Airway Wall Remodelling In Asthma
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Airway Wall Remodelling In Asthma
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Author : A. G. Stewart
language : en
Publisher: CRC Press
Release Date : 2020-10-28
Airway Wall Remodelling In Asthma written by A. G. Stewart and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-10-28 with Medical categories.
Asthma is a disease of high prevalence that has shown a trend toward increasing incidence, morbidity, and mortality over the last three decades despite apparently effective drug treatments and increasing awareness of the need for better disease management. Often the inflammatory component of asthma is studied; however, the tissue remodelling process is a significant process that should not be overlooked. This valuable reference synthesizes current data and concepts developed to determine the relationship between airway wall remodelling and the pathogenesis of asthma. It discusses evidence for structural changes in asthmatic airway, the relationship between airway thickening and hyperresponsiveness, the relationship between cytokine production and tissue remodelling and inflammation, the significance of epithelial changes and the extracellular matrix, and in vivo and in vitro experimental approaches to the assessment of remodelling. Pharmacological and biochemical mechanisms that control cell proliferation are also examined. The consequences of airway wall remodelling for airway hyperresponsiveness is the unique focus of this volume, offering a fresh perspective of advances in asthma research.
Airway Wall Remodelling In Asthma
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Author : A. G. Stewart
language : en
Publisher: CRC-Press
Release Date : 1996-09-24
Airway Wall Remodelling In Asthma written by A. G. Stewart and has been published by CRC-Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-09-24 with Medical categories.
Asthma is a disease of high prevalence that has shown a trend toward increasing incidence, morbidity, and mortality over the last three decades despite apparently effective drug treatments and increasing awareness of the need for better disease management. Often the inflammatory component of asthma is studied; however, the tissue remodelling process is a significant process that should not be overlooked. This valuable reference synthesizes current data and concepts developed to determine the relationship between airway wall remodelling and the pathogenesis of asthma. It discusses evidence for structural changes in asthmatic airway, the relationship between airway thickening and hyperresponsiveness, the relationship between cytokine production and tissue remodelling and inflammation, the significance of epithelial changes and the extracellular matrix, and in vivo and in vitro experimental approaches to the assessment of remodelling. Pharmacological and biochemical mechanisms that control cell proliferation are also examined. The consequences of airway wall remodelling for airway hyperresponsiveness is the unique focus of this volume, offering a fresh perspective of advances in asthma research.
Airway Remodeling
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Author : Peter Howarth
language : en
Publisher: CRC Press
Release Date : 2001
Airway Remodeling written by Peter Howarth and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with MEDICAL categories.
This landmark volume discusses the characteristics and impact of the remodeling process on airway function and clinical disease expression within the airway in asthma, covering pharmacological therapies and possible future targets relevant to regulating the remodeling process. Emphasizes the importance of treating underlying airway inflammation and the relevance of structural alterations to the airway wall, including glandular increases, enhanced collagen deposition within the submucosa, increased vasculature, smooth hypertrophy, and hyperplasias! Tracing the development and maintenance of bronchial hyperresponsiveness, decline in lung function, and loss of reversibility evident in chronic asthma, Airway Remodelingdescribes the contribution of inflammatory cells in the development of airway structural changes examines how pharmaceutical agents act and whether existing treatments modify or prevent remodeling in chronically inflamed asthmatic airways considers whether neural pathways initiate as well as contribute to the airway inflammatory cascade that leads to remodeling reviews the action of cytokines and growth factors on ASM signaling outlines novel approaches to regulating smooth muscle growth clarifies whether permanent ventilatory incapacity in asthma is caused by the uncoupling of the airway and the role of the lung parenchyma details high-resolution computerized tomography scan to measure the internal size of the airway at baseline, during challenge, or after bronchodilatation and more!Improving lung function and quality of life by reducing the need for emergency care, hospital admissions, and systemic steroid administration, Airway Remodeling is a superb reference for pulmonologists and respiratory system specialists; physiologists; pneumologists; allergists; pharmacologists; molecular, cellular, and lung biologists; and graduate and medical school students in these disciplines.
Bronchial Vascular Remodeling In Asthma And Copd
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Author : Aili Lazaar
language : en
Publisher: CRC Press
Release Date : 2006-08-04
Bronchial Vascular Remodeling In Asthma And Copd written by Aili Lazaar and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-08-04 with Medical categories.
Responding to the growth of research in the field over the past decade, this book brings together leading investigators with expertise in pulmonology, pathology, and developmental biology to clarify the mechanisms that regulate the development of bronchial vascular remodeling in asthma and COPD, as well as explore the pathophysiological processes t
Airway Smooth Muscle In Asthma And Copd
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Author : Kian Fan Chung
language : en
Publisher: John Wiley & Sons
Release Date : 2008-04-30
Airway Smooth Muscle In Asthma And Copd written by Kian Fan Chung and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-04-30 with Science categories.
In this book, leading researchers in medicine and molecular pharmacology explain the cellular mechanisms that control airway smooth muscle. The means by which these are disrupted in disease, and the pharmacologic strategies by which they may be modified are discussed and future therapeutic interventions are identified. Aimed at specialists in pulmonology, this volume provides the clinician with the most up to date information on one of the core physiological processes in airway disease, and offers insights into current and future approaches to management. Authoritative update on key mechanisms of airway constriction in Asthma and COPD Relates latest research to bronchodilator therapy Multi-contributed text, co-coordinated by two of the leading authorities in the field.
Asthma And Copd
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Author : Peter J. Barnes
language : en
Publisher: Elsevier
Release Date : 2009-03-19
Asthma And Copd written by Peter J. Barnes and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-03-19 with Medical categories.
The Second Edition of Asthma and COPD: Basic Mechanisms and Clinical Management continues to provide a unique and authoritative comparison of asthma and COPD. Written and edited by the world's leading experts, it continues to be a comprehensive review of the most recent understanding of the basic mechanisms of both conditions, specifically comparing their etiology, pathogenesis, and treatments. * Each chapter considers Asthma and COPD in side-by-side contrast and comparison – not in isolation - in the context of mechanism, triggers, assessments, therapies, and clinical management * Presents the latest and most comprehensive understandings of the mechanisms of inflammation in both Asthma and COPD * Most extensive reference to primary literature on both Asthma and COPD in one source. * Easy-to-read summaries of the latest advances alongside clear illustrations
Asthma Targeted Biological Therapies
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Author : Girolamo Pelaia
language : en
Publisher: Springer
Release Date : 2018-06-28
Asthma Targeted Biological Therapies written by Girolamo Pelaia and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-06-28 with Medical categories.
This book focuses on the fundamentals of the use of biologics in asthma, describing the rationale, principles, mechanisms of action, and indications. It offers an excellent balance between basic science and the analysis of clinical trials, updating readers with new developments that are changing the global scenario for targeted biological anti-asthma therapies, especially with regard to more severe disease. A range of therapies are considered, from the humanized monoclonal anti-IgE antibody omalizumab, widely approved as add-on treatment for inadequately controlled disease, through to emerging biologics for which evidence supportive of efficacy is accumulating, including anti-IL-5, anti-IL-4, and anti-IL-13 therapies. One aspect to emerge is the variability in individual response, which suggests a need for characterization of different asthma subtypes to permit the effective implementation of phenotype-targeted treatments. This book will be of interest for pulmonologists, clinical immunologists, and physicians seeking sound information on these therapies, but also for scientists and pharmacologists wishing to enhance their knowledge of the therapeutic implications of the cellular and molecular mechanisms that underlie severe, uncontrolled asthma.
Airways And Vascular Remodelling In Asthma And Cardiovascular Disease
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Author : Clive Page
language : en
Publisher: Academic Press
Release Date : 1994-11-10
Airways And Vascular Remodelling In Asthma And Cardiovascular Disease written by Clive Page and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994-11-10 with Medical categories.
Vascular diseases and asthma are two common diseases associated with considerable morbidity and mortality. Both are chronic, each has an inflammatory component, both are accompanied by remodelling of hollow tubes and both are amenable to early intervention. This book compares and contrasts research progress made in each area, including our current understanding of the pathophysiology involved and the results of large-scale multicentre trials.
Airways Smooth Muscle
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Author : David Raeburn
language : en
Publisher: Springer Science & Business Media
Release Date : 1996-05
Airways Smooth Muscle written by David Raeburn and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-05 with Medical categories.
For researchers using animals to investigate human asthma, explains physiological and pharmacological process in the lung , and reviews the animal models available for studying the bronchospasm and inflammation associated with human asthma. Also discusses such methodological aspects as administering drugs to animal airways and the mechanics of assessing lung function. Also considers the use of genetically altered animals as research models. The sixth volume in the sub- series. Annotation c. by Book News, Inc., Portland, Or.
Severe Asthma
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Author : Kian Fan Chung
language : en
Publisher: European Respiratory Society
Release Date : 2019-06-01
Severe Asthma written by Kian Fan Chung and has been published by European Respiratory Society this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-06-01 with Medical categories.
Severe asthma is a form of asthma that responds poorly to currently available medication, and its patients represent those with greatest unmet needs. In the last 10 years, substantial progress has been made in terms of understanding some of the mechanisms that drive severe asthma; there have also been concomitant advances in the recognition of specific molecular phenotypes. This ERS Monograph covers all aspects of severe asthma – epidemiology, diagnosis, mechanisms, treatment and management – but has a particular focus on recent understanding of mechanistic heterogeneity based on an analytic approach using various ‘omics platforms applied to clinically well-defined asthma cohorts. How these advances have led to improved management targets is also emphasised. This book brings together the clinical and scientific expertise of those from around the world who are collaborating to solve the problem of severe asthma.