A Systems Biology Approach To Study Metabolic Syndrome
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A Systems Biology Approach To Study Metabolic Syndrome
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Author : Matej Orešič
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-09-24
A Systems Biology Approach To Study Metabolic Syndrome written by Matej Orešič and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-09-24 with Medical categories.
The aim of this book is to provide the target audience, specifically students of Medicine, Biology, Systems Biology and Bioinformatics, as well as experienced researchers in research fields relevant to metabolic syndrome (MetS) with an overview of the challenges and opportunities in systems biology and how it can be used to tackle MetS. In particular, the aims are: (1) to provide an introduction to the key biological processes involved in the pathophysiology of MetS; (2) through the use of specific examples, provide an introduction to the latest technologies that use a systems biology approach to study MetS; and (3) to give an overview of the mathematical modeling approaches for studying MetS. The clearly written chapters by leading experts in the field provides detailed descriptions crucial for the unique position of this book and its focus on the application of systems biology to tackle specific pathophysiologically relevant aspects of MetS and provides a valuable practical guide to this research community.
Metabolome Analyses
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Author : Seetharaman Vaidyanathan
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-03-20
Metabolome Analyses written by Seetharaman Vaidyanathan and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-03-20 with Science categories.
Metabolome analysis is now recognized as a crucial component of functional genomic and systems biology investigations. Innovative approaches to the study of metabolic regulation in microbial, plant and animal systems are increasingly facilitating the emergence of systems approaches in biology. This book highlights analytical and bioinformatics strategies now available for investigating metabolic networks in microbial, plant and animal systems. The contributing authors are world leaders in this field and they present an unambiguous case for pursuing metabolome analysis as a means to attain a systems level understanding of complex biological systems.
Metabolomics And Systems Biology In Human Health And Medicine
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Author : Oliver A.H. Jones
language : en
Publisher: CABI
Release Date : 2014-10-24
Metabolomics And Systems Biology In Human Health And Medicine written by Oliver A.H. Jones and has been published by CABI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-10-24 with Science categories.
The metabolomics and systems biology approach to research can be applied to many disciplines. This book provides a solid introduction to medical metabolomics and systems biology, and demonstrates how they have been applied to studies in medicine and human health, including nutrition and pathogenic microorganisms. Following core themes of diagnosis, pathology and aetiology of disease, this book provides a reference for health care professionals interested in how to use metabolomics for medical research.
Systems Biology
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Author : Jens Nielsen
language : en
Publisher: John Wiley & Sons
Release Date : 2017-05-30
Systems Biology written by Jens Nielsen and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-05-30 with Computers categories.
Comprehensive coverage of the many different aspects of systems biology, resulting in an excellent overview of the experimental and computational approaches currently in use to study biological systems. Each chapter represents a valuable introduction to one specific branch of systems biology, while also including the current state of the art and pointers to future directions. Following different methods for the integrative analysis of omics data, the book goes on to describe techniques that allow for the direct quantification of carbon fluxes in large metabolic networks, including the use of 13C labelled substrates and genome-scale metabolic models. The latter is explained on the basis of the model organism Escherichia coli as well as the human metabolism. Subsequently, the authors deal with the application of such techniques to human health and cell factory engineering, with a focus on recent progress in building genome-scale models and regulatory networks. They highlight the importance of such information for specific biological processes, including the ageing of cells, the immune system and organogenesis. The book concludes with a summary of recent advances in genome editing, which have allowed for precise genetic modifications, even with the dynamic control of gene expression. This is part of the Advances Biotechnology series, covering all pertinent aspects of the field with each volume prepared by eminent scientists who are experts on the topic in question.
A Network Based Approach To Cell Metabolism
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Author : Oriol Güell
language : en
Publisher: Springer
Release Date : 2017-08-16
A Network Based Approach To Cell Metabolism written by Oriol Güell and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-16 with Technology & Engineering categories.
This thesis uses a systems-level approach to study the cellular metabolism, unveiling new mechanisms and responses that were impossible to reach with traditional reductionists procedures. The results reported here have a potential application in areas like metabolic engineering and disease treatment. They could also be used in determining the accuracy of the gene essentiality of new genome-scale reconstructions. Different methods and techniques, within the contexts of Systems Biology and the field known as Complex Networks Analysis have been applied in this work to show different features of the robustness of metabolic networks. The specific issues addressed here range from pure topological aspec ts of the networks themselves to the balance of biochemical fluxes.
The Impact Of Systems Medicine On Human Health And Disease
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Author : Adil Mardinoglu
language : en
Publisher: Frontiers Media SA
Release Date : 2017-03-24
The Impact Of Systems Medicine On Human Health And Disease written by Adil Mardinoglu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-03-24 with Electronic book categories.
Complex disorders including obesity, diabetes, fatty liver disease, cardiovascular disease and cancer are results from a combination of genetic, environmental and lifestyle factors. The prevalence of such disorders has increased dramatically in the last two decades and there is an urgent need for the development of new prognostic tools for the treatment of such diseases. However, this requires a deep understanding of the underlying molecular mechanisms involved in the occurrence of the diseases. With the advances in high throughput technologies, biological components of cells can be measured with a very high resolution and these data can be used for investigating whole systems properties using a network-based approach. Systems medicine provides an integrative platform for studying the interactions between the biological components of the cell using a holistic approach and generating mechanistic explanations for the emergent systems properties. This inter-disciplinary field of study allows for understanding biological processes of cells in health and disease states, gaining new insights into what drives the appearance of the disease and finally identifying proteins and metabolites implicated in human disease. Systems medicine utilizes mathematical approaches to generate models which can be employed for designing new sets of experiments and for mapping the response of the system to perturbations quantitatively. These models as well as the developed tools can accelerate the emergence of personalized medicine which can transform the practice of medicine and offer better targets for drug development with minimum side effects.
Aging And Health A Systems Biology Perspective
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Author : A.I. Yashin
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2014-10-14
Aging And Health A Systems Biology Perspective written by A.I. Yashin and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-10-14 with Medical categories.
Aging is a major risk factor for chronic diseases, which in turn can provide information about the aging of a biological system. This publication serves as an introduction to systems biology and its application to biological aging. Key pathways and processes that impinge on aging are reviewed, and how they contribute to health and disease during aging is discussed. The evolution of this situation is analyzed, and the consequences for the study of genetic effects on aging are presented. Epigenetic programming of aging, as a continuation of development, creates an interface between the genome and the environment. New research into the gut microbiome describes how this interface may operate in practice with marked consequences for a variety of disorders. This analysis is bolstered by a view of the aging organism as a whole, with conclusions about the mechanisms underlying resilience of the organism to change, and is expanded with a discussion of circadian rhythms in aging. Finally, the book presents an outlook for the development of interventions to delay or to reverse the features of aging. The publication is recommended to students, researchers as well as professionals dealing with public health and public policy related to an aging society.
Periparturient Diseases Of Dairy Cows
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Author : Burim N. Ametaj
language : en
Publisher: Springer
Release Date : 2017-12-21
Periparturient Diseases Of Dairy Cows written by Burim N. Ametaj and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-12-21 with Science categories.
This book summarizes the results achieved so far by application of various biological systems (including genomics, transcriptomics, proteomics, and metabolomics) involved in the pathomechanisms and early diagnosis of periparturient diseases as specific biomarkers of disease in cattle. These emerging technologies help to extensively enhance our understanding of the etiology and pathogenesis of periparturient diseases of transition dairy cows. The book includes a chapter dedicated to ‘omics’ sciences and one that discusses the myths established in animal and veterinary sciences in recent decades and emerging, new paradigms. The diseases discussed include metritis, mastitis, laminitis, ketosis, rumen acidosis, periparturient immunosuppression, gastrointestinal microbiota and their involvement in disease, infertility, fatty liver, milk fever, and retained placenta. This book is intended for academics, veterinarians, animal nutritionists, researchers, and graduate students working in the field of ‘omics sciences’ with a special interest in dairy cattle health.
The Handbook Of Metabolic Phenotyping
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Author : John C. Lindon
language : en
Publisher: Elsevier
Release Date : 2018-10-04
The Handbook Of Metabolic Phenotyping written by John C. Lindon and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-10-04 with Science categories.
The Handbook of Metabolic Phenotyping is the definitive work on the rapidly developing subject of metabolic phenotyping. It explores in detail the wide array of analytical chemistry and statistical modeling techniques used in the field, coupled with surveys of the various application areas in human development, nutrition, disease, therapy, and epidemiology to create a comprehensive exploration of the area of study. It covers recent studies that integrate the various -omics data sets to derive a systems biology view. It also addresses current issues on standardization, assay and statistics validation, and data storage and sharing. Written by experts with many years of practice in the field who pioneered many of the approaches widely used today, The Handbook of Metabolic Phenotyping is a valuable resource for postgrads and research scientists studying and furthering the field of metabolomics. Contains theoretical and practical explanations of all the main analytical chemistry techniques used in metabolic phenotyping Explores, in detail, the many diverse statistical approaches used in the field Offers practical tips for successfully conducting metabolic phenotyping studies Features reviews of all of the various fields of activity relating to human studies
Systems Biology
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Author : Lilia Alberghina
language : en
Publisher: Springer Science & Business Media
Release Date : 2005-09-22
Systems Biology written by Lilia Alberghina and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-09-22 with Computers categories.
Annotation. The wealth of genomic and post-genomic data needs to be structured so that the understanding of complex cellular processes can be achieved by creating computational models able to describe and predict phenotypes at the cell or organism level in health and disease. This book provides a detailed presentation of systems biology studies that are paving the way towards the above-mentioned goal and discusses the most efficient experimental and computational strategies for this purpose. The potential benefits for bioindustry, in particular the discovery of new drugs and better management, are also presented.