Accelerated Path To Cures
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Accelerated Path To Cures
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Author : Josep Bassaganya-Riera
language : en
Publisher: Springer
Release Date : 2018-04-25
Accelerated Path To Cures written by Josep Bassaganya-Riera and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-04-25 with Medical categories.
Accelerated Path to Cures provides a transformative perspective on the power of combining advanced computational technologies, modeling, bioinformatics and machine learning approaches with nonclinical and clinical experimentation to accelerate drug development. This book discusses the application of advanced modeling technologies, from target identification and validation to nonclinical studies in animals to Phase 1-3 human clinical trials and post-approval monitoring, as alternative models of drug development. As a case of successful integration of computational modeling and drug development, we discuss the development of oral small molecule therapeutics for inflammatory bowel disease, from the application of docking studies to screening new chemical entities to the development of next-generation in silico human clinical trials from large-scale clinical data. Additionally, this book illustrates how modeling techniques, machine learning, and informatics can be utilized effectively at each stage of drug development to advance the progress towards predictive, preventive, personalized, precision medicine, and thus provide a successful framework for Path to Cures.
21st Century Cures
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Author : United States. Congress. House. Committee on Energy and Commerce. Subcommittee on Health
language : en
Publisher:
Release Date : 2015
21st Century Cures written by United States. Congress. House. Committee on Energy and Commerce. Subcommittee on Health and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with Clinical trials categories.
The World S Medicine Chest
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Author : Sally C. Pipes
language : en
Publisher: Encounter Books
Release Date : 2025-02-04
The World S Medicine Chest written by Sally C. Pipes and has been published by Encounter Books this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-02-04 with Political Science categories.
The World's Medicine Chest details how America became the world's leader in biopharmaceutical innovation and reveals how new threats to this industry will have disastrous consequences for patients and the U.S. economy. In the 1970s, Europe was the global hub for pharmaceutical innovation. European drug companies developed more than twice as many drugs in that decade as their U.S.-based counterparts. But times have changed. Today, nearly half of all new drugs come from the United States. Just 22 percent are of European origin. And U.S. patients get access to innovative medicines before anyone else in the world. Drawing on her decades of experience as a health policy scholar, Sally Pipes details how America became the world’s leader in biopharmaceutical innovation. She argues that efforts over the last few years by Democrats and Republicans alike to impose price controls on prescription drugs will have disastrous consequences for patients and for the U.S. Economy.
Accelerated Path To Cures
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Author : Josep Bassaganya-Riera
language : en
Publisher:
Release Date : 2018
Accelerated Path To Cures written by Josep Bassaganya-Riera and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with Drug development categories.
Accelerated Path to Cures provides a transformative perspective on the power of combining advanced computational technologies, modeling, bioinformatics and machine learning approaches with nonclinical and clinical experimentation to accelerate drug development. This book discusses the application of advanced modeling technologies, from target identification and validation to nonclinical studies in animals to Phase 1-3 human clinical trials and post-approval monitoring, as alternative models of drug development. As a case of successful integration of computational modeling and drug development, we discuss the development of oral small molecule therapeutics for inflammatory bowel disease, from the application of docking studies to screening new chemical entities to the development of next-generation in silico human clinical trials from large-scale clinical data. Additionally, this book illustrates how modeling techniques, machine learning, and informatics can be utilized effectively at each stage of drug development to advance the progress towards predictive, preventive, personalized, precision medicine, and thus provide a successful framework for Path to Cures.
Target Discovery For Anticancer Therapy Facilitated By Artificial Intelligence
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Author : Feng Zhu
language : en
Publisher: Frontiers Media SA
Release Date : 2021-08-19
Target Discovery For Anticancer Therapy Facilitated By Artificial Intelligence written by Feng Zhu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-08-19 with Science categories.
Second Generation Cell And Gene Based Therapies
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Author : Alain Vertes
language : en
Publisher: Academic Press
Release Date : 2020-02-07
Second Generation Cell And Gene Based Therapies written by Alain Vertes and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-02-07 with Science categories.
Second Generation Cell and Gene-Based Therapies: Biological Advances, Clinical Outcomes, and Strategies for Capitalisation serves as the only volume to the market to bridge basic science, clinical therapy, technology development, and business in the field of cellular therapy/cytotherapy. After more than two decades of painstaking fundamental research, the concept of therapeutic cells (stem cells, genes, etc.), beyond the concept of vaccines, is reaching clinical trial, with mounting confidence in the safety and efficacy of these products. Nonetheless, numerous incremental technical advances remain to be achieved. Thus, this volume highlights the possible R&D paths, which will ultimately facilitate clinical delivery of cutting edge curative products.The next waves of innovation are reviewed in depth for hematopoietic stem cells, mesenchymal stem cells, tissue engineering, CAR-T cells, and cells of the immune system, as well as for enabling technologies such as gene and genome editing. Additionally, deep dives in product fundamentals, history of science, pathobiology of diseases, scientific and technological bases, and financing and technology adoption constraints are taken to unravel what will shape the cytotherapy industry to the horizon 2025 and beyond. The outcome is not simply a scientific book, but a global perspective on the nascent field combining science, business, and strategic fundamentals. - Helps readers learn about the most current trends in cell-based therapy, their overall effectiveness from a clinical prospective, and how the industry is moving therapies forward for capitalization - "Perspectives" section at the end of each chapter summarizes key learnings, hypotheses, and objectives highlighted and combines scientific and business insights - Edited and authored by scientists representing both basic and clinical research and industry, presenting a complete story of the current state and future promise of cellular therapies
Postbiotics In Metabolic Disorders
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Author : Sumel Ashique
language : en
Publisher: CRC Press
Release Date : 2025-08-20
Postbiotics In Metabolic Disorders written by Sumel Ashique and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-08-20 with Medical categories.
This book discusses the role of postbiotics in human health. The initial chapter highlights the potential of postbiotics beyond traditional prebiotics and probiotics. Subsequent chapters present the beneficial effects on various health conditions, including cardiovascular disorders, cancer, diabetes, gestational diabetes, obesity, and mitochondrial disorders. The book covers the role of postbiotics in immune system modulation and inflammation-mediated metabolic disorders. It also explores the interaction of postbiotics with gut microbiota, detailing molecular mechanisms and signaling pathways. In addition, it offers current and future perspectives on postbiotics in human health, addressing their role in managing insulin resistance, glucose metabolism, metabolic endotoxemia, and inflammation in type 2 diabetes. The text provides an in-depth analysis of the impact of postbiotics on non-alcoholic fatty liver disease (NAFLD), lipid profiles, and hypertension. In addition, the chapters: 1) Explore the promising concept of postbiotics and their potential beyond prebiotics and probiotics. 2) Examine the beneficial effects of postbiotics on cardiovascular health, cancer, diabetes, and other conditions. 3) Discuss the role of postbiotics in immune system modulation and inflammation-mediated metabolic disorders. 4) Cover the interaction of postbiotics with gut microbiota, highlighting molecular mechanisms and signaling pathways. 5) Analyze the current and future perspectives on postbiotics, including their impact on various metabolic disorders. This book is a useful resource for researchers and students of pharmacology and biotechnology.
Herpes Cure A Research Backed Guide Healing Herbal Medicine
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Author : Dr Arjun Kumar
language : en
Publisher: Bowker
Release Date : 2025-04-23
Herpes Cure A Research Backed Guide Healing Herbal Medicine written by Dr Arjun Kumar and has been published by Bowker this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-04-23 with Health & Fitness categories.
For decades, patients have been told that viruses like Herpes Simplex Virus (HSV), Cytomegalovirus (CMV), and Epstein-Barr Virus (EBV) are lifelong. Conventional medicine focuses on suppression—not elimination. But what if those assumptions were outdated? What if modern lab results could prove otherwise? In this evidence-based book, Dr. Arjun Kumar challenges the prevailing medical belief that chronic viral infections cannot be cured. Using the time-tested science of Ayurveda, he presents a structured treatment approach that has helped patients achieve what was once considered impossible—negative IgG antibody levels and virus-free DNA PCR qualitative test results. This is not theory. It is based on clinical observation, diagnostic follow-up, and repeatable results. The author himself underwent treatment after an HSV diagnosis, applying Ayurvedic protocols based on Rasayana therapy and mineral formulations. Through consistent follow-up testing, the virus was no longer detectable. This book offers: A clear framework for Ayurvedic viral elimination—not suppression Scientific explanation of why these viruses persist and how to target them Laboratory data and case studies to support each step A personalized treatment model based on constitution and immune terrain A detailed breakdown of herbal and mineral formulations used in recovery Whether you are a patient searching for a solution, a practitioner seeking better outcomes, or a medical researcher open to data-driven alternatives, this book offers a clinically sound path toward complete recovery. Cure is not a myth. It’s a protocol.
Transfusion Medicine An Issue Of Hematology Oncology Clinics Of North America
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Author : Edward L Snyder
language : en
Publisher: Elsevier Health Sciences
Release Date : 2019-09-03
Transfusion Medicine An Issue Of Hematology Oncology Clinics Of North America written by Edward L Snyder and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-09-03 with Medical categories.
This issue of Hematology/Oncology Clinics, Guest Edited by Drs. Edward Snyder and Eric A. Gehrie, with Consulting Editors George P. Canellos and H. Franklin Bunn, will focus on Transfusion Medicine. Topics include, but are not limited to, Pathogen Reduction, Transfusion Reactions-Infectious Complications, Txn Rxn-Non-Infectious Complications, Iron Deficiency and Teen Blood Donors, Advances in RBC Serology, Advances in Immunotherapy, Therapeutic Monoclonal Antibody Effect on RBC Compatibility Testing, Cell Therapy-New Regulations and Standards, Alternatives to Platelet and RBC Transfusions, New Hemostatic Agents, Tx Practices for Children with Cancer, and Relevance of Cold Platelets and WB to the Bleeding Oncology Patient.
Regulatory Affairs In The Pharmaceutical Industry
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Author : Javed Ali
language : en
Publisher: Academic Press
Release Date : 2021-11-14
Regulatory Affairs In The Pharmaceutical Industry written by Javed Ali and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-14 with Medical categories.
Regulatory Affairs in the Pharmaceutical Industry is a comprehensive reference that compiles all the information available pertaining to regulatory procedures currently followed by the pharmaceutical industry. Designed to impart advanced knowledge and skills required to learn the various concepts of regulatory affairs, the content covers new drugs, generic drugs and their development, regulatory filings in different countries, different phases of clinical trials, and the submission of regulatory documents like IND (Investigational New Drug), NDA (New Drug Application) and ANDA (Abbreviated New Drug Application). Chapters cover documentation in the pharmaceutical industry, generic drug development, code of Federal Regulation (CFR), the ANDA regulatory approval process, the process and documentation for US registration of foreign drugs, the regulation of combination products and medical devices, the CTD and ECTD formats, and much more. Updated reference on drug approval processes in key global markets Provides comprehensive coverage of concepts and regulatory affairs Presents a concise compilation of the regulatory requirements of different countries Introduces the fundamentals of manufacturing controls and their regulatory importance