Wt1 Role In Mammary Gland And Breast Cancer Biology
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Wt1 Role In Mammary Gland And Breast Cancer Biology
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Author : Mara Artibani
language : en
Publisher:
Release Date : 2015
Wt1 Role In Mammary Gland And Breast Cancer Biology written by Mara Artibani and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with categories.
Perspectives In Mammary Gland Development And Breast Cancer Research
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Author : Zuzana Koledova
language : en
Publisher: Frontiers Media SA
Release Date : 2020-10-27
Perspectives In Mammary Gland Development And Breast Cancer Research written by Zuzana Koledova and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-10-27 with Science categories.
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Methods In Mammary Gland Biology And Breast Cancer Research
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Author : Margot M. Ip
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Methods In Mammary Gland Biology And Breast Cancer Research written by Margot M. Ip and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
approaches to the experimental problems that still face us in understanding this most fascinating of organs. Too many people contributed to the completion of this volume to allow acknowledg ment of all the individual efforts, but we particularly thank the reviewers whose input into the editorial process was invaluable and the authors of these chapters who revised their text, sometimes more than once, to bring it to the high standards set by the Editors. The Com mittee gratefully acknowledges the support ofVysis, Inc. , in the publication of a color figure in Chapter 19, by S. Weber-Hall and Trevor Dale. Finally, we wish to express our heartfelt appreciation to Margot Ip and Bonnie Asch, who worked long and hard to bring this volume to fruition. Margaret C. Neville for the Committee on Mammary Gland Biology Preface One of the most exciting and beneficial developments in research on mammary gland biology and breast cancer has been the influx of increased funding to support this work. This influx, which has been due primarily to the tireless efforts of breast cancer activists to gamer addi tional money from various federal and state sources, has led to a rapid expansion of research efforts by attracting numerous new investigators into the field. These new investigators include students, postdoctoral fellows, and scientists from other fields.
Mammary Tumorigenesis And Malignant Progression
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Author : Robert B. Dickson
language : en
Publisher: Springer
Release Date : 1994-07-31
Mammary Tumorigenesis And Malignant Progression written by Robert B. Dickson and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994-07-31 with Health & Fitness categories.
The current volume represents the fourth over a period of five years in our series on Advances in the Cellular and Molecular Biology of Breast Cancer. The first three volumes were entitled Breast Cancer: Cellular and Molecular Biology, Regulatory Mechanisms in Breast Cancer, and Genes, Oncogenes, and Hormones, respectively. Throughout this series, we have tried to take a broad look at cutting-edge topics in basic science research into breast cancer. This attempt has resulted in a wide range of subject material, including rodent and human model systems, oncogenes, suppressor genes, growth factors, hormones, tumor-host interactions, and determinants of metastases. Since our last volume, research in breast cancer has continued to proceed at an explosive rate. We hope the current volume will provide the reader with some of the excitement felt by the editors and authors as we begin to understand this all-too-common disease. The first section of this book is devoted to the basic processes of proli feration, differentiation, and malignant progression of breast cancer. T.l. Anderson and W.R. Miller lead off with a detailed description of controls on proliferation in the normal human breast and in breast cancer. This chapter strongly emphasizes pathological aspects. The second chapter, by M.R. Stampfer and P. Yaswen, presents a corresponding viewpoint through a presentation of experiments with human mammary epithelial cells in culture. The second section of the book emphasizes the genetic basis for breast cancer onset and malignant progression. Chapter 3, by M.-C. King and S.
Cellular And Molecular Biology Of Mammary Cancer
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Author : Daniel Medina
language : en
Publisher: Springer
Release Date : 1987
Cellular And Molecular Biology Of Mammary Cancer written by Daniel Medina and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1987 with Medical categories.
The idea for this book arose during the 1985 Gordon Conference on "Mammary Gland Biology". New developments in the methodology of cell biology and the explosive growth of molecular biology had begun to impact upon our understanding of mammary gland growth and function. It seemed a propitious time for summarizing the current status of knowledge of the cell and molecular biology of mammary cancer and for attempting to outline future areas of concern and interest. The reviews presented here were completed by the Fall of 1986. Although new insights will surely continue to emerge, it is hoped that the material in this volume will form not only a current update but a basic core of information for future experiments. We have not attempted to cover all areas of mammary gland transformation. Those areas where recent detailed reviews are already available have been omitted. Also, the areas of normal gland development, cell ultrastructure, hormone responsiveness, chemotherapy and clinical aspects of mammary cancer have not been included. Instead, we have selected those areas where the development of new methodology, reagents and results have led to new ideas about mammary gland function and development as they are related to neoplasia.
Discerning The Role Of Foxa1 In Mammary Gland Development And Breast Cancer
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Author : Gina M. Bernardo
language : en
Publisher:
Release Date : 2011
Discerning The Role Of Foxa1 In Mammary Gland Development And Breast Cancer written by Gina M. Bernardo and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Breast categories.
Breast cancer is a heterogeneous disease with distinct subtypes that are predictive of patient prognosis. Luminal subtype tumors confer the most favorable prognosis due to ERa-positivity and response to endocrine therapies. In contrast, basal-like subtype tumors confer the worst prognosis due to intrinsic resistance to chemotherapy and the lack of targeted therapies. The forkhead box transcription factor, FOXA1, is found exclusively in luminal tumors, and positively correlates with ERa and survival. Prior to our study, FOXA1 was known to mediate the development of many tissues and be required for ERa transcriptional activity in breast cancer cells. Given these findings, along with the requirement for ERa in mammary morphogenesis, we hypothesized that FOXA1 would be similarly necessary in this process. Using Foxa1 null mice, we found FOXA1 is required for hormone-induced ductal invasion. Mammary glands null for Foxa1 lack epithelial ERa. The regulation of ERa by FOXA1 is similarly observed in breast cancer cells. These results revealed that FOXA1 is not only required for ERa activity, but also for its expression, and provided a mechanism for the ductal phenotype in Foxa1 knockout glands. The positive correlation between FOXA1 and ERa in breast tumors is significant, but not perfect. FOXA1 is also expressed in luminal breast tumors and cell lines in the absence of ERa prompting us to investigate an ERa-independent role for FOXA1 in maintaining the luminal subtype. FOXA1 silencing in ERa-positive and ERa-negative luminal breast cancer cells decreases luminal gene expression, and concomitantly increases basal gene expression. These cells are also more aggressive in vitro, indicating a shift toward the basal phenotype. FOXA1 binds to a subset of basal genes, and thus, is likely orchestrating repression of these genes at the transcriptional level. These data implicate FOXA1 as a mediator of breast cellular plasticity, and suggest that therapeutically reducing FOXA1 in luminal tumors will increase disease aggressiveness. Combined, this dissertation research has detailed the role for FOXA1 in the normal mammary gland and its importance in luminal breast cancer. Our results have led to numerous testable hypotheses that will continue to advance our understanding of FOXA1 in breast cancer.
Breast Cancer
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Author : Phuc Van Pham
language : en
Publisher: BoD – Books on Demand
Release Date : 2017-04-05
Breast Cancer written by Phuc Van Pham and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-04-05 with Medical categories.
Breast Cancer - From Biology to Medicine thoroughly examines breast cancer from basic definitions, to cellular and molecular biology, to diagnosis and treatment. This book also has some additional focus on preclinical and clinical results in diagnosis and treatment of breast cancer. The book begins with introduction on epidemiology and pathophysiology of breast cancer in Section 1. In Section 2, the subsequent chapters introduce molecular and cellular biology of breast cancer with some particular signaling pathways, the gene expression, as well as the gene methylation and genomic imprinting, especially the existence of breast cancer stem cells. In Section 3, some new diagnostic methods and updated therapies from surgery, chemotherapy, hormone therapy, immunotherapy, radiotherapy, and some complementary therapies are discussed. This book provides a succinct yet comprehensive overview of breast cancer for advanced students, graduate students, and researchers as well as those working with breast cancer in a clinical setting.
Introduction To The Cellular And Molecular Biology Of Cancer
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Author : Leonard Maurice Franks
language : en
Publisher: Oxford University Press, USA
Release Date : 1997
Introduction To The Cellular And Molecular Biology Of Cancer written by Leonard Maurice Franks and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with Medical categories.
The third edition of this repected textbook has been extensively revised and updated by the authors and editors to achieve the same objectives as the two earlier editions -- to provide a relatively brief but comprehensive introduction to the initiation, development, and treatment of cancer.After an introduction describing the pathology and natural history of the disease, subsequent chapters survey particular areas of research, concentrating on the principles involved and recent developments. Each topic is reviewed authoritatively by acknowledged experts, in a way that will beunderstood by non-experts in the field.The chapters on epidemiology, genetic and chromosome changes, oncogenes, chemical and radiation carcinogenesis, growth factors, the biology of human leukaemia, and hormones and cancer have been rewritten and/or extensively revised and new developments resulting from the wide application of currenttechniques in cellular and molecular biology to the study of cancer are included. Other chapters have been revised and brought up to date, and new chapters are inclueed on cytokines and cancer, the molecular pathology of cancer, and cancer prevention and screening.Introduction to the Molecular and Celluar Bilogy of Cancer provides a general survey of the whole field of cancer as a basis for research and will serve as a valuable introduction to students and scientists new to the field.
Immunohistochemical Expression
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Author : Rosario Caltabiano
language : en
Publisher: MDPI
Release Date : 2021-09-02
Immunohistochemical Expression written by Rosario Caltabiano and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-09-02 with Medical categories.
Immunohistochemistry (IHC) is an ancillary method, widely used in pathologists’ practice, that allows identifying diagnostic and prognostic/predictive of therapeutic response protein markers on tissue samples by the use of specific monoclonal antibodies and chromogenic substances that guarantee the visualization of an antibody–antigene binding complex under a light microscope [1]. Coon et al., in 1941 [2], first introduced the use of fluorochrome-conjugated antibodies in clinical practice. Since then, IHC has gone from being a useful tool for identifying the differentiation line of otherwise undifferentiated cells to a technique capable of providing not only diagnostic but also prognostic and predictive indications of responses to specific therapeutic options [1,3]. The abovementioned peculiarities have made IHC one of the most used ancillary methods in the histopathological approach to human neoplastic and non-neoplastic diseases [3-5]. This Special Issue contains 11 accepted papers that provide readers with a comprehensive update on current and future applications of IHC in medical practice.
Breast Disease
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Author : Adnan Aydiner
language : en
Publisher: Springer
Release Date : 2019-03-07
Breast Disease written by Adnan Aydiner and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-03-07 with Medical categories.
This first of two fully updated volumes provides an in-depth account of breast disease characteristics, imaging and diagnosis. Covering from breast anatomy and tumor biology to benign and malignant lesions this is an indispensable companion for breast specialists, medical oncologists, radiologists and pathologists. The new edition contains chapters covering nuclear medicine and a chapter explaining biostatistical and epidemiological terms and has been updated to reflect the latest changes in biomarkers and cancer staging. The book explores topics such as epidemiology, risk factors, pathological evaluation of tumors and biopsy techniques. With a high number of colored illustrations and edited by highly experienced clinicians, this work enables readers to gain an interdisciplinary perspective on breast diseases. Contributions from an international team of experts present invaluable insight into pathological and epidemiological aspects of breast disease. Covering both theoretical and practical aspects of breast cancer this is a highly informative and carefully presented book which will appeal to an international audience of breast cancer practitioners.