Abeta Peptide And Alzheimer S Disease
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Abeta Peptide And Alzheimer S Disease
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Author : Colin J. Barrow
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-12-22
Abeta Peptide And Alzheimer S Disease written by Colin J. Barrow and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-12-22 with Medical categories.
Recent advances in genetics and brain biochemistry point to the Abeta peptide as the major culprit in causing neurodegeneration in Alzheimer’s Disease (AD). This book summarizes current knowledge of the Abeta peptide and its role in AD. Written by specialists in this fast moving area, the book covers fundamental biochemical studies on this peptide, the genetic impact on Abeta expression and processing, and various AD therapeutic strategies that target Abeta.
Alzheimer S Disease Cellular And Molecular Aspects Of Amyloid Beta
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Author : J. Robin Harris
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-11-22
Alzheimer S Disease Cellular And Molecular Aspects Of Amyloid Beta written by J. Robin Harris and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-11-22 with Science categories.
To understand Alzheimer's disease (AD) is one of the major thrusts of present-day clinical research, strongly supported by more fimdamental cellular, biochemical, immunological and structural studies. It is these latter that receive attention within this book. This compilation of 20 chapters indicates the diversity of work currently in progress and summarizes the current state of knowledge. Experienced authors who are scientifically active in their fields of study have been selected as contributors to this book, in an attempt to present a reasonably complete survey of the field. Inevitably, some exciting topics for one reason or another have not been included, for which we can only apologize. Standardization of terminology is often a problem in science, not least in the Alzheimer field; editorial effort has been made to achieve standardization between the Chapters, but some minor yet acceptable personal / author variation is still present, i. e. P-amyloid/amyloid-P; Ap42/Apl-42/APi. 42! The book commences with a broad survey of the contribution that the range of available microscopical techniques has made to the study of Alzheimer's amyloid plaques and amyloid fibrillogenesis. This chapter also serves as an Introduction to the book, since several of the topics introduced here are expanded upon in later chapters. Also, it is significant to the presence of this chapter that the initial discovery of brain plaques, by Alois Alzheimer, utilized light microscopy, a technique that continues to be extremely valuable in present-day AD research.
Alzheimer S Disease
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Author : George Perry
language : en
Publisher: IOS Press
Release Date : 2013
Alzheimer S Disease written by George Perry and has been published by IOS Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with Medical categories.
This volume is a companion to the highly successful book published in association with the Journal of Alzheimer's Disease (JAD) on the centennial of Alzheimer's discovery: "Alzheimer's Disease: A Century of Scientific and Clinical Research". Instead of looking back, this collection, "Alzheimer's Disease: Advances for a New Century", will look forward. Using scientometric analysis the most promising developments since the Alzheimer Centennial in 2006 have been substantiated. While prior trends and advances in genetics, amyloid-β, tau, neuropathology, and oxidative stress continue as active areas, emergent areas impacting the transition from normal cognition to Alzheimer's disease such as diagnostic imaging, biomarkers, metabolism, and lifestyle (areas conceived only a few years ago) now dominate the debate.Invited contributors have summarized their landmark publications identified by our analysis and have put them into perspective, explaining the impetus behind the work, the contribution of the results to the field, and who played a role in the work.
Alzheimer S Disease Insights Into Low Molecular Weight And Cytotoxic Aggregates From In Vitro And Computer Experiments Molecular Basis Of Amyloid Beta Protein Aggregation And Fibril Formation
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Author : Philippe Derreumaux
language : en
Publisher: World Scientific
Release Date : 2012-12-31
Alzheimer S Disease Insights Into Low Molecular Weight And Cytotoxic Aggregates From In Vitro And Computer Experiments Molecular Basis Of Amyloid Beta Protein Aggregation And Fibril Formation written by Philippe Derreumaux and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-31 with Medical categories.
Alzheimer's disease is the most common form of senile dementia, affecting more than 24 million people worldwide. It is characterised pathologically by abnormally high levels of neurofibrillary tangles resulting from the accumulation of tau protein in dead and dying neurons, and by elevated numbers of senile plaques in the cortex and hippocampus of the brain. The major component of senile plaques is a small protein of 39-43 amino acids called amyloid-β (Aβ). Thus far, no treatment has been shown to slow the progression of sporadic and familial Alzheimer's disease.A large body of evidence points, however, to the early Aβ-formed oligomers as the primary toxic species in Alzheimer's disease. A powerful strategy for developing pharmaceutical treatments against Alzheimer's is to elucidate the pathways of oligomer formation and determine the structures of the toxic aggregates.This book provides a panoramic view across recent in vitro and in vivo studies along with state-of-the-art computer simulations, designed to increase the readers' understanding of Aβ oligomerisation and fibril formation. At the same time, the book delves into the pathogenesis of familial and sporadic Alzheimer's disease at the atomic level of detail.Written by leading authors in their respective fields, this book will be valuable to all scientists working on Alzheimer's disease./a
Alzheimer S Disease
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Author : Philippe Derreumaux
language : en
Publisher: World Scientific
Release Date : 2012
Alzheimer S Disease written by Philippe Derreumaux and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Medical categories.
Alzheimer's disease is the most common form of senile dementia, affecting more than 24 million people worldwide. It is characterised pathologically by abnormally high levels of neurofibrillary tangles resulting from the accumulation of tau protein in dead and dying neurons, and by elevated numbers of senile plaques in the cortex and hippocampus of the brain. The major component of senile plaques is a small protein of 39OCo43 amino acids called amyloid-? (A?). Thus far, no treatment has been shown to slow the progression of sporadic and familial Alzheimer's disease.A large body of evidence points, however, to the early A?-formed oligomers as the primary toxic species in Alzheimer's disease. A powerful strategy for developing pharmaceutical treatments against Alzheimer's is to elucidate the pathways of oligomer formation and determine the structures of the toxic aggregates.This book provides a panoramic view across recent in vitro and in vivo studies along with state-of-the-art computer simulations, designed to increase the readers' understanding of A? oligomerisation and fibril formation. At the same time, the book delves into the pathogenesis of familial and sporadic Alzheimer's disease at the atomic level of detail.Written by leading authors in their respective fields, this book will be valuable to all scientists working on Alzheimer's disease."
A Beta Metabolism And Alzheimer S Disease
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Author : Takaomi Comings Saido
language : en
Publisher: CRC Press
Release Date : 2003-02-18
A Beta Metabolism And Alzheimer S Disease written by Takaomi Comings Saido and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-02-18 with Science categories.
This book provides information regarding three major aspects of Aβ metabolism: generation from its precursor, degradation within the brain, and transport out of the brain. It is useful for graduate students, post-doctoral fellows, and scientists both in this and other disciplines.
The Role Of Amyloid Beta Peptide In The Development Of Alzheimer S Disease
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Author : Tracy Ngoc Huynh
language : en
Publisher:
Release Date : 2001
The Role Of Amyloid Beta Peptide In The Development Of Alzheimer S Disease written by Tracy Ngoc Huynh and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with categories.
Characterization Of Novel Amyloid Beta Peptide A Beta Binding Ligands
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Author : Silke Dornieden
language : en
Publisher: Forschungszentrum Jülich
Release Date : 2012
Characterization Of Novel Amyloid Beta Peptide A Beta Binding Ligands written by Silke Dornieden and has been published by Forschungszentrum Jülich this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with categories.
Emerging Drugs And Targets For Alzheimer S Disease
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Author : Ana Martínez
language : en
Publisher: Royal Society of Chemistry
Release Date : 2010
Emerging Drugs And Targets For Alzheimer S Disease written by Ana Martínez and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Medical categories.
This volume describes the discovery and development history of the most promising drugs now in development for combating Alzheimer's disease.
Molecular Biology Of Alzheimer S Disease
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Author : Christian Haass
language : en
Publisher: CRC Press
Release Date : 2003-09-02
Molecular Biology Of Alzheimer S Disease written by Christian Haass and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-09-02 with Science categories.
Highlighting the latest and the most timely aspects of Alzheimer's disease research, this text will enable scientists in related research fields, as well as physicians working with Alzheimer's disease patients, to obtain a quick and complete overview of the current state of the art in one of the most exciting fields in neuroscience research. Leading scientists have contributed articles focusing on key developments in this field. This includes an overview about the pathology, the genetics of familial Alzheimer's disease, proteolytic generation and aggregation of amyloid -peptide, presenilins, risk factors such as ApoE, and transgenic animal models. Some of the latest developments in Alzheimer's disease research, including the effect of presenilin knock outs on amyloid -peptide generation, are also included.