Advancing Development Of Synthetic Gene Regulators
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Advancing Development Of Synthetic Gene Regulators
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Author : Anandhakumar Chandran
language : en
Publisher: Springer
Release Date : 2017-09-19
Advancing Development Of Synthetic Gene Regulators written by Anandhakumar Chandran and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-09-19 with Science categories.
This book focuses on an “outside the box” notion by utilizing the powerful applications of next-generation sequencing (NGS) technologies in the interface of chemistry and biology. In personalized medicine, developing small molecules targeting a specific genomic sequence is an attractive goal. N-methylpyrrole (P)–N-methylimidazole (I) polyamides (PIPs) are a class of small molecule that can bind to the DNA minor groove. First, a cost-effective NGS (ion torrent platform)-based Bind-n-Seq was developed to identify the binding specificity of PIP conjugates in a randomized DNA library. Their biological influences rely primarily on selective DNA binding affinity, so it is important to analyze their genome-wide binding preferences. However, it is demanding to enrich specifically the small-molecule-bound DNA without chemical cross-linking or covalent binding in chromatinized genomes. Herein is described a method that was developed using high-throughput sequencing to map the differential binding sites and relative enriched regions of non-cross-linked SAHA-PIPs throughout the complex human genome. SAHA-PIPs binding motifs were identified and the genome-level mapping of SAHA-PIPs-enriched regions provided evidence for the differential activation of the gene network. A method using high-throughput sequencing to map the binding sites and relative enriched regions of alkylating PIP throughout the human genome was also developed. The genome-level mapping of alkylating the PIP-enriched region and the binding sites on the human genome identifies significant genomic targets of breast cancer. It is anticipated that this pioneering low-cost, high through-put investigation at the sequence-specific level will be helpful in understanding the binding specificity of various DNA-binding small molecules, which in turn will be beneficial for the development of small-molecule-based drugs targeting a genome-level sequence.
Synthetic Biology Genetics And Advanced Topics
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Author : Edenilson Brandl
language : en
Publisher: Edenilson Brandl
Release Date :
Synthetic Biology Genetics And Advanced Topics written by Edenilson Brandl and has been published by Edenilson Brandl this book supported file pdf, txt, epub, kindle and other format this book has been release on with Health & Fitness categories.
Synthetic Biology is a scientific discipline that has the potential to revolutionize the way we understand and manipulate life. Combining knowledge from biology, genetics, engineering and computing, Synthetic Biology opens up new possibilities for creating personalized biological systems, with applications ranging from regenerative medicine to the production of biofuels. In this book, we will explore the principles, techniques, and applications of synthetic biology, with the aim of providing a comprehensive and up-to-date overview of this ever-evolving field. Throughout the chapters, we will delve into the molecular foundations of Synthetic Biology, exploring the biological components and processes involved in building synthetic biological systems. We will present several applications of Synthetic Biology in different sectors, highlighting its role in the pharmaceutical industry, in the production of biofuels, in the development of personalized vaccines and in regenerative medicine. We will see how the manipulation of synthetic stem cells can revolutionize the area of tissue regeneration and how metabolic engineering allows us to design microorganisms capable of producing valuable compounds. Bioinformatics plays a crucial role in Synthetic Biology, and we will dedicate a chapter to exploring how the analysis of genomic data and the use of bioinformatics algorithms contribute to the advancement of this discipline. In addition, we will cover topics such as genome editing using CRISPR technology, synthetic protein engineering, and directed evolution in the laboratory. With the advancement of technology, it has become possible to manufacture living tissue in the laboratory, and we will discuss biofabrication and 3D printing of living tissue, as well as the use of microfluidics in the manipulation and analysis of synthetic biological systems on a microscopic scale. We will also address ethical and biosafety issues related to Synthetic Biology, recognizing the importance of a responsible approach in all its applications. This book is intended for students, researchers, and practitioners interested in exploring the frontiers of synthetic biology. We hope it will be an inspiring source of knowledge, awakening the curiosity and innovative spirit of all readers. We invite you to embark on this exciting journey through Synthetic Biology, in search of a deeper understanding of life and its transformative possibilities.
Advancing Regulatory Science For Medical Countermeasure Development
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Author : Institute of Medicine
language : en
Publisher: National Academies Press
Release Date : 2011-08-27
Advancing Regulatory Science For Medical Countermeasure Development written by Institute of Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-08-27 with Medical categories.
Whether or not the United States has safe and effective medical countermeasures-such as vaccines, drugs, and diagnostic tools-available for use during a disaster can mean the difference between life and death for many Americans. The Food and Drug Administration (FDA) and the scientific community at large could benefit from improved scientific tools and analytic techniques to undertake the complex scientific evaluation and decision making needed to make essential medical countermeasures available. At the request of FDA, the Institute of Medicine (IOM) held a workshop to examine methods to improve the development, evaluation, approval, and regulation of medical countermeasures. During public health emergencies such as influenza or chemical, biological, radiological/nuclear (CBRN) attacks, safe and effective vaccines, treatments, and other medical countermeasures are essential to protecting national security and the well being of the public. Advancing Regulatory Science for Medical Countermeasure Development examines current medical countermeasures, and investigates the future of research and development in this area. Convened on March 29-30, 2011, this workshop identified regulatory science tools and methods that are available or under development, as well as major gaps in currently available regulatory science tools. Advancing Regulatory Science for Medical Countermeasure Development is a valuable resource for federal agencies including the Food and Drug Administration (FDA), the Department of Health and Human Services (HHS), the Department of Defense (DoD), as well as health professionals, and public and private health organizations.
The Science And Applications Of Synthetic And Systems Biology
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Author : Institute of Medicine
language : en
Publisher: National Academies Press
Release Date : 2011-12-30
The Science And Applications Of Synthetic And Systems Biology written by Institute of Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-12-30 with Science categories.
Many potential applications of synthetic and systems biology are relevant to the challenges associated with the detection, surveillance, and responses to emerging and re-emerging infectious diseases. On March 14 and 15, 2011, the Institute of Medicine's (IOM's) Forum on Microbial Threats convened a public workshop in Washington, DC, to explore the current state of the science of synthetic biology, including its dependency on systems biology; discussed the different approaches that scientists are taking to engineer, or reengineer, biological systems; and discussed how the tools and approaches of synthetic and systems biology were being applied to mitigate the risks associated with emerging infectious diseases. The Science and Applications of Synthetic and Systems Biology is organized into sections as a topic-by-topic distillation of the presentations and discussions that took place at the workshop. Its purpose is to present information from relevant experience, to delineate a range of pivotal issues and their respective challenges, and to offer differing perspectives on the topic as discussed and described by the workshop participants. This report also includes a collection of individually authored papers and commentary.
Advances In Synthetic Biology
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Author : Vijai Singh
language : en
Publisher: Springer
Release Date : 2021-08-26
Advances In Synthetic Biology written by Vijai Singh and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-08-26 with Science categories.
This book addresses the design of emerging conceptual tools, technologies and systems including novel synthetic parts, devices, circuits, oscillators, biological gates, and small regulatory RNAs (riboregulators and riboswitches), which serve as versatile control elements for regulating gene expression. Synthetic biology, a rapidly growing field that involves the application of engineering principles in biology, is now being used to develop novel systems for a wide range of applications including diagnostics, cell reprogramming, therapeutics, enzymes, vaccines, biomaterials, biofuels, fine chemicals and many more. The book subsequently summarizes recent developments in technologies for assembling synthetic genomes, minimal genomes, synthetic biology toolboxes, CRISPR-Cas systems, cell-free protein synthesis systems and microfluidics. Accordingly, it offers a valuable resource not only for beginners in synthetic biology, but also for researchers, students, scientists, clinicians, stakeholders and policymakers interested in the potential held by synthetic biology.
A Complete Guide To Gene Cloning From Basic To Advanced
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Author : Nayana Patil
language : en
Publisher: Springer Nature
Release Date : 2022-04-26
A Complete Guide To Gene Cloning From Basic To Advanced written by Nayana Patil and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-04-26 with Science categories.
This comprehensive guide to gene cloning provides beginning and advanced readers with the background, standard techniques, practical applications, and ethical and safety considerations in the field. A one-stop reference for students, researchers in academia and industry, and anyone interested in a thorough but accessible overview.
Non Genetic Heterogeneity In Development And Disease
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Author : Mohit Kumar Jolly
language : en
Publisher: Frontiers Media SA
Release Date : 2021-11-01
Non Genetic Heterogeneity In Development And Disease written by Mohit Kumar Jolly and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-01 with Science categories.
Advanced Fermentation And Cell Technology
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Author : Byong H. Lee
language : en
Publisher: John Wiley & Sons
Release Date : 2021-10-25
Advanced Fermentation And Cell Technology written by Byong H. Lee and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-10-25 with Technology & Engineering categories.
ADVANCED FERMENTATION AND CELL TECHNOLOGY A comprehensive and up-to-date reference covering both conventional and novel industrial fermentation technologies and their applications Fermentation and cell culture technologies encompass more than the conventional microbial and enzyme systems used in the agri-food, biochemical, bioenergy and pharmaceutical industries. New technologies such as genetic engineering, systems biology, protein engineering, and mammalian cell and plant cell systems are expanding rapidly, as is the demand for sustainable production of bioingredients, drugs, bioenergy and biomaterials. As the growing biobased economy drives innovation, industrial practitioners, instructors, researchers, and students must keep pace with the development and application of novel fermentation processes and a variety of cell technologies. Advanced Fermentation and Cell Technology provides a balanced and comprehensive overview of the microbial, mammalian, and plant cell technologies used by the modern biochemical process industry to develop new and improved processes and products. This authoritative volume covers the essential features of advanced fermentation and cell technology, and highlights the interaction of food fermentation and cell culture biopharmaceutical actives. Detailed chapters, organized into five sections, cover microbial cell technology, animal and plant cell technology, safety issues of new biotechnologies, and applications of microbial fermentation to food products, chemicals, and pharmaceuticals. Written by an internationally-recognized expert in food biotechnology, this comprehensive volume: Covers both conventional and novel industrial fermentation technologies and their applications in a range of industries Discusses current progress in novel fermentation, cell culture, commercial recombinant bioproducts technologies Includes overviews of the global market size of bioproducts and the fundamentals of cell technology Highlights the importance of sustainability, Good Manufacturing Practices (GMP), quality assurance, and regulatory practices Explores microbial cell technology and culture tools and techniques such as genome shuffling and recombinant DNA technology, RNA interference and CRISPR technology, molecular thermodynamics, protein engineering, proteomics and bioinformatics, and synthetic biology Advanced Fermentation and Cell Technology is an ideal resource for students of food science, biotechnology, microbiology, agricultural sciences, biochemical engineering, and biochemistry, and is a valuable reference for food scientists, researchers, and technologists throughout the food industry, particularly the dairy, bakery, and fermented beverage sectors.
Advancement Of Melatonin Research In Plants
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Author : Aryadeep Roychoudhury
language : en
Publisher: CRC Press
Release Date : 2023-12-22
Advancement Of Melatonin Research In Plants written by Aryadeep Roychoudhury and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-12-22 with Medical categories.
Melatonin (N-acetyl-5-methoxytryptamine) is a widely studied biomolecule, and its function has been investigated in bacteria, mammals, birds, amphibians, reptiles, fish and plants. Melatonin research in plants the last five years has attained an exponential growth phase and the number of publications related to phytomelatonin has significantly increased in present times. All this research is directed towards establishing multifarious roles of melatonin in plants, including the promotion of seed germination and seedling growth, influencing plant development and senescence, alteration of flowering and fruiting time and grain yield, modulating circadian rhythms, improving resistance against biotic stress as well as tolerance to abiotic stress, reducing oxidative stress, and stimulating plant immune response. However, to date, an exhaustive book, solely and exclusively dedicated to melatonin research on various aspects of plant biology, has not been published by any renowned publisher or is available in the market. Keeping all these facts in mind, this book aims to compile the most recent developments in the arena of melatonin-mediated regulation of plant physiology under optimal and sub-optimal conditions. This book will initiate and introduce the readers to the state-of-the-art developments and trends in this field of study and will largely cater to the scientific need of scientists engaged in melatonin research across the globe. The book will be unique of its kind and will draw the attention of scientific and research communities engaged in the field of melatonin research. The key features of this book: Authors will address the topics which would provide advances in the understanding of diverse functions of melatonin in plants, encompassing almost all the aspects that have been investigated so far Integrate the overall mechanistic function of melatonin, genomics and proteomics tools, and genetic engineering to manipulate endogenous melatonin levels, thus giving a holistic view of plant-level studies under normal or challenging situations Largely help the readers to design future research programs in exploiting melatonin as a protective agent to develop climate-resilient and pathogen-resistant plants Benefit the crop protection program and ensure food security Chapters will be supplemented with ample illustrations and figures This book will be beneficial to research scholars and Ph.D. students involved in melatonin research and working on stress physiology, stress proteins, genomics, proteomics and genetic engineering in different universities and research institutes all over the world. The book can also be used as an advanced reference book for the coursework of research and master’s level students. It will be of use to people involved in improving plant growth and yield, as well as the performance of plant species in the face of climate change and pathogen infection, using melatonin as the prime protective agent and signaling molecule. Although the book will directly benefit the academic and scientific community, it will also indirectly draw the attention of industries or companies that manufacture or sell chemical products, since the book will highlight in detail the antioxidative potential of melatonin. This will create impetus at the industrial level for the isolation and synthesis of melatonin as a beneficial chemical agent. Applying melatonin as an ameliorating agent against different stresses at the field level will also increase the demand for this chemical among the farmers and will promote large-scale sales and utilization of melatonin for ensuring crop protection and increasing yield.
Advanced Textbook On Gene Transfer Gene Therapy And Genetic Pharmacology Principles Delivery And Pharmacological And Biomedical Applications Of Nucleotide Based Therapies Second Edition
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Author : Daniel Scherman
language : en
Publisher: World Scientific
Release Date : 2019-07-16
Advanced Textbook On Gene Transfer Gene Therapy And Genetic Pharmacology Principles Delivery And Pharmacological And Biomedical Applications Of Nucleotide Based Therapies Second Edition written by Daniel Scherman and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-07-16 with Science categories.
This unique advanced textbook provides a clear and comprehensive overview of gene delivery, gene therapy and genetic pharmacology, with descriptions of the main gene transfer vectors and a set of selected therapeutic applications, along with safety considerations. The second edition features new groundbreaking material on genome editing using the recently discovered CRISPR/Cas9 system and on cancer immunotherapy by CAR-T cells. It also presents the historical milestone of gene therapy application in the field of severe combined immunodeficiency, and other fields of gene therapy and molecular medicine.The use of gene transfer is exponentially growing in the scientific and medical communities for day-to-day cell biology experiments and swift development of gene therapy, which is already revolutionizing medicine. In this advanced textbook, more than 30 leading scientists come together to explore these topics.This educational introduction provides the background material needed to further explore the subject as well as relevant research literature. It is an invaluable resource to Master, PhD or MD students, post-doctoral scientists or medical doctors, as well as any scientist wishing to deliver a gene or synthetic nucleotide or develop a gene therapy strategy. The second edition's simple and synthetic content will be of value to any reader interested in the biological and medical revolution derived from the elucidation of the human genome.