Alzheimer S Disease Drug Development
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Alzheimer S Disease Drug Development
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Author : Jeffrey Cummings
language : en
Publisher: Cambridge University Press
Release Date : 2022-03-31
Alzheimer S Disease Drug Development written by Jeffrey Cummings and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-03-31 with Business & Economics categories.
Provides a definitive overview of the complex ecosystem facilitating Alzheimer's Disease drug research and development. Demonstrates a drug's journey from in the lab, clinical trial testing, regulatory review, and marketing by pharmaceutical companies. Details the use of artificial intelligence, clinical trial management, and financing models.
Biomarkers For Alzheimer S Disease Drug Development
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Author : Robert Perneczky
language : en
Publisher: Springer Nature
Release Date : 2024
Biomarkers For Alzheimer S Disease Drug Development written by Robert Perneczky and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024 with Alzheimer's disease categories.
Zusammenfassung: This fully updated volume provides an up-to-date and comprehensive overview of the current state of technologies helping to accelerate Alzheimer's disease drug development. Addressing the latest advances in preclinical and clinical research, including new insights into the molecular mechanisms and emerging therapeutic strategies, the book continues by exploring digital biomarkers and advanced neuroimaging analysis which will transform how clinical trials in the Alzheimer's disease field are performed. Written for the highly successful Methods in Molecular Biology series, chapters feature the kind of detailed implementation advice that leads to greater success in the lab or clinic. Authoritative and practical, Biomarkers for Alzheimer's Disease Drug Development, Second Edition seeks to inspire and inform future efforts to develop effective treatments for this devastating disease
Computational Modeling Of Drugs Against Alzheimer S Disease
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Author : Kunal Roy
language : en
Publisher: Springer Nature
Release Date : 2023-06-30
Computational Modeling Of Drugs Against Alzheimer S Disease written by Kunal Roy and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-06-30 with Medical categories.
This second edition volume expands on the previous edition with updated descriptions on different computational methods encompassing ligand-based, structure-based, and combined approaches with their recent applications in anti-Alzheimer drug design. Different background topics like recent advancements in research on the development of novel therapies and their implications in the treatment of Alzheimer’s Disease (AD) have also been covered for completeness. Special topics like basic information science methods for insight into neurodegenerative pathogenesis, drug repositioning and network pharmacology, and online tools to predict ADMET behavior with reference to anti-Alzheimer drug development have also been included. In the Neuromethods series style, chapter include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and thorough, Computational Modeling of Drugs Against Alzheimer’s Disease, Second Edition is a valuable resource for all researchers and scientists interested in learning more about this important and developing field.
Biomarkers For Alzheimer S Disease Drug Development
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Author : Robert Perneczky
language : en
Publisher: Humana
Release Date : 2024-03-02
Biomarkers For Alzheimer S Disease Drug Development written by Robert Perneczky and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-03-02 with Medical categories.
This fully updated volume provides an up-to-date and comprehensive overview of the current state of technologies helping to accelerate Alzheimer’s disease drug development. Addressing the latest advances in preclinical and clinical research, including new insights into the molecular mechanisms and emerging therapeutic strategies, the book continues by exploring digital biomarkers and advanced neuroimaging analysis which will transform how clinical trials in the Alzheimer’s disease field are performed. Written for the highly successful Methods in Molecular Biology series, chapters feature the kind of detailed implementation advice that leads to greater success in the lab or clinic. Authoritative and practical, Biomarkers for Alzheimer’s Disease Drug Development, Second Edition seeks to inspire and inform future efforts to develop effective treatments for this devastating disease.
Alzheimer S Disease
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Author : Neal R. Cutler
language : en
Publisher: Wiley
Release Date : 1994-09-27
Alzheimer S Disease written by Neal R. Cutler and has been published by Wiley this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994-09-27 with Psychology categories.
Both prescriptive and descriptive, this outstanding guide directs readers toward improved drug development strategies in Alzheimer's disease. Profiles the importance of designing clinical trial protocols that ensure adequate evaluation of the efficacy and safety of potential pharmacological treatments.
Drug Design And Discovery In Alzheimer S Disease
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Author : Atta-ur-Rahman
language : en
Publisher: Elsevier
Release Date : 2015-06-27
Drug Design And Discovery In Alzheimer S Disease written by Atta-ur-Rahman and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-06-27 with Science categories.
Drug Design and Discovery in Alzheimer’s Disease includes expert reviews of recent developments in Alzheimer's disease (AD) and neurodegenerative disease research. Originally published by Bentham as Frontiers in Drug Design and Discovery, Volume 6and now distributed by Elsevier, this compilation of the sixteen articles, written by leading global researchers, focuses on key developments in the understanding of the disease at molecular levels, identification and validation of molecular targets, as well as innovative approaches towards drug discovery, development, and delivery. Beginning with an overview of AD pharmacotherapy and existing blockbuster drugs, the reviews cover the potential of both natural and synthetic small molecules; the role of cholinesterases in the on-set and progression of AD and their inhibition; the role of beta-site APP clearing enzyme-1 (BACE-1) in the production of ß-amyloid proteins, one of the key reasons of the progression of AD; and other targets identified for AD drug discovery. Edited and written by leading experts in Alzheimer’s disease (AD) and other neurodegenerative disease drug development Describes existing drugs for AD and current molecular understanding of the condition Reviews recent advances in the field, including coverage of cholinesterases, BACE-1, and other drug development targets
Drug Discovery Approaches For The Treatment Of Neurodegenerative Disorders
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Author : Adeboye Adejare
language : en
Publisher: Academic Press
Release Date : 2016-09-20
Drug Discovery Approaches For The Treatment Of Neurodegenerative Disorders written by Adeboye Adejare and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-09-20 with Medical categories.
Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders: Alzheimer’s Disease examines the drug discovery process for neurodegenerative diseases by focusing specifically on Alzheimer’s Disease and illustrating the paradigm necessary to ensure future research and treatment success. The book explores diagnosis, epidemiology, drug discovery strategies, current therapeutics, and much more to provide a holistic approach to the discovery, development, and treatment of Alzheimer’s Disease. Through its coverage of the latest research in targeted drug design, preclinical studies, and mouse and rat models, the book is a must-have resource for all pharmaceutical scientists, pharmacologists, neuroscientists, and clinical researchers working in this area. It illustrates why these drugs tend to fail at the clinical stage, and examines Alzheimer’s Disease within the overall context of improving the drug discovery process for the treatment of other neurodegenerative disorders. Provides a compilation of chemical considerations required in drug discovery for the treatment of neurodegenerative disorders Examines different classes of compounds currently being used in discovery and development stages Explores in vitro and in vivo models with respect to their ability to translate these models to human conditions Distills the most significant information across multiple areas of Alzheimer’s disease research to provide a single, comprehensive, and balanced resource
Developing Therapeutics For Alzheimer S Disease
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Author : Michael S. Wolfe
language : en
Publisher: Academic Press
Release Date : 2016-05-27
Developing Therapeutics For Alzheimer S Disease written by Michael S. Wolfe and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-05-27 with Medical categories.
Developing Therapeutics for Alzheimer's Disease: Progress and Challenges provides a thorough overview of the latest advances toward the development of therapeutics for Alzheimer’s disease, along with the major hurdles that still must be overcome and potential solutions to these problems. Despite the lack of progress toward developing therapeutics that can slow or stop the progression of this disease, important discoveries have been made and many promising approaches are advancing in preclinical studies and clinical trials. This book outlines the special challenges related to specific targets and approaches, while presenting a realistic, comprehensive and balanced view of drug discovery and development in this area. Written by international leaders in the field, the book assesses prospects for the emergence of effective agents and allows readers to better understand the challenges, failures, and future potential for research in Alzheimer’s disease. This book is a valuable resource to academic scientists carrying out translational research in Alzheimer’s disease, industrial scientists engaged in Alzheimer's drug discovery, executives in biopharmaceutical companies making strategic decisions regarding the direction of internal research and potential outside partnerships, and graduate-level students pursuing courses on Alzheimer's therapeutics. Provides a realistic but promising assessment of the potential of various therapeutic approaches to Alzheimer’s disease Focuses primarily on neuroprotective agents and cognitive enhancers, as well as approaches to targeting the amyloid B-peptide, tau and Apolipoprotein E Discusses alternative approaches, preclinical and clinical development issues, related biomarkers and diagnostics, and prevention and nonpharmacological approaches
Advances In Alzheimer S Disease Drug Development
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Author : Reading Reading Press
language : en
Publisher:
Release Date : 2016-02-13
Advances In Alzheimer S Disease Drug Development written by Reading Reading Press and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-02-13 with categories.
Alzheimer's disease (AD) is the foremost cause of dementia worldwide. Clinically, AD manifests as progressive memory impairment followed by a gradual decline in other cognitive abilities leading to complete functional dependency. Recent biomarker studies indicate that AD is characterized by a long asymptomatic phase, with the development of pathology occurring at least a decade prior to the onset of any symptoms. Current FDA-approved treatments target neurotransmitter abnormalities associated with the disease but do not affect what is believed to be the underlying etiology. In this review, we briefly discuss the most recent therapeutic strategies being employed in AD clinical trials, as well the scientific rationale with which they have been developed.
Computational Approaches For Identifying Drugs Against Alzheimer S Disease
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Author : Radha Mahendran
language : en
Publisher: Anchor Academic Publishing
Release Date : 2017-05
Computational Approaches For Identifying Drugs Against Alzheimer S Disease written by Radha Mahendran and has been published by Anchor Academic Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-05 with Computers categories.
Alzheimer’s disease is the most common form of dementia which is incurable. Although some kinds of memory loss are normal during aging, these are not severe enough to interfere with the level of function. ß-Secretase is an important protease in the pathogenesis of Alzheimer’s disease. Some statine-based peptidomimetics show inhibitory activities to the ß-secretase. To explore the inhibitory mechanism, molecular docking and three-dimensional quantitative structure-activity relationship (3D-QSAR) studies on these analogues were performed. Quantitative structure-activity relationship (QSAR) modeling pertains to the construction of predictive models of biological activities as a function of structural and molecular information of a compound library. The concept of QSAR has typically been used for drug discovery and development and has gained wide applicability for correlating molecular information with not only biological activities but also with other physicochemical properties, which has therefore been termed quantitative structure-property relationship (QSPR). In this study, 3D QSAR and pharmacophore mapping studies were carried out using Accelrys Discovery Studio 2.1. The best nine drugs were selected from the 16 ligands and pharmacophore features were generated.