A G Ria Brasileira Dos Marginais S Classes De Elite
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Translational Medicine
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Author : Joy A. Cavagnaro
language : en
Publisher: CRC Press
Release Date : 2021-11-26
Translational Medicine written by Joy A. Cavagnaro and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-26 with Medical categories.
Translational Medicine: Optimizing Preclinical Safety Evaluation of Biopharmaceuticals provides scientists responsible for the translation of novel biopharmaceuticals into clinical trials with a better understanding of how to navigate the obstacles that keep innovative medical research discoveries from becoming new therapies or even making it to clinical trials. The book includes sections on protein-based therapeutics, modified proteins, oligonucleotide-based therapies, monoclonal antibodies, antibody–drug conjugates, gene and cell-based therapies, gene-modified cell-based therapies, combination products, and therapeutic vaccines. Best practices are defined for efficient discovery research to facilitate a science-based, efficient, and predictive preclinical development program to ensure clinical efficacy and safety. Key Features: Defines best practices for leveraging of discovery research to facilitate a development program Includes general principles, animal models, biomarkers, preclinical toxicology testing paradigms, and practical applications Discusses rare diseases Discusses "What-Why-When-How" highlighting different considerations based upon product attributes. Includes special considerations for rare diseases About the Editors Joy A. Cavagnaro is an internationally recognized expert in preclinical development and regulatory strategy with an emphasis on genetic medicines.. Her 40-year career spans academia, government (FDA), and the CRO and biotech industries. She was awarded the 2019 Arnold J Lehman Award from the Society of Toxicology for introducing the concept of science-based, case-by-case approach to preclinical safety evaluation, which became the foundation of ICH S6. She currently serves on scientific advisory boards for advocacy groups and companies and consults and lectures in the area of preclinical development of novel therapies. Mary Ellen Cosenza is a regulatory toxicology consultant with over 30 years of senior leadership experience in the biopharmaceutical industry in the U.S., Europe, and emerging markets. She has held leadership position in both the American College of Toxicology (ACT) and the International Union of Toxicology (IUTOX) and is also an adjunct assistant professor at the University of Southern California where she teaches graduate-level courses in toxicology and regulation of biologics.
The Flowering Of Apomixis
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Author : Yves Savidan
language : en
Publisher: CIMMYT
Release Date : 2001
The Flowering Of Apomixis written by Yves Savidan and has been published by CIMMYT this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with Science categories.
Global Brazil And U S Brazil Relations
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Author : Samuel W. Bodman
language : en
Publisher: Council on Foreign Relations
Release Date : 2011
Global Brazil And U S Brazil Relations written by Samuel W. Bodman and has been published by Council on Foreign Relations this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Political Science categories.
July 12, 2011-Over the course of a generation, Brazil has emerged as both a driver of growth in South America and as an active force in world politics. A new Council on Foreign Relations (CFR)-sponsored Independent Task Force report asserts "that it is in the interest of the United States to understand Brazil as a complex international actor whose influence on the defining global issues of the day is only likely to increase."Brazil currently ranks as the world's fifth-largest landmass, fifth-largest population, and expects to soon be ranked the fifth largest economy. The report, Global Brazil and U.S.-Brazil Relations, recommends that "U.S. policymakers recognize Brazil's standing as a global actor, treat its emergence as an opportunity for the United States, and work with Brazil to develop complementary policies."The Task Force is chaired by former secretary of energy Samuel W. Bodman and former president of the World Bank James D. Wolfensohn, and directed by CFR Senior Fellow and Director for Latin America Studies, and Director of the Global Brazil Initiative Julia E. Sweig.Recognizing Brazil's global role, the report recommends that the Obama administration now fully endorse the country's bid for a seat as a permanent member of the United Nations Security Council (UNSC). It argues that "a formal endorsement from the United States for Brazil would go far to overcome lingering suspicion within the Brazilian government that the U.S. commitment to a mature relationship between equals is largely rhetorical."Domestically, Brazil's "inclusive growth has translated into a significant reduction of inequality, an expansion of the middle class, and a vibrant economy, all framed within a democratic context." Consequently, Brazil has been able to use its economic bona fides to leverage a stronger position in the international, commercial, and diplomatic arena.The report stresses the importance of regular communication between the presidents of both countries. "Cooperation between the United States and Brazil holds too much promise for miscommunication or inevitable disagreements to stand in the way of potential gains." A mature, working relationship means that "the United States and Brazil can help each other advance mutual interests even without wholesale policy agreements between the two," notes the report.The Task Force further recommends that- the U.S. Congress "include an elimination of the ethanol tariff in any bill regarding reform to the ethanol and biofuel tax credit regime."- the United States "take the first step to waive visa requirements for Brazilians by immediately reviewing Brazil's criteria for participation in the Visa Waiver Program."- the U.S. State Department create an Office for Brazilian Affairs and the National Security Council (NSC) centralize its efforts under a NSC director for Brazil in order to better coordinate the current decentralized U.S. policy.The bipartisan Task Force includes thirty distinguished experts on Brazil who represent a range of perspectives and backgrounds. The report includes a number of additional views by Task Force members, including one that notes, "We believe that a more gradual approach [regarding Brazil's inclusion as a full UNSC member] would likely have more success in navigating the diplomatic complexities presented by U.S. support for Brazil." Another view asserts, "If the United States supports, as the Obama administration has said it does, leadership structures in international institutions that are more reflective of international realities, it must support without qualifications Brazil's candidacy [for the UNSC]."
Disrupted Cities
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Author : Stephen Graham
language : en
Publisher: Routledge
Release Date : 2010-06-10
Disrupted Cities written by Stephen Graham and has been published by Routledge this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-06-10 with Science categories.
Bringing together leading researchers from geography, political science, sociology, public policy and technology studies, Disrupted Cities exposes the politics of well-known disruptions such as devastation of New Orleans in 2005, the global SARS outbreak in 2002-3, and the great power collapse in the North Eastern US in 2003. But the book also excavates the politics of more hidden disruptions: the clogging of city sewers with fat; the day-to-day infrastructural collapses which dominate urban life in much of the global south; the deliberate devastation of urban infrastructure by state militaries; and the ways in which alleged threats of infrastructural disruption have been used to radically reorganize cities as part of the ‘war on terror’. Accessible, topical and state-of-the art, Disrupted Cities will be required reading for anyone interested in the intersections of technology, security and urban life as we plunge headlong into this quintessentially urban century. The book’s blend of cutting-edge theory with visceral events means that it will be particularly useful for illuminating urban courses within geography, sociology, planning, anthropology, political science, public policy, architecture and technology studies.
De Los Recursos Naturales A La Econom A Del Conocimiento
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Author : David M. De Ferranti
language : es
Publisher: World Bank Publications
Release Date : 2002
De Los Recursos Naturales A La Econom A Del Conocimiento written by David M. De Ferranti and has been published by World Bank Publications this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Business & Economics categories.
The study questions whether, after a decade of remarkable progress in trade reform, Latin America and the Caribbean really integrates into the global market, offering a promising rapid growth, and good jobs for its workers. For despite the incidence of the loosely called "knowledge economy", the concern prevails that most countries' rich natural resources, still are the determining factor for exports. Policy recommendations include fostering openness to trade, market access, and foreign direct investment flows, in addition to building human capital, institutions, and public infrastructure, without disregarding the natural advantages. To this end, policymakers should aim at developing educational systems that provide quality education, focused on lifelong learning, and training activities to build human capital. Emphasis should follow on research and development (R&D) incentives, and innovations systems, arguing that countries should experiment with taxation incentives, and subsidies to promote both private, and public investments in R&D, (dependent on the institutional capacity of governments to enforce tax laws, and monitor the quality of investments). Moreover, evidence in this report, suggests that information, and communications technology (ICT) can reduce coordination costs, enabling an effective industrialization, and market access.
Culture And Global Change
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Author : Lourdes Arizpe S.
language : en
Publisher: University of Michigan Press
Release Date : 1996
Culture And Global Change written by Lourdes Arizpe S. and has been published by University of Michigan Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with Deforestation categories.
Offers a model for how to gather information on the human dimensions of global change
Fugitive Modernities
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Author : Jessica A. Krug
language : en
Publisher: Duke University Press
Release Date : 2018-11-15
Fugitive Modernities written by Jessica A. Krug and has been published by Duke University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-11-15 with History categories.
During the early seventeenth century, Kisama emerged in West Central Africa (present-day Angola) as communities and an identity for those fleeing expanding states and the violence of the trans-Atlantic slave trade. The fugitives mounted effective resistance to European colonialism despite—or because of—the absence of centralized authority or a common language. In Fugitive Modernities Jessica A. Krug offers a continent- and century-spanning narrative exploring Kisama's intellectual, political, and social histories. Those who became Kisama forged a transnational reputation for resistance, and by refusing to organize their society around warrior identities, they created viable social and political lives beyond the bounds of states and the ruthless market economy of slavery. Krug follows the idea of Kisama to the Americas, where fugitives in the New Kingdom of Grenada (present-day Colombia) and Brazil used it as a means of articulating politics in fugitive slave communities. By tracing the movement of African ideas, rather than African bodies, Krug models new methods for grappling with politics and the past, while showing how the history of Kisama and its legacy as a global symbol of resistance that has evaded state capture offers essential lessons for those working to build new and just societies.
Pulping The South
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Author : Ricardo Carriere
language : en
Publisher: Zed Books
Release Date : 1996-08-15
Pulping The South written by Ricardo Carriere and has been published by Zed Books this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-08-15 with Business & Economics categories.
The expansion of the pulp and paper industry is one of the most important causes of land and water conflicts in the South. This book examines the threat to livelihood, soil and biodiversity generated by large-scale pulpwood plantations in the South.
Milton Santos A Pioneer In Critical Geography From The Global South
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Author : Lucas Melgaço
language : en
Publisher: Springer
Release Date : 2017-05-08
Milton Santos A Pioneer In Critical Geography From The Global South written by Lucas Melgaço and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-05-08 with Political Science categories.
For decades, Milton Santos (1926-2001) has been considered one of the most influential thinkers in Brazilian and Latin American social sciences and geography. Yet his writings, most of which have not been translated into English, are largely unknown to European and North American audiences. This book introduces English-speaking scholars to Professor Santos through critical engagement with his ideas and writings. The chapters presented here reveal the breadth and originality of his critical thought, as well as its ongoing importance to contemporary debates. The book features a biography of Santos and includes an annotated translation of one of his most-cited texts, The Return of the Territory, offered here for the first time in English. This text demonstrates how Santos’s provocative insights continue to transform core concepts of political and human geography. The book also includes a number of short chapters written by scholars from Brazil, Spain and France. Through reflections on Santos’s work, the various authors demonstrate the value and possibilities of extending the geographer’s theories. They explore key geographical themes across political economy, rural studies, territorial planning, environmental crisis, digital networks, indigenous peoples, transportation and public health. This collection invites geographers from around the world to engage with this rich intellectual tradition from Brazil.
Embedded Autonomy
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Author : Peter B. Evans
language : en
Publisher: Princeton University Press
Release Date : 2012-01-12
Embedded Autonomy written by Peter B. Evans and has been published by Princeton University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-12 with Political Science categories.
In recent years, debate on the state's economic role has too often devolved into diatribes against intervention. Peter Evans questions such simplistic views, offering a new vision of why state involvement works in some cases and produces disasters in others. To illustrate, he looks at how state agencies, local entrepreneurs, and transnational corporations shaped the emergence of computer industries in Brazil, India, and Korea during the seventies and eighties. Evans starts with the idea that states vary in the way they are organized and tied to society. In some nations, like Zaire, the state is predatory, ruthlessly extracting and providing nothing of value in return. In others, like Korea, it is developmental, promoting industrial transformation. In still others, like Brazil and India, it is in between, sometimes helping, sometimes hindering. Evans's years of comparative research on the successes and failures of state involvement in the process of industrialization have here been crafted into a persuasive and entertaining work, which demonstrates that successful state action requires an understanding of its own limits, a realistic relationship to the global economy, and the combination of coherent internal organization and close links to society that Evans called "embedded autonomy."