100 Jahre St Martinskirche Weinb Hla

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Mhc Class I Loss And Cancer Immune Escape

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Author : Federico Garrido
language : en
Publisher: Springer
Release Date : 2019-05-28

Mhc Class I Loss And Cancer Immune Escape written by Federico Garrido and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-05-28 with Medical categories.

This book is about the escape strategies used by cancer cells to avoid the immune response of the host. The main characters of this story are the “Antigen Presenting Molecules” and the “T Lymphocytes”. The former are known as the Major Histocompatibility Complex (MHC): the H-2 and the HLA molecules. The latter are a subgroup of white cells travelling all over our body which are capable to distinguish between “self and non self”. Readers will know from the inside about the history of the HLA genetic system and will discover how T lymphocytes recognize and destroy cancer cells. One of the key important questions is: Why tumors arise, develop and metastasize? This book tries to answer this question and will explain how cancer cells become invisible to killer T lymphocytes. The loss of the HLA molecules is a major player in this tumor escape mechanism. Cancer immunotherapy is aimed at stimulating T lymphocytes to destroy tumor cells. However, the clinical response rate is not as high as expected. The molecular mechanisms responsible for MHC/HLA antigen loss play a crucial role in this resistance to immunotherapy. This immune escape mechanism will be discussed in different types of tumors: lung, prostate, bladder and breast...ect. as well as melanoma and lymphoma. This book will be useful to Oncologists, Pathologists and Immunologist that will enter this fascinating area of research. It will be also interesting for biologist, doctoral students and medical residents interested in “Tumor Immunology”.

Acute Rheumatic Fever And Rheumatic Heart Disease

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Author : Dr. Scott Dougherty
language : en
Publisher: Elsevier Health Sciences
Release Date : 2020-02-22

Acute Rheumatic Fever And Rheumatic Heart Disease written by Dr. Scott Dougherty and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-02-22 with Medical categories.

Acute Rheumatic Fever and Rheumatic Heart Disease is a concise, yet comprehensive, clinical resource highlighting must-know information on rheumatic heart disease and acute rheumatic fever from a global perspective. Covering the major issues dominating the field, this practical resource presents sufficient detail for a deep and thorough understanding of the latest treatment options, potential complications, and disease management strategies to improve patient outcomes. Divided into four distinct sections for ease of navigation: Acute Rheumatic Fever, Rheumatic Heart Disease, Population-Based Strategies for Disease Control, and Acute and Emergency Presentations. International editors and chapter authors ensure a truly global perspective. Covers all clinical aspects, including epidemiology, pathophysiology, clinical features, diagnosis, management, and treatment. Includes key topics on population-based measures for disease control for effective primary, secondary, and tertiary prevention. Consolidates today’s available information and guidance into a single, convenient resource.

Hla In Health And Disease

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Author : Robert Lechler
language : en
Publisher: Academic Press
Release Date : 2000-05-09

Hla In Health And Disease written by Robert Lechler and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-05-09 with Medical categories.

This comprehensive and definitive work succeeds and expands on the highly successful HLA and Disease published in 1994. This new edition has been updated, redesigned and reorganised into three sections making it an invaluable reference. The introductory section summarises current knowledge on the structure, function, genetics and evolution of the HLA system. It clarifies its complex and ever changing nomenclature and discusses the mechanisms underlying disease associations with HLA alleles. The second section deals with the importance of HLA in the context of different clinical specialities. Individual chapters describe the association between HLA polymorphism and each disease. The final section features chapters on current laboratory practice in histocompatibility and tissue typing. HLA in Health and Disease is essential reading for basic and clinical researchers working in immunology and immunogenetics, transplantation medicine and autoimmunity. It will also be of interest to anyone in the fields of rheumatology, diabetology, nephrology, allergy, dermatology, neurology, endocrinology, cancer biology, respiratory medicine, haematology, molecular biology and biochemistry. Key Features Structure, function and genetics of HLA HLA nomenclature Evolution of HLA polymorphisms HLA associations in arthritis and rheumatology, renal disease, neurology, diabetes and endocrinology, gastroenterology, respiratory disease, ophthalmology, infections, dermatology and psychiatry HLA and organ transplantation Serological and PCR-based methods in HLA typing Cellular techniques in testing histocompatibility Edited and written by an international panel of experts in the field

Molecular Evolution Of The Major Histocompatibility Complex

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Author : Jan Klein
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29

Molecular Evolution Of The Major Histocompatibility Complex written by Jan Klein and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Medical categories.

From molecules to populations and back In biology, the most vigorous organisms often ensue from a union of two disparate, pure lines. In science, too, laws of hybrid vigor seem to operate at the interface between two disciplines, an interface that often proves to be fertile ground for germinating concepts and new outlooks. The fringes of research into the major histocompatibility complex (Mhc) have provided such an interface several times in the past and the encounters have invigorated fields such as transplantation biology, cellular immunology, and immunogenetics. In the last few years, a new interface has been emerging between Mhc and evolutionary genetics, and particularly the branch of evolutionary genetics dealing with molecular evolution. Mhc research relies upon molecular evolutionary genetics, with its grand superstructure of mathematical formulations, to come to grips with the events leading to and maintaining the Mhc polymorphism. Without the armament of rigorous statistical procedures developed by evolutionary geneticists, the intricate relationships among Mhc genes cannot be resolved. It will undoubtedly be a molecular geneticist who is the final arbiter in the dispute concerning the nature of the selection pressure molding the Mhc genes. And it is doubtful whether the true function of Mhc can ever be comprehended without the vantage point afforded by the elucidation of its evolutionary history.

Arthrogryposis

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Author : Lynn T. Staheli
language : en
Publisher: Cambridge University Press
Release Date : 1998-04-28

Arthrogryposis written by Lynn T. Staheli and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-04-28 with Medical categories.

The term arthrogryposis describes a range of congenital contractures that lead to childhood deformities. It encompasses a number of syndromes and sporadic deformities that are rare individually but collectively are not uncommon. Yet, the existing medical literature on arthrogryposis is sparse and often confusing. The aim of this book is to provide individuals affected with arthrogryposis, their families, and health care professionals with a helpful guide to better understand the condition and its therapy. With this goal in mind, the editors have taken great care to ensure that the presentation of complex clinical information is at once scientifically accurate, patient oriented, and accessible to readers without a medical background. The book is authored primarily by members of the medical staff of the Arthrogryposis Clinic at Children's Hospital and Medical Center in Seattle, Washington, one of the leading teams in the management of the condition, and will be an invaluable resource for both health care professionals and families of affected individuals.

How Tobacco Smoke Causes Disease

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Author :
language : en
Publisher:
Release Date : 2010

How Tobacco Smoke Causes Disease written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Government publications categories.

This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

Toxicological Profile For Beryllium

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Author :
language : en
Publisher:
Release Date : 1993

Toxicological Profile For Beryllium written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with Beryllium categories.

Stem Cells In Aesthetic Procedures

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Author : Melvin A. Shiffman
language : en
Publisher: Springer
Release Date : 2014-07-21

Stem Cells In Aesthetic Procedures written by Melvin A. Shiffman and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-07-21 with Medical categories.

Interest in the use of stem cells in aesthetic procedures has been increasing rapidly, reflecting the widespread acknowledgment of the tremendous potential of stem cell fat transfer. This is, however, the first book to be devoted entirely to the subject. The book opens by reviewing the history of the development of pluripotent stem cells and the results of research into the biochemistry and physiology of stem cells. Adipose tissue anatomy and survival are discussed and the wide range of aesthetic procedures involving stem cell fat transfer are then described in detail. These procedures relate to the face, breast, buttocks, legs, hands, penis and Poland syndrome. In addition, potential risks and complications are identified. The book has been written by leading experts and will be an invaluable source of information for students, beginners and experienced surgeons in a range of specialties.

Allogeneic Stem Cell Transplantation

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Author : Hillard M. Lazarus
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-03-02

Allogeneic Stem Cell Transplantation written by Hillard M. Lazarus and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-03-02 with Medical categories.

Since the original publication of Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Allogeneic hematopoietic stem cell transplantation (HSC) has undergone several fast-paced changes. In this second edition, the editors have focused on topics relevant to evolving knowledge in the field in order to better guide clinicians in decision-making and management of their patients, as well as help lead laboratory investigators in new directions emanating from clinical observations. Some of the most respected clinicians and scientists in this discipline have responded to the recent advances in the field by providing state-of-the-art discussions addressing these topics in the second edition. The text covers the scope of human genomic variation, the methods of HLA typing and interpretation of high-resolution HLA results. Comprehensive and up-to-date, Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Second Edition offers concise advice on today's best clinical practice and will be of significant benefit to all clinicians and researchers in allogeneic HSC transplantation.

An Introduction To Criminological Theory

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Author : Roger Hopkins Burke
language : en
Publisher: Routledge
Release Date : 2018-11-01

An Introduction To Criminological Theory written by Roger Hopkins Burke and has been published by Routledge this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-11-01 with Law categories.

This book provides a comprehensive and up-to-date introduction to criminological theory for students taking courses in criminology at both undergraduate and postgraduate level. Building on previous editions, this book presents the latest research and theoretical developments. The text is divided into five parts, the first three of which address ideal type models of criminal behaviour: the rational actor, predestined actor and victimized actor models. Within these, the various criminological theories are located chronologically in the context of one of these different traditions, and the strengths and weaknesses of each theory and model are clearly identified. The fourth part of the book looks closely at more recent attempts to integrate theoretical elements from both within and across models of criminal behaviour, while the fifth part addresses a number of key recent concerns of criminology: postmodernism, cultural criminology, globalization and communitarianism, the penal society, southern criminology and critical criminology. All major theoretical perspectives are considered, including: classical criminology, biological and psychological positivism, labelling theories, feminist criminology, critical criminology and left realism, situation action, desistance theories, social control theories, the risk society, postmodern condition and terrorism. The new edition also features comprehensive coverage of recent developments in criminology, including ‘the myth of the crime drop’, the revitalization of critical criminology and political economy, shaming and crime, defiance theory, coerced mobility theory and new developments in social control and general strain theories. This revised and expanded fifth edition of An Introduction to Criminological Theory includes chapter summaries, critical thinking questions, policy implications, a full glossary of terms and theories and a timeline of criminological theory, making it essential reading for those studying criminology and taking courses on theoretical criminology, understanding crime, and crime and deviance