Advances In Antifungal Drug Development
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Advances In Antifungal Drug Development
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Author : Nikhat Manzoor
language : en
Publisher: Springer
Release Date : 2024-09-30
Advances In Antifungal Drug Development written by Nikhat Manzoor and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-09-30 with Medical categories.
This book explores the antifungal properties of natural products and reviews their antifungal mechanism. An introductory chapter illustrates the various fungal pathogenic species, common fungal diseases, and general mechanisms of action of various antifungal classes, including natural products. The book comprises seven sections and each section contains chapters on the efficacy and antifungal mode of action of plant extracts, essential oils, natural compounds, their derivatives, and plant-based nanoparticles. A section summarizes the antifungal efficacy of compounds derived from sources other than plants, like microbes. Besides compound toxicity, the book explores the antifungal mode of action and efficacy against the virulence and pathogenicity of fungal pathogens like Candida, Aspergillus, Cryptococcus, Histoplasma, and other pathogenic fungi. Further, the book also describes recent advancements in the discovery of novel drug targets and therapeutic strategies that are non-toxic and more efficacious for combating drug resistance. This book is an invaluable source for researchers working in the field of fungal biochemistry, anti-microbial, and anti-bacterial and undergraduate and postgraduate students of microbiology and pharmacology.
Antifungal Drug Discovery New Theories And New Therapies
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Author : Chaminda Jayampath Seneviratne
language : en
Publisher: Frontiers Media SA
Release Date : 2016-09-13
Antifungal Drug Discovery New Theories And New Therapies written by Chaminda Jayampath Seneviratne and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-09-13 with Microbiology categories.
Fungal infections such as candidoses can range from superficial mucous membrane infection to life-threatening systemic mycoses. Candida infections are a significant clinical problem globally due to rapid rise in compromised host populations including HIV/AIDS, organ transplant recipients and patients on chemotherapy. In addition, sharp increase in aging populations which are susceptible to fungal infections is expected in next few decades. Antifungal drugs are relatively difficult to develop compared to the antibacterial drugs owing to the eukaryotic nature of the cells. Therefore, only a handful of antifungal agents are currently available to treat the myriad of fungal infections. Moreover, rising antifungal resistance and host-related adverse reactions have limited the antifungal arsenal against fungal pathogens. In this research topic, we tried to update the theoretical aspects pertaining to the antifungal drug discovery i.e. proposed novel mechanisms, new drug targets and pathways. In addition, invited authors explored the new antifungal drugs derived from natural and synthetic sources which are currently under development. Contributors were encouraged to bring new insight into the antifungal drug discovery. We hope the reader may arrive at a general consensus on the possible strategies to combat ever increasing ubiquitous fungal infection in this new century.
Advances In Antifungal Development Discovery Of New Drugs And Drug Repurposing
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Author : Jong Heon Kim
language : en
Publisher:
Release Date : 2022
Advances In Antifungal Development Discovery Of New Drugs And Drug Repurposing written by Jong Heon Kim and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022 with categories.
This reprint describes recent advances made in the field of antifungal development, especially the discovery of new drugs and drug repurposing. The articles presented in this book provide useful information and insight for the development of new antifungal drugs or intervention strategies. The identification of new, safe molecules, and cellular targets, as well as the elucidation of their antifungal mechanisms of action, will further the effective control of fungal pathogens, especially those resistant to current therapeutic agents.
Combating Fungal Infections
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Author : Iqbal Ahmad
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-08-03
Combating Fungal Infections written by Iqbal Ahmad and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-08-03 with Medical categories.
Fungi are eukaryotic microorganisms that are closely related to humans at cellular level. Human fungal pathogens belong to various classes of fungi, mainly zygo- cetes, ascomycetes, basidiomycetes, and deuteromycetes. In recent years, fungal infections have dramatically increased as a result of improved diagnosis, high frequency of catheterization, instrumentation, etc. However, the main cause remains the increasing number of immunosuppressed patients, mostly because of HIV infection and indiscriminate usage of antineoplastic and immunosuppressive agents, broad-spectrum antibiotics and prosthetic devices, and grafts in clinical settings. Presently available means of combating fungal infections are still weak and clumsy compared to control of bacterial infection. The present scenario of antifungal therapy is still based on two classes of antifungal drugs (polyenes and azoles). These drugs are effective in many cases, but display toxicity and limited spectrum of ef?cacy. The recent trend towards emergence of drug-resistant isolates in the clinic is an additional problem. In recent years, a few new antifungal drugs have entered the clinics, but they are expected to undergo same fate as the older antifungal drugs. The application of fungal genomics offers an unparalleled opportunity to develop novel antifungal drugs. However, it is too early to expect any novel drugs, as the antifungal drug discovery program is in the stage of infancy. Interestingly, several novel antifungal drug targets have been identi?ed and validated.
Anticandidal Therapeutics
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Author : Awanish Kumar
language : en
Publisher: Elsevier
Release Date : 2023-01-20
Anticandidal Therapeutics written by Awanish Kumar and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-01-20 with Science categories.
Developments of antifungal agents have declined as compared to other antibiotics that have displayed a potent development with time. There is an urgent need for both prophylactic and therapeutic treatments worldwide to control the severity of infections caused by Candida. Anticandidal Therapeutics: Discovery and Development provides the readers with a compiled knowledge of the fungal human infection Candida and the development of anticandidal drugs. Anticandidal Therapeutics helps researchers form the basis for the discovery and development of novel anticandidal therapies. In 14 chapters this book provides collective information on anticandidal agents and their discovery and development with respect to major drug transporter families, different stages of anticandidal agent development, recent trends and progress in antifungal translational research, clinical studies status of anticandidal therapeutic agents, and drug repurposing for development of novel anticandidal agents. Highlights the mechanistic actions of some therapeutic agents against Candida Focuses on anticandidal agents rather than general antifungal agents Discusses the stage of development of new antifungal drugs, the repositioning of drugs, and how this could help in treatment
Antimicrobial Drug Discovery
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Author : George Tegos
language : en
Publisher: CABI
Release Date : 2012
Antimicrobial Drug Discovery written by George Tegos and has been published by CABI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Medical categories.
Resistance is on the rise among a variety of human pathogenic microorganisms associated with common and potentially life-threatening infections, including penicillin-resistant Streptococcus pneumonia and Methicillin-resistant Staphylococcus aureus (MRSA). There is increasing demand to approach the threat of multidrug resistance incorporating novel multidisciplinary methodologies and technological platforms. This book documents the latest research, covering current and promising activities in four key areas: computational chemistry and chemoinformatics, High Throughput Screening (HTS), non-vertebrate model hosts and light and nano-based technologies. It is essential reading for researchers and students in microbiology, biotechnology, pharmacology, chemistry and biology as well as medical professionals.
Antifungal Drug Discovery New Theories And New Therapies
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Author :
language : en
Publisher:
Release Date : 2016
Antifungal Drug Discovery New Theories And New Therapies written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with categories.
Fungal infections such as candidoses can range from superficial mucous membrane infection to life-threatening systemic mycoses. Candida infections are a significant clinical problem globally due to rapid rise in compromised host populations including HIV/AIDS, organ transplant recipients and patients on chemotherapy. In addition, sharp increase in aging populations which are susceptible to fungal infections is expected in next few decades. Antifungal drugs are relatively difficult to develop compared to the antibacterial drugs owing to the eukaryotic nature of the cells. Therefore, only a handful of antifungal agents are currently available to treat the myriad of fungal infections. Moreover, rising antifungal resistance and host-related adverse reactions have limited the antifungal arsenal against fungal pathogens. In this research topic, we tried to update the theoretical aspects pertaining to the antifungal drug discovery i.e. proposed novel mechanisms, new drug targets and pathways. In addition, invited authors explored the new antifungal drugs derived from natural and synthetic sources which are currently under development. Contributors were encouraged to bring new insight into the antifungal drug discovery. We hope the reader may arrive at a general consensus on the possible strategies to combat ever increasing ubiquitous fungal infection in this new century.
Recent Developments In Anti Fungal Agents
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Author : Mohd. Shahid
language : en
Publisher: LAP Lambert Academic Publishing
Release Date : 2011-01
Recent Developments In Anti Fungal Agents written by Mohd. Shahid and has been published by LAP Lambert Academic Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-01 with categories.
Invasive fungal infections (IFIs) demand a tremendous levy in terms of human life and healthcare costs, despite the fact that fungal diseases are still under-diagnosed and under reported. Several factors such as patient characteristics, antifungal prophylaxis and others appear to have contributed to a change in the spectrum of invasive fungal pathogens (i.e. Candida species, Non-Candida species, Aspergillus species and Non-Aspergillus species). Therefore, it is important to recognize and minimize the major risk factors associated with infection, and expanding the antifungal drug research for new antifungal agents to treat life-threatening invasive infections. This book would highlight past and current research on fungal pathogens and antifungal therapies, and also novel targets for antifungal agents for future development in medical practice to prevent invasive fungal infections. The book will describe novel antifungal agents, its targets, and various development phases and potential benefits of combination therapy.
Vaccines Immunotherapy And New Antifungal Therapy Against Fungi Updates In The New Frontier
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Author : Carlos P. Taborda
language : en
Publisher: Frontiers Media SA
Release Date : 2017-11-15
Vaccines Immunotherapy And New Antifungal Therapy Against Fungi Updates In The New Frontier written by Carlos P. Taborda and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-11-15 with categories.
Invasive fungal diseases have increased many fold over the past 50 years. Current treatment regimens typically require prolonged administration of antifungal medications that can have significant toxicity. Moreover, our present potent antifungal armamentarium fails to eradicate fungal pathogens from certain compromised hosts. Additionally, invasive fungal diseases continue to have unacceptably high mortality rates. A growing body of work has focused on the utility of vaccines and/or immunotherapy as a powerful tool in combating mycoses, either for the active treatment, as an adjuvant, or in the prevention of specific fungal pathogens. Also, it is growing the interest over new drugs development as second choice for treatment when traditional chemotherapy fail. This Research Topic will detail the exciting progress in developing vaccines, immunotherapy and new drugs for fungi.
Antifungal Agents
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Author : Ernst M. Jucker
language : en
Publisher: Birkhäuser
Release Date : 2012-12-06
Antifungal Agents written by Ernst M. Jucker and has been published by Birkhäuser this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
This second volume of PDR SPECIAL TOPICS contains five review articles, covering nearly the entire field of fungal diseases in humans as well as therapeutic approaches. The main emphasis of the book lies in antifungal therapy: the most relevant information on the present state of the art of antifungal chemotherapy for dermatomycoses, subcutaneous and invasive mycoses is summarized, and open questions and unsolved problems are presented. The book is ideal for both the practitioner as well as advanced student.