A Survey Of Models For Tumor Immune System Dynamics
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A Survey Of Models For Tumor Immune System Dynamics
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Author : John A. Adam
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-10-06
A Survey Of Models For Tumor Immune System Dynamics written by John A. Adam and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-10-06 with Mathematics categories.
Mathematical Modeling and Immunology An enormous amount of human effort and economic resources has been directed in this century to the fight against cancer. The purpose, of course, has been to find strategies to overcome this hard, challenging and seemingly endless struggle. We can readily imagine that even greater efforts will be required in the next century. The hope is that ultimately humanity will be successful; success will have been achieved when it is possible to activate and control the immune system in its competition against neoplastic cells. Dealing with the above-mentioned problem requires the fullest pos sible cooperation among scientists working in different fields: biology, im munology, medicine, physics and, we believe, mathematics. Certainly, bi ologists and immunologists will make the greatest contribution to the re search. However, it is now increasingly recognized that mathematics and computer science may well able to make major contributions to such prob lems. We cannot expect mathematicians alone to solve fundamental prob lems in immunology and (in particular) cancer research, but valuable sup port, however modest, can be provided by mathematicians to the research aspirations of biologists and immunologists working in this field.
A Survey Of Models For Tumor Immune System Dynamics
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Author : John A. Adam
language : en
Publisher: Springer Science & Business Media
Release Date : 1997
A Survey Of Models For Tumor Immune System Dynamics written by John A. Adam and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with Mathematics categories.
This unique book is a collection of seven interdisciplinary surveys on modeling tumor dynamics and interactions between tumors and immune system. The goal is to provide an accessible, comprehensive report on the field and to help define a framework for future interdisciplinary research activity. Modeling and simulation of general behaviors of immune systems are also discussed. Each survey carefully covers a specialized field and provides a detailed description of the present state-of-the-art in research. The reader will be able to obtain essential information on the methodological approach used and on the models that are categorized and used. The book is an excellent resource and survey for applied mathematicians, mathematical biologists and biologists interested in modeling methods in immunology and related sciences.
A Survey Of Models For Tumor Immune System Dynamics
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Author : John A Adam
language : en
Publisher:
Release Date : 1996-12-01
A Survey Of Models For Tumor Immune System Dynamics written by John A Adam and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-12-01 with categories.
Mathematical Models Of Tumor Immune System Dynamics
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Author : Amina Eladdadi
language : en
Publisher: Springer
Release Date : 2014-11-06
Mathematical Models Of Tumor Immune System Dynamics written by Amina Eladdadi and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-11-06 with Mathematics categories.
This collection of papers offers a broad synopsis of state-of-the-art mathematical methods used in modeling the interaction between tumors and the immune system. These papers were presented at the four-day workshop on Mathematical Models of Tumor-Immune System Dynamics held in Sydney, Australia from January 7th to January 10th, 2013. The workshop brought together applied mathematicians, biologists, and clinicians actively working in the field of cancer immunology to share their current research and to increase awareness of the innovative mathematical tools that are applicable to the growing field of cancer immunology. Recent progress in cancer immunology and advances in immunotherapy suggest that the immune system plays a fundamental role in host defense against tumors and could be utilized to prevent or cure cancer. Although theoretical and experimental studies of tumor-immune system dynamics have a long history, there are still many unanswered questions about the mechanisms that govern the interaction between the immune system and a growing tumor. The multidimensional nature of these complex interactions requires a cross-disciplinary approach to capture more realistic dynamics of the essential biology. The papers presented in this volume explore these issues and the results will be of interest to graduate students and researchers in a variety of fields within mathematical and biological sciences.
Mathematical Oncology 2013
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Author : Alberto d'Onofrio
language : en
Publisher: Springer
Release Date : 2014-10-16
Mathematical Oncology 2013 written by Alberto d'Onofrio and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-10-16 with Mathematics categories.
With chapters on free boundaries, constitutive equations, stochastic dynamics, nonlinear diffusion–consumption, structured populations, and applications of optimal control theory, this volume presents the most significant recent results in the field of mathematical oncology. It highlights the work of world-class research teams, and explores how different researchers approach the same problem in various ways. Tumors are complex entities that present numerous challenges to the mathematical modeler. First and foremost, they grow. Thus their spatial mean field description involves a free boundary problem. Second, their interiors should be modeled as nontrivial porous media using constitutive equations. Third, at the end of anti-cancer therapy, a small number of malignant cells remain, making the post-treatment dynamics inherently stochastic. Fourth, the growth parameters of macroscopic tumors are non-constant, as are the parameters of anti-tumor therapies. Changes in these parameters may induce phenomena that are mathematically equivalent to phase transitions. Fifth, tumor vascular growth is random and self-similar. Finally, the drugs used in chemotherapy diffuse and are taken up by the cells in nonlinear ways. Mathematical Oncology 2013 will appeal to graduate students and researchers in biomathematics, computational and theoretical biology, biophysics, and bioengineering.
Handbook Of Research On Modeling Analysis And Control Of Complex Systems
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Author : Azar, Ahmad Taher
language : en
Publisher: IGI Global
Release Date : 2020-12-05
Handbook Of Research On Modeling Analysis And Control Of Complex Systems written by Azar, Ahmad Taher and has been published by IGI Global this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-05 with Mathematics categories.
The current literature on dynamic systems is quite comprehensive, and system theory’s mathematical jargon can remain quite complicated. Thus, there is a need for a compendium of accessible research that involves the broad range of fields that dynamic systems can cover, including engineering, life sciences, and the environment, and which can connect researchers in these fields. The Handbook of Research on Modeling, Analysis, and Control of Complex Systems is a comprehensive reference book that describes the recent developments in a wide range of areas including the modeling, analysis, and control of dynamic systems, as well as explores related applications. The book acts as a forum for researchers seeking to understand the latest theory findings and software problem experiments. Covering topics that include chaotic maps, predictive modeling, random bit generation, and software bug prediction, this book is ideal for professionals, academicians, researchers, and students in the fields of electrical engineering, computer science, control engineering, robotics, power systems, and biomedical engineering.
Mathematical Methods And Models In Biomedicine
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Author : Urszula Ledzewicz
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-10-21
Mathematical Methods And Models In Biomedicine written by Urszula Ledzewicz and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-10-21 with Mathematics categories.
Mathematical biomedicine is a rapidly developing interdisciplinary field of research that connects the natural and exact sciences in an attempt to respond to the modeling and simulation challenges raised by biology and medicine. There exist a large number of mathematical methods and procedures that can be brought in to meet these challenges and this book presents a palette of such tools ranging from discrete cellular automata to cell population based models described by ordinary differential equations to nonlinear partial differential equations representing complex time- and space-dependent continuous processes. Both stochastic and deterministic methods are employed to analyze biological phenomena in various temporal and spatial settings. This book illustrates the breadth and depth of research opportunities that exist in the general field of mathematical biomedicine by highlighting some of the fascinating interactions that continue to develop between the mathematical and biomedical sciences. It consists of five parts that can be read independently, but are arranged to give the reader a broader picture of specific research topics and the mathematical tools that are being applied in its modeling and analysis. The main areas covered include immune system modeling, blood vessel dynamics, cancer modeling and treatment, and epidemiology. The chapters address topics that are at the forefront of current biomedical research such as cancer stem cells, immunodominance and viral epitopes, aggressive forms of brain cancer, or gene therapy. The presentations highlight how mathematical modeling can enhance biomedical understanding and will be of interest to both the mathematical and the biomedical communities including researchers already working in the field as well as those who might consider entering it. Much of the material is presented in a way that gives graduate students and young researchers a starting point for their own work.
Tutorials In Mathematical Biosciences Iii
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Author : Avner Friedman
language : en
Publisher: Springer Science & Business Media
Release Date : 2005-12-19
Tutorials In Mathematical Biosciences Iii written by Avner Friedman and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-12-19 with Mathematics categories.
This volume introduces some basic mathematical models for cell cycle, proliferation, cancer, and cancer therapy. Chapter 1 gives an overview of the modeling of the cell division cycle. Chapter 2 describes how tumor secretes growth factors to form new blood vessels in its vicinity, which provide it with nutrients it needs in order to grow. Chapter 3 explores the process that enables the tumor to invade the neighboring tissue. Chapter 4 models the interaction between a tumor and the immune system. Chapter 5 is concerned with chemotherapy; it uses concepts from control theory to minimize obstacles arising from drug resistance and from cell cycle dynamics. Finally, Chapter 6 reviews mathematical results for various cancer models.
Mathematical Models Of The Cell And Cell Associated Objects
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Author : Viktor V. Ivanov
language : en
Publisher: Elsevier
Release Date : 2006-05-10
Mathematical Models Of The Cell And Cell Associated Objects written by Viktor V. Ivanov and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-05-10 with Computers categories.
This book gives the reader a survey of hundreds results in the field of the cell and cell associated objects modeling. Applications to modeling in the areas of AIDS, cancers and life longevity are investigated in this book. - Introduces and proves fundamental properties of evolutionary systems on optimal distribution of their various resources on their internal and external functions - Gives detailed analysis of applications to modeling AIDS, cancers, and life longevity - Introducing and grounding the respective numerical algorithms and software - Detailed analysis of hundreds of scientific works in the field of mathematical modeling of the cell and cell associated objects
The Role Of Model Integration In Complex Systems Modelling
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Author : Manish I. Patel
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-09-08
The Role Of Model Integration In Complex Systems Modelling written by Manish I. Patel and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-09-08 with Technology & Engineering categories.
Model integration – the process by which different modelling efforts can be brought together to simulate the target system – is a core technology in the field of Systems Biology. In the work presented here model integration was addressed directly taking cancer systems as an example. An in-depth literature review was carried out to survey the model forms and types currently being utilised. This was used to formalise the main challenges that model integration poses, namely that of paradigm (the formalism on which a model is based), focus (the real-world system the model represents) and scale. A two-tier model integration strategy, including a knowledge-driven approach to address model semantics, was developed to tackle these challenges. In the first step a novel description of models at the level of behaviour, rather than the precise mathematical or computational basis of the model, is developed by distilling a set of abstract classes and properties. These can accurately describe model behaviour and hence describe focus in a way that can be integrated with behavioural descriptions of other models. In the second step this behaviour is decomposed into an agent-based system by translating the models into local interaction rules. The book provides a detailed and highly integrated presentation of the method, encompassing both its novel theoretical and practical aspects, which will enable the reader to practically apply it to their model integration needs in academic research and professional settings. The text is self-supporting. It also includes an in-depth current bibliography to relevant research papers and literature. The review of the current state of the art in tumour modelling provides added value.