Alloimmune Disorders Of Pregnancy
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Alloimmune Disorders Of Pregnancy
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Author : Andrew Hadley
language : en
Publisher: Cambridge University Press
Release Date : 2002
Alloimmune Disorders Of Pregnancy written by Andrew Hadley and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Medical categories.
Overview of the alloimmune disorders of pregnancy which arise from maternal immunisation to fetal blood cells.
Reproductive And Hormonal Aspects Of Systemic Autoimmune Diseases
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Author : Michael Lockshin
language : en
Publisher: Gulf Professional Publishing
Release Date : 2006-01-04
Reproductive And Hormonal Aspects Of Systemic Autoimmune Diseases written by Michael Lockshin and has been published by Gulf Professional Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-01-04 with Medical categories.
This volume of the Handbook of Systemic Autoimmune Diseases series represents a medical collaboration focusing primarily on female aspects of rheumatic diseases. This collaboration recognizes the need to understand and optimally manage the care of women with autoimmune conditions that may affect their reproduction and hormonal status. This handbook will prove useful to clinicians and researchers alike. It covers practical points, ranging from which anti-rheumatic medications are safe in pregnancy to how to counsel women with scleroderma contemplating pregnancy. * Authors share an academic interest in the unique relationship between being a woman and having an autoimmune disease * Touches on controversial topics, such as the mechanism of antiphospholipid-related fetal loss and whether or not non-steroidal anti-inflammatory agents should be used in pregnancy * Includes critical and balanced reviews of the controversial association between autoimmune disease and female infertility
Therapeutic Implications For Pregnant Women With Systemic Autoimmune Diseases And Their Children
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Author : Cecilia Beatrice Chighizola
language : en
Publisher: Frontiers Media SA
Release Date : 2022-01-13
Therapeutic Implications For Pregnant Women With Systemic Autoimmune Diseases And Their Children written by Cecilia Beatrice Chighizola and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-13 with Science categories.
Disorders Of Thrombosis And Hemostasis In Pregnancy
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Author : Hannah Cohen
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-15
Disorders Of Thrombosis And Hemostasis In Pregnancy written by Hannah Cohen and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-15 with Medical categories.
This book will offer a comprehensive guide to disorders of thrombosis and haemostasis in pregnancy. It will highlight the latest developments and controversial issues. The multidisciplinary approach will provide authoritative clinical advice on state-of-the-art management. The disorders to be covered are highly pertinent to successful pregnancy outcome, and many may be associated with significant maternal and/or fetal morbidity, and even mortality. This book will be relevant for individuals in all disciplines involved in the care of women with disorders of thrombosis and haemostasis in pregnancy.
Hematological Complications In Obstetrics Pregnancy And Gynecology
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Author : Rodger L. Bick
language : en
Publisher: Cambridge University Press
Release Date : 2006-04-20
Hematological Complications In Obstetrics Pregnancy And Gynecology written by Rodger L. Bick and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-04-20 with Medical categories.
There are many haematological complications associated with obstetrics, pregnancy and gynaecology, and unfortunately, they often lead to significant morbidity or mortality for both mother and child. As the first comprehensive reference on all aspects of haematological complications of obstetrics, pregnancy and gynaecology this book will be a valuable resource to haematologists, obstetricians, gynaecologists, reproductive medicine specialists, internists, anaesthesiologists and others. The chapters are written by acknowledged experts in the field, and for each condition covered the etiology, pathophysiology, clinical and laboratory diagnosis and management are discussed where appropriate.
Immunology Of Pregnancy And Its Disorders
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Author : C.M. Stern
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Immunology Of Pregnancy And Its Disorders written by C.M. Stern and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The purpose of this book is to describe the nature of the materno-fetal immunobiological relationship and to suggest the direction in which the management of reproduction and its failure in man is moving. The several authors, who have written about their special fields of interest, need to be read within a framework designed to blend their contributions into a whole. This preamble provides a part of that framework, by describing the early development of the embryo, that of the placenta and its membranes and their anatomical relationship with maternal tissues: in other words, the stage upon which this materno-fetal dialogue takes place. Professor Maureen Young's 'tour de force', encapsulating the whole of fetal physiology into a single chapter, completes the background information. After Maureen Young's summary of fetal physiology, Matteo Adinolfi describes the development of the immune system in the fetus, including new information that allows more accurate speculation concerning the gestational age at which fetal immune responses of various kinds may begin. Charles Loke examines the nature of antigens which are found in the placenta, concentrating on those which occur on syncytiotrophoblast and suggesting roles for them in fetal development. Arnold Klopper covers the wide range of proteins and hormones which have been studied during pregnancy and found to vary in a potentially significant way. He has been careful to distinguish between observation and hypothesis, as far as any immunomodulating action is concerned, and his analysis is a model of scientific scepticism.
Effects Of Pregnancy And Hormones On T Cell Immune Regulation In Multiple Sclerosis
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Author : Sandra Hellberg
language : en
Publisher: Linköping University Electronic Press
Release Date : 2019-10-22
Effects Of Pregnancy And Hormones On T Cell Immune Regulation In Multiple Sclerosis written by Sandra Hellberg and has been published by Linköping University Electronic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-22 with categories.
Multiple sclerosis (MS) is characterized by a dysregulated immune system leading to chronic inflammation in the central nervous system. Despite increasing number of treatments, many patients continue to deteriorate. A better understanding of the underlying disease mechanisms involved in driving disease is a pre-requisite for finding new biomarkers and new treatment targets. The improvement of MS during pregnancy, comparable to the beneficial effects of the most effective treatment, suggests that the transient and physiological immune tolerance established during pregnancy could serve as a model for successful immune regulation. Most likely the immune-endocrine alterations that take place during pregnancy to accommodate the presence of the semi-allogenic fetus contribute to the observed disease improvement. The aim of this thesis was to characterize the dysregulated immune system in MS and define potential factors and mechanisms established during pregnancy that could be involved in the pregnancy-induced effects in MS, focusing on CD4+ T cells as one of the main drivers in immunity and in the MS pathogenesis. Using a network-based modular approach based on gene expression profiling, we could show that CD4+ T cells from patients with MS displayed an altered dynamic gene response to activation, in line with a dysregulated immune system in MS. The resulting gene module disclosed cell activation and chemotaxis as central components in the deviating response, results that form a basis for further studies on its modulation during pregnancy. Moreover, a combination of secreted proteins (OPN+CXCL1-3+CXCL10-CCL2), identified from the module, could be used to separate patients and controls, predict disease activity after 2 years and discriminate between high and low responders to treatment, highlighting their potential use as biomarkers for predicting disease activity and response to treatment. The pregnancy hormone progesterone (P4), a potential factor involved in the pregnancy-induced amelioration of MS, was found to significantly dampen CD4+ T cell activation. Further detailed transcriptomic profiling revealed that P4 almost exclusively down-regulated immune-related pathways in activated T cells, several related to or downstream of T cell activation such as JAKSTAT signaling, T cell receptor signaling and cytokine-cytokine receptor interaction. In particular, P4 significantly affected genes of relevance to diseases known to be modulated during pregnancy, where genes associated to MS were most significantly affected, supporting a role for P4 in the pregnancy-induced immunomodulation. By using another approach, the role of thymus in T cell regulation during pregnancy was assessed. Two established measures of thymic output, CD31 expression and TREC content, were used and showed that thymic output of T cells is maintained during human pregnancy, or even possibly increased in terms of regulatory T cells. This thesis further supports a pivotal role for CD4+ T cells and T cell activation in the MS pathogenesis and adds to the knowledge of how they could be involved in driving disease. We identified a novel strategy for capturing central aspects of the deviating response to T cell activation that could be translated into potentially clinically relevant biomarkers. Further, P4 is emerging as a promising candidate for the pregnancy-induced immunomodulation that could be of importance as a future treatment option. Lastly, maintained thymic output of T cells during human pregnancy challenges the rodent-based dogma of an inactive thymus during pregnancy. Thymic dysfunction has been reported not only in MS but also in rheumatoid arthritis, another inflammatory disease that improves during pregnancy, which highlights a potential role for thymus in immune regulation that could be involved in the pregnancy-induced amelioration.
The Obstetric Hematology Manual
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Author : Sue Pavord
language : en
Publisher: Cambridge University Press
Release Date : 2010-04-15
The Obstetric Hematology Manual written by Sue Pavord and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-04-15 with Medical categories.
Obstetric hematology is a fast-growing area of medicine covering the diagnosis and management of hematological problems of pregnancy. Comprehensive in approach, The Obstetric Hematology Manual addresses the many hematological conditions that can cause serious problems in pregnancy, delivery and the post-partum period for both mother and baby. Written by a team of international authorities, this text provides up-to-date, evidence-based guidelines on best care, as well as sound advice based on the experience and opinion of experts. Where appropriate, basic principles are discussed to clarify the rationale for management, and systems and procedures for disease prevention are highlighted. Many conditions and cases are discussed, including venous thromboembolism, pre-eclampsia, anemia, thrombocytopenia and inherited disorders. This book will appeal to both trainees and practitioners in obstetrics, obstetric medicine, obstetric anesthesia and hematology. It is also an accessible text for midwives, nurses, and laboratory staff.
Women S Health In Autoimmune Diseases
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Author : Shefali Khanna Sharma
language : en
Publisher: Springer Nature
Release Date : 2020-07-28
Women S Health In Autoimmune Diseases written by Shefali Khanna Sharma and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-28 with Medical categories.
This book focuses on conveying autoimmune disease expertise to gynecologists and other clinicians, allowing them to approach the treatment of each disease in a pragmatic manner. Each chapter reviews the current literature on treatments for autoimmune diseases, especially under special circumstances like pregnancy; rating disease severity; and providing practical guidelines based on the current state of knowledge. How autoimmune diseases affect fertility, and how to best prepare patients with these diseases for pregnancy, is also addressed. Unfortunately the current literature does not provide effective guidelines. This book addresses that shortcoming, and will help clinicians to implement appropriate treatments, while also outlining possible alternatives in order to provide effective treatment for women living with autoimmune diseases. It also explores important issues concerning autoimmune diseases in women such as: lupus nephritis, vasculitis, Sjogren’s syndrome, anti phospholipid syndrome and systemic sclerosis, and their potential effects on unborn children. Given its scope, the book offers a valuable reference guide for Practicing Clinicians, Rheumatologists and Gynecologists, among others.
Contraception And Pregnancy In Patients With Rheumatic Disease
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Author : Lisa R. Sammaritano
language : en
Publisher: Springer
Release Date : 2016-09-17
Contraception And Pregnancy In Patients With Rheumatic Disease written by Lisa R. Sammaritano and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-09-17 with Medical categories.
Rheumatic (or systemic autoimmune) diseases disproportionately affect young women: the female-to-male ratio for patients with systemic lupus erythematosus during the reproductive years is approximately 9:1. In the mid- to late-twentieth century, women with rheumatic disease diagnoses were often advised to avoid pregnancy due to fear of disease exacerbation and adverse outcome. In more recent years, many women with rheumatic disease have deferred childbearing until a later age due to active disease or unsafe therapies. However, with advances in rheumatology therapies, obstetric monitoring, and reproductive medicine technologies, increasing numbers of women with rheumatic diseases are pursuing pregnancy. As a result, obstetricians and rheumatologists need to be aware of the current state of knowledge and the recommendations for management of pregnancy in these patients. Contraception and Pregnancy in Patients with Rheumatic Disease explains the basics of contraception, fertility treatment, and pregnancy in rheumatic disease patients and serves as a guide and reference tool for both rheumatologists and OB/GYNs. Most general rheumatologists and OB/GYNs have limited experience in caring for rheumatic disease patients during pregnancy, and many do not have ready access to expert colleagues in this area. This book summarizes the current state of knowledge and presents a general approach for assessment of the rheumatic disease patient considering pregnancy, hormonal contraception or infertility treatment.