Advanced Delivery And Therapeutic Applications Of Rnai
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Advanced Delivery And Therapeutic Applications Of Rnai
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Author : Kun Cheng
language : en
Publisher: John Wiley & Sons
Release Date : 2013-04-19
Advanced Delivery And Therapeutic Applications Of Rnai written by Kun Cheng and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-19 with Science categories.
Commonly used by researchers to develop technologies for modifying and studying genetic process, RNA interference (RNAi) has many potential uses in medicine, biotechnology, and functional genomics. This book covers all essential aspects involved in the development of RNAi therapeutics, providing detailed guidance on the challenges and opportunities of bringing RNAi technologies from bench to clinic. It explores the design and mechanism of RNAi molecules, delivery strategies, and therapeutic applications in various diseases. Preclinical, regulatory, market, and intellectual aspects of RNAi technologies are also covered.
Rna Interference
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Author : Ibrokhim Y. Abdurakhmonov
language : en
Publisher: BoD – Books on Demand
Release Date : 2016-04-06
Rna Interference written by Ibrokhim Y. Abdurakhmonov and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-06 with Medical categories.
RNA interference (RNAi), a hallmark of all biological sciences of twenty-first century, is an evolutionarily conserved and double-stranded RNA-dependent eukaryotic cell defense process. Opportunity to utilize an organisms own gene and to systematically induce and trigger RNAi for any desired sequence made RNAi an efficient approach for functional genomics, providing a solution for conventional longstanding obstacles in life sciences. RNAi research and application have significantly advanced during past two decades. This book RNA interference provides an updated knowledge and progress on RNAi in various organisms, explaining basic principles, types, and property of inducers, structural modifications, delivery systems/methodologies, and various successful bench-to-field or clinic applications and disease therapies with some aspects of limitations, alternative tools, safety, and risk assessment.
Nanoparticle Based Drug Delivery In Cancer Treatment
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Author : Loutfy H. Madkour
language : en
Publisher: CRC Press
Release Date : 2022-02-27
Nanoparticle Based Drug Delivery In Cancer Treatment written by Loutfy H. Madkour and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-27 with Science categories.
The careful choice of nanoparticles as targets and in drug delivery routes enhances therapeutic efficacy in cancer. Nanoparticle-Based Drug Delivery in Cancer Treatment discusses nanotechnological developments of interfering RNA-based nanoparticles, delivery vehicles, and validated therapeutic RNAi–molecular target interactions and explains the results of clinical and preclinical trials. The book also gives strategies for universal methods of constructing hybrid organic–inorganic nanomaterials that can be widely applied in the biomedical field. Key Features: Reviews recent advances of nanoparticle-mediated siRNA delivery systems and their application in clinical trials for cancer therapy Focuses on material platforms that establish NPs and both localized and controlled gene silencing Emphasizes the most promising systems for clinical application Surveys progress in nanoparticle-based nanomedicine in cancer treatment Describes the most advanced of the nonviral nanocarriers for delivery of oligonucleotides to malignant blood cancer cells This book is a valuable resource for researchers, professors, and students researching drug delivery, gene carriers, cancer therapy, nanotechnology, and nanomaterials.
Advances In Pulmonary Drug Delivery
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Author : Philip Chi Lip Kwok
language : en
Publisher: CRC Press
Release Date : 2016-12-19
Advances In Pulmonary Drug Delivery written by Philip Chi Lip Kwok and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-12-19 with Medical categories.
The respiratory tract has been used to deliver biologically active chemicals into the human body for centuries. However, the lungs are complex in their anatomy and physiology, which poses challenges to drug delivery. Inhaled formulations are generally more sophisticated than those for oral and parenteral administration. Pulmonary drug development is therefore a highly specialized area because of its many unique issues and challenges. Rapid progress is being made and offers novel solutions to existing treatment problems. Advances in Pulmonary Drug Delivery highlights the latest developments in this field.
Application Of New Genetic Technologies To Animal Breeding
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Author : Association for the Advancement of Animal Breeding and Genetics,
language : en
Publisher: CSIRO PUBLISHING
Release Date : 2005-09-01
Application Of New Genetic Technologies To Animal Breeding written by Association for the Advancement of Animal Breeding and Genetics, and has been published by CSIRO PUBLISHING this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-09-01 with Technology & Engineering categories.
The 16th Biennial Conference of the Association for the Advancement of Animal Breeding and Genetics (AAABG) gathers together scientists, extension workers, producers and industry personnel to review developments in the application of new technologies to animal breeding. Conference presentations include 30 invited reviews and papers, and 95 contributed papers. All papers are peer-reviewed, and cover session topics that focus on genetic evaluation systems, gene expression profiling, identification and manipulation of quantitative trait loci, progress in applied programs and advanced statistical and computing techniques. Industry applications are discussed for improvement in production, health and reproduction of domestic livestock, aquaculture species and even crocodiles and ostriches. Institutions and industries in Australia, New Zealand, USA, South Africa, South-East Asia and Japan are represented with significant participation of major Cooperative Research Centres. These proceedings contain the full text of all contributed papers and summaries of the invited reviews which are published separately in the Australian Journal of Experimental Agriculture.
Carbon Based Nanomaterials For Sustainable And Technological Applications
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Author : Loutfy H. Madkour
language : en
Publisher: CRC Press
Release Date : 2024-10-29
Carbon Based Nanomaterials For Sustainable And Technological Applications written by Loutfy H. Madkour and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-10-29 with Science categories.
Carbon-Based Nanomaterials for Sustainable and Technological Applications covers the fundamentals of carbon-based nanomaterials (CNMs) and their potential for technological and industrial applications. Addressing recent advancements in technology and improvement in material synthesis, the book outlines how functionalized CNMs are used in nanobiotechnology, for active sorbent materials, and in pharmaceutical applications. Chapters cover macro-scale applications, biosensors and drug delivery, and treatment in cancer and coronavirus diseases. Key features: Through up-to-date references, this book demonstrates that carbon-based nanomaterials are one of the most promising nanomaterials in medical applications, such as drug and gene delivery carriers, as well as nonmedical, environmental applications. Discusses the synthesis methods of processing (CQDs), (GQDs), (CPDs), and (g-C3N4) materials-based nanocomposites for biotechnological applications. Chapters address various classes of carbon nanomaterials and their innovative technologies. Opens up further exploration of environmental nanotechnology, bionanotechnology, and biomedical applications of novel carbon nanomaterials. Full references can be found via the Support Material: www.routledge.com/9781032635934. Written by a leading expert, this volume provides the reader with thorough coverage of bionanotechnology and biomedical applications of novel carbon nanomaterials.
Rna Interference From Biology To Therapeutics
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Author : Kenneth A. Howard
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-10-19
Rna Interference From Biology To Therapeutics written by Kenneth A. Howard and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-10-19 with Medical categories.
The enormous potential of siRNA as a therapeutic has led to an explosion of interest from the scientific community. There has been intense interest from Big Pharma to capitalise on this new technology but the fact remains that delivery is a key determinant in realizing the full clinical potential of RNA interference. There is an urgent need for better delivery methods to take this technology forward. This book addresses the role of different RNAi molecules in cellular processes as rational for diagnostic and therapeutic approaches. This book will cover RNAi therapeutic design to optimize siRNA potency and reduce off-target effects and current delivery technologies to overcome both intracellular and extracellular barriers. The reader will gain an insight into RNA interference from the cellular mechanisms to screening to siRNA design right through to diagnostic and therapeutic applications.
Fetal Gene Therapy For Fetal Phenylketonuria
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Author : Edenilson Brandl
language : en
Publisher: Edenilson Brandl
Release Date : 2025-06-28
Fetal Gene Therapy For Fetal Phenylketonuria written by Edenilson Brandl and has been published by Edenilson Brandl this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-06-28 with Health & Fitness categories.
It is with great enthusiasm that I present this comprehensive work on the cutting edge of medical science: "Fetal Gene Therapy for Fetal Phenylketonuria". At the heart of this work, we explore the fascinating horizons of genetic intervention in fetal development, particularly aimed at correcting the manifestations of fetal phenylketonuria. Throughout these pages, we navigate the intricate intricacies of messenger RNA (mRNA) injection, viral vectors, and gene-editing technologies such as TALENs and CRISPR-Cas9, revealing innovative strategies for expressing or correcting specific proteins in the fetal environment. The journey includes not only technological advances, but also explores the intersections between advanced fetal medicine, legislation, ethics, and the psychosocial implications of fetal gene therapy. However, we cannot ignore the significant challenges and complexities associated with genetic manipulation at such a crucial stage of human development. Each chapter is meticulously crafted to provide a comprehensive understanding, from an introduction to the fundamentals of fetal gene therapy to future perspectives and potential long-term implications. This book is intended for researchers, healthcare professionals, students, and anyone interested in delving into the frontiers of modern medicine. By sharing these findings and reflections, I hope to contribute to the advancement of knowledge and stimulate dialogue about the promising future and ethical challenges associated with fetal gene therapy. May this work inspire those who seek to understand and shape the future of fetal medicine.
Materials For Biomedical Engineering
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Author : Mohamed N. Rahaman
language : en
Publisher: John Wiley & Sons
Release Date : 2021-11-01
Materials For Biomedical Engineering written by Mohamed N. Rahaman and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-01 with Science categories.
MATERIALS FOR BIOMEDICAL ENGINEERING A comprehensive yet accessible introductory textbook designed for one-semester courses in biomaterials Biomaterials are used throughout the biomedical industry in a range of applications, from cardiovascular devices and medical and dental implants to regenerative medicine, tissue engineering, drug delivery, and cancer treatment. Materials for Biomedical Engineering: Fundamentals and Applications provides an up-to-date introduction to biomaterials, their interaction with cells and tissues, and their use in both conventional and emerging areas of biomedicine. Requiring no previous background in the subject, this student-friendly textbook covers the basic concepts and principles of materials science, the classes of materials used as biomaterials, the degradation of biomaterials in the biological environment, biocompatibility phenomena, and the major applications of biomaterials in medicine and dentistry. Throughout the text, easy-to-digest chapters address key topics such as the atomic structure, bonding, and properties of biomaterials, natural and synthetic polymers, immune responses to biomaterials, implant-associated infections, biomaterials in hard and soft tissue repair, tissue engineering and drug delivery, and more. Offers accessible chapters with clear explanatory text, tables and figures, and high-quality illustrations Describes how the fundamentals of biomaterials are applied in a variety of biomedical applications Features a thorough overview of the history, properties, and applications of biomaterials Includes numerous homework, review, and examination problems, full references, and further reading suggestions Materials for Biomedical Engineering: Fundamentals and Applications is an excellent textbook for advanced undergraduate and graduate students in biomedical materials science courses, and a valuable resource for medical and dental students as well as students with science and engineering backgrounds with interest in biomaterials.
Chemistry And Pharmacology Of Anticancer Drugs
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Author : David E. Thurston
language : en
Publisher: CRC Press
Release Date : 2021-03-17
Chemistry And Pharmacology Of Anticancer Drugs written by David E. Thurston and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-17 with Medical categories.
While drug therapies developed in the last 80 years have markedly improved treatment outcomes and the management of some types of cancers, the lack of effectiveness and side effects associated with the most common treatment types remain unacceptable. However, recent technological advances are leading to improved therapies based on targeting distinct biological pathways in cancer cells. Chemistry and Pharmacology of Anticancer Drugs is a comprehensive survey of all families of anticancer agents and therapeutic approaches currently in use or in advanced stages of clinical trials, including biological-based therapies. The book is unique in providing molecular structures for all anticancer agents, discussing them in terms of history of development, chemistry, mechanism of action, structure–function relationships, and pharmacology. It also provides relevant information on side effects, dosing, and formulation. The authors, renowned scientists in cancer research and drug discovery, also provide up-to-date information on the drug discovery process, including discussions of new research tools, tumor-targeting strategies, and fundamental concepts in the relatively new areas of precision medicine and chemoprevention. Chemistry and Pharmacology of Anticancer Drugs is an indispensable resource for cancer researchers, medicinal chemists and other biomedical scientists involved in the development of new anticancer therapies. Its breadth of coverage, clear explanations, and illustrations also make it suitable for undergraduate and postgraduate courses in medicine, pharmacy, nursing, dentistry, nutrition, the biomedical sciences, and related disciplines. Key Features: Summarizes the fundamental causes of cancer, modes of treatment, and strategies for cancer drug discovery Brings together a broad spectrum of information relating to the chemistry and pharmacology of all families of anticancer agents and therapies Includes up-to-date information on cutting-edge aspects of cancer treatments such as biomarkers, pharmacogenetics, and pharmacogenomics Features new chapters on the "Evolution of Anticancer Therapies", "Antibody-Based Therapies", and "Cancer Chemoprevention"