Abc Transporters 40 Years On
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Abc Transporters 40 Years On
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Author : Anthony M. George
language : en
Publisher: Springer
Release Date : 2015-12-16
Abc Transporters 40 Years On written by Anthony M. George and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-12-16 with Science categories.
This book provides new structural, biochemical, and clinical information on ABC transporters. The authors explore and describe the state of the art of research, knowledge, and prospects for the future for this important family of proteins. The first ABC transporter was discovered in 1973 and was named P-glycoprotein. It elicits resistance to cytotoxic drugs, chiefly in human tumours, within which chemotherapy failure is observed in about 50% of cases. Together with its complex pharmacology, and even a suspected role in Alzheimer’s disease, this ABC transporter still eludes a clinical solution to its multidrug resistance property. ABC transporters are integral membrane active proteins and they belong to one of the largest protein families across all species. Their myriad roles encompass the import or export of a diverse range of allocrites, including ion, nutrients, peptides, polysaccharides, lipids, and xenobiotics. They are of major medical importance with many members elaborating multidrug resistance in bacteria, fungi, yeast, parasites, and humans. Other ABC transporters are involved in a number of inherited diseases, including cystic fibrosis, macular degeneration, gout, and several other metabolic disorders
The Human Atp Binding Cassette Abc Transporter Superfamily
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Author : Michael Carlton Dean
language : en
Publisher:
Release Date : 2002
The Human Atp Binding Cassette Abc Transporter Superfamily written by Michael Carlton Dean and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with categories.
Plant Abc Transporters
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Author : Markus Geisler
language : en
Publisher: Springer
Release Date : 2014-09-06
Plant Abc Transporters written by Markus Geisler and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-09-06 with Science categories.
This book is devoted to the fascinating superfamily of plant ATP-binding cassette (ABC) transporters and their variety of transported substrates. It highlights their exciting biological functions, covering aspects ranging from cellular detoxification, through development, to symbiosis and defense. Moreover, it also includes a number of chapters that center on ABC transporters from non-Arabidopsis species. ABC proteins are ubiquitous, membrane-intrinsic transporters that catalyze the primary (ATP-dependent) movement of their substrates through biological membranes. Initially identified as an essential aspect of a vacuolar detoxification process, genetic work in the last decade has revealed an unexpectedly diverse variety of ABC transporter substrates, which include not only xenobiotic conjugates, but also heavy metals, lipids, terpenoids, lignols, alkaloids and organic acids. The discovery that members of the ABCB and ABCG family are involved in the movement of phytohormones has further sparked their exploration and provided a new understanding of the whole family. Accordingly, the trafficking, regulation and structure-function of ABCB-type auxin transporters are especially emphasized in this book.
Abc Proteins
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Author : I Barry Holland
language : en
Publisher: Elsevier
Release Date : 2003-01-07
Abc Proteins written by I Barry Holland and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-01-07 with Science categories.
ABC Proteins is an in-depth, up-to-date analysis of all that is known about the subject to date. It discusses and compares evolution, biology and mechanism of action of all known ABC proteins, including the first structural studies as well as clinical implications. It will be useful to anyone trying to stay abreast of the latest findings. This book is sure to become a classic and will regularly be updated. Phylogeny and Evoloution of ABC Transporters Fundamental Aspects of the Mechanism of Action of ABC Transporters Prokaryote ABC Transporters Non-Mammalian Transporters Multidrug Transporters ABC Transporters, Physiological Roles and Human Disease Full color throughout
Biochemistry And Molecular Biology Compendium
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Author : Roger L. Lundblad
language : en
Publisher: CRC Press
Release Date : 2019-11-11
Biochemistry And Molecular Biology Compendium written by Roger L. Lundblad and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-11 with Medical categories.
This book is an accessible resource offering practical information not found in more database-oriented resources. The first chapter lists acronyms with definitions, and a glossary of terms and subjects used in biochemistry, molecular biology, biotechnology, proteomics, genomics, and systems biology. There follows chapters on chemicals employed in biochemistry and molecular biology, complete with properties and structure drawings. Researchers will find this book to be a valuable tool that will save them time, as well as provide essential links to the roots of their science. Key selling features: Contains an extensive list of commonly used acronyms with definitions Offers a highly readable glossary for systems and techniques Provides comprehensive information for the validation of biotechnology assays and manufacturing processes Includes a list of Log P values, water solubility, and molecular weight for selected chemicals Gives a detailed listing of protease inhibitors and cocktails, as well as a list of buffers
Drug Transporters In Drug Disposition Effects And Toxicity
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Author : Xiaodong Liu
language : en
Publisher: Springer Nature
Release Date : 2019-09-30
Drug Transporters In Drug Disposition Effects And Toxicity written by Xiaodong Liu and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-09-30 with Medical categories.
This book provides with a comprehensive overview of the role of drug transporters in drug disposition and efficacy/toxicity, as well as drug-drug interactions and recent advances in the field. Transporters are known determinants of drug disposition and efficacy/toxicity. In general, they are divided into solute carrier (SLC) and ATP binding cassette (ABC) families, and are located along cell membranes, where they mediate drug uptake into cells and export out of cells. Drug transporters are essential in maintaining cell homeostasis, and their gene mutations may cause or contribute to severe human genetic disorders, such as cystic fibrosis, neurological disease, retinal degeneration, anemia, and cholesterol and bile transport defects. Conversely, some diseases may also alter transporter functions and expressions, in turn aggravating disease process. Further, since over-expression of some ABC transporters is a potential contributor to multidrug-resistance (MDR), the book presents a number of strategies to overcome MDR, including ABC transporter inhibitors and applying epigenetic methods to modulate transporter expressions and functions. This book is useful for graduate students and professionals who are looking to refresh or expand their knowledge of this exciting field.
Rising Stars In Cancer Metabolism 2022
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Author : Domenica Scumaci
language : en
Publisher: Frontiers Media SA
Release Date : 2023-06-29
Rising Stars In Cancer Metabolism 2022 written by Domenica Scumaci and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-06-29 with Medical categories.
Abc Transporters And Cancer
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Author :
language : en
Publisher: Academic Press
Release Date : 2015-01-27
Abc Transporters And Cancer written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-01-27 with Science categories.
ABC Transporters and Cancer provides invaluable information on the exciting and fast-moving field of cancer research. Here, outstanding and original reviews are presented on a variety of topics. This volume covers ABC transporters and cancer, and is suitable for researchers and students alike. Provides information on cancer research Outstanding and original reviews Suitable for researchers and students
Responses Of Plants To Environmental Stresses
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Author : Renata Szymańska
language : en
Publisher: MDPI
Release Date : 2021-09-01
Responses Of Plants To Environmental Stresses written by Renata Szymańska and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-09-01 with Science categories.
Environmental abiotic stresses, such as extreme temperatures, drought, excess light, salinity, and nutrient deficiency, have detrimental effects on plant growth, development, and yield. Plants are equipped with various adaptation mechanisms to cope with such unfavorable conditions. Our understanding of plants’ abiotic stress responses is crucial to maintaining efficient plant productivity. This book on the responses of plants to environmental stresses is an attempt to find answers to several basic questions related to their adaptation and protective mechanisms against abiotic stresses. The following chapters of the book describe examples of plants’ protective strategies, which cover physiological, cellular, biochemical, and genomic mechanisms. This book is aimed for use by advanced students and researchers in the area of stress biology, plant molecular biology and physiology, agriculture, biochemistry, as well as environmental sciences.
Transporters As Drug Targets
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Author : Gerhard F. Ecker
language : en
Publisher: John Wiley & Sons
Release Date : 2017-04-10
Transporters As Drug Targets written by Gerhard F. Ecker and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-04-10 with Medical categories.
As opposed to other books on the topic, this volume is unique in also covering emerging transporter targets. Following a general introduction to the importance of targeting transporter proteins with drugs, the book systematically presents individual transporter classes and explains their pharmacology and physiology. The text covers all transporter families with known or suspected importance as drug targets, including neurotransmitter transporters, ABC transporters, glucose transporters and organic ion transporters. The final part discusses recent advances in structural studies of transport proteins, assay methods for transport activity, and the systems biology of transporters and their regulation. With its focus on drug development issues, this authoritative overview is required reading for researchers in industry and academia targeting transport proteins for the treatment of disease.