A Novel Method For The Selective Elimination Of Hiv Infected Cells
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A Novel Method For The Selective Elimination Of Hiv Infected Cells
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Author : Najoua Elbourakadi
language : en
Publisher:
Release Date : 2011
A Novel Method For The Selective Elimination Of Hiv Infected Cells written by Najoua Elbourakadi and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with HIV infections categories.
"It has been established that various combinations of three or more antiretroviral drugs will lead to durable inhibition of HIV replication in patients. Despite its success in controlling the infection, highly active antiretroviral therapy (HAART) does not eradicate the virus; systemic infection re-emerges upon treatment interruption in all but exceptional cases, necessitating a lifetime of expensive drug therapy with an ever-present risk of emerging drug resistance. Thus, there is a critical need for the development of new treatment modalities not based solely on virally-encoded targets, and with the potential to actually cure HIV infection. Using standard colorimetric and fluorometric live/dead cell labeling methods, we have developed a novel "selective cell death" assay, and identified a lead drug combination for elimination of infected cells, involving a patented combination of 2 generic FDA approved drugs or their metabolites: the glucocorticoid dexamethasone (Dex) and N, N-diethylaminoethanolamine (DEAE, a metabolite of procaine). Neither drug alone, but only the combination, is effective in cell killing, and only in HIV-infected cells (P
Hiv 1 Latency
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Author : Guido Silvestri
language : en
Publisher: Springer
Release Date : 2018-10-11
Hiv 1 Latency written by Guido Silvestri and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-10-11 with Medical categories.
This volume summarizes recent advances in understanding the mechanisms of HIV-1 latency, in characterizing residual viral reservoirs, and in developing targeted interventions to reduce HIV-1 persistence during antiretroviral therapy. Specific chapters address the molecular mechanisms that govern and regulate HIV-1 transcription and latency; assays and technical approaches to quantify viral reservoirs in humans and animal models; the complex interchange between viral reservoirs and the host immune system; computational strategies to model viral reservoir dynamics; and the development of therapeutic approaches that target viral reservoir cells. With contributions from an interdisciplinary group of investigators that cover a broad spectrum of subjects, from molecular virology to proof-of-principle clinical trials, this book is a valuable resource for basic scientists, translational investigators, infectious-disease physicians, individuals living with HIV/AIDS and the general public.
Molecular Biology Of The Cell
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Author : Bruce Alberts
language : en
Publisher:
Release Date : 2002
Molecular Biology Of The Cell written by Bruce Alberts and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Cytology categories.
Immunotoxin Methods And Protocols
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Author : Walter A. Hall
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-02
Immunotoxin Methods And Protocols written by Walter A. Hall and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-02 with Medical categories.
Immunotoxins represent a new class of human therapeutics that have widespread applications and a potential that has not yet been fully recognized since they were first conceived of by Paul Ehrlich in 1906. The majority of advances in the development and implementation of immunotoxins has occurred over the last 20 years. The reasons for this use of immunotoxins in basic science and clinical research are the powerful concurrent advances in genetic engineering and receptor physiology. Recombinant technology has allowed investigators to produce sufficient quantities of a homogeneous c- pound that allows clinical trials to be performed. The identification of specific receptors on malignant cell types has enabled scientists to generate immunotoxins that have had positive results in clinical trials. As more cellular targets are identified in coming years, additional trials will be conducted in different disease states affecting still larger patient populations. Modulation of the immune system to decrease the humoral response to immunotoxins may improve their overall efficacy. As increasingly more effective compounds are generated, it will be necessary to decrease the local and systemic toxicity - sociated with these agents, and methods for doing so are presently being - veloped. The work presented in Immunotoxin Methods and Protocols focuses on three specific areas of immunotoxin investigation that are being conducted by experts throughout the world. The first section describes the construction and development of a variety of immunotoxins.
Novel Insights Into A Functional Hiv Cure
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Author : Taisuke Izumi
language : en
Publisher: Frontiers Media SA
Release Date : 2022-01-17
Novel Insights Into A Functional Hiv Cure written by Taisuke Izumi and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-17 with Science categories.
Exploring Novel Approaches To Eliminate Hiv Reservoirs To Achieve A Cure For Hiv
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Author : Renee Marije Van Der Sluis
language : en
Publisher: Frontiers Media SA
Release Date : 2021-04-07
Exploring Novel Approaches To Eliminate Hiv Reservoirs To Achieve A Cure For Hiv written by Renee Marije Van Der Sluis and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-04-07 with Science categories.
Sars Mers And Other Viral Lung Infections
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Author : David S. Hui
language : en
Publisher: European Respiratory Society
Release Date : 2016-06-01
Sars Mers And Other Viral Lung Infections written by David S. Hui and has been published by European Respiratory Society this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-06-01 with Medical categories.
Viral respiratory tract infections are important and common causes of morbidity and mortality worldwide. In the past two decades, several novel viral respiratory infections have emerged with epidemic potential that threaten global health security. This Monograph aims to provide an up-to-date and comprehensive overview of severe acute respiratory syndrome, Middle East respiratory syndrome and other viral respiratory infections, including seasonal influenza, avian influenza, respiratory syncytial virus and human rhinovirus, through six chapters written by authoritative experts from around the globe.
Hiv 1 Integrase
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Author : Nouri Neamati
language : en
Publisher: John Wiley & Sons
Release Date : 2011-08-10
Hiv 1 Integrase written by Nouri Neamati and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-08-10 with Science categories.
This book comprehensively covers the mechanisms of action and inhibitor design for HIV-1 integrase. It serves as a resource for scientists facing challenging drug design issues and researchers in antiviral drug discovery. Despite numerous review articles and isolated book chapters dealing with HIV-1 integrase, there has not been a single source for those working to devise anti-AIDS drugs against this promising target. But this book fills that gap and offers a valuable introduction to the field for the interdisciplinary scientists who will need to work together to design drugs that target HIV-1 integrase.
Human Herpesviruses
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Author : Ann Arvin
language : en
Publisher: Cambridge University Press
Release Date : 2007-08-16
Human Herpesviruses written by Ann Arvin and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-08-16 with Medical categories.
This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.
Cumulated Index Medicus
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Author :
language : en
Publisher:
Release Date : 2000
Cumulated Index Medicus written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with Medicine categories.