Advances In Statistical Methods For The Genetic Dissection Of Complex Traits In Plants
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Advances In Statistical Methods For The Genetic Dissection Of Complex Traits In Plants
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Author : Yuan-Ming Zhang
language : en
Publisher: Frontiers Media SA
Release Date : 2024-01-26
Advances In Statistical Methods For The Genetic Dissection Of Complex Traits In Plants written by Yuan-Ming Zhang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-01-26 with Science categories.
Genome-wide association studies (GWAS) have been widely used in the genetic dissection of complex traits. However, there are still limits in current GWAS statistics. For example, (1) almost all the existing methods do not estimate additive and dominance effects in quantitative trait nucleotide (QTN) detection; (2) the methods for detecting QTN-by-environment interaction (QEI) are not straightforward and do not estimate additive and dominance effects as well as additive-by-environment and dominance-by-environment interaction effects, leading to unreliable results; and (3) no or too simple polygenic background controls have been employed in QTN-by-QTN interaction (QQI) detection. As a result, few studies of QEI and QQI for complex traits have been reported based on multiple-environment experiments. Recently, new statistical tools, including 3VmrMLM, have been developed to address these needs in GWAS. In 3VmrMLM, all the trait-associated effects, including QTN, QEI and QQI related effects, are compressed into a single effect-related vector, while all the polygenic backgrounds are compressed into a single polygenic effect matrix. These compressed parameters can be accurately and efficiently estimated through a unified mixed model analysis. To further validate these new GWAS methods, particularly 3VmrMLM, they should be rigorously tested in real data of various plants and a wide range of other species.
Molecular Dissection Of Complex Traits
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Author : Andrew H. Paterson
language : en
Publisher: CRC Press
Release Date : 2019-09-17
Molecular Dissection Of Complex Traits written by Andrew H. Paterson and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-09-17 with Science categories.
In the past 10 years, contemporary geneticists using new molecular tools have been able to resolve complex traits into individual genetic components and describe each such component in detail. Molecular Dissection of Complex Traits summarizes the state of the art in molecular analysis of complex traits (QTL mapping), placing new developments in thi
Advanced Crop Improvement Volume 2
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Author : Aamir Raina
language : en
Publisher: Springer Nature
Release Date : 2023-09-07
Advanced Crop Improvement Volume 2 written by Aamir Raina and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-07 with Science categories.
As per the reports of FAO, the human population will rise to 9 billion by the end of 2050 and 70% of more food must be produced over the next three decades to feed the additional population. The breeding approaches for crop improvement programs are dependent on the availability and accessibility of genetic variation, either spontaneous or induced by the mutagens. Plant breeders, agronomists, and geneticists are under constant pressure to expand food production by employing innovative breeding strategies to enhance yield, adaptability, nutrition, resistance to biotic and abiotic stresses. In conventional breeding approaches, introgression of genes in crop varieties is laborious and time-consuming. Nowadays, new innovative plant breeding techniques such as molecular breeding and plant biotechnology, supplement the traditional breeding approaches to achieve the desired goals of enhanced food production. With the advent of recent molecular tools like genomics, transgenics, molecular marker-assisted back-crossing, TILLING, Eco-TILLING, gene editing, CRISPR CAS, non-targeted protein abundant comparative proteomics, genome wide association studies have made possible mapping of important QTLs, insertion of transgenes, reduction of linkage drags, and manipulation of genome. In general, conventional and modern plant breeding approaches would be strategically ideal for developing new elite crop varieties to meet the feeding requirement of the increasing world population. This book highlights the latest progress in the field of plant breeding, and their applicability in crop improvement. The basic concept of this 2-volume work is to assess the use of modern breeding strategies in supplementing the conventional breeding toward the development of elite crop varieties, for obtaining desired goals of food production.
The Applications Of New Multi Locus Gwas Methodologies In The Genetic Dissection Of Complex Traits
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Author : Yuan-Ming Zhang
language : en
Publisher: Frontiers Media SA
Release Date : 2019-06-19
The Applications Of New Multi Locus Gwas Methodologies In The Genetic Dissection Of Complex Traits written by Yuan-Ming Zhang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-06-19 with categories.
Genome-Wide Association Studies (GWAS) are widely used in the genetic dissection of complex traits. Most existing methods are based on single-marker association in genome-wide scans with population structure and polygenic background controls. To control the false positive rate, the Bonferroni correction for multiple tests is frequently adopted. This stringent correction results in the exclusion of important loci, especially for GWAS in crop genetics. To address this issue, multi-locus GWAS methodologies have been recommended, i.e., FASTmrEMMA, ISIS EM-BLASSO, mrMLM, FASTmrMLM, pLARmEB, pKWmEB and FarmCPU. In this Research Topic, our purpose is to clarify some important issues in the application of multi-locus GWAS methods. Here we discuss the following subjects: First, we discuss the advantages of new multi-locus GWAS methods over the widely-used single-locus GWAS methods in the genetic dissection of complex traits, metabolites and gene expression levels. Secondly, large experiment error in the field measurement of phenotypic values for complex traits in crop genetics results in relatively large P-values in GWAS, indicating the existence of small number of significantly associated SNPs. To solve this issue, a less stringent P-value critical value is often adopted, i.e., 0.001, 0.0001 and 1/m (m is the number of markers). Although lowering the stringency with which an association is made could identify more hits, confidence in these hits would significantly drop. In this Research Topic we propose a new threshold of significant QTN (LOD=3.0 or P-value=2.0e-4) in multi-locus GWAS to balance high power and low false positive rate. Thirdly, heritability missing in GWAS is a common phenomenon, and a series of scientists have explained the reasons why the heritability is missing. In this Research Topic, we also add one additional reason and propose the joint use of several GWAS methodologies to capture more QTNs. Thus, overall estimated heritability would be increased. Finally, we discuss how to select and use these multi-locus GWAS methods.
Meeting The Challenges Of Global Climate Change And Food Security Through Innovative Maize Research Proceedings Of The National Maize Workshop Of Ethiopia 3 Addis Ababa Ethiopia 18 20 April 2011
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Author :
language : en
Publisher: CIMMYT
Release Date :
Meeting The Challenges Of Global Climate Change And Food Security Through Innovative Maize Research Proceedings Of The National Maize Workshop Of Ethiopia 3 Addis Ababa Ethiopia 18 20 April 2011 written by and has been published by CIMMYT this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.
International Encyclopedia Of Statistical Science
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Author : Miodrag Lovric
language : en
Publisher: Springer Nature
Release Date : 2025-06-19
International Encyclopedia Of Statistical Science written by Miodrag Lovric and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-06-19 with Mathematics categories.
The International Encyclopedia of Statistical Science stands as a monumental effort to enrich statistics education globally, particularly in regions facing educational challenges. By amalgamating the expertise of over 700 authors from 110 countries, including Nobel Laureates and presidents of statistical societies, it offers an unparalleled resource for readers worldwide. This encyclopedia is not just a collection of entries; it is a concerted effort to revive statistics as a vibrant, critical field of study and application. Providing a comprehensive and accessible account of statistical terms, methods, and applications, it enables readers to gain a quick insight into the subject, regardless of their background. This work serves to refresh and expand the knowledge of researchers, managers, and practitioners, highlighting the relevance and applicability of statistics across various fields, from economics and business to healthcare and public policy. Furthermore, it aims to inspire students by demonstrating the significance of statistics in solving real-world problems, thus encouraging a new generation to explore and contribute to the field.
Advances In Breeding Techniques For Cereal Crops
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Author : Prof Frank Ordon
language : en
Publisher: Burleigh Dodds Science Publishing
Release Date : 2019-06-28
Advances In Breeding Techniques For Cereal Crops written by Prof Frank Ordon and has been published by Burleigh Dodds Science Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-06-28 with Technology & Engineering categories.
Assesses performance of conventional techniques such as backcross and hybrid breeding in introducing new traits Maps current progress in methods to identify quantitative trait loci (QTL) linking phenotypic traits with genetic information for selection Shows comparative strengths and weaknesses of marker-assisted selection (MAS) techniques such as genome wide association studies (GWAS) and nested association mapping (NAM)
Molecular Techniques In Crop Improvement
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Author : Shri Mohan Jain
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-11-05
Molecular Techniques In Crop Improvement written by Shri Mohan Jain and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-11-05 with Science categories.
This book provides comprehensive information on the latest tools and techniques of molecular genetics and their applications in crop improvement. It thoroughly discusses advanced techniques used in molecular markers, QTL mapping, marker-assisted breeding, and molecular cytogenetics.
The Third Report On The State Of The World S Plant Genetic Resources For Food And Agriculture
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Author : Food and Agriculture Organization of the United Nations
language : en
Publisher: Food & Agriculture Org.
Release Date : 2025-03-24
The Third Report On The State Of The World S Plant Genetic Resources For Food And Agriculture written by Food and Agriculture Organization of the United Nations and has been published by Food & Agriculture Org. this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-03-24 with Social Science categories.
Plant genetic resources for food and agriculture (PGRFA) are the essence of sustainable agrifood systems. They encompass the genetic diversity in both improved and farmers’ varieties, as well as in crop wild relatives, wild food plants and breeding materials.The third report on the State of the World’s Plant Genetic Resources for Food and Agriculture presents a comprehensive assessment of the conservation and sustainable use of PGRFA, as well as the human and institutional capacities to support these efforts. Based on information from 128 countries and four regional and 13 international research centres and the contribution from over 1 600 experts, it presents an overview of progress since 2012, as well as current needs and challenges in the future management of PGRFA. The report provides a sound basis for recalibrating relevant polices and strategies, including the rolling Global Plan of Action for Plant Genetic Resources for Food and Agriculture.
Biological Shape Analysis Proceedings Of The 3rd International Symposium
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Author : Pete E Lestrel
language : en
Publisher: World Scientific
Release Date : 2015-06-11
Biological Shape Analysis Proceedings Of The 3rd International Symposium written by Pete E Lestrel and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-06-11 with Science categories.
The proceedings were designed to bring together researchers who share a common interest in the quantitative description of the biological form. Participants came from very diverse disciplines such as agricultural genetics, botany, entomology, forensics, human anatomy, paleontology, human evolution, primatology, dentistry, etc. The participants applied various methodological approaches that are being increasingly used to describe aspects of the biological form. These techniques include neural networks, Fourier descriptors, shape mapping, genome-wide association studies (GWAS), Riemann curves, surface mapping, etc. A number of the contributions in the proceedings represent state of the art research that reflects advances in that discipline.