Alcoholic And Non Alcoholic Fatty Liver Disease
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Alcoholic And Non Alcoholic Fatty Liver Disease
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Author : Naga Chalasani
language : en
Publisher: Springer
Release Date : 2015-12-10
Alcoholic And Non Alcoholic Fatty Liver Disease written by Naga Chalasani and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-12-10 with Medical categories.
This volume is the first text to concisely yet comprehensively cover developments for both alcoholic and nonalcoholic fatty liver disease in an organized fashion. Aspects of these two diseases covered in the book include global epidemiology and risk factors, pathogenesis, animal models, hepatic and extra-hepatic malignancies, treatment models, and current and emerging therapies. Written by experts in the field, Alcoholic and Non-Alcoholic Fatty Liver Disease: Bench to Bedside is a valuable resource for gastroenterologists, pathologists, and hepatologists who treat patients with alcoholic and nonalcoholic fatty liver disease.
Non Alcoholic Fatty Liver Disease
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Author : Geoffrey C. Farrell
language : en
Publisher: John Wiley & Sons
Release Date : 2013-02-06
Non Alcoholic Fatty Liver Disease written by Geoffrey C. Farrell and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-02-06 with Medical categories.
The sharp rise in cases of Non-alcoholic fatty liver disease is fast becoming one of the major concerns for hepatologists worldwide. This comprehensive clinical guide explains how to diagnose NAFLD and manage patients according to the best standards of care. Contributors from the world's leading institutions concentrate on patient care, drawing on their extensive experience.
Non Alcoholic Fatty Liver Disease
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Author : Elisabetta Bugianesi
language : en
Publisher: Springer Nature
Release Date : 2020-09-28
Non Alcoholic Fatty Liver Disease written by Elisabetta Bugianesi and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-09-28 with Medical categories.
The goal of this book is to promote awareness of non-alcoholic fatty liver disease (NAFLD) – which is rapidly replacing viral hepatitis as the leading cause of chronic liver disease in Europe, North and South America and Asia – and to share the latest information on evolving approaches to diagnosis and treatment. The book offers a comprehensive overview of the current topics of interest in the field, and provides clinical guidance on NAFLD through a multidisciplinary approach based on the latest scientific understanding of this multisystemic disease, involving the expertise of specialists including hepatologists, diabetologists, and cardiologists. The respective contributions address various aspects, including the newly released international guidelines, novel diagnostic modalities, and new experimental drugs. The work will appeal to a broad readership, from residents in internal medicine to specialists.
Fatty Liver Disease
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Author : Geoffrey C. Farrell
language : en
Publisher: John Wiley & Sons
Release Date : 2008-04-15
Fatty Liver Disease written by Geoffrey C. Farrell and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-04-15 with Medical categories.
Fatty Liver Diseases: NASH and Related Disorders is an unusual book: it combines a practical approach for students and physicians concerned with the problem with a clear overview on the causative mechanisms. It appeals to doctors and other health care workers who encounter this problem, as well as to pathologists and investigators interested in the field of liver disease. It will improve your diagnostic acumen for people with abnormal liver tests, advance your knowledge about this important subject and help with your specialist or undergraduate exams, and management of a common disorder.
Non Alcoholic Fatty Liver Disease
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Author : Rodrigo Valenzuela Baez
language : en
Publisher: BoD – Books on Demand
Release Date : 2018-03-21
Non Alcoholic Fatty Liver Disease written by Rodrigo Valenzuela Baez and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-03-21 with Medical categories.
Nonalcoholic fatty liver disease (NAFLD) with a prevalence of 20-30% worldwide is characterized by the buildup of fat in the liver (liver steatosis) with no or little alcohol consumption. Its principal causes are modern diet and occidental lifestyle. It is characterized by metabolic disturbances such as insulin resistance, inflammation, and oxidative stress, considered as the hepatic manifestation of metabolic syndrome. There is no effective drug therapy for this disease; therefore, lifestyle interventions remain as the first-line treatment. Nevertheless, the adherence rates to this type of treatment are very low, so great efforts are focused at finding novel therapeutic agents for the prevention of hepatic steatosis and its progression. This book presents a systematic and comprehensive revision about NAFLD, highlighting its epidemiological and molecular aspects, as well as its prevention and treatment.
Non Alcoholic Fatty Liver Disease
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Author : Patrik Nasr
language : en
Publisher: Linköping University Electronic Press
Release Date : 2019-09-25
Non Alcoholic Fatty Liver Disease written by Patrik Nasr and has been published by Linköping University Electronic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-09-25 with categories.
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease affecting approximately 25% of the global population and is commonly recognized as the hepatic manifestation of the metabolic syndrome. The histological spectrum of NAFLD ranges from isolated steatosis to non-alcoholic steatohepatitis (NASH), with risk of developing fibrosis and subsequent cirrhosis and hepatocellular carcinoma. The gold standard for diagnosing NAFLD is liver biopsy. However, because of its invasive nature, several non-invasive methods have been developed and validated in evaluating fat and fibrosis in patients with NAFLD. Liver fat content can be assessed using various methods. The conventional histopathological method consists of a visual semiquantitative approach in which the pathologist uses a four-point scale: grade 0 corresponds to fat deposition in <5% of hepatocytes and grade 1?3 (which is needed for the diagnosis of NAFLD) corresponds to ?5%. An alternate approach is to quantitatively assess steatosis using stereological point counting (SPC) – which rely on liver biopsy. However, in vivo proton magnetic resonance spectroscopy (1H-MRS) is a reliable noninvasive method that can be used to quantitatively assess total hepatic lipid content, or proton density fat fraction (PDFF). In Paper I we compared the conventional semiquantitative histological method (grade 0-3) with SPC and 1H-MRS. We found a strong positive correlation between 1H-MRS and SPC, whereas the correlations between 1H-MRS or SPC and histopathological grading were substantially weaker. Using the widely used cut-off value of PDFF ?5%, all participants were found to have steatosis (specificity 100%, sensitivity 53%). Reducing the cut-off value to 3% maintained 100% specificity while increasing sensitivity to 79%. In Paper IV we evaluated quantitative steatosis, by SPC, in 106 biopsy-proven NAFLD patients during a 20-year follow-up. SPC was independently associated with an increased risk of all-cause mortality and development of T2DM. Moreover, in the 59 patients with sequential biopsies (approximately 10 years apart), a reduction of quantitative hepatic steatosis decreased the all-time risk of developing T2DM. NASH is commonly seen as a histological feature portending a worse prognosis in NAFLD. Interestingly, no dual biopsy study has ever shown that NASH predicts fibrosis progression. Yet, NASH is seen as a surrogate marker in pharmaceutical trials – were resolution in NASH is equivalent to future resolution of fibrosis. In Paper II we conducted a long-term follow-up study (20 years) in a large cohort of biopsy-proven NAFLD patients (n=646), in a collaboration with Karolinska Institute. We could not ascertain that NASH had any effect on all-cause, or disease-specific mortality. However, higher stages of fibrosis predicted all-cause and disease specific mortality. In Paper III, we present 129 biopsy-proven NAFLD patients, in which we had prospective, longitudinal data. They were included between 1988 and 1993. All patients alive, were re-invited 2003-2005 and 2013-2015. Dual biopsies were present in 68 patients, and three consecutive biopsies were available in 33 patients. Results showed that NAFLD is a highly heterogeneous disease, with 9.3% developing end-stage liver disease and 16% progressing to advanced stages of fibrosis without any clinically significant baseline data predicting disease progression. In summary, when using 1H-MRS as a diagnostic method for NAFLD, the diagnostic cut-off should be reduced from 5% to 3%. Furthermore, quantitative amount of hepatic steatosis could be used to stratify patients with NAFLD related to future risk of developing T2DM. Moreover, we have shown that NASH does not predict future all-cause or disease-specific mortality nor end-stage liver disease, therefore a different surrogate marker should be used in clinical trials when assessing NAFLD improvement, so to not imbue false reliance in new therapies. Lastly, we have shown that NAFLD has a more dismal prognosis than previously reported, and that it is unexpectedly difficult to predict fibrosis progression in individual NAFLD patients, emphasizing the need for robust non-invasive biomarkers suitable to monitor large number of patients.
Clinical Dilemmas In Non Alcoholic Fatty Liver Disease
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Author : Roger Williams
language : en
Publisher: John Wiley & Sons
Release Date : 2016-02-16
Clinical Dilemmas In Non Alcoholic Fatty Liver Disease written by Roger Williams and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-02-16 with Medical categories.
Clinical Dilemmas in Non-Alcoholic Fatty Liver Disease offers hepatologists practical, up-to-date and expert guidance on the most topical dilemmas, difficulties and areas of controversy/difficulty surrounding this ever-increasing area of liver disease they face in daily practice. Roger Williams and Simon Taylor-Robinson, two of Europe’s leading hepatologists, have recruited leading figures from across the world to assist them, resulting in a truly international approach. Each chapter covers a specific area of difficulty, containing clear learning points and providing evidence-based expert guidance on the latest hot topics in clinical management such as: Is NAFLD different in absence of Metabolic Syndrome? Are the pros outweighed by the cons of obtaining a liver biopsy? Is progression to cirrhosis more likely in children with NAFLD? What are the dangers as well as the true benefits of bariatric surgery? How is it best to use antifibrotic agents in clinical practice? Clinical Dilemmas in Non-Alcoholic Fatty Liver Disease provides the answers to the questions and challenges that clinicians face every day in this area. It is essential reading for hepatologists of all levels and researchers in hepatology, as well as all those involved in the care of patients with NAFLD, including gastroenterologists, pathologists and specialist hepatology nurses.
Nutritional Intake And The Risk For Non Alcoholic Fatty Liver Disease Nafld
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Author : Ina Bergheim
language : en
Publisher: MDPI
Release Date : 2019-02-13
Nutritional Intake And The Risk For Non Alcoholic Fatty Liver Disease Nafld written by Ina Bergheim and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-02-13 with Nutrition. Foods and food supply categories.
This book is a printed edition of the Special Issue "Nutritional Intake and the Risk for Non-alcoholic Fatty Liver Disease (NAFLD)" that was published in Nutrients
Non Alcoholic Fatty Liver Disease Ecab
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Author : Sudeep Khanna
language : en
Publisher: Elsevier Health Sciences
Release Date : 2013-04-15
Non Alcoholic Fatty Liver Disease Ecab written by Sudeep Khanna and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-15 with Medical categories.
Non-alcoholic fatty liver disease is a common cause of chronic liver disease, and its incidence is rising worldwide. Understanding its pathogenesis, biochemical parameters, histological grading and staging, and its management is a vital issue in today’s clinical practice. It appears to be linked directly to the growing epidemic of obesity in adults as well as in children. Thus, in a sense, NAFLD is a self-inflicted liver disease, much like alcoholic liver disease. The exact causes responsible for the development of NAFLD have not been established yet. However, some researchers consider that cluster of disorders that increases the risk of developing heart disease, diabetes, and stroke may be the factor behind development of NAFLD. Most patients with NAFLD have no symptoms or signs of liver disease at the time of diagnosis. In these patients, abnormal liver function tests are often discovered incidentally. Non-alcoholic steatohepatitis (NASH) is that stage of the spectrum that involves fat accumulation (steatosis), inflammation (hepatitis), and scarring (fibrosis) in the liver. Those who have fatty liver or hepatic steatosis with non-specific inflammation as fatty liver with non-specific inflammation generally have a benign longterm prognosis, whereas those who have NASH can progress to cirrhosis. NASH-related cirrhosis may have similar prognosis as cirrhosis from other causes. Hepatocellular carcinoma (HCC) is part of the spectrum of NAFLD, and screening for HCC seems reasonable in patients who have NASH-related cirrhosis. No established treatment is available for NAFLD. Some empiric treatment strategies have been suggested. Presumably, weight loss through exercise and diet modification along with insulinsensitizing agents will help reverse fatty infiltration of the liver. Its incidence is reportedly on the rise the world over as well as in India. Realizing its significance, there is now greater understanding of its etiology, pathogenesis, and management. The efforts of Elsevier have been directed toward addressing these aspects. Elsevier has thus pooled its existing resources with those of the internationally acclaimed Gastroenterologists of India who have chosen to share their rich clinical knowledge, experience, and expertize to serve the practitioners and patient community.
Ecab Non Alcoholic Fatty Liver Disease E Book
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Author : Gourdas Choudhuri
language : en
Publisher: Elsevier Health Sciences
Release Date : 2014-12-11
Ecab Non Alcoholic Fatty Liver Disease E Book written by Gourdas Choudhuri and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-12-11 with Medical categories.
ECAB Non-alcoholic Fatty Liver Disease - E-Book