A Journey Through 50 Years Of Structural Bioinformatics In Memoriam Of Cyrus Chothia
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A Journey Through 50 Years Of Structural Bioinformatics In Memoriam Of Cyrus Chothia
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Author : Alfredo Iacoangeli
language : en
Publisher: Frontiers Media SA
Release Date : 2022-08-16
A Journey Through 50 Years Of Structural Bioinformatics In Memoriam Of Cyrus Chothia written by Alfredo Iacoangeli and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-08-16 with Science categories.
The cover image for this Research Topic was designed by Claire Marks.
Effective Techniques For Bioinformatic Exploration
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Author : Fazendeiro, Paulo
language : en
Publisher: IGI Global
Release Date : 2024-11-01
Effective Techniques For Bioinformatic Exploration written by Fazendeiro, Paulo and has been published by IGI Global this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-11-01 with Science categories.
The field of biology and technology is constantly changing and growing. However, the abundance and intricacy of biological data present significant challenges for researchers, educators, and students. Deciphering this vast sea of information to extract meaningful insights can be difficult. Traditional approaches often fail to provide comprehensive solutions to these intricate problems, leaving many struggling to navigate the complexities of bioinformatics. Effective Techniques for Bioinformatic Exploration brings new clarity to the world of bioinformatics, offering a comprehensive solution to the challenges scholars face. Through its meticulously crafted chapters, this book provides a structured approach to understanding and applying bioinformatics principles. Bridging the gap between theory and practice equips readers with the tools needed to tackle complex biological problems effectively. Whether delving into genomics, proteomics, or machine learning models, this book offers a roadmap for success. This book empowers readers to overcome challenges and make meaningful contributions to the field by embracing the scientific method and showcasing the practical application of bioinformatics techniques.
Mass Action Law Dynamics Theory And Algorithm For Translational And Precision Medicine Informatics
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Author : Ting-Chao Chou
language : en
Publisher: Elsevier
Release Date : 2024-04-09
Mass Action Law Dynamics Theory And Algorithm For Translational And Precision Medicine Informatics written by Ting-Chao Chou and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-04-09 with Science categories.
"Mass-Action Law Dynamics Theory and Algorithm for Translational and Precision Medicine Informatics provides a comprehensive overview and update of the mass-action law-based unified dose-effect biodynamics, pharmacodynamics, bioinformatics, and the combination index theorem for synergy definition (MAL-BD/PD/BI/CI). Contents advocate the fundamental MAL-PD/BI/CI/BI principle for biomedical R&D, clinical trials protocol design computerized data analysis, illustrates the MAL-dynamics theory with sample analysis, and includes data entry and automated computer report print-outs. In 11 sections "Mass-Action Law Dynamics Theory and Algorithm for Translational and Precision Medicine Informatics leads the reader from an introduction and overview, to trial protocols and MAL-PD/CI approach for biomedical R&D in vitro and in animals. It describes the current Landscape of International FDA Drug Evaluation, Clinical Pharmacology, and Clinical Trials Guidance. This is a valuable resource for biomedical researchers, healthcare professionals, and students seeking to harness the power of data informatics in precision medicine.• gives insight into that index equation (DRIE) that digitally determines how many folds of dose-reduction is needed for each drug in synergistic combinations • provides a comprehensive overview and update of mass-action law-based unified bioinformatics, dose effect biodynamics, pharmacodynamics, and the combination index theorem for synergy definition (MAL-BD/PD/BI/CI) • describes how the MAL theory/algorithm-based "Top-Down digital approach is the opposite and yet is a complementary alternative to the observation/statistics-based "Bottom-Up traditional approach in R&D
Sequence Evolution Function
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Author : Eugene Koonin
language : en
Publisher: Springer Science & Business Media
Release Date : 2002-11-30
Sequence Evolution Function written by Eugene Koonin and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-11-30 with Science categories.
Sequence - Evolution - Function is an introduction to the computational approaches that play a critical role in the emerging new branch of biology known as functional genomics. The book provides the reader with an understanding of the principles and approaches of functional genomics and of the potential and limitations of computational and experimental approaches to genome analysis. Sequence - Evolution - Function should help bridge the "digital divide" between biologists and computer scientists, allowing biologists to better grasp the peculiarities of the emerging field of Genome Biology and to learn how to benefit from the enormous amount of sequence data available in the public databases. The book is non-technical with respect to the computer methods for genome analysis and discusses these methods from the user's viewpoint, without addressing mathematical and algorithmic details. Prior practical familiarity with the basic methods for sequence analysis is a major advantage, but a reader without such experience will be able to use the book as an introduction to these methods. This book is perfect for introductory level courses in computational methods for comparative and functional genomics.
Sequence Analysis Primer
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Author : Michael Gribskov
language : en
Publisher: Springer
Release Date : 1991-06-01
Sequence Analysis Primer written by Michael Gribskov and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991-06-01 with Technology & Engineering categories.
Covers the basic computer analyses used for new DNA sequences and attempts to provide the researcher with the necessary background in order to understand and use efficiently these programs.
Molecules And Life
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Author : Fruton J. S.
language : en
Publisher:
Release Date : 1962
Molecules And Life written by Fruton J. S. and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1962 with categories.
Protein Refolding
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Author : George Georgiou
language : en
Publisher:
Release Date : 1991
Protein Refolding written by George Georgiou and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with SCIENCE categories.
the refolding process is often the critical bottleneck in the production of high-value proteins, and recently acquired insights have yet to be translated into technological advantages. These proceedings bridge the gap between fundamental and applied studies, addressing such issues as in vivo protein folding, protein aggregation and inclusion body formation, elucidation of the folding pathway, characterization of folding intermediates, and practical considerations in protein renaturation. The symposium was part of the 199th ACS National Meeting, Boston, April 1990. Annotation copyrighted by Book News, Inc., Portland, OR
Bioinformatics And Rna
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Author : Dolly Sharma
language : en
Publisher: CRC Press
Release Date : 2021-08-17
Bioinformatics And Rna written by Dolly Sharma and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-08-17 with Mathematics categories.
This book offers a unique balance between a basic introductory knowledge of bioinformatics and a detailed study of algorithmic techniques. Bioinformatics and RNA: A Practice-Based Approach is a complete guide on the fundamental concepts, applications, algorithms, protocols, new trends, challenges, and research results in the area of bioinformatics and RNA. The book offers a broad introduction to the explosively growing new discipline of bioinformatics. It covers theoretical topics along with computational algorithms. It explores RNA bioinformatics, which contribute to therapeutics and drug discovery. Implementation of algorithms in a DotNet Framework with code and complete insight on the state-of-the-art and recent advancements are presented in detail. The book targets both novice readers as well as practitioners in the field. FEATURES Offers a broad introduction to the explosively growing new discipline of bioinformatics Covers theoretical topics and computational algorithms Explores RNA bioinformatics to unleash the potential from therapeutics to drug discovery Discusses implementation of algorithms in DotNet Frameworks with code Presents insights into the state of the art and recent advancements in bioinformatics The book is useful to undergraduate students with engineering, science, mathematics, or biology backgrounds. Researchers will be equally interested.
Data Mining In Bioinformatics
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Author : Jason T. L. Wang
language : en
Publisher: Springer Science & Business Media
Release Date : 2005-09-02
Data Mining In Bioinformatics written by Jason T. L. Wang and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-09-02 with Computers categories.
8. 1. 1 Protein Subcellular Location The life sciences have entered the post-genome era where the focus of biologicalresearchhasshiftedfromgenomesequencestoproteinfunctionality. Withwhole-genomedraftsofmouseandhumaninhand,scientistsareputting more and more e?ort into obtaining information about the entire proteome in a given cell type. The properties of a protein include its amino acid sequences, its expression levels under various developmental stages and in di?erenttissues,its3Dstructureandactivesites,itsfunctionalandstructural binding partners, and its subcellular location. Protein subcellular location is important for understanding protein function inside the cell. For example, the observation that the product of a gene is localized in mitochondria will support the hypothesis that this protein or gene is involved in energy metabolism. Proteins localized in the cytoskeleton are probably involved in intracellular tra?cking and support. The context of protein functionality is well represented by protein subcellular location. Proteins have various subcellular location patterns [250]. One major category of proteins is synthesized on free ribosomes in the cytoplasm. Soluble proteins remain in the cytoplasm after their synthesis and function as small factories catalyzing cellular metabolites. Other proteins that have a target signal in their sequences are directed to their target organelle (such as mitochondria) via posttranslational transport through the organelle membrane. Nuclear proteins are transferred through pores on the nuclear envelope to the nucleus and mostly function as regulators. The second major category of proteins is synthesized on endoplasmic reticulum(ER)-associated ribosomes and passes through the reticuloendothelial system, consisting of the ERand the Golgi apparatus.
Immunoglobulin Genes
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Author : Tasuku Honjo
language : en
Publisher: Elsevier
Release Date : 1995-09-27
Immunoglobulin Genes written by Tasuku Honjo and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995-09-27 with Medical categories.
The immunoglobulin gene complex is responsible for generating an extraordinarily wide range of antibodies, each possessing a unique antigen specificity. The Second Edition of Immunoglobulin Genes brings the reader up to date with the rapid progress in our understanding of this system. Firmly established as the definitive book on the topic, it provides a fully comprehensive account of the organization, function, rearrangement and expression of these and related genes. Since the publication of the first edition, the work has been extensively revised and updated to cover new research data on human immunoglobulin genes as well as mammalian and lower vertebrate systems. New chapters include "Somatic mutation and B cell Maturation", "Antigen receptors" and "B lymphocyte tolerance in the mouse."For the immunologist, there are detailed descriptions of the molecular mechanisms which generate this diverse range of antibodies and the tight regulation of the genes encoding them. Molecular biologists will find discussions of important phenomena including gene rearrangement, differential splicing and deletion in the context of immunoglobulin genes.The excitement of research on immunoglobulin genes is conveyed by the range and complexity of issues discussed here; the book contains invaluable information for clinicians and research scientists with an interest in the immune response.* Conveys the excitement of research on immunoglobulin genes by the range and complexity of issues* Contains invaluable information for clinicians and research scientists with an interest in the immune response* For the Immunologist* Detailed descriptions of the molecular mechanisms generating this diverse range of antibodies and the regulation of genes encoding them* For the Molecular Biologist* Discusses important phenomena including gene rearrangement, differential splicing, and deletion in the context of immunoglobulin genes.