Advanced Techniques In Central Nervous System Metastases
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Advanced Techniques In Central Nervous System Metastases
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Author : R. J. Maciunas
language : en
Publisher:
Release Date : 1999-01-01
Advanced Techniques In Central Nervous System Metastases written by R. J. Maciunas and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-01-01 with categories.
Advanced Techniques In Central Nervous System Metastases
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Author : Robert J. Maciunas
language : en
Publisher: Thieme
Release Date : 1998
Advanced Techniques In Central Nervous System Metastases written by Robert J. Maciunas and has been published by Thieme this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with Cancer invasiveness categories.
The neurosurgical treatment of metastatic tumors involving the central nervous system is being transformed by recent advances in interactive image-guided technologies and cell-specific targeted biotherapeutics. Advanced Techniques in Central Nervous System Metastases presents the research and developments being incorporated into clinical practice. Advanced Techniques in Central Nervous System Metastases covers: The current treatment of brain metastases Metastases of primary CNS tumors Craniotomy for single and multiple cerebral metastases CNS involvement by systemic malignancy in children Cranial base surgery for invasive carcinomas Interactive image-guided techniques for the biopsy and resection of metastatic cerebral tumors Use of the free-electron laser for metastatic brain tumors Gamma knife radiosurgery Endovascular treatment Decompression and stabilization of spine metastases Plus much more! (Distributed by Thieme for the American Association of Neurological Surgeons)
Central Nervous System Metastases
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Author : Manmeet Ahluwalia
language : en
Publisher: Springer Nature
Release Date : 2019-11-05
Central Nervous System Metastases written by Manmeet Ahluwalia and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-05 with Medical categories.
This book provides a comprehensive overview of brain metastases, from the molecular biology aspects to therapeutic management and perspectives. Due to the increasing incidence of these tumors and the urgent need to effectively control brain metastatic diseases in these patients, new therapeutic strategies have emerged in recent years. The volume discusses all these innovative approaches combined with new surgical techniques (fluorescence, functional mapping, integrated navigation), novel radiation therapy techniques (stereotactic radiosurgery) and new systemic treatment approaches such as targeted- and immunotherapy. These combination strategies represent a new therapeutic model in brain metastatic patients in which each medical practitioner (neurosurgeon, neurologist, medical oncologist, radiation oncologist) plays a pivotal role in defining the optimal treatment in a multidisciplinary approach. Written by recognized experts in the field, this book is a valuable tool for neurosurgeons, neuro-oncologists, neuroradiologists, medical oncologists, radiation oncologists, cognitive therapists, basic scientists and students working in the area of brain tumors.
Central Nervous System Metastases In Lung Cancer Patients From Prevention To Diagnosis And Treatment
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Author : Lizza E.L Hendriks
language : en
Publisher: Frontiers Media SA
Release Date : 2019-01-21
Central Nervous System Metastases In Lung Cancer Patients From Prevention To Diagnosis And Treatment written by Lizza E.L Hendriks and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-01-21 with categories.
Approximately 40% of lung cancer patients will develop central nervous system (CNS) metastases during the course of their disease. Most of these are brain metastases, but up to 10% will develop leptomeningeal metastases. Known risk factors for CNS metastases development are small cell lung cancer (SCLC), adenocarcinoma histology, epidermal growth factor receptor (EGFR) mutant or anaplastic lymphoma kinase (ALK) rearranged lung cancer, advanced nodal status, tumor stage and younger age. CNS metastases can have a negative impact on quality of life (QoL) and overall survival (OS). The proportion of lung cancer patients diagnosed with CNS metastases has increased over the years due to increased use of brain imaging as part of initial cancer staging, advances in imaging techniques and better systemic disease control. Post contrast gadolinium enhanced magnetic resonance imaging (gd-MRI) is preferred, however when this is contra-indicated a contrast enhanced computed tomography (CE-CT) is mentioned as an alternative option. When CNS metastases are diagnosed, local treatment options consist of radiotherapy (stereotactic or whole brain) and surgery. Local treatment can be complicated by symptomatic radiation necrosis for which no high level evidence based treatment exists. Moreover, differential diagnosis with metastasis progression is difficult. Systemic treatment options have expanded over the last years. Until recently, chemotherapy was the only treatment option with a poor penetration in the CNS. Angiogenesis inhibitors are promising in the treatment of primary CNS tumors as well as radiation necrosis but clinical trials of anti-angiogenic agents in NSCLC have largely excluded patients with CNS metastases. Furthermore, research has also focused on methods to prevent development of CNS disease, for example with prophylactic cranial irradiation. Recently, checkpoint inhibitors have become available for NSCLC patients, and tyrosine kinase inhibitors (TKIs) have improved prognosis significantly in those with a druggable driver mutation. Newer TKIs are often designed to have better CNS penetration compared to first-generation TKIs. Despite advances in treatment options CNS metastases remain a problem in lung cancer and cause morbidity and mortality. This Research Topic provides an extensive resource of articles describing advances in CNS metastases management in lung cancer patients, from prevention to diagnosis and treatment.
Central Nervous System Metastases
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Author : Rohan Ramakrishna
language : en
Publisher: Springer Nature
Release Date : 2020-05-27
Central Nervous System Metastases written by Rohan Ramakrishna and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-05-27 with Medical categories.
This is a multi-specialty book on the diagnosis, evaluation, and treatment of CNS metastases of the brain and spine. Written by renowned experts in their fields, the book covers essential contemporary topics in CNS metastases care. The book is divided into seven parts that begin with chapters that cover the fundamental biology of disease so that subsequent chapters on imaging, diagnosis, treatment, and palliation can be properly contextualized. This text also provides a framework for understanding the biology of radiation therapy so that radiation treatment options of the brain and spine can be more fully understood. New medications and technologies are reviewed from the perspective of maximizing efficacy and minimizing toxicity, independently and as combinatorial therapy. Central Nervous System Metastases: Diagnosis and Treatment serves as a practical reference for health care providers and trainees. It provides the comprehensive, detailed perspective required to provide holistic care to patients with metastatic disease to the brain and spine.
Central Nervous System Metastases In Lung Cancer Patients From Prevention To Diagnosis And Treatment
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Author :
language : en
Publisher:
Release Date : 2019
Central Nervous System Metastases In Lung Cancer Patients From Prevention To Diagnosis And Treatment written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with categories.
Approximately 40% of lung cancer patients will develop central nervous system (CNS) metastases during the course of their disease. Most of these are brain metastases, but up to 10% will develop leptomeningeal metastases. Known risk factors for CNS metastases development are small cell lung cancer (SCLC), adenocarcinoma histology, epidermal growth factor receptor (EGFR) mutant or anaplastic lymphoma kinase (ALK) rearranged lung cancer, advanced nodal status, tumor stage and younger age. CNS metastases can have a negative impact on quality of life (QoL) and overall survival (OS). The proportion of lung cancer patients diagnosed with CNS metastases has increased over the years due to increased use of brain imaging as part of initial cancer staging, advances in imaging techniques and better systemic disease control. Post contrast gadolinium enhanced magnetic resonance imaging (gd-MRI) is preferred, however when this is contra-indicated a contrast enhanced computed tomography (CE-CT) is mentioned as an alternative option. When CNS metastases are diagnosed, local treatment options consist of radiotherapy (stereotactic or whole brain) and surgery. Local treatment can be complicated by symptomatic radiation necrosis for which no high level evidence based treatment exists. Moreover, differential diagnosis with metastasis progression is difficult. Systemic treatment options have expanded over the last years. Until recently, chemotherapy was the only treatment option with a poor penetration in the CNS. Angiogenesis inhibitors are promising in the treatment of primary CNS tumors as well as radiation necrosis but clinical trials of anti-angiogenic agents in NSCLC have largely excluded patients with CNS metastases. Furthermore, research has also focused on methods to prevent development of CNS disease, for example with prophylactic cranial irradiation. Recently, checkpoint inhibitors have become available for NSCLC patients, and tyrosine kinase inhibitors (TKIs) have improved prognosis significantly in those with a druggable driver mutation. Newer TKIs are often designed to have better CNS penetration compared to first-generation TKIs. Despite advances in treatment options CNS metastases remain a problem in lung cancer and cause morbidity and mortality. This Research Topic provides an extensive resource of articles describing advances in CNS metastases management in lung cancer patients, from prevention to diagnosis and treatment.
Metastases To The Central Nervous System An Issue Of Neurosurgery Clinics Of North America
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Author : Edjah K. Nduom
language : en
Publisher: Elsevier Health Sciences
Release Date : 2020-09-24
Metastases To The Central Nervous System An Issue Of Neurosurgery Clinics Of North America written by Edjah K. Nduom and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-09-24 with Medical categories.
This issue of Neurosurgery Clinics, guest edited by Drs. Edjah Nduom and Jeff Olson, will focus on Metastases to the Central Nervous System. This issue is one of four selected each year by our series consulting editors, Dr. Russell R. Lonser and Dr. Daniel K. Resnick. Topics discussed in this issue will include: Epidemiology of metastatic CNS disease, Initial approach to the patient with a newly diagnosed solitary brain metastasis, Initial approach to the patient with multiple newly diagnosed brain metastases, When to consider a stereotactic biopsy for brain metastases, Techniques for open surgical resection of cerebral metastases, Laser ablation for cerebral metastases, Histopathological features and laboratory markers of common brain metastases, Recurrence vs radiation necrosis – evaluation and treatment, Anti-epileptic drugs for the management of cerebral metastases, Chemotherapy for the management of cerebral metastases, Approach to the management of metastatic leptomeningeal disease, Immune therapy for CNS metastases, Novel therapeutic targets for the treatment of cerebral metastases, Skull base metastases – diagnosis and management, and more.
Central Nervous System Metastasis The Biological Basis And Clinical Considerations
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Author : Diane Palmieri
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-30
Central Nervous System Metastasis The Biological Basis And Clinical Considerations written by Diane Palmieri and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-30 with Medical categories.
Here is a thorough survey of the biology and treatment of CNS metastasis, including natural history, risk factors, molecular biology, the blood-brain barrier, imaging, quality of life, surgery, chemotherapy, radiation and the future of targeted therapies.
Combined Modality Therapy Of Central Nervous System Tumors
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Author : Zbigniew Petrovich
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Combined Modality Therapy Of Central Nervous System Tumors written by Zbigniew Petrovich and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The American Cancer Society anticipates that 16,500 patients will be diagnosed with primary malignant tumors of the central nervous system in 2000, with about 200,000 individuals presenting with brain metastases. The advances in the treatment of solid tumors have contributed significantly to the major increase in metastatic cancers to the brain. Of the primary malignant tumors of the brain, more than 50% are high-grade gliomas; the incidence has been increasing among older patients over the past decade. Major developments in new technologies in the treatment of primary brain tumors as well as metastatic disease are covered in depth. Even though management is difficult, advances are being made. This book is a concerted effort to present data regarding basic science research efforts alongside their translation into clinical practice using combined, integrated multimodal programs of treatment. Progress has been made, but innovatice approaches need to be pursued.
Mechanisms And Therapy For Cancer Metastasis To The Central Nervous System
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Author : Haotian Zhao
language : en
Publisher: Frontiers Media SA
Release Date : 2019-05-15
Mechanisms And Therapy For Cancer Metastasis To The Central Nervous System written by Haotian Zhao and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-05-15 with categories.