A Handbook On Estrogen Receptors In The Brain
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A Handbook On Estrogen Receptors In The Brain
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Author : Vijay Paramanik
language : en
Publisher:
Release Date : 2016
A Handbook On Estrogen Receptors In The Brain written by Vijay Paramanik and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with Medical categories.
The present book covers estrogen, its receptors and estrogen mediated gene regulation in the brain. Further, it explains the mechanism of estrogen action and dysfunction leading to diseases. Briefly, estrogen mediates its multiple functions in the brain through two well-characterized receptors: ER? and ER?. Upon binding with estrogen, ER recruits coregulators, which are responsible for tissue specific regulation. When coregulators activate the transcription of a particular gene, they become coactivators; when they repress the activity of particular gene, they are called corepressors. These coregulators make a bridge between the basal transcription machinery and the receptors by protein-protein interaction. Estrogen disrupters are also explained in this book. Furthermore, the role of estrogen and its receptors are explained in the context of aging. Taken together, this book shall be self-explanatory concerning estrogen action in the brain in various aspects. Therefore, it is intended for researchers interested in the aforementioned aspects.
Handbook On Estrogen Receptors In The Brain
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Author : Vijay Paramanik
language : en
Publisher: Nova Biomedical Books
Release Date : 2016
Handbook On Estrogen Receptors In The Brain written by Vijay Paramanik and has been published by Nova Biomedical Books this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with Estrogen categories.
The present book covers estrogen, its receptors and estrogen mediated gene regulation in the brain. Further, it explains the mechanism of estrogen action and dysfunction leading to diseases. Briefly, estrogen mediates its multiple functions in the brain through two well-characterised receptors: ERα and ERβ. Upon binding with estrogen, ER recruits coregulators, which are responsible for tissue specific regulation. When coregulators activate the transcription of a particular gene, they become coactivators; when they repress the activity of particular gene, they are called corepressors. These coregulators make a bridge between the basal transcription machinery and the receptors by protein-protein interaction. Estrogen disrupters are also explained in this book. Furthermore, the role of estrogen and its receptors are explained in the context of aging. Taken together, this book shall be self-explanatory concerning estrogen action in the brain in various aspects. Therefore, it is intended for researchers interested in the aforementioned aspects.
Brain Aromatase Estrogens And Behavior
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Author : Jacques Balthazart
language : en
Publisher: Oxford University Press
Release Date : 2012-09-21
Brain Aromatase Estrogens And Behavior written by Jacques Balthazart and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-09-21 with Psychology categories.
It is well known that the class of steroid hormones known as estrogens have powerful effects on organs related to reproduction such as the uterus and the breast. What is less well known is that estrogens also profoundly modulate brain function and behavior. Estrogens, such as estradiol, can occur in brain as the result of ovarian secretion of the hormone into the blood that then finds its way to the brain. In male vertebrates, the testes secrete androgens, such as testosterone, into the blood and this class of steroid hormones can be converted into estrogens in the brain via the action of the enzyme aromatase which is expressed in the male brain in many species. Finally estradiol can be synthesized de novo from cholesterol as it has been shown in a variety of species that all the enzymes required to synthesize estrogens are expressed in the brain. This book collects chapters by experts in the field that considers, how estradiol is synthesized in the brain and what its effects are on a variety of behaviors. Special attention is paid to the enzyme aromatase that is distributed in discrete regions of the brain and is highly regulated in a sex specific and seasonal specific manner. Recently it has become clear that estrogens can act in the brain at two very different time scales, one is rather long lasting (days to weeks) and involves the modulation of gene transcription by the hormone-receptor complex. A second mode of action is much quicker and involves the action of estrogens on cell membranes that can result in effects on second messenger systems and ultimately behavior within minutes. Thus this book highlights novel views of estrogen action that are still under-appreciated namely that estrogens have significant effects on the male brain and that they can act on two very different times scales. This volume will be of interest to both basic researchers and clinicians interested in the action of estrogens.
Hormones And The Brain
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Author : Claude Kordon
language : en
Publisher: Springer Science & Business Media
Release Date : 2005-08-29
Hormones And The Brain written by Claude Kordon and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-08-29 with Medical categories.
Peripheral hormones have a major impact on the brain: they are able to interfere with its development, to affect release of neurotransmitters and concentrations of receptors, to trigger growth factors involved in lesion repair. These multiple actions account for their capacity to modulate a number of physiological parameters, from reproductive functions to memory, behavior and aging. This book based on contributions of pioneer investigators in the field, outlines the role of hormones in pathogenic processes such as mental disturbances or neurodegenerative diseases.
Estrogen Receptors
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Author : Kathleen M. Eyster
language : en
Publisher: Humana
Release Date : 2022-03-10
Estrogen Receptors written by Kathleen M. Eyster and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-03-10 with Science categories.
This fully updated collection includes chapters on a wide array of techniques that are vital for advancing our understanding of the physiological and pathological effects of estrogen, mediated by estrogen receptor α (ERα) and estrogen receptor β (ERβ) as well as the non-genomic membrane-bound G-protein coupled estrogen receptor (GPER/GPR30). The protocols range from standard methods and important laboratory workhorses such as immunoblot and RT-qPCR, to newer technologies such as PET imaging, reporter animal models, polysome fractionation, and many others, involving a broad range of tissue types to demonstrate the variety of estrogen receptor effects. Written for this highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Estrogen Receptors: Methods and Protocols, Second Edition serves as an ideal guide to researchers working to explore the vibrancy and excitement of the field of estrogen receptors and estrogen actions.
Hormone Receptors In The Brain
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Author : Junzo Kato
language : en
Publisher: Ardent Media
Release Date : 1973
Hormone Receptors In The Brain written by Junzo Kato and has been published by Ardent Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 1973 with Medical categories.
Estrogen Mystery Drug For The Brain
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Author : Christian Behl
language : en
Publisher: Springer Science & Business Media
Release Date : 2001-06-22
Estrogen Mystery Drug For The Brain written by Christian Behl and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-06-22 with Medical categories.
It is well known that estrogen is "somehow” a protective hormone for various age-related disorders. This book provides a solid knowledge of estrogen’s neuroprotective activities in the brain with a special emphasis on neurodegenerative disorders such as Alzheimer’s Disease. The focus is (1) to describe the biochemical, molecular, and cellular basis of the protective activity of estrogen and (2) to transfer this knowledge into the hospitals by discussing preventive and therapeutic approaches such as estrogen replacement therapy for post-menopausal women. Besides up-to-date information on estrogen and the brain, this book explains in a highly understandable manner molecular and cellular techniques by which basic data have been collected. The reader, which may include the professional specialist as well as the interested non-specialist, will also gain insight into the scientific transfer process of knowledge from basic science to the clinical situation and therefore "from bench to bed”.
Hormones And The Brain
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Author : Pieter A. Van Keep
language : en
Publisher:
Release Date : 1980
Hormones And The Brain written by Pieter A. Van Keep and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1980 with Brain Chemistry categories.
The Female Brain
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Author : Cynthia L. Darlington
language : en
Publisher: CRC Press
Release Date : 2003-08-29
The Female Brain written by Cynthia L. Darlington and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-08-29 with Science categories.
Ironically, the organ with the greatest reason to differ between the sexes, the brain, is often viewed as the most androgynous of all. Are there differences? Almost by convention, male animals are used in laboratory experiments in neuroscience. Even in clinical drug trials in humans, females are often excluded from the early phases of testing becau
The Female Brain
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Author : Louann Brizendine
language : en
Publisher: Random House
Release Date : 2009-05-04
The Female Brain written by Louann Brizendine and has been published by Random House this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-05-04 with Science categories.
Accessible, fun and compelling, and based on more than three decades of research, The Female Brain will help women to better understand themselves - and the men in their lives. In this groundbreaking book, Dr Louann Brizendine describes the uniquely flexible structure of the female brain and its constant, dynamic state of change - the key difference that separates it from that of the male - and reveals how women think, what they value, how they communicate, and whom they'll love. She also reveals the neurological explanations behind why... - A woman remembers fights that a man insists never happened... - Thoughts about sex enter a woman's brain perhaps once every couple of days, but may enter a man's brain up to once every minute... - A woman's brain goes on high alert during pregnancy - and stays that way long after giving birth... - A woman over 50 is more likely to initiate divorce than a man... - Women tend to know what people are feeling, while men can't spot an emotion unless someone cries or threatens them with bodily harm!