Adhesion Molecules And Chemokines In Lymphocyte Trafficking
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Adhesion Molecules And Chemokines In Lymphocyte Trafficking
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Author : Alf Hamann
language : en
Publisher: CRC Press
Release Date : 1998-01-26
Adhesion Molecules And Chemokines In Lymphocyte Trafficking written by Alf Hamann and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-01-26 with Science categories.
Summarizes the latest research in the field, with particular emphasis on molecular mechanisms involved in lymphocyte traffic, for scientists, clinicians, and students. Subjects include the role of homing to mucosal tissue, adhesion molecules, and chemokines in regulation of lymphocyte and leukocyte migration, roles of integrins in the interactions of lymphocytes with intestinal mucosa, lymphocyte trafficking through the central nervous system, and implications for tumor immunotherapy. Includes bandw drawings. Annotation copyrighted by Book News, Inc., Portland, OR
Lymphocyte Trafficking In Health And Disease
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Author : Raffaele Badolato
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-09-05
Lymphocyte Trafficking In Health And Disease written by Raffaele Badolato and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-09-05 with Medical categories.
This book deals with the description of the role of chemokines in immune response and underlines potential targets of therapeutical intervention. It offers a series of international contributions of the most challenging aspects of lymphocyte migration in homeostasis and in disease, and has a special focus on diseases and targets of therapeutical intervention. The book will interest researchers and clinicians from inflammation research.
Leukocyte Trafficking
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Author : Alf Hamann
language : en
Publisher: John Wiley & Sons
Release Date : 2006-05-12
Leukocyte Trafficking written by Alf Hamann and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-05-12 with Medical categories.
Written by known specialists in the field, this is a comprehensive and timely overview of a central and expanding topic. Simultaneously an introduction and a description of the latest concepts, findings and methods, the handbook provides basic knowledge on technical issues required for those intending to research in the field. It covers the functional role of involved molecules and the cellular mechanisms, and addresses selected examples for their possible application in therapy -- bridging the gap between trafficking mechanisms and novel therapeutic strategies. In addition, it includes selection of proven and timesaving methods for studying cell trafficking in vitro and in vivo. The accompanying CD-ROM makes leukocyte migration videos available to a broad audience for the first time.
Lymphocyte Trafficking In Health And Disease
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Author : Raffaele Badolato
language : en
Publisher: Birkhäuser
Release Date : 2009-09-03
Lymphocyte Trafficking In Health And Disease written by Raffaele Badolato and has been published by Birkhäuser this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-09-03 with Medical categories.
This book deals with the description of the role of chemokines in immune response and underlines potential targets of therapeutical intervention. It offers a series of international contributions of the most challenging aspects of lymphocyte migration in homeostasis and in disease, and has a special focus on diseases and targets of therapeutical intervention. The book will interest researchers and clinicians from inflammation research.
Lymphocyte Trafficking In Health And Disease
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Author : Raffaele Badolato
language : en
Publisher: Birkhäuser
Release Date : 2006-07-18
Lymphocyte Trafficking In Health And Disease written by Raffaele Badolato and has been published by Birkhäuser this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-07-18 with Medical categories.
This book deals with the description of the role of chemokines in immune response and underlines potential targets of therapeutical intervention. It offers a series of international contributions of the most challenging aspects of lymphocyte migration in homeostasis and in disease, and has a special focus on diseases and targets of therapeutical intervention. The book will interest researchers and clinicians from inflammation research.
Lymphocyte Homing To The Skin
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Author : Wolf-Henning Boehncke
language : en
Publisher: CRC Press
Release Date : 2004-12-28
Lymphocyte Homing To The Skin written by Wolf-Henning Boehncke and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-12-28 with Medical categories.
Over the last decade, enormous progress in the understanding of T-cell homing has made it possible to identify the multitude of molecules involved, such as cytokines, chemokines, and adhesion molecules, and to unravel their complex interactions resulting in controlled, non-random T-cell recirculation. These insights are now being explored therapeutically, with several compounds close to approval. Highlighting key findings in the field, Lymphocyte Homing to the Skin: Immunology, Immunopathology, and Therapeutic Perspectives brings insight to the physiology and pathophysiology of T-cell homing as a process, as well as to the manipulation of this process for therapeutic benefit. The book begins with a review of the role of T-lymphocytes in skin biology, followed by coverage of the process of lymphocyte recruitment, and lymphocyte homing to the skin. Subsequent chapters describe in vitro techniques to investigate lymphocyte extravasation, in vivo methods to study lymphocyte homing to the skin, and cutaneous T-lymphocytic infiltrates in skin pathology. The text concludes with discussions on translating cutaneous T-cell recruitment to patients. Providing a timely update on T-cell homing, this book clarifies our understanding of this complex process and offers guidance on potential therapies. It fulfills the needs of those involved in skin biology, skin toxicology, and dermatology, and proposes new directions for innovative research.
Arrest Chemokines
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Author : Klaus Ley
language : en
Publisher: Frontiers Media SA
Release Date : 2015-05-20
Arrest Chemokines written by Klaus Ley and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-05-20 with Chemokines categories.
Arrest chemokines are a small group of chemokines that promote leukocyte arrest from rolling by triggering rapid integrin activation. Arrest chemokines have been described for neutrophils, monocytes, eosinophils, naïve lymphocytes and effector memory T cells. Most arrest chemokines are immobilized on the endothelial surface by binding to heparin sulfate proteoglycans. Whether soluble chemokines can promote integrin activation and arrest is controversial (Alon-Gerszten). Many aspects of the signaling pathway from the GPCR chemokine receptor to integrin activation are the subject of active investigation. Leukocyte adhesion deficiency III is a human disease in which chemokine-triggered integrin activation is defective because of a mutation in the cytoskeletal protein kindlin-3. About 10 different such mutations have been described. The defects seen in patients with LAD-III elucidate the importance of rapid integrin activation for host defense in humans. We welcome reports that help clarifying this crucial first step in the process of leukocyte transendothelial migration.
Adhesion Molecules
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Author : Victor R. Preedy
language : en
Publisher: CRC Press
Release Date : 2016-04-19
Adhesion Molecules written by Victor R. Preedy and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-19 with Medical categories.
This book covers the structure and classification of adhesion molecules in relation to signaling pathways and gene expression. It discusses immunohistochemical localization, neutrophil migration, and junctional, functional, and inflammatory adhesion molecules in pathologies such as leukocyte decompression sickness and ischemia reperfusion injury. H
Microcirculation
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Author : Ronald F. Tuma
language : en
Publisher: Academic Press
Release Date : 2011-04-28
Microcirculation written by Ronald F. Tuma and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-04-28 with Science categories.
This reference is a volume in the Handbook of Physiology, co-published with The American Physiological Society. Growth in knowledge about the microcirculation has been explosive with the field becoming fragmented into numerous subdisciplines and subspecialties. This volume pulls all of the critical information into one volume. Meticulously edited and reviewed. Benefit: Provides investigators a unique tool to explore the significance of their findings in the context of other aspects of the microcirculation. In this way, the updated edition has a direct role in helping to develop new pathways of research and scholarship Highlights the explosive growth in knowledge about the microcirculation including the biology of nitric oxide synthase (NOS), endothelial cell signaling, angiogenesis, cell adhesion molecules, lymphocyte trafficking, ion channels and receptors, and propagated vasomotor responses. Benefit: Microcirculatory biology has become fragmented into numerous sub-disciplines and subspecialties, and these reference reintegrates the information in one volume
Inflammation And The Microcirculation
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Author : D. Neil Granger
language : en
Publisher: Morgan & Claypool Publishers
Release Date : 2010
Inflammation And The Microcirculation written by D. Neil Granger and has been published by Morgan & Claypool Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Medical categories.
The microcirculation is highly responsive to, and a vital participant in, the inflammatory response. All segments of the microvasculature (arterioles, capillaries, and venules) exhibit characteristic phenotypic changes during inflammation that appear to be directed toward enhancing the delivery of inflammatory cells to the injured/infected tissue, isolating the region from healthy tissue and the systemic circulation, and setting the stage for tissue repair and regeneration. The best characterized responses of the microcirculation to inflammation include impaired vasomotor function, reduced capillary perfusion, adhesion of leukocytes and platelets, activation of the coagulation cascade, and enhanced thrombosis, increased vascular permeability, and an increase in the rate of proliferation of blood and lymphatic vessels. A variety of cells that normally circulate in blood (leukocytes, platelets) or reside within the vessel wall (endothelial cells, pericytes) or in the perivascular space (mast cells, macrophages) are activated in response to inflammation. The activation products and chemical mediators released from these cells act through different well-characterized signaling pathways to induce the phenotypic changes in microvessel function that accompany inflammation. Drugs that target a specific microvascular response to inflammation, such as leukocyte-endothelial cell adhesion or angiogenesis, have shown promise in both the preclinical and clinical studies of inflammatory disease. Future research efforts in this area will likely identify new avenues for therapeutic intervention in inflammation. Table of Contents: Introduction / Historical Perspectives / Anatomical Considerations / Impaired Vasomotor Responses / Capillary Perfusion / Angiogenesis / Leukocyte-Endothelial Cell Adhesion / Platelet-Vessel Wall Interactions / Coagulation and Thrombosis / Endothelial Barrier Dysfunction / Epilogue / References