Advances In Phage Therapy Present Challenges And Future Perspectives
DOWNLOAD eBooks
Download Advances In Phage Therapy Present Challenges And Future Perspectives PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Advances In Phage Therapy Present Challenges And Future Perspectives book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Advances In Phage Therapy Present Challenges And Future Perspectives
DOWNLOAD eBooks
Author : Andrzej Gorski
language : en
Publisher: Frontiers Media SA
Release Date : 2021-08-02
Advances In Phage Therapy Present Challenges And Future Perspectives written by Andrzej Gorski and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-08-02 with Science categories.
This Research Topic is dedicated to Prof. Elisabeth Kutter on the occasion of her 80th birthday. Dr. Kutter’s career as a phage scientist has extended nearly 60 years. She has been a pioneer as a woman in science. She started to work with phage at the University of Rochester, New York working with Dr. Wiberg on radioisotopes making excellent progress in the field – progress which was even cited in Luria’s 1969 Nobel Prize talk. Betty first encountered phage therapy during a visit to Georgia in 1990 which was part of a longer stay in the former Soviet Union under a US-USSR research exchange program. Dr. Kutter was one of the first Americans to advocate for phage therapy in the post antibiotic era. Betty started hosting the Evergreen International Phage meetings in Olympia, Washington, from 1975 onward, which helped to develop a strong phage community with participation increasing over the years to 350 at the 23 rd biannual last year. Betty continues to be an active member in the phage community, sharing her experience and working with all of us toward her ultimate goal of making phage therapy available worldwide thus reducing the burden caused by antibiotic resistant bacterial infections.
Phage Therapy Past Present And Future
DOWNLOAD eBooks
Author : Stephen T. Abedon
language : en
Publisher: Frontiers Media SA
Release Date : 2017-09-05
Phage Therapy Past Present And Future written by Stephen T. Abedon and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-09-05 with Electronic book categories.
Historically, the first observation of a transmissible lytic agent that is specifically active against a bacterium (Bacillus anthracis) was by a Russian microbiologist Nikolay Gamaleya in 1898. At that time, however, it was too early to make a connection to another discovery made by Dmitri Ivanovsky in 1892 and Martinus Beijerinck in 1898 on a non-bacterial pathogen infecting tobacco plants. Thus the viral world was discovered in two of the three domains of life, and our current understanding is that viruses represent the most abundant biological entities on the planet. The potential of bacteriophages for infection treatment have been recognized after the discoveries by Frederick Twort and Felix d’Hérelle in 1915 and 1917. Subsequent phage therapy developments, however, have been overshadowed by the remarkable success of antibiotics in infection control and treatment, and phage therapy research and development persisted mostly in the former Soviet Union countries, Russia and Georgia, as well as in France and Poland. The dramatic rise of antibiotic resistance and especially of multi-drug resistance among human and animal bacterial pathogens, however, challenged the position of antibiotics as a single most important pillar for infection control and treatment. Thus there is a renewed interest in phage therapy as a possible additive/alternative therapy, especially for the infections that resist routine antibiotic treatment. The basis for the revival of phage therapy is affected by a number of issues that need to be resolved before it can enter the arena, which is traditionally reserved for antibiotics. Probably the most important is the regulatory issue: How should phage therapy be regulated? Similarly to drugs? Then the co-evolving nature of phage-bacterial host relationship will be a major hurdle for the production of consistent phage formulae. Or should we resort to the phage products such as lysins and the corresponding engineered versions in order to have accurate and consistent delivery doses? We still have very limited knowledge about the pharmacodynamics of phage therapy. More data, obtained in animal models, are necessary to evaluate the phage therapy efficiency compared, for example, to antibiotics. Another aspect is the safety of phage therapy. How do phages interact with the immune system and to what costs, or benefits? What are the risks, in the course of phage therapy, of transduction of undesirable properties such as virulence or antibiotic resistance genes? How frequent is the development of bacterial host resistance during phage therapy? Understanding these and many other aspects of phage therapy, basic and applied, is the main subject of this Topic.
Hurdles For Phage Therapy Pt To Become A Reality
DOWNLOAD eBooks
Author : Harald Brüssow
language : en
Publisher: MDPI
Release Date : 2019-08-20
Hurdles For Phage Therapy Pt To Become A Reality written by Harald Brüssow and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-20 with Science categories.
Alternative treatment modes for antibiotic-resistant bacterial pathogens have become a public health priority. Bacteriophages are bacterial viruses that infect and lyse bacterial cells. Since bacteriophages are frequently bacterial host species-specific and can often also infect antibiotic-resistant bacterial cells, they could represent ideal antimicrobials for fighting the antibiotic resistance crisis. The medical use of bacteriophages has become known as phage therapy. It is widely used in Russia, where phage cocktails are sold in pharmacies as an over-the-counter drug. However, no phage product has been registered for medical purposes outside of the former Soviet Union. The current Special Issue of Viruses contains a collection of papers from opinion leaders in the field who explore hurdles to the introduction of phage therapy in western countries. The articles cover diverse topics ranging from patent to regulatory issues, the targeting of suitable bacterial infections, and the selection and characterization of safe and efficient phage cocktails. Phage resistance is discussed, and gaps in our knowledge of phage–bacterium interactions in the mammalian body are revealed, while other articles explore the use of phages in food production and processing.
The Forgotten Cure
DOWNLOAD eBooks
Author : Anna Kuchment
language : en
Publisher: Springer
Release Date : 2014-03-03
The Forgotten Cure written by Anna Kuchment and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-03-03 with Medical categories.
Before the arrival of penicillin in the 1940s, phage therapy was one of the few weapons doctors had against bacterial infections. It saved the life of Hollywood legend Tom Mix before being abandoned by Western science. Now, researchers and physicians are rediscovering the treatment, which pits phage viruses against their natural bacterial hosts, as a potential weapon against antibiotic-resistant infections. The Forgotten Cure traces the story of phages from Paris, where they were discovered in 1917; to Tbilisi, Georgia, where one of phage therapy’s earliest proponents died at the hands of Stalin; to the Nobel podium, where prominent scientists have been recognized for breakthroughs stemming from phage research. Today, a crop of biotech startups and dedicated physicians is racing to win regulatory approval for phage therapy before superbugs exhaust the last drug in the medical arsenal. Will they clear the hurdles in time?
Bacteriophages In Health And Disease
DOWNLOAD eBooks
Author : Paul Hyman
language : it
Publisher: CABI
Release Date : 2012
Bacteriophages In Health And Disease written by Paul Hyman and has been published by CABI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Medical categories.
Bacteriophages are viruses that infect bacteria; as such, they have many potential uses for promoting health and combating disease. This book covers the many facets of phage-bacterial-human interaction in three sections: the role and impact of phages on natural bacterial communities, the potential to develop phage-based therapeutics and other aspects in which phages can be used to combat disease, including bacterial detection, bacterial epidemiology, the tracing of fecal contamination of water and decontamination of foods.
Rising Plague
DOWNLOAD eBooks
Author : Brad Spellberg, M.D.
language : en
Publisher: Prometheus Books
Release Date : 2009-12-04
Rising Plague written by Brad Spellberg, M.D. and has been published by Prometheus Books this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-12-04 with Health & Fitness categories.
Spellberg's book is a powerful and compelling journey into the antibiotic resistance problem . . . [written] in a personal, compelling, and easy-to-understand manner. It's a must read.--Michael Osterholm, M.D., author of "Living Terrors."
The Perfect Predator
DOWNLOAD eBooks
Author : Steffanie Strathdee
language : en
Publisher: Hachette UK
Release Date : 2019-02-26
The Perfect Predator written by Steffanie Strathdee and has been published by Hachette UK this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-02-26 with Science categories.
An electrifying memoir of one woman's extraordinary effort to save her husband's life-and the discovery of a forgotten cure that has the potential to save millions more. "A memoir that reads like a thriller." -New York Times Book Review "A fascinating and terrifying peek into the devastating outcomes of antibiotic misuse-and what happens when standard health care falls short." -Scientific American Epidemiologist Steffanie Strathdee and her husband, psychologist Tom Patterson, were vacationing in Egypt when Tom came down with a stomach bug. What at first seemed like a case of food poisoning quickly turned critical, and by the time Tom had been transferred via emergency medevac to the world-class medical center at UC San Diego, where both he and Steffanie worked, blood work revealed why modern medicine was failing: Tom was fighting one of the most dangerous, antibiotic-resistant bacteria in the world. Frantic, Steffanie combed through research old and new and came across phage therapy: the idea that the right virus, aka "the perfect predator," can kill even the most lethal bacteria. Phage treatment had fallen out of favor almost 100 years ago, after antibiotic use went mainstream. Now, with time running out, Steffanie appealed to phage researchers all over the world for help. She found allies at the FDA, researchers from Texas A&M, and a clandestine Navy biomedical center -- and together they resurrected a forgotten cure. A nail-biting medical mystery, The Perfect Predator is a story of love and survival against all odds, and the (re)discovery of a powerful new weapon in the global superbug crisis.
Phage Therapy A Practical Approach
DOWNLOAD eBooks
Author : Andrzej Górski
language : en
Publisher: Springer Nature
Release Date : 2019-10-25
Phage Therapy A Practical Approach written by Andrzej Górski and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-25 with Medical categories.
This book gives a detailed yet clear insight into the current state of the art of the therapeutic application of bacteriophages in different conditions. The authors bring in their practical expertise within their respective fields of expertise and provide an excellent overview of the potential and actual use of phage therapy. Topics like economic feasibility compared to traditional antibiotics and also regulatory issues are discussed in far detail. This new volume is therefore a valuable resource for individuals engaged in the medical application of novel phage therapies.
Bacteriophages
DOWNLOAD eBooks
Author : David R. Harper
language : en
Publisher: Springer Nature
Release Date : 2021-01-30
Bacteriophages written by David R. Harper and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-01-30 with Medical categories.
This first major reference work dedicated to the mannifold industrial and medical applications of bacteriophages provides both theoretical and practical insights into the emerging field of bacteriophage biotechnology. The book introduces to bacteriophage biology, ecology and history and reviews the latest technologies and tools in bacteriophage detection, strain optimization and nanotechnology. Usage of bacteriophages in food safety, agriculture, and different therapeutic areas is discussed in detail. This book serves as essential guide for researchers in applied microbiology, biotechnology and medicine coming from both academia and industry.
Pharmaceutical Freedom
DOWNLOAD eBooks
Author : Jessica Flanigan
language : en
Publisher: Oxford University Press
Release Date : 2017
Pharmaceutical Freedom written by Jessica Flanigan and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with Law categories.
Jessica Flanigan defends patients' rights of self-medication on the grounds that same moral reasons against medical paternalism in clinical contexts are also reasons against paternalistic pharmaceutical policies, including prohibitive approval processes and prescription requirements.--