A Modern Approach To Biofilm Related Orthopaedic Implant Infections
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A Modern Approach To Biofilm Related Orthopaedic Implant Infections
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Author : Lorenzo Drago
language : en
Publisher: Springer
Release Date : 2017-05-16
A Modern Approach To Biofilm Related Orthopaedic Implant Infections written by Lorenzo Drago and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-05-16 with Medical categories.
This book discusses Prosthetic Joint Infection (PJI), which remains one of the most common problems necessitating revision arthroplasty. It pursues a multidisciplinary approach, bringing together opinions from the leading experts in the field. The book identifies the potential causes of these infections, provides sound diagnostic criteria guidelines, and explains how these prosthetic infections are managed from orthopedic surgery, clinical and diagnostic perspectives. PJI can lead to multiple revision surgeries and significant patient morbidity. Periprosthetic infection rates remain around 1–2% after primary total hip and knee arthroplasty and account for approximately 7–12% of all revision cases. Orthopedic hardware infections are much-feared and costly complications that can occur when these devices are implemented both in traumatic cases as well as in joint replacement surgery. Because these infections can lead to higher morbidity, it is important to understand their pathophysiology and the principles behind their diagnosis and initial treatment. The pathogenesis of these kinds of infections is intimately connected to the biofilm-producing trait characteristic of many microorganisms, which can have a critical effect on the likely success of treatments. The book offers a unique guide for all scientists working in arthroplasty who are seeking an update on the field, and for newcomers alike.
Culture Negative Orthopedic Biofilm Infections
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Author : Garth D. Ehrlich
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-18
Culture Negative Orthopedic Biofilm Infections written by Garth D. Ehrlich and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-18 with Science categories.
During the recent transition between acute diseases caused by swarms of single planktonic bacteria, and chronic infections caused by bacteria growing in slime-enclosed biofilms, a general clinical consensus has emerged that pathologies with bacterial etiologies are frequently culture negative. Because biofilm infections now affect 17 million Americans per year (killing approximately 450,000), the suggestion that these common and lethal infections regularly go unnoticed by the only FDA-approved method for their detection and characterization is a matter of urgent concern. Biologically, we would expect that planktonic bacterial cells would colonize any new surface, including the surface of an agar plate, while the specialized sessile cells of a biofilm community would have no such proclivity. In the study of biofilm diseases ranging from otitis media to prostatitis, it was found that direct microscopy and DNA- and RNA-based molecular methods regularly document the presence of living bacteria in tissues and samples that are culture negative. The editors selected orthopedic biofilm infections as the subject of this book because these infections occur against a background of microbiological sterility in which modern molecular methods would be expected to find bacterial DNA, RNA-based microscopic methods would be expected to locate bacterial cells, and cultures would be negative. Moreover, in Orthopedics we find an already biofilm-adapted surgical group in which current strategies are based on the meticulous removal of compromised tissues, antibiotic options as based on high biofilm-killing local doses, and there are practical bedside strategies for dealing with biofilm infections. So here is where the new paradigm of biofilm infection meets the equally new paradigm of the culture negativity of biofilms, and this volume presents a conceptual synthesis that may soon combine the most effective molecular methods for the detection and identification of bacteria with a surgical discipline that is ready to help patients.
Microbial Biofilms In Chronic And Recurrent Infections
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Author : Axel Cloeckaert
language : en
Publisher: Frontiers Media SA
Release Date : 2022-01-19
Microbial Biofilms In Chronic And Recurrent Infections written by Axel Cloeckaert and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-19 with Science categories.
Musculoskeletal Infection
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Author : Melanie Coathup
language : en
Publisher: Springer Nature
Release Date : 2022-02-01
Musculoskeletal Infection written by Melanie Coathup and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-01 with Medical categories.
This book gathers international knowledge and contemporary clinical and scientific evidence on infections associated with the musculoskeletal system at a time when we are confronted with significant challenges and uncertainty. A key focus of the book is enhancing and advancing future discovery in the detection, prevention and treatment of musculoskeletal infection. This is an ideal book for physicians, surgeons, research scientists, university students, as well as medical and allied health students.
Tissue Engineering Using Ceramics And Polymers
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Author : Aldo R. Boccaccini
language : en
Publisher: Woodhead Publishing
Release Date : 2021-10-27
Tissue Engineering Using Ceramics And Polymers written by Aldo R. Boccaccini and has been published by Woodhead Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-10-27 with Technology & Engineering categories.
Tissue Engineering Using Ceramics and Polymers, Third Edition is a valuable reference tool for both academic researchers and scientists involved in biomaterials or tissue engineering, including the areas of bone and soft-tissue reconstruction, repair and organ regeneration. With its distinguished editors and international team of contributors, this book reviews the latest research and advances in this thriving area and how they can be used to develop treatments for disease states. New sections cover nanobiomaterials, drug delivery, advanced imaging and MRI for tissue engineering, and characterization of vascularized scaffolds. Technology and research in the field of tissue engineering has drastically increased within the last few years to the extent that almost every tissue and organ of the human body could potentially be regenerated with the aid of biomaterials. Provides updated and new information on ceramic and polymer biomaterials for tissue engineering Presents readers with systematic coverage of the processing, characterization and modeling of each material Includes content that will be relevant to a range of readers, including biomedical engineers, materials scientists, and those interested in regenerative medicine
Prosthetic Joint Infections
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Author : Trisha Peel
language : en
Publisher: Springer
Release Date : 2017-11-28
Prosthetic Joint Infections written by Trisha Peel and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-11-28 with Medical categories.
This book outlines the most updated clinical guidelines that are vital for the prevention infections and care of patients with joint infections following a replacement surgery, one of the highest volume medical interventions globally. Sections address the diagnosis, management approaches and prevention of prosthetic joint infections. Written by experts in the field, this text provides a brief overview of the literature and current recommendations in each of the specified areas. Given the rapidly evolving state-of-play in this clinical area, this compendium grows increasingly important to clinicians in their management decisions. Prosthetic Joint Infections is a valuable resource for infectious disease specialists, epidemiologists, surgeons, and orthopedic specialists who may work with patients with prosthetic joint infections.
Biofilms And Implantable Medical Devices
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Author : Ying Deng
language : en
Publisher: Woodhead Publishing
Release Date : 2016-10-24
Biofilms And Implantable Medical Devices written by Ying Deng and has been published by Woodhead Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-10-24 with Technology & Engineering categories.
Biofilms and Implantable Medical Devices: Infection and Control explores the increasing use of permanent and semi-permanent implants and indwelling medical devices. As an understanding of the growth and impact of biofilm formation on these medical devices and biomaterials is vital for protecting the health of the human host, this book provides readers with a comprehensive treatise on biofilms and their relationship with medical devices, also reporting on infections and associated strategies for prevention. Provides useful information on the fundamentals of biofilm problems in medical devices Discusses biofilm problems in a range of medical devices Focuses on strategies for prevention of biofilm formation
Regenerative Medicine And Plastic Surgery
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Author : Dominik Duscher
language : en
Publisher: Springer Nature
Release Date : 2019-11-26
Regenerative Medicine And Plastic Surgery written by Dominik Duscher and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-26 with Science categories.
This book discusses the current research concepts and the emerging technologies in the field of stem cells and tissue engineering. It is the first authoritative reference documenting all the ways that plastic surgical practice and regenerative medicine science overlap or provide a road map for the future of both specialties. The Editors have provided a valuable service by gathering in one place the leading voices in these two fields in clear and concise manner. Divided into five parts, the book opens with a description of the elements of regenerative medicine including definitions, basic principles of soft and bone tissue regeneration, biomaterials and scaffolds. Current research concepts are explored in the second part of this book, for example mechanotransduction and the utility of extracellular vesicles. In the third part, the editors present the emerging technologies and highlight the novel perspectives on bionic reconstruction and biomimetics in surgery and regenerative medicine. Part four deals with translational aspects including practical information on moving scientific findings from bench to bedside. The final part then describes in detail applications in clinical plastic surgery. Written by leading experts this book is an invaluable resource for researchers, students, beginners and experienced clinicians in a range of specialties. "In your hands is a comprehensive encyclopedia of two rapidly converging fields. Drs Duscher and Shiffman have done an outstanding job of highlighting the interdependent relationship between plastic surgery and regenerative medicine. Ultimately, this is to the benefit of both fields." - Geoffrey C. Gurtner, MD, FACS Johnson and Johnson Distinguished Professor of Surgery Professor (by courtesy) of Bioengineering and Materials Science Inaugural Vice Chairman of Surgery for Innovation Stanford University School of Medicine
Biofilm Infections
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Author : Thomas Bjarnsholt
language : en
Publisher: Springer
Release Date : 2014-10-11
Biofilm Infections written by Thomas Bjarnsholt and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-10-11 with Science categories.
This book will cover both the evidence for biofilms in many chronic bacterial infections as well as the problems facing these infections such as diagnostics and treatment regimes. A still increasing interest and emphasis on the sessile bacterial lifestyle biofilms has been seen since it was realized that that less than 0.1% of the total microbial biomass lives in the planktonic mode of growth. The term was coined in 1978 by Costerton et al. who defined the term biofilm for the first time.In 1993 the American Society for Microbiology (ASM) recognised that the biofilmmode of growth was relevant to microbiology. Lately many articles have been published on the clinical implications of bacterial biofilms. Both original articles and reviews concerning the biofilm problem are available.
Bone And Joint Infections
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Author : W. Zimmerli
language : en
Publisher: John Wiley & Sons
Release Date : 2015-01-27
Bone And Joint Infections written by W. Zimmerli and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-01-27 with Science categories.
Infections of the bones (osteomyelitis) and joints (septic arthritis) are serious health problems which require antibiotics and often surgery. Awareness among health professionals of the causes and treatment options for various types of bone and joint infections is essential for effective resolution. Bone and Joint Infections takes a multidisciplinary approach in covering the diagnostic and therapeutic treatment of osteomyelitis and septic arthritis, including different types of implant-associated infections. Correct and rapid diagnosis of bone and joint infection is crucial, and requires the input of a variety of specialists. Bone and Joint Infection takes a similarly collaborative and comprehensive approach, including chapters authored by clinicians, laboratory specialists, and surgeons. Covering the basic microbiology and clinical aspects of bone and joint infection, this book will be a valuable resource both for researchers in the lab and for physicians and surgeons seeking a comprehensive reference on osteomyelitis and septic arthritis.