Advances In Neutron Capture Therapy
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Advances In Neutron Capture Therapy
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Author : R.F. Barth
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Advances In Neutron Capture Therapy written by R.F. Barth and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Binary systems for the treatment of cancer potentially are among the most attractive of the new therapeutic modalities that currently are under investigation. The basicconcept is to selectivelydestroy malignantcells whileconcomitantlysparing normal tissue. Neutron capture therapy (NCT) is the binary system that has been the subject of the Fifth International Symposium on Neutron Capture Therapy, which was held September13-17, 1992, in Columbus, Ohio, undertheauspicesoftheInternational Society for Neutron Capture Therapy. Its objective was to bring together researchers from throughout the world and to provide a forum at which they could present the latest advances in the development of Neutron capture therapy. Neutron capture therapy has largely, but not exclusively, focused on the use of boron-10 as the target nuclide. Boron neutron capture therapy (BNCT) is based on the nuclear reaction that occurs when the stable isotope, boron-10, absorbs low-energy non ionizing thermal neutrons to yield alphaparticles and recoiling lithium-7 nuclei. The size and energy of these high linear energy transfer (LET) particles result in their being confined largely to the cells in which the capture reaction occurs. For BNCT to be successful, a sufficient numberof I~atoms mustbe localized within neoplastic cells, and enough thermal neutrons must be delivered and absorbed by the I~ to produce a lethal 1~(n,QVLi reaction. Two major problems must be surmounted.
Advances In Neutron Capture Therapy
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Author : Börje Larsson
language : en
Publisher:
Release Date : 1997
Advances In Neutron Capture Therapy written by Börje Larsson and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with Boron-neutron capture therapy categories.
Advances In Neutron Capture Therapy
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Author :
language : en
Publisher:
Release Date : 1997
Advances In Neutron Capture Therapy written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with categories.
Progress In Neutron Capture Therapy For Cancer
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Author : B.J. Allen
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Progress In Neutron Capture Therapy For Cancer written by B.J. Allen and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Despite the many advances made in the diagnosis and therapy of cancer, the mortality rate is still about half that of the incidence rate. However, the odds are not evenly distributed. Prognosis for some cancers is good, but for others, few patients will survive 12 months. This latter group of cancers is characterised by a proclivity to disseminate malignant cells in the host organ. The degree of surgery possible may be limited by the critical nature of the organ, and chemotherapy and radiotherapy are of palliative value only. In some cases systemic metastases occur, but in other cases, failure to achieve local control results in death. First among these cancers are the high grade brain tumours, astrocytoma 3,4 and glioblastoma multiforme. Local control of these tumours should lead to cure. Other cancers melanoma metastatic to the brain, for which a useful palliative therapy is not yet available, and pancreatic cancer for which localised control at an early stage could bring about improved prognosis. Patients with these cancers have little grounds for hope. Our primary objective is to reverse this situation with Neutron Capture Therapy (NCT). The purpose of this fourth symposium is to hasten the day whereby patients with these cancers can reasonably hope for substantial remissions. The first symposium on NCT was held in Boston in 1983, followed by Tokyo in 1985 and Bremen, Germany in 1988.
Frontiers In Neutron Capture Therapy
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Author : M. Frederick Hawthorne
language : en
Publisher: Springer
Release Date : 2013-11-11
Frontiers In Neutron Capture Therapy written by M. Frederick Hawthorne and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-11 with Medical categories.
Frontiers in Neutron Capture Therapy contains current research results originally presented at the Eighth International Symposium on Neutron Capture Therapy for Cancer in La Jolla, CA. This comprehensive collection of peer-reviewed manuscripts is showcased in two volumes covering all aspects of the development of this multidisciplinary approach to cancer therapy. Volume I of this work includes clinical results and current progress in treatment planning, neutron sources and dosimetry, while Volume II presents the synthesis, pharmacology and tissue-targeting design of boron compounds, including work on preclinical dosimetry and radiobiology. Intended for researchers and clinicians involved with or interested in new modes of cancer therapy, this volume will also serve as a useful guideline for scientists, students, and practitioners in the field.
Advances In Neutron Capture Therapy
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Author : Börje Larsson
language : en
Publisher:
Release Date : 1997
Advances In Neutron Capture Therapy written by Börje Larsson and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with Boron-neutron capture therapy categories.
Advances In Neutron Capture Therapy 2006
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Author : 義信·中川
language : en
Publisher:
Release Date : 2006
Advances In Neutron Capture Therapy 2006 written by 義信·中川 and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with categories.
Advances In Boron Neutron Capture Therapy
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Author : International Atomic Energy Agency
language : en
Publisher:
Release Date : 2023-07-31
Advances In Boron Neutron Capture Therapy written by International Atomic Energy Agency and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-07-31 with categories.
Boron neutron capture therapy (BNCT) is a neutron-based technique that allows selective cancer treatment at the tumour cellular level. BNCT is especially suitable for the treatment of brain, head, neck and skin cancers. Using the reaction between a neutron and boron to selectively destroy cancer cells, BNCT is a treatment that differs radically from conventional radiotherapy and promises to become a more widely adopted option for cancer treatment. BNCT is undergoing a major resurgence of interest around the world as some recent progress in accelerator technology allows the procedure to be undertake in clinics. In addition, the approval of BNCT in Japan as a routine clinical treatment for certain tumour types offers valuable insights for other states considering a similar approach. This publication comprehensively reports on the current state of the science as well as the supporting technology. It covers accelerator-based neutron sources, beam design, physical dosimetry, facility design and operation, pharmaceuticals, radiobiology, dose calculation, treatment planning and clinical trials. It has been written to assist in decision making at the national level as well as offering practical guidance for all those involved in implementation and ongoing management of BNCT programmes.
Advances In Neutron Optics
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Author : Maria L. Calvo
language : en
Publisher: CRC Press
Release Date : 2019-12-05
Advances In Neutron Optics written by Maria L. Calvo and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-12-05 with Medical categories.
Neutron optics studies the interactions of a beam of slow neutrons with matter. This book updates various advances on neutron optics. There will be a focus on the very active topics of neutron imaging (NI) and neutron spin optics (NSO). The book will also present applications of neutron beams in biomedicine, such as Boron Neutron Capture Therapy (BNCT) and related techniques. Features: Discusses diffraction and interference of slow neutrons, including computational approaches Reviews neutron imaging (NI) and neutron spin optics (NSO) Treats two major sources of slow neutron beams: (1) fission reactions at nuclear reactors and (2) collisions in particle accelerators (small ones, spallation sources) of charged particle beams with targets of heavy atoms Selects subjects on fundamental quantum aspects of slow neutrons and on confined propagation and waveguiding thereof Updates slow neutron beams and BNCT
Boron Neutron Capture Therapy
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Author : Detlef Gabel
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Boron Neutron Capture Therapy written by Detlef Gabel and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The European Collaboration on Boron Neutron Capture Therapy (BNCT), conceived in 1987 and successful in 1989 in gaining financial support as a Concerted Action through the Medical and Health Research Programme of the Commission ofthe European Communities (CEC) in Brussels, considered it an opportune moment to hold its annual Plenary Meeting on 18-20 Septem ber 1991 as an International Workshop entitled "Towards Clinical Trials of Glioma with BNCT". The background to this consideration was influenced by the world-wide resurgence ofinterest in NCT over the last 2 decades and by the exemplifica tions at the Fourth International Symposium on Neutron Capture Therapy for Cancer held in Sydney in December 1990, where it was strongly indicated that within the next 2 years clinical trials would be started both in Europe and the United States. In particular at the High Flux Reactor of the Joint Research Centre of the CEC at Petten in The Netherlands, an epithermal neutron beam designed and installed in the summer of 1990 recently became operable at full reactor power. An extensive series ofexperiments, including the nuclear and radiobiological characterisation of the beam and a healthy tissue tolerance study on canines has started and has the aim to define the preconditions for clinical trials onpatients with Grade III/IV glioma. However, as with any other new therapy modality, it must be demon strated that BNCT is safe for the patient and has a reasonable chance of being an effective therapy.