Hla In Health And Disease
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Hla In Health And Disease
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Author : Robert Lechler
language : en
Publisher: Academic Press
Release Date : 2000-05-09
Hla In Health And Disease written by Robert Lechler and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-05-09 with Medical categories.
This comprehensive and definitive work succeeds and expands on the highly successful HLA and Disease published in 1994. This new edition has been updated, redesigned and reorganised into three sections making it an invaluable reference. The introductory section summarises current knowledge on the structure, function, genetics and evolution of the HLA system. It clarifies its complex and ever changing nomenclature and discusses the mechanisms underlying disease associations with HLA alleles. The second section deals with the importance of HLA in the context of different clinical specialities. Individual chapters describe the association between HLA polymorphism and each disease. The final section features chapters on current laboratory practice in histocompatibility and tissue typing. HLA in Health and Disease is essential reading for basic and clinical researchers working in immunology and immunogenetics, transplantation medicine and autoimmunity. It will also be of interest to anyone in the fields of rheumatology, diabetology, nephrology, allergy, dermatology, neurology, endocrinology, cancer biology, respiratory medicine, haematology, molecular biology and biochemistry. Key Features Structure, function and genetics of HLA HLA nomenclature Evolution of HLA polymorphisms HLA associations in arthritis and rheumatology, renal disease, neurology, diabetes and endocrinology, gastroenterology, respiratory disease, ophthalmology, infections, dermatology and psychiatry HLA and organ transplantation Serological and PCR-based methods in HLA typing Cellular techniques in testing histocompatibility Edited and written by an international panel of experts in the field
Hla And Disease Associations
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Author : J.L. Tiwari
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Hla And Disease Associations written by J.L. Tiwari and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The human leukocyte antigen (HLA) or tissue types are the products of a rapidly developing field of knowledge within the last 20 years. In the early stages of the research many investigators suspected the existence of a complex series of transplantation antigens, but it was widely believed that these antigens would not be well-defined even in this century. Yet in the last two decades as many as 124 different HLA antigens determined by at least 7 very closely linked genes located on the short arm of chromosome 6 have been identified and subsequently agreed upon by an international nomenclature committee. 1 Extensive international collaboration fueled by the potential clinical application of these antigens to clinical transplantation has advanced the field rapidly. There were nine inter national histocompatibility workshops held during this period. Although iden tification of HLA antigens was of primary clinical importance in transplantation 2 and of great basic interest in human genetics and anthropology, a rather un expected bonus has been the determination that HLA antigens are associated with disease susceptibility to a greater extent than any other known genetic marker in man. In the past, many genetic polymorphisms have been suspected to be associated with diseases. The most extensively studied markers are blood groups, enzymes, and serum proteins. A comprehensive account of published studies, totalling approximately 1,000, of these markers is available in a book by Mourant et al.
Hla And Associated Important Diseases
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Author : Yongzhi Xi
language : en
Publisher: BoD – Books on Demand
Release Date : 2014-03-19
Hla And Associated Important Diseases written by Yongzhi Xi and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-03-19 with Medical categories.
This year marks the 60th anniversary of HLA discovery by the French Nobel laureate physician Jean Dausset, as well as the 55th anniversary of the identification and naming of the first HLA. Under such circumstances, both basic HLA research and its clinical applications need a new book that comprehensively reflects the latest achievements in the field. Thus, Professor Xi as Editor has contributed to organize international experts in the areas of HLA-related basic research and clinical applications, to unite their knowledge in chapters covering various related topics, and finally to finish the book "HLA and Associated Important Diseases". The book consists of three sections which mainly include basic theoretical and technological developments, several important HLA-associated autoimmune diseases and HLA-associated infectious diseases.
Hla And Disease
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Author : Robert Lechler
language : en
Publisher:
Release Date : 1994
Hla And Disease written by Robert Lechler and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994 with Medical categories.
This text describes the genetics and products of the HLA region and their relationship to diseases including diabetes, rheumatoid arthritis and SLE. The statistical principles relevant to the design and interpretation of HLA and disease studies are presented in simple and accessible language.
The Hla Complex In Biology And Medicine
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Author : Narinder K Mehra
language : en
Publisher: Boydell & Brewer Ltd
Release Date : 2010-11-26
The Hla Complex In Biology And Medicine written by Narinder K Mehra and has been published by Boydell & Brewer Ltd this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-11-26 with Medical categories.
A comprehensive guide to the HLA (Human Leukocyte Antigen) system for immunologists and clinicians, this book contains up-to-date information on the MHC (Major Histocompatibility Complex) and its role in the immune response and in various diseases. The book explores the biological significance and role of the HLA system in organ and haematopoietic stem cell transplantation management. This volume is an invaluable guide to the full spectrum of HLA-related science while also serving as a conceptual and technical resource for those involved in HLA-related research and in clinical or surgical practice. In addition, it will be a primary point of contact for individuals working in other areas who suddenly find that their research is drawing them into the complexities of HLA genetics.
Hla And Mhc
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Author : Michael Browning
language : en
Publisher:
Release Date : 1999-09-01
Hla And Mhc written by Michael Browning and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-09-01 with Medical categories.
The major histocompatibility complex (MHC) and its gene products have a major impact on health and disease through their central role in the regulation of the immune response. While the MHC has evolved as part of the host's defense strategy to protect against infection with pathogenic microorganisms, its gene products also form the major targets for rejection of allogenetic tissues in organ transplantation and susceptibility to a variety of diseases. This complex role in the health of the host has made the MHC the focus of attention in many fields of biological research. HLA and MHC: Genes, Molecules and Function is an authoritative review of the major histocompatibility complex, from the molecular genetics of the MHC through the structure and function of MHC-encoded molecules and their role in health and disease. The emphasis is on the human MHC, but relevant animal studies are also included to provide a comprehensive coverage of the subject. Internationally recognized experts in their respective fields of research have contributed individual chapters. This major new publication will be of interest not only to immunologists, but also to scientists and clinicians in a wide range of fields in which immune response plays a role.
Major Histocompatibility Complex Mhc In Health And Disease
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Author : Jerzy K. Kulski
language : en
Publisher: MDPI
Release Date : 2020-01-15
Major Histocompatibility Complex Mhc In Health And Disease written by Jerzy K. Kulski and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-15 with Science categories.
The major histocompatibility complex (MHC) is a highly polymorphic and diverse multigene locus in all jawed vertebrate species that has an integral role in adaptive/innate immune systems, transplantation, and infectious and autoimmune diseases. The MHC supra-locus in mammalian vertebrates is usually partitioned into three distinct regions, known as classes I, II, and III, which, to varying extents, can be found conserved in nonmammalian jawed vertebrates, such as bony fish, amphibians, and bird lineages. The MHC gene region is characterized particularly by the expression of class I and class II glycoproteins that bind peptides derived from intracellular or extracellular antigens to circulating T-cells. While this expressed antigenic specificity remains the predominant interest with respect to MHC function and polymorphism in a population, a broader concept has emerged that examines the MHC as a multifunctional polymorphic controller that facilitates and regulates genome diversity with a much greater array of functions and effects than just MHC-restricted antigen recognition. This volume of 19 reprints presented by various experts and collected from the Special Issue of Cells on “MHC in Health and Disease” covers a broad range of topics on the genomic diversity of the MHC regulatory system in various vertebrate species, including MHC class I, II, and III genes; innate and adaptive immunity; neurology; transplantation; haplotypes; infectious and autoimmune diseases; fecundity; conservation; allelic lineages; and evolution. Taken together, these articles demonstrate the immense complexity and diversity of the MHC structure and function within and between different vertebrate species.
Hla And Disease An Issue Of The Clinics In Laboratory Medicine
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Author : Julio Delgado
language : en
Publisher: Elsevier Health Sciences
Release Date : 2018-11-16
Hla And Disease An Issue Of The Clinics In Laboratory Medicine written by Julio Delgado and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-11-16 with Medical categories.
This issue of Clinics in Laboratory Medicine, edited by Drs. Julio Delgado and Eszter Lazar-Molnar, will focus on HLA and Disease. Topics include, but are not limited to, The potential impact of NGS in HLA and disease association studies, HLA typing by NGS, HLA Antibody Testing: Evolution and Challenges, Diversity of killer cell immunoglobulin-like receptors and disease, Technical Aspects of Crossmatching in Transplantation, HLA Markers in Celiac Disease, HLA Associations in Drug Hypersensitivity Reactions, HLA in BMT, Post-transplant monitoring, HLA epitope matching in transplantation, and Molecular Testing in Post-Transplant Monitoring.
Hla And Disease
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Author : Werner E. Braun
language : en
Publisher: CRC Press
Release Date : 2019-07-23
Hla And Disease written by Werner E. Braun and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-07-23 with Science categories.
This book discusses the topic of the HLA antigen system. Chapters discuss topics such as; animal studies, the possible mechanisms of HLA and disease associations, statistical and genetic considerations, the clinical use of HLA typing, as well as the current status of HLA and disease associations.
Janeway S Immunobiology
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Author : Kenneth Murphy
language : en
Publisher: Garland Science
Release Date : 2010-06-22
Janeway S Immunobiology written by Kenneth Murphy and has been published by Garland Science this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-06-22 with Medical categories.
The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.