnaro and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-26 with Medical categories.


Translational Medicine: Optimizing Preclinical Safety Evaluation of Biopharmaceuticals provides scientists responsible for the translation of novel biopharmaceuticals into clinical trials with a better understanding of how to navigate the obstacles that keep innovative medical research discoveries from becoming new therapies or even making it to clinical trials. The book includes sections on protein-based therapeutics, modified proteins, oligonucleotide-based therapies, monoclonal antibodies, antibody–drug conjugates, gene and cell-based therapies, gene-modified cell-based therapies, combination products, and therapeutic vaccines. Best practices are defined for efficient discovery research to facilitate a science-based, efficient, and predictive preclinical development program to ensure clinical efficacy and safety. Key Features: Defines best practices for leveraging of discovery research to facilitate a development program Includes general principles, animal models, biomarkers, preclinical toxicology testing paradigms, and practical applications Discusses rare diseases Discusses "What-Why-When-How" highlighting different considerations based upon product attributes. Includes special considerations for rare diseases About the Editors Joy A. Cavagnaro is an internationally recognized expert in preclinical development and regulatory strategy with an emphasis on genetic medicines.. Her 40-year career spans academia, government (FDA), and the CRO and biotech industries. She was awarded the 2019 Arnold J Lehman Award from the Society of Toxicology for introducing the concept of science-based, case-by-case approach to preclinical safety evaluation, which became the foundation of ICH S6. She currently serves on scientific advisory boards for advocacy groups and companies and consults and lectures in the area of preclinical development of novel therapies. Mary Ellen Cosenza is a regulatory toxicology consultant with over 30 years of senior leadership experience in the biopharmaceutical industry in the U.S., Europe, and emerging markets. She has held leadership position in both the American College of Toxicology (ACT) and the International Union of Toxicology (IUTOX) and is also an adjunct assistant professor at the University of Southern California where she teaches graduate-level courses in toxicology and regulation of biologics.



Palms And People In The Amazon


Palms And People In The Amazon
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Author : Nigel Smith
language : en
Publisher: Springer
Release Date : 2014-09-26

Palms And People In The Amazon written by Nigel Smith and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-09-26 with Science categories.


This book explores the degree to which landscapes have been enriched with palms by human activities and the importance of palms for the lives of people in the region today and historically. Palms are a prominent feature of many landscapes in Amazonia, and they are important culturally, economically, and for a variety of ecological roles they play. Humans have been reorganizing the biological furniture in the region since the first hunters and gatherers arrived over 20,000 years ago.



The Land Within


The Land Within
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Author : Pedro García Hierro
language : en
Publisher: IWGIA
Release Date : 2005

The Land Within written by Pedro García Hierro and has been published by IWGIA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Science categories.


By describing the fabric of relationships indigenous peoples weave with their environment, The Land Within attempts to define a more precise notion of indigenous territoriality. A large part of the work of titling the South American indigenous territories may now be completed but this book aims to demonstrate that, in addition to management, these territories involve many other complex aspects that must not be overlooked if the risk of losing these areas to settlers or extraction companies is to be avoided. Alexandre Surralls holds a doctorate in anthropology from the School for Higher Studies in Social Sciences and is a researcher on the staff of the National Centre for Scientific Research. Pedro Garca Hierro is a lawyer from Madrid Complutense University and the Pontifical Catholic University of Peru. He has worked with various indigenous organizations, on issues related to the identification and development of collective rights and the promotion of intercultural democratic reforms.



Exotic Nations


Exotic Nations
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Author : Renata Ruth Mautner Wasserman
language : en
Publisher: Cornell University Press
Release Date : 1994

Exotic Nations written by Renata Ruth Mautner Wasserman and has been published by Cornell University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994 with Literary Criticism categories.


In this highly original and critically informed book, Renata R. Mautner Wasserman looks at how, during the first decades following political independence, writers in the United States and Brazil assimilated and subverted European images of an "exotic" New World to create new literatures that asserted cultural independence and defined national identity. Exotic Nations demonstrates that the language of exoticism thus became part of the New World's interpretation of its own history and natural environment.



Landforms And Landscapes Of Portugal


Landforms And Landscapes Of Portugal
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Author : Gonçalo Vieira
language : en
Publisher: Springer
Release Date : 2016-01-08

Landforms And Landscapes Of Portugal written by Gonçalo Vieira and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-01-08 with Science categories.


The book brings together contributions from over 35 Portuguese geomorphologists, presenting a thorough overview of the main highlights of the landscape of Portugal's mainland, Azores and Madeira. The book, which is a tribute to Professor António de Brum Ferreira, first President of the Portuguese Association of Geomorphologists and former Professor at the University of Lisbon, who passed away in January 2013, is organized in 3 parts: a) Introduction, which presents a general framework of the physical geography of Portugal, b) Geomorphological landscapes, presenting ca. 30 short papers with regional focus on key geomorphological areas, c) Applied geomorphology, providing an updated vision on the protection of geomorphological heritage with a focus on geoparks, as well as on Geomorphological hazards in Portugal. This first book ever to concentrate on the geomorphology of Portugal will surely become a benchmark for Portuguese geomorphology.



The Family In Question


The Family In Question
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Author : R. D. Grillo
language : en
Publisher: Amsterdam University Press
Release Date : 2008

The Family In Question written by R. D. Grillo and has been published by Amsterdam University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Social Science categories.


The family lives of immigrants and ethnic minority populations have become central to arguments about the right and wrong ways of living in multicultural societies. While the characteristic cultural practices of such families have long been scrutinized by the media and policy makers, these groups themselves are beginning to reflect on how to manage their family relationships. Exploring case studies from Austria, the Netherlands, Norway, Portugal, Spain, Switzerland, the United Kingdom, and Australia, The Family in Question explores how those in public policy often dangerously reflect the popular imagination, rather than recognizing the complex changes taking place within the global immigrant community. In hoeverre allochtonen vrij zijn hun cultuur te uiten in de multiculturele samenleving staat bijna dagelijks ter discussie in de media en politiek. Vaak wordt vergeten dat ook migrantenfamilies zelf worstelen om hun tradities en gebruiken vorm te geven in een pluriforme samenleving waarin relaties met familie zeer complex kunnen zijn. In The Family Question worden migrantenfamilies in onder andere Nederland, Oostenrijk en Noorwegen onderzocht. Hieruit blijkt dat spelers op het vlak van beleidsvorming vaak toegeven aan populaire misverstanden over allochtonen en zo bijdragen aan de heersende xenofobie en stereotypering van immigranten.



Science Voyages And Encounters In Oceania 1511 1850


Science Voyages And Encounters In Oceania 1511 1850
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Author : Bronwen Douglas
language : en
Publisher: Springer
Release Date : 2014-03-26

Science Voyages And Encounters In Oceania 1511 1850 written by Bronwen Douglas and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-03-26 with History categories.


Blending global scope with local depth, this book throws new light on important themes. Spanning four centuries and vast space, it combines the history of ideas with particular histories of encounters between European voyagers and Indigenous people in Oceania (Island Southeast Asia, New Guinea, Australia, New Zealand, and the Pacific Islands).



Spatial And Temporal Dimensions For Legal History


Spatial And Temporal Dimensions For Legal History
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Author : Massimo Meccarelli
language : en
Publisher: Max Planck Institute for European Legal History
Release Date : 2016-07-01

Spatial And Temporal Dimensions For Legal History written by Massimo Meccarelli and has been published by Max Planck Institute for European Legal History this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-07-01 with Law categories.


http://dx.doi.org/10.12946/gplh6http://www.epubli.de/shop/buch/53894"The spatiotemporal conjunction is a fundamental aspect of the juridical reflection on the historicity of law. Despite the fact that it seems to represent an issue directly connected with the question of where legal history is heading today, it still has not been the object of a focused inquiry. Against this background, the book’s proposal consists in rethinking key confluences related to this problem in order to provide coordinates for a collective understanding and dialogue. The aim of this volume, however, is not to offer abstract methodological considerations, but rather to rely both on concrete studies, out of which a reflection on this conjunction emerges, as well as on the reconstruction of certain research lines featuring a spatiotemporal component. This analytical approach makes a contribution by providing some suggestions for the employment of space and time as coordinates for legal history. Indeed, contrary to those historiographical attitudes reflecting a monistic conception of space and time (as well as a Eurocentric approach), the book emphasises the need for a delocalized global perspective. In general terms, the essays collected in this book intend to take into account the multiplicity of the spatiotemporal confines, the flexibility of those instruments that serve to create chronologies and scenarios, as well as certain processes of adaptation of law to different times and into different spaces. The spatiotemporal dynamism enables historians not only to detect new perspectives and dimensions in foregone themes, but also to achieve new and compelling interpretations of legal history. As far as the relationship between space and law is concerned, the book analyses experiences in which space operates as a determining factor of law, e.g. in terms of a field of action for law. Moreover, it outlines the attempted scales of spatiality in order to develop legal historical research. With reference to the connection between time and law, the volume sketches the possibility of considering the factor of time, not just as a descriptive tool, but as an ascriptive moment (quasi an inner feature) of a legal problem, thus making it possible to appreciate the synchronic aspects of the ‘juridical experience’. As a whole, the volume aims to present spatiotemporality as a challenge for legal history. Indeed, reassessing the value of the spatiotemporal coordinates for legal history implies thinking through both the thematic and methodological boundaries of the discipline."



A Comparative History Of Literatures In The Iberian Peninsula


A Comparative History Of Literatures In The Iberian Peninsula
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Author : Fernando Cabo Aseguinolaza
language : en
Publisher: John Benjamins Publishing
Release Date : 2010-05-26

A Comparative History Of Literatures In The Iberian Peninsula written by Fernando Cabo Aseguinolaza and has been published by John Benjamins Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-05-26 with Literary Criticism categories.


A Comparative History of Literatures in the Iberian Peninsula is the second comparative history of a new subseries with a regional focus, published by the Coordinating Committee of the International Comparative Literature Association. As its predecessor for East-Central Europe, this two-volume history distances itself from traditional histories built around periods and movements, and explores, from a comparative viewpoint, a space considered to be a powerful symbol of inter-literary relations. Both the geographical pertinence and its symbolic condition are obviously discussed, when not even contested. Written by an international team of researchers who are specialists in the field, this history is the first attempt at applying a comparative approach to the plurilingual and multicultural literatures in the Iberian Peninsula. The aim of comprehensiveness is abandoned in favor of a diverse and extensive array of key issues for a comparative agenda. A Comparative History of Literatures in the Iberian Peninsula undermines the primacy claimed for national and linguistic boundaries, and provides a geo-cultural account of literary inter-systems which cannot otherwise be explained.



The Object Of The Atlantic


The Object Of The Atlantic
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Author : Rachel Price
language : en
Publisher: Northwestern University Press
Release Date : 2014-11-30

The Object Of The Atlantic written by Rachel Price and has been published by Northwestern University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-11-30 with Literary Criticism categories.


The Object of the Atlantic is a wide-ranging study of the transition from a concern with sovereignty to a concern with things in Iberian Atlantic literature and art produced between 1868 and 1968. Rachel Price uncovers the surprising ways that concrete aesthetics from Cuba, Brazil, and Spain drew not only on global forms of constructivism but also on a history of empire, slavery, and media technologies from the Atlantic world. Analyzing Jose Marti’s notebooks, Joaquim de Sousandrade’s poetry, Ramiro de Maeztu’s essays on things and on slavery, 1920s Cuban literature on economic restructuring, Ferreira Gullar’s theory of the “non-object,” and neoconcrete art, Price shows that the turn to objects—and from these to new media networks—was rooted in the very philosophies of history that helped form the Atlantic world itself.