3d Printed Microfluidic Devices
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3d Printed Microfluidic Devices
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Author : Savas Tasoglu
language : en
Publisher: MDPI
Release Date : 2019-01-10
3d Printed Microfluidic Devices written by Savas Tasoglu and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-01-10 with Botanical chemistry categories.
This book is a printed edition of the Special Issue "3D Printed Microfluidic Devices" that was published in Micromachines
3d Printed Microfluidic Devices
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Author : Tasoglu Savas
language : en
Publisher:
Release Date : 2018
3d Printed Microfluidic Devices written by Tasoglu Savas and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with Electronic books categories.
3D printing has revolutionized the microfabrication prototyping workflow over the past few years. With the recent improvements in 3D printing technologies, highly complex microfluidic devices can be fabricated via single-step, rapid, and cost-effective protocols as a promising alternative to the time consuming, costly and sophisticated traditional cleanroom fabrication. Microfluidic devices have enabled a wide range of biochemical and clinical applications, such as cancer screening, micro-physiological system engineering, high-throughput drug testing, and point-of-care diagnostics. Using 3D printing fabrication technologies, alteration of the design features is significantly easier than traditional fabrication, enabling agile iterative design and facilitating rapid prototyping. This can make microfluidic technology more accessible to researchers in various fields and accelerates innovation in the field of microfluidics. Accordingly, this Special Issue seeks to showcase research papers, short communications, and review articles that focus on novel methodological developments in 3D printing and its use for various biochemical and biomedical applications.
Utilization Of Embedded Printing For Fabrication Of 3d Complex Shaped Microfluidic Devices In Hydrogels And Silicone Composites
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Author : Mecit Altan Alioglu
language : en
Publisher:
Release Date : 2023
Utilization Of Embedded Printing For Fabrication Of 3d Complex Shaped Microfluidic Devices In Hydrogels And Silicone Composites written by Mecit Altan Alioglu and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023 with categories.
The demand for fabrication of tissue and organ models is being driven by emerging requirements in biomedicine, drug screening, and organ transplantation. To fulfill this demand the field of bioprinting has emerged. Despite the fact that several approaches have been created, new ways are still required to produce the complicated geometries of vascular networks and materials that mimic natural tissues. Recently, embedded printing technique has been developed. By overcoming the limitations imposed by gravity, embedded printing enables the creation of complicated structures that would otherwise be impossible to produce with traditional layer-by-layer deposition from the bottom. Even though embedded printing has enormous potential it is still in its infancy and ample amount of research is going on to develop new materials and methods to advance its capabilities and increase its potential applications. Over the last two decades, microfluidic devices have rapidly emerged as revolutionary platforms for research and medicine. Various kinds of materials and fabrication strategies have been used to manufacture microfluidic devices; however, most of these strategies face challenges including complexity, time consumption, and cost in recreating delicate and intricate structural organizations. Herein, a silicone composite was developed and employed as a functional support bath in which a sacrificial ink was 3D printed using embedded printing, enabling freeform fabrication of complex-shaped microfluidic devices. Si-Co was a soft material that had high optical transparency and tunable mechanical properties and yield stress with self-recovering ability. Sacrificial ink filaments formed inside the Si-Co support bath were found to be stable and circular with a wide range of resolution reaching up to 50 [mu]m in channel size. The strategy was exemplified by fabricating microfluidic devices for generation of stable microgels of various sizes. To confirm biocompatibility of Si-Co, induced-pluripotent stem cell-derived endothelial cells were lined up inside microfluidic channels to obtain vascular mimics. Additionally, proof-of-concept spheroid fabrication devices were generated. Overall, the presented strategy allows for facile, rapid, cost-effective, and high-resolution printing and presents potential for the development of microfluidic devices for various applications. After the development of first silicone composite for the use of embedded printing, we developed a novel, transparent, 3D printable, photocrosslinkable, and tunable silicone composite that can be utilized as a support bath or an extrudable ink for embedded printing. The proposed silicone composite can be tuned to achieve ideal rheological properties, such as optimal self-recovery and yield stress, for use in 3D printing. When used as a support bath, it facilitated the generation microfluidic devices with circular channels of diameter up to 30 [mu]m. To demonstrate its utility, flow focusing microfluidic devices were fabricated for generation of Janus microrods, which can be easily modified for multitude of applications. When used as an extrudable ink, 3D printing of complex-shaped micro and macro constructs were achieved with integrated electronics, which greatly extends its potential applications towards developing complex flexible parts for soft robotics and prosthetics. Further, its biocompatibility was tested with multiple cell types to validate its applicability for medical and tissue engineering use. Altogether, this material offers a myriad of potential applications in material and medical fields by providing a facile approach to developing complicated 3D structures and interconnected channels that can lift microfluidics and soft-robotics research to the next level. Finally, we have developed a novel method of "intraembedded printing" as an improvement for embedded printing. Intraembedded printing is achieved by printing within printed constructs. By using this technique potential applications with embedded printing can be significantly expanded and intricate organ models or microfluidic devices can be fabricated in a facile and rapid manner. To demonstrate the capabilities of this method, a novel breast cancer model and a pancreas model was fabricated. Overall, intraembedded printing technique presents an enormous potential in the fields of tissue engineering and biomedical research and applications by offering a platform for fabrication of microfluidic devices, tissue and organ models.
Hidden In Plain Sight
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Author : Albert Folch
language : en
Publisher: MIT Press
Release Date : 2022-04-26
Hidden In Plain Sight written by Albert Folch and has been published by MIT Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-04-26 with Technology & Engineering categories.
Stories behind essential microfluidic devices, from the inkjet printer to DNA sequencing chip. Hidden from view, microfluidics underlies a variety of devices that are essential to our lives, from inkjet printers to glucometers for the monitoring of diabetes. Microfluidics—which refers to the technology of miniature fluidic devices and the study of fluids at submillimeter levels—is invisible to most of us because it is hidden beneath ingenious user interfaces. In this book, Albert Folch, a leading researcher in microfluidics, describes the development and use of key microfluidic devices. He explains not only the technology but also the efforts, teams, places, and circumstances that enabled these inventions. Folch reports, for example, that the inkjet printer was one of the first microfluidic devices invented, and traces its roots back to nineteenth-century discoveries in the behavior of fluid jets. He also describes how rapid speed microfluidic DNA sequencers have enabled the sequencing of animal, plant, and microbial species genomes; organs on chips facilitate direct tests of drugs on human tissue, leapfrogging over the usual stage of animal testing; at-home pregnancy tests are based on clever microfluidic principles; microfluidics can be used to detect cancer cells in the early stages of metastasis; and the same technology that shoots droplets of ink on paper in inkjet printers enables 3D printers to dispense layers of polymers. Folch tells the stories behind these devices in an engaging style, accessible to nonspecialists. More than 100 color illustrations show readers amazing images of microfluids under the microscope.
Microfluidic Biosensors
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Author : Wing Cheung Mak
language : en
Publisher: Elsevier
Release Date : 2022-11-05
Microfluidic Biosensors written by Wing Cheung Mak and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-05 with Technology & Engineering categories.
Microfluidic Biosensors provides a comprehensive overview covering the most recent emerging technologies on the design, fabrication, and integration of microfluidics with transducers. These form various integrated microfluidic biosensors with device configurations ranging from 2D to 4D levels. Coverage also includes advanced printed microfluidic biosensors, flexible microfluidics for wearable biosensors, autonomous lab-on-a-chip biosensors, CMOS-base microanalysis systems, and microfluidic devices for mobile phone biosensing. The editors and contributors of this book represent both academia and industry, come from a varied range of backgrounds, and offer a global perspective. This book discusses the design and principle of microfluidic systems and uses them for biosensing applications. The microfluidic fabrication technologies covered in this book provide an up-to-date view, allowing the community to think of new ways to overcome challenges faced in this field. The focus is on existing and emerging technologies not currently being analyzed extensively elsewhere, providing a unique perspective and much-needed content. The editors have crafted this book to be accessible to all levels of academics from graduate students, researchers, and professors working in the fields of biosensors, microfluidics design, material science, analytical chemistry, biomedical devices, and biomedical engineering. It can also be useful for industry professionals working for microfluidic device manufacturers, or in the industry of biosensors and biomedical devices. Presents an in-depth overview of microfluidic biosensors and associated emerging technologies such as printed microfluidics and novel transducers Addresses a range of microfluidic biosensors with device configurations ranging from 2D to 4D levels Includes the commercialization aspects of microfluidic biosensors that provide insights for scientists and engineers in research and development
Biomaterials And Microfluidics Based Tissue Engineered 3d Models
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Author : J. Miguel Oliveira
language : en
Publisher: Springer Nature
Release Date : 2020-04-13
Biomaterials And Microfluidics Based Tissue Engineered 3d Models written by J. Miguel Oliveira and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-13 with Medical categories.
This contributed volume reviews the latest advances on relevant 3D tissue engineered in vitro models of disease making use of biomaterials and microfluidics. The main focus of this book is on advanced biomaterials and microfluidics technologies that have been used in in vitro mimetic 3D models of human diseases and show great promise in revolutionizing personalized medicine. Readers will discover important topics involving biomaterials and microfluidics design, advanced processing techniques, and development and validation of organ- and body-on-a-chip models for bone, liver, and cancer research. An in depth discussion of microfabrication methods for microfluidics development is also provided. This work is edited by two truly multidisciplinary scientists and includes important contributions from well-known experts in their fields. The work is written for both early stage and experienced researchers, and well-established scientists enrolled in the fields of biomaterials, microfluidics, and tissue engineering, and is especially suited to those who wish to become acquainted with the principles and latest developments of in vitro models of diseases, such as professionals working in pharma, medicine, and engineering.
Microfluidic Devices For Biomedical Applications
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Author : Xiujun James Li
language : en
Publisher: Woodhead Publishing
Release Date : 2013-10-31
Microfluidic Devices For Biomedical Applications written by Xiujun James Li and has been published by Woodhead Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-31 with Technology & Engineering categories.
Microfluidics or lab-on-a-chip (LOC) is an important technology suitable for numerous applications from drug delivery to tissue engineering. Microfluidic devices for biomedical applications discusses the fundamentals of microfluidics and explores in detail a wide range of medical applications. The first part of the book reviews the fundamentals of microfluidic technologies for biomedical applications with chapters focussing on the materials and methods for microfabrication, microfluidic actuation mechanisms and digital microfluidic technologies. Chapters in part two examine applications in drug discovery and controlled-delivery including micro needles. Part three considers applications of microfluidic devices in cellular analysis and manipulation, tissue engineering and their role in developing tissue scaffolds and stem cell engineering. The final part of the book covers the applications of microfluidic devices in diagnostic sensing, including genetic analysis, low-cost bioassays, viral detection, and radio chemical synthesis. Microfluidic devices for biomedical applications is an essential reference for medical device manufacturers, scientists and researchers concerned with microfluidics in the field of biomedical applications and life-science industries.
Microfluidics For Biological Applications
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Author : Michael Kohlmann
language : en
Publisher: Springer
Release Date : 1979
Microfluidics For Biological Applications written by Michael Kohlmann and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1979 with Mathematics categories.
Microfluidics for Biological Applications provides researchers and scientists in the biotechnology, pharmaceutical, and life science industries with an introduction to the basics of microfluidics and also discusses how to link these technologies to various biological applications at the industrial and academic level. Readers will gain insight into a wide variety of biological applications for microfluidics. The material presented here is divided into four parts, Part I gives perspective on the history and development of microfluidic technologies, Part II presents overviews on how microfluidic systems have been used to study and manipulate specific classes of components, Part III focuses on specific biological applications of microfluidics: biodefense, diagnostics, high throughput screening, and tissue engineering and finally Part IV concludes with a discussion of emerging trends in the microfluidics field and the current challenges to the growth and continuing success of the field.
High Throughput Production Of Micrometer Sized Double Emulsions And Microgel Capsules In Parallelized 3d Printed Microfluidic Devices
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Author : Alexander Jans
language : en
Publisher:
Release Date : 2019
High Throughput Production Of Micrometer Sized Double Emulsions And Microgel Capsules In Parallelized 3d Printed Microfluidic Devices written by Alexander Jans and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with categories.
Microfluidics And Lab On A Chip
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Author : Andreas Manz
language : en
Publisher: Royal Society of Chemistry
Release Date : 2020-09-24
Microfluidics And Lab On A Chip written by Andreas Manz and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-09-24 with Science categories.
Responding to the need for an affordable, easy-to-read textbook that introduces microfluidics to undergraduate and postgraduate students, this concise book will provide a broad overview of the important theoretical and practical aspects of microfluidics and lab-on-a-chip, as well as its applications.