Waken The Silent Majority Principles And Pathogenic Significance Of Non Acetyl Acylation And Other Understudied Post Translational Modifications
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Waken The Silent Majority Principles And Pathogenic Significance Of Non Acetyl Acylation And Other Understudied Post Translational Modifications
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Author : Yong Liu
language : en
Publisher: Frontiers Media SA
Release Date : 2022-05-04
Waken The Silent Majority Principles And Pathogenic Significance Of Non Acetyl Acylation And Other Understudied Post Translational Modifications written by Yong Liu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-05-04 with Science categories.
Post Traumatic Stress Disorder
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Author : Peter Shiromani
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-03-06
Post Traumatic Stress Disorder written by Peter Shiromani and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-03-06 with Medical categories.
Post-traumatic stress disorder is a psychiatric illness that can occur in anyone who has experienced a life-threatening or violent event. The trauma can be due to war, terrorism, torture, natural disasters, violence, or rape. In PTSD the brain areas that are likely to be affected are the hippocampus (memory), amygdala (fear association), the prefrontal cortex (cognitive processing), and the ascending reticular activating system (arousal). The chemical of interest is norepinephrine, which is released during a stressful event and is part of the fight-or-flight response meant to mobilize the body to action.The objective of this title is to outline the neurobiology of post-traumatic stress disorder and provide treatment strategies for clinicians. The chapter material from this book has evolved from a seminar on PTSD held recently under the auspices of the VA Boston Healthcare System, Boston University Medical Center and Harvard Medical School. We propose a book that will focus on the epidemiology, neurobiology, MRI studies, animal models, arousal and sleep issues, clinical trials, and treatment strategies for clinicians. Treatment will cover such topics as guidelines for treating posttraumatic stress disorder, PTSD and the use of mental health services, cognitive intervention therapy, and large scale clinical trials in PTSD. This collection will be a vital source of information to clinicians and neuroscientists.
Eukaryome Impact On Human Intestine Homeostasis And Mucosal Immunology
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Author : Nancy Guillen
language : en
Publisher: Springer Nature
Release Date : 2020-06-01
Eukaryome Impact On Human Intestine Homeostasis And Mucosal Immunology written by Nancy Guillen and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-06-01 with Medical categories.
Multiple demographic or economic parameters contribute to the origin of emerging infections, for example: poverty, urbanization, climate change, conflicts and population migrations. All these factors are a challenge to assess the impact (present and future) of parasitic diseases on public health. The intestine is a major target of these infections; it is a nutrient-rich environment harbouring a complex and dynamic population of 100 trillion microbes: the microbiome. Most researches on the microbiome focus on bacteria, which share the gut ecosystem with a population of uni- and multi cellular eukaryotic organisms that may prey on them. Our interest focuses on the families of eukaryotic microbes inhabiting the intestine, called “intestinal eukaryome”, that include fungi, protists and helminths. Knowledge on the reciprocal influence between the microbiome and the eukaryome, and on their combined impact on homeostasis and intestinal diseases is scanty and can be considered as an important emerging field. Furthermore, the factors that differentiate pathogenic eukaryotes from commensals are still unknown. This book presents an overview of the science presented and discussed in the First Eukaryome Congress held from October 16th to 18th, 2019 at the Pasteur Institute in Paris. This book covers the following topics: Phylogenetic, prevalence, and diversity of intestinal eukaryotic microbes; and their (still enigmatic) historical evolution and potential contributions to mucosal immune homeostasis. Integrative biology to study the molecular cell biology of parasite-host interactions and the multiple parameters underlining the infectious process. The exploitation of tissue engineering and microfluidics to establish three-dimensional (3D) systems that help to understand homeostasis and pathological processes in the human intestine.
The Science And Practice Of Lithium Therapy
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Author : Gin S. Malhi
language : en
Publisher: Springer
Release Date : 2016-11-24
The Science And Practice Of Lithium Therapy written by Gin S. Malhi and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-11-24 with Medical categories.
This book provides a clear and comprehensive guide to the clinical prescription of lithium that draws upon evidence-based knowledge of its mechanisms of action. The book is divided into two parts, on the science of lithium and the practice of lithium therapy. The former covers aspects such as the properties of the lithium ion, pharmacokinetics and pharmacodynamics, impact on neurotransmission, and gene expression modulation. The section on practice includes discussion of variability in response to lithium, use of lithium in the treatment of bipolar disorders, its value in suicide prevention, administration during pregnancy and in the pediatric age group, and side effects. Lithium is arguably the only true mood stabilizer, and its multifaceted effects across many clinical domains have given rise to a resurgence of interest in recent years, fuelled by both researchers and clinicians. Nevertheless, its use remains constrained by exaggerated concerns about potential side-effects. In reality, lithium is a simple molecule that is relatively straightforward to administer and monitor and has potentially profound benefits at a fraction of the cost of contemporary agents. This book dispels the many myths and concerns that surround its use and will be of interest for clinicians and researchers worldwide, and those that are recipients of lithium therapy.
Molecular Basis Of Resilience
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Author : Patrick L. Iversen
language : en
Publisher: Springer
Release Date : 2019-01-05
Molecular Basis Of Resilience written by Patrick L. Iversen and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-01-05 with Medical categories.
This book illuminates mechanisms of resilience. Threats and defense systems lead to adaptive changes in gene expression. Environmental conditions may dampen adaptive responses at the level of RNA expression. The first seven chapters elaborate threats to human health. Human populations spontaneously invade niche boundaries exposing us to threats that drive the resilience process. Emerging RNA viruses are a significant threat to human health. Antiviral drugs are reviewed and how viral genomes respond to the environment driving genome sequence plasticity. Limitations in predicting the human outcome are described in “nonlinear anomalies.” An example includes medical countermeasures for Ebola and Marburg viruses under the “Animal Rule.” Bacterial infections and a review of antibacterial drugs and bacterial resilience mediated by horizontal gene transfer follow. Chapter 6 shifts focus to cancer and discovery of novel therapeutics for leukemia. The spontaneous resolution of AML in children with Down syndrome highlights human resilience. Chapter 7 explores chemicals in the environment. Examples of chemical carcinogenesis illustrate how chemicals disrupt genomes. Historic research ignored RNA damage from chemically induced nucleic acid damage. The emergence of important forms of RNA and their possible role in resilience is proposed. Chapters 8-10 discuss threat recognition and defense systems responding to improve resilience. Chapter 8 describes the immune response as a threat recognition system and response via diverse RNA expression. Oligonucleotides designed to suppress specific RNA to manipulate the immune response including exon-skipping strategies are described. Threat recognition and response by the cytochrome P450 enzymes parallels immune responses. The author proposes metabolic clearance of small molecules is a companion to the immune system. Chapter 10 highlights RNA diversity expressed from a single gene. Molecular Resilience lists paths to RNA transcriptome plasticity forms the molecular basis for resilience. Chapter 11 is an account of ExonDys 51, an approved drug for the treatment of Duchenne muscular dystrophy. Chapter 12 addresses the question “what informs molecular mechanisms of resilience?” that drives the limits to adaptation and boundaries for molecular resilience. He speculates that radical oxygen, epigenetic modifications, and ligands to nuclear hormone receptors play critical roles in regulating molecular resilience.
Fungal Secondary Metabolism
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Author : Nancy P. Keller
language : en
Publisher: Humana Press
Release Date : 2012-10-14
Fungal Secondary Metabolism written by Nancy P. Keller and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-10-14 with Science categories.
Filamentous fungi have long been known for their ability to produce an enormous range of unusual chemical compounds known as secondary metabolites, many of which have potentially useful antibiotic or pharmacological properties. Recent focus on fungal genomics coupled with advances in detection and molecular manipulation techniques has galvanized a revitalization of this field. Fungal Secondary Metabolism: Methods and Protocols is aimed at providing the key methodologies currently in use and necessary for accessing and exploiting the natural product information provided by the genomes of this large and varied kingdom. Written by active researchers in the field, the chapters deal with all the steps necessary, from optimization of fungal culture conditions for metabolite production, through rapid genome sequencing and bioinformatics, and genetic manipulations for functional analysis, to detection and testing of metabolites. In addition, chapters on basic science address approaches to the genetic regulation, protein biochemistry, and cellular localization of the biosynthetic pathways. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and hands-on, Fungal Secondary Metabolism: Methods and Protocols encourages new investigators to enter the field and expands upon the expertise and range of skills of those already researching fungal natural products.
Medicinal Chemistry
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Author : Thomas Nogrady
language : en
Publisher: Oxford University Press
Release Date : 2005-08-11
Medicinal Chemistry written by Thomas Nogrady and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-08-11 with Medical categories.
Fully updated and rewritten by a basic scientist who is also a practicing physician, the third edition of this popular textbook remains comprehensive, authoritative and readable. Taking a receptor-based, target-centered approach, it presents the concepts central to the study of drug action in a logical, mechanistic way grounded on molecular and principles. Students of pharmacy, chemistry and pharmacology, as well as researchers interested in a better understanding of drug design, will find this book an invaluable resource. Starting with an overview of basic principles, Medicinal Chemistry examines the properties of drug molecules, the characteristics of drug receptors, and the nature of drug-receptor interactions. Then it systematically examines the various families of receptors involved in human disease and drug design. The first three classes of receptors are related to endogenous molecules: neurotransmitters, hormones and immunomodulators. Next, receptors associated with cellular organelles (mitochondria, cell nucleus), endogenous macromolecules (membrane proteins, cytoplasmic enzymes) and pathogens (viruses, bacteria) are examined. Through this evaluation of receptors, all the main types of human disease and all major categories of drugs are considered. There have been many changes in the third edition, including a new chapter on the immune system. Because of their increasingly prominent role in drug discovery, molecular modeling techniques, high throughput screening, neuropharmacology and genetics/genomics are given much more attention. The chapter on hormonal therapies has been thoroughly updated and re-organized. Emerging enzyme targets in drug design (e.g. kinases, caspases) are discussed, and recent information on voltage-gated and ligand-gated ion channels has been incorporated. The sections on antihypertensive, antiviral, antibacterial, anti-inflammatory, antiarrhythmic, and anticancer drugs, as well as treatments for hyperlipidemia and peptic ulcer, have been substantially expanded. One new feature will enhance the book's appeal to all readers: clinical-molecular interface sections that facilitate understanding of the treatment of human disease at a molecular level.
Autoimmune Neurology
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Author :
language : en
Publisher: Elsevier
Release Date : 2016-03-11
Autoimmune Neurology written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-03-11 with Science categories.
Autoimmune Neurology presents the latest information on autoimmune neurologic disease, the immune response to the body where organs run wild, causing the immune system to attack itself. Autoimmunity is a main element in numerous nervous system diseases and can target any structure within the central or peripheral nervous system. Over the past 20 years, significant advances in our understanding of the pathophysiology of autoimmune disorders, including the use of biomarkers has led to new diagnosis and treatment options. Neurologic conditions associated with autoimmune reactions include dementia, neuromuscular disease, epilepsy, sleep disorders, diabetes, and other common neurologic disorders and disease. This current tutorial-reference will be a must-have title for clinical neurologists, research neurologists, neuroscientists, and any medical professional working with autoimmune disease and disorders. Includes comprehensive coverage of autoimmune neurology Details the latest techniques for the study, diagnosis, and treatment of diseases and disorders, including dementia, neuromuscular disease, epilepsy, and sleep disorders Presents a focused reference for clinical practitioners and the clinical neurology and neurology research communities
Critical Care Nursing
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Author : Kathy J. Booker
language : en
Publisher: John Wiley & Sons
Release Date : 2014-12-11
Critical Care Nursing written by Kathy J. Booker and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-12-11 with Medical categories.
Providing an easy-to-use reference, Critical Care Nursing outlines best practice for the assessment, monitoring and treatment of critically ill adult patients. Each chapter includes research and evidence-based strategies for treating commonly-seen conditions. Initial chapters introduce ICU set-up and operation, the rapid response team, vitals measurement and shock management strategies. Subsequent chapters, structured by organ system, focus on care relating to specific organ function and dysfunction, including the respiratory, cardiovascular, neurologic, renal and gastrointestinal systems. Key information on monitoring for overdoses, special considerations in traumatic injury and end-of-life concerns is also included. Critical Care Nursing is a comprehensive and informative resource for experienced staff nurses and advanced practice nurses working with critically ill patients on ICUs, PCUs, transitional care units and within emergency care departments.
Precision Psychiatry
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Author : Leanne M. Williams, Ph.D.
language : en
Publisher: American Psychiatric Pub
Release Date : 2021-10-15
Precision Psychiatry written by Leanne M. Williams, Ph.D. and has been published by American Psychiatric Pub this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-10-15 with Medical categories.
Precision psychiatry, as outlined in this groundbreaking book, presents a new path forward. By integrating findings from basic and clinical neuroscience, clinical practice, and population-level data, the field seeks to develop therapeutic approaches tailored for specific individuals with a specific constellation of health issues, characteristics, strengths, and symptoms.