Advancing Alternatives


Advancing Alternatives
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The History Of Alternative Test Methods In Toxicology


The History Of Alternative Test Methods In Toxicology
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Author :
language : en
Publisher: Academic Press
Release Date : 2018-10-20

The History Of Alternative Test Methods In Toxicology written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-10-20 with Medical categories.


The History of Alternative Test Methods in Toxicology uses a chronological approach to demonstrate how the use of alternative methods has evolved from their conception as adjuncts to traditional animal toxicity tests to replacements for them. This volume in the History of Toxicology and Environmental Health series explores the history of alternative test development, validation, and use, with an emphasis on humanity and good science, in line with the Three Rs (Replacement,Reduction, Refinement) concept expounded by William Russell and Rex Burch in 1959 in their now classic volume, The Principles of Humane Experimental Technique. The book describes the historical development of technologies that have influenced the application of alternatives in toxicology and safety testing. These range from single cell monocultures to sophisticated, miniaturised and microfluidic organism-on-a-chip devices, and also include molecular modelling, chemoinformatics and QSAR analysis, and the use of stem cells, tissue engineering and hollow fibre bioreactors. This has been facilitated by the wider availability of human tissues, advances in tissue culture, analytical and diagnostic methods, increases in computational processing, capabilities, and a greater understanding of cell biology and molecular mechanisms of toxicity. These technological developments have enhanced the range and information content of the toxicity endpoints detected, and therefore the relevance of test systems and data interpretation, while new techniques for non-invasive diagnostic imaging and high resolution detection methods have permitted an increased role for human studies. Several key examples of how these technologies are being harnessed to meet 21st century safety assessment challenges are provided, including their deployment in integrated testing schemes in conjunction with kinetic modelling, and in specialized areas, such as inhalation toxicity studies. The History of Alternative Test Methods in Toxicology uses a chronological approach to demonstrate how the use of alternative methods has evolved from their conception as adjuncts to traditional animal toxicity tests to replacements for them. This volume in the History of Toxicology and Environmental Health series explores the history of alternative test development, validation, and use, with an emphasis on humanity and good science, in line with the Three Rs (Replacement, Reduction, Refinement) concept expounded by William Russell and Rex Burch in 1959 in their now-classic volume, The Principles of Humane Experimental Technique. The book describes the historical development of technologies that have influenced the application of alternatives in toxicology and safety testing. These range from single cell monocultures to sophisticated miniaturised and microfluidic organism-on-a-chip devices, and also include molecular modelling, chemoinformatics and QSAR analysis, and the use of stem cells, tissue engineering and hollow fibre bioreactors. This has been facilitated by the wider availability of human tissues, advances in tissue culture, analytical and diagnostic methods, increases in computational processing capabilities, and a greater understanding of cell biology and molecular mechanisms of toxicity. These technological developments have enhanced the range and information content of the toxicity endpoints detected, and therefore the relevance of test systems and data interpretation, while new techniques for non-invasive diagnostic imaging and high resolution detection methods have permitted an increased role for human studies. Several key examples of how these technologies are being harnessed to meet 21st century safety assessment challenges are provided, including their deployment in integrated testing schemes in conjunction with kinetic modelling, and in specialised areas, such as inhalation toxicity studies.



Advancing Alternatives


Advancing Alternatives
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Author : Elisa Lynch
language : en
Publisher:
Release Date : 2000

Advancing Alternatives written by Elisa Lynch and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with Urban pests categories.




Spaulding Turnpike Improvements Nhs 027 1 37 11238 Newington To Dover Strafford And Rockingham Counties


Spaulding Turnpike Improvements Nhs 027 1 37 11238 Newington To Dover Strafford And Rockingham Counties
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Author :
language : en
Publisher:
Release Date : 2007

Spaulding Turnpike Improvements Nhs 027 1 37 11238 Newington To Dover Strafford And Rockingham Counties written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with categories.




Perspectives On Social And Material Fractures In Care


Perspectives On Social And Material Fractures In Care
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Author : Greer, Colleen R.
language : en
Publisher: IGI Global
Release Date : 2024-02-12

Perspectives On Social And Material Fractures In Care written by Greer, Colleen R. and has been published by IGI Global this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-02-12 with Medical categories.


The COVID-19 pandemic functioned as a stark illuminator, exposing the deep-seated cracks in social and material support for those in caregiving roles. Despite the resilience of care workers and essential personnel, the lack of robust connections and infrastructure became apparent, impacting these individuals but resonating across the broader public. The pandemic laid bare the lengths people must go to care for others and the urgent need for interconnectedness and support within caregiving realms. Perspectives on Social and Material Fractures in Care offers a multi-disciplinary exploration of care, drawing on existing theoretical frameworks, empirical research, and personal stories. By navigating the complexities of care at various levels, the book aims to provide a profound understanding of the current state of affairs. Moreover, it does not stop at diagnosis; it seeks to propel the conversation forward by delving into ethical, intersectional, and life-sustaining approaches to enhance the very fabric of caregiving. As we confront the pressing issues surrounding who receives care, who is expected to care, and the seemingly off-limits aspects of societal concern, the book becomes a vital resource for academics, higher education professionals, and students eager to grasp the intricate dynamics of care in the contemporary United States.



Alternatives To Privatization


Alternatives To Privatization
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Author : David A. McDonald
language : en
Publisher: Routledge
Release Date : 2012-04-23

Alternatives To Privatization written by David A. McDonald and has been published by Routledge this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-04-23 with Political Science categories.


There is a vast literature for and against privatizing public services. Those who are against privatization are often confronted with the objection that they present no alternative. This book takes up that challenge by establishing theoretical models for what does (and does not) constitute an alternative to privatization, and what might make them ‘successful’, backed up by a comprehensive set of empirical data on public services initiatives in over 40 countries. This is the first such global survey of its kind, providing a rigorous and robust platform for evaluating different alternatives and allowing for comparisons across regions and sectors. The book helps to conceptualize and evaluate what has become an important and widespread movement for better public services in the global South. The contributors explore historical, existing and proposed non-commercialized alternatives for primary health, water/sanitation and electricity. The objectives of the research have been to develop conceptual and methodological frameworks for identifying and analyzing alternatives to privatization, and testing these models against actually existing alternatives on the ground in Asia, Africa and Latin America. Information of this type is urgently required for practitioners and analysts, both of whom are seeking reliable knowledge on what kind of public models work, how transferable they are from one place to another and what their main strengths and weaknesses are.



Spencer Creek Bridge Us Highway 101 Lincoln County


Spencer Creek Bridge Us Highway 101 Lincoln County
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Author :
language : en
Publisher:
Release Date : 2006

Spencer Creek Bridge Us Highway 101 Lincoln County written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with categories.




The Climate Crisis


The Climate Crisis
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Author : Vishwas Satgar
language : en
Publisher: NYU Press
Release Date : 2018-02-01

The Climate Crisis written by Vishwas Satgar and has been published by NYU Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-02-01 with Political Science categories.


Essays that address the question: how can people and class agency change this destructive course of history? Capitalism’s addiction to fossil fuels is heating our planet at a pace and scale never before experienced. Extreme weather patterns, rising sea levels and accelerating feedback loops are a commonplace feature of our lives. The number of environmental refugees is increasing and several island states and low-lying countries are becoming vulnerable. Corporate-induced climate change has set us on an ecocidal path of species extinction. Governments and their international platforms such as the Paris Climate Agreement deliver too little, too late. Most states, including South Africa, continue on their carbon-intensive energy paths, with devastating results. Political leaders across the world are failing to provide systemic solutions to the climate crisis. This is the context in which we must ask ourselves: how can people and class agency change this destructive course of history? Volume three in the Democratic Marxism series, The Climate Crisis investigates eco-socialist alternatives that are emerging. It presents the thinking of leading climate justice activists, campaigners and social movements advancing systemic alternatives and developing bottom-up, just transitions to sustain life. Through a combination of theoretical and empirical work, the authors collectively examine the challenges and opportunities inherent in the current moment. This volume builds on the class-struggle focus of Volume 2 by placing ecological issues at the centre of democratic Marxism. Most importantly, it explores ways to renew historical socialism with democratic, eco-socialist alternatives to meet current challenges in South Africa and the world.



Miller Creek Road Missoula County


Miller Creek Road Missoula County
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Author :
language : en
Publisher:
Release Date : 2008

Miller Creek Road Missoula County written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with categories.




Rare Genetic Disorders


Rare Genetic Disorders
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Author : Muhammad Umair
language : en
Publisher: Springer Nature
Release Date :

Rare Genetic Disorders written by Muhammad Umair and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.




Nationalism On The Internet


Nationalism On The Internet
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Author : Christian Fuchs
language : en
Publisher: Routledge
Release Date : 2019-09-17

Nationalism On The Internet written by Christian Fuchs and has been published by Routledge this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-09-17 with Social Science categories.


In this timely book, critical theorist Christian Fuchs asks: What is nationalism and what is the role of social media in the communication of nationalist ideology? Advancing an applied Marxist theory of nationalism, Fuchs explores nationalist discourse in the world of contemporary digital capitalism that is shaped by social media, big data, fake news, targeted advertising, bots, algorithmic politics, and a high-speed online attention economy. Through two case studies of the German and Austrian 2017 federal elections, the book goes on to develop a critical theory of nationalism that is grounded in the works of Karl Marx, Rosa Luxemburg, and Eric J. Hobsbawm. Advanced students and scholars of Marxism, nationalism, media, and politics won't want to miss Fuchs' latest in-depth study of social media and politics that uncovers the causes, structures, and consequences of nationalism in the age of social media and fake news.