A Mechanistic And Functional Study Of White Opaque Phenotypic Switching In Candida Albicans
DOWNLOAD
Download A Mechanistic And Functional Study Of White Opaque Phenotypic Switching In Candida Albicans PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get A Mechanistic And Functional Study Of White Opaque Phenotypic Switching In Candida Albicans book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
A Mechanistic And Functional Study Of White Opaque Phenotypic Switching In Candida Albicans
DOWNLOAD
Author : Mathew Gregory Miller
language : en
Publisher:
Release Date : 2005
A Mechanistic And Functional Study Of White Opaque Phenotypic Switching In Candida Albicans written by Mathew Gregory Miller and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with categories.
Candida albicans is a major fungal pathogen of humans. It is a harmless commensal in healthy individuals, but it can cause serious infections in immune-compromised hosts. C. albicans undergoes a meta-stable and reversible switch between two distinct cell types known as white and opaque. The role of white-opaque switching in the biology of C. albicans was originally not well understood. We discovered an unexpected relationship between white-opaque switching and the sexual cycle of C. albicans . The mating type locus of C. albicans (MTL) encodes transcriptional regulatory proteins that regulate mating. We demonstrated that two MTL -encoded homeodomain proteins, a 1 and alpha2, work together to repress white-opaque switching in C. albicans . The observations that the MTL locus controlled both mating and white-opaque switching led us to hypothesize that opaque cells played a role in mating. Indeed, we found that opaque cells mate one million times more efficiently than do white cells. Additionally, opaque cells, but not white cells, developed specialized mating projections when exposed to mating pheromone. Thus, opaque cells are a specialized mating form of C. albicans . As white cells are generally more robust in a mammalian host than opaque cells, this strategy allows the organism to survive the rigors of life within a mammalian host, while generating a small population of mating-competent cells. The mechanism that controls white-opaque switching is not well understood. To better understand the mechanism, we investigated the regulation of white-opaque switching by a 1-alpha2. We demonstrated that a 1-alpha2 regulates white-opaque switching by destabilizing opaque cells, and we monitored gene expression during the transition from opaque to white using DNA microarrays. We used a candidate approach to identify additional regulators of white-opaque switching among genes enriched for their expression in the opaque phase. We identified two potent positive regulators of white-opaque switching: the opaque-specific transcriptional regulatory proteins Czf1 and Naf1. We also further investigated the role of Efg1, a previously identified regulator of white-opaque switching, and found that efg1/efg1 mutants were unable to bypass a 1-alpha2 repression of switching. Finally, we determined the epistatic and regulatory relationships between Efg1, Czf1 and Naf1.
Dissertation Abstracts International
DOWNLOAD
Author :
language : en
Publisher:
Release Date : 2005
Dissertation Abstracts International written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Dissertations, Academic categories.
Structure And Function Of The Aspartic Proteinases
DOWNLOAD
Author : Ben M. Dunn
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Structure And Function Of The Aspartic Proteinases written by Ben M. Dunn and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
In September, 1990, a group of 160 scientists from 19 countries and 21 of the United States met at the Red Lion Inn in Rohnert Park, Sonoma County, California. The purpose of this meeting was to share new information from recent research on the Aspartic Proteinases. This book is a compilation of the information transferred in that forum. The Aspartic Proteinases include all those enzymes from the "fourth" class of proteolytic enzymes, the first three being the Serine, Cysteine and Metalloproteinases. Of course, all the scientists in attendance at the Sonoma Aspartic Proteinase Conference would agree that our current level of understanding of the structure and function of the Aspartic Proteinase class of enzymes is clearly first class. The reasons for this require a bit of historical perspective. The group of scientists who are engaged in study of this family of enzymes first met as a separate entity in 1976, in Norman, Oklahoma, at a meeting organized by Jordan Tang of the Oklahoma Medical Research Foundation. This was an exciting time, as the first crystal structures of some of these enzymes were described by Blundell, James and Davies. During that conference, the relationship between the two halves of the mammalian and fungal enzymes was recognized and this has provided a structural foundation for analysis of the retroviral enzymes, which came later. A book was published by Plenum Press documenting l this conference, and the current book is an update to that important work.
Candida Albicans
DOWNLOAD
Author : Rajendra Prasad
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Candida Albicans written by Rajendra Prasad and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
Candida, which was discovered more than a century ago as a causative organism of oral thrush, is now thought to potentially infect almost every tissue of the human body. Although we still do not have a safe anti-candida drug, the growing pace of progess of research on Candida albicans holds promise that a breakthrough is imminent. Though many monographs and articles on candida and candidoses have appeared in recent years, they mostly cover the clinical aspects. This particular text, however, explains the more basic features of candida including the molecular genetics, molecular biology and immunology of the cell wall, the molecular basis of morphogenesis and the structure and function of the plasma membrane. The role of anti-candida drugs and their mechanism of action are also discussed.
Growing Fungus
DOWNLOAD
Author : N.A. Gow
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-08-28
Growing Fungus written by N.A. Gow and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-08-28 with Science categories.
This book is about the growth and differentiation processes underlying the growth and differentia of filamentous fungi. The impetus for this work tion of fungi and that it provides the reader with stems from our perception that the coverage of adequate source references for further information. this highly diverse and important group of organ It is estimated conservatively that there are more isms has been neglected in recent years, despite than 1. 5 million species of fungi - more than five many significant advances in our understanding of times the number of vascular plants and second the underlying mechanisms of growth. This situ only in diversity to the insects. The extreme ation contrasts with the treatment of Saccharomyces diversity of form in the fungi has always been a cerevisiae, for example, which because of its ideal source of inspiration for mycologists. This book is properties for genetic analyses, has established concerned mainly with those systems that have itself as the model eukaryote for the analysis of the been well characterized from the biochemical, cell cycle, and basic studies of biochemical and physiological or genetic points of view. Although genetic regulation. This book does not deal with it has not been possible to illustrate the breadth of the detailed growth phYSiology of S.
Molecular Biology Of Fungal Development
DOWNLOAD
Author : Heinz D. Osiewacz
language : en
Publisher: CRC Press
Release Date : 2002-05-07
Molecular Biology Of Fungal Development written by Heinz D. Osiewacz and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-05-07 with Science categories.
This text gives an overview of the fundamental aspects of molecular fungal development in one comprehensive volume, highlighting different elements in the maturational and reproductive cycles of selected fungal taxa.
Fungal Pathogenesis
DOWNLOAD
Author : Richard Calderone
language : en
Publisher: CRC Press
Release Date : 2001-10-12
Fungal Pathogenesis written by Richard Calderone and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-10-12 with Science categories.
Stresses molecular and biochemical studies of opportunistic and frank fungal pathogens! This book gives a comprehensive overview of human pathogenic fungi that offers a current and concise survey of virulence factors, host responses and recognition, treatment and diagnosis of infections, invasive enzymes, intracellular survival, morphogenesi
Population Genomics Microorganisms
DOWNLOAD
Author : Martin F. Polz
language : en
Publisher: Springer
Release Date : 2019-01-07
Population Genomics Microorganisms written by Martin F. Polz and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-01-07 with Science categories.
Population genomics is a rapidly emerging field that has the potential to transform our understanding of how evolutionary forces shape genomic diversity among microbes. There have already been considerable advances in understanding gene flow and spread of adaptive traits, and in linking epidemiology with evolutionary biology. The current challenge is to find unifying evolutionary principles for organisms that display a wide range of reproductive biology – from highly clonal to promiscuous – and for which the vast majority have eluded cultivation. This requires interdisciplinary approaches that incorporate novel computational tools, testing of existing and novel population genetic models, and creative new ways of linking genetic diversity to ecological factors. This pioneering book will discuss the advances made and promises of population genomics in microorganisms, outlining some of the key theoretical and practical challenges for microbial population genomics, including defining and identifying populations, genomics-based reverse ecology and building appropriate tools to understand microbes in a variety of complex environments.
Proceedings Of The National Academy Of Sciences Of The United States Of America
DOWNLOAD
Author : National Academy of Sciences (U.S.).
language : en
Publisher:
Release Date : 2006
Proceedings Of The National Academy Of Sciences Of The United States Of America written by National Academy of Sciences (U.S.). and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with Science categories.
Cumulated Index Medicus
DOWNLOAD
Author :
language : en
Publisher:
Release Date : 1989
Cumulated Index Medicus written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1989 with Medicine categories.