Amyloidogenesis And The Cholinergic System In Alzheimer S Disease
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Amyloidogenesis And The Cholinergic System In Alzheimer S Disease
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Author : Fracisca C. Bronfman
language : en
Publisher:
Release Date : 2000-10-01
Amyloidogenesis And The Cholinergic System In Alzheimer S Disease written by Fracisca C. Bronfman and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-10-01 with Medical categories.
Beta Amyloidosis And The Cholinergic System In Aging And Alzheimer S Disease
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Author : Martin Huw Griffiths
language : en
Publisher:
Release Date : 1997
Beta Amyloidosis And The Cholinergic System In Aging And Alzheimer S Disease written by Martin Huw Griffiths and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with categories.
Beta Amyloidosis And The Cholinergic System In Ageing And Alzheimer S Disease
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Author : Martin Huw Griffiths
language : en
Publisher:
Release Date : 1998
Beta Amyloidosis And The Cholinergic System In Ageing And Alzheimer S Disease written by Martin Huw Griffiths and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with categories.
Alzheimer Disease
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Author : Ezio Giacobini
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Alzheimer Disease written by Ezio Giacobini and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Since the apoE4 allele is a risk factor or susceptibility gene in late-onset familial and sporadic AD, the mechanism of disease expression may involve metabolic effects that are isoform specific. Isoform-specific interactions of apoE therefore become critical in the mechanism of AD pathogenesis. Detailed characterization of the binding of the apoE isoforms with proteins and peptides relevant to the pathology of the disease may be critical in understanding disease pathogenesis. These critical isoform-specific interactions of apoE may involve interactions with proteins and pep tides in the defining neuropathologic lesions of the disease, the neurofibrillary tangle and senile plaque. Other possible critical isoform-specific interactions include the mechanism of internalization, intracellular trafficking, and subsequent metabolism. In addition, differential post-translational modifications of apoE isoforms may determine differences in metabolism contributing to the pathogenesis of the disease. Oxidation of apoE may confer several isoform-specific, biochemically distinct properties. Since {3A peptide binds apoE in the lipoprotein binding domain of the protein and not in the receptor-binding domain, apoE could target bound {3A4 peptide to neurons via the LRP receptor. Internalization of the apoEI {3A peptide complex into the cell, by the same route as the apoE-containing lipoproteins, would result in incorporation into primary lysosomes and pH dependent dissociation. The demonstration of apoE in the cytoplasm of neurons, with isoform-specific interactions of apoE with the microtubule-binding protein tau demonstrated in vitro, suggest additional, testable hypotheses of disease pathogenesis.
The Cholinergic System And Pharmacological Inhibition Of Mmp 9 In The Mcgill Thy 1app Mouse Model Of Alzheimer S Disease
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Author : Aaron Hackett
language : en
Publisher:
Release Date : 2013
The Cholinergic System And Pharmacological Inhibition Of Mmp 9 In The Mcgill Thy 1app Mouse Model Of Alzheimer S Disease written by Aaron Hackett and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with categories.
"Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and ultimately death. The primary pathological hallmark of (AD) is the presence of amyloid beta protein which can accumulate intracellularly and eventually aggregate into extracellular plaques. Amyloid beta has a variety of toxic effects and is particularly disruptive to the brain's cholinergic system, a neural network essential for learning and memory function. In this study, the McGill THY-1-APP mouse model of AD, which overexpresses the precursor of amyloid beta, has been used to profile the region and time-specific impact of amyloid pathology on cholinergic synaptic integrity. As a point of comparison, the impact of amyloid pathology on the glutamatergic system has also been investigated. Finally, in an effort to protect the cholinergic system from amyloid beta toxicity, a matrix metalloproteinase 9 inhibitor (MMP9i) has been administered to aged THY-1-APP transgenics and their respective C56Bl/6 wild type controls. This study was unable to confirm the cholinergic early up-regulation hypothesis which postulates that there is a compensatory increase in cholinergic structure and function prior to extensive amyloidosis and plaque deposition. However, this study was able to confirm end-stage cholinergic synaptic losses and the relative resilience of the glutamatergic system to amyloid toxicity. At the present time, whether or not administration of the MMP9i is capable of preventing end-stage cholinergic losses remains unclear as the results are inconclusive. On the one hand, with the relatively small sample sizes used, there is some preliminary evidence to suggest that administration has a protective effect. This is because the density of cholinergic boutons in transgenic THY-1-APP MMP9i-treated mice did not differ significantly from wild type C57Bl/6 vehicle-treated mice, while the density of cholinergic boutons was significantly lower in vehicle-treated THY-1-APP transgenic mice as compared to wild type C57Bl/6 vehicle-treated mice. On the other hand, the THY-1-APP transgenic MMP9i treated mice failed to attain a statistically significant elevation in cholinergic bouton density when compared directly with the THY-1-APP transgenic vehicle treated mice, suggesting that the drug was unable to prevent cholinergic bouton loss after all. Further testing will be required in animal models with a larger sample size and less variance before firm conclusions can be drawn as to the status of the MMP9i's putative protective ability. Finally, the MMP9 inhibitor failed to improve the performance of treated wild type C57Bl/6 mice or THY-1-APP transgenic mice on a behavioural test for episodic-like memory. The author concludes that the MMP9i is worthy of future investigation as a therapeutic agent and that if one hopes to correct cognitive dysfunction then co-administration of other therapeutic agents may also be necessary." --
Muscarinic Agonists And The Treatment Of Alzheimer S Disease
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Author : Abraham Fisher
language : en
Publisher: Landes Bioscience
Release Date : 1996
Muscarinic Agonists And The Treatment Of Alzheimer S Disease written by Abraham Fisher and has been published by Landes Bioscience this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with Medical categories.
Details recent advances in basic, applied, and clinical sciences relevant to the etiology and treatment of Alzheimer's disease, focusing on m1 agonists. Reviews findings in the involvement of the cholinergic systems in Alzheimer's; the rationale for designing m1 agonists; and the involvement of m1 receptors in amyloid precursor proteins, neurotrophic activities, and the effects on phosphorylation of tau protein. Emphasis is on the structure-activity relationship of the interaction of agonists with muscarine receptor subtypes and m1 receptors. For researchers in molecular biology and medicine. Annotation copyright by Book News, Inc., Portland, OR
Alzheimer S Disease Pathogenesis
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Author : Suzanne De La Monte
language : en
Publisher: BoD – Books on Demand
Release Date : 2011-09-12
Alzheimer S Disease Pathogenesis written by Suzanne De La Monte and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-12 with Medical categories.
Alzheimer's Disease Pathogenesis: Core Concepts, Shifting Paradigms, and Therapeutic Targets, delivers the concepts embodied within its title. This exciting book presents the full array of theories about the causes of Alzheimer's, including fresh concepts that have gained ground among both professionals and the lay public. Acknowledged experts provide highly informative yet critical reviews of the factors that most likely contribute to Alzheimer's, including genetics, metabolic deficiencies, oxidative stress, and possibly environmental exposures. Evidence that Alzheimer's resembles a brain form of diabetes is discussed from different perspectives, ranging from disease mechanisms to therapeutics. This book is further energized by discussions of how neurotransmitter deficits, neuro-inflammation, and oxidative stress impair neuronal plasticity and contribute to Alzheimer's neurodegeneration. The diversity of topics presented in just the right depth will interest clinicians and researchers alike. This book inspires confidence that effective treatments could be developed based upon the expanding list of potential therapeutic targets.
Alzheimer S Disease Cellular And Molecular Aspects Of Amyloid Beta
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Author : J. Robin Harris
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-11-22
Alzheimer S Disease Cellular And Molecular Aspects Of Amyloid Beta written by J. Robin Harris and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-11-22 with Science categories.
To understand Alzheimer's disease (AD) is one of the major thrusts of present-day clinical research, strongly supported by more fimdamental cellular, biochemical, immunological and structural studies. It is these latter that receive attention within this book. This compilation of 20 chapters indicates the diversity of work currently in progress and summarizes the current state of knowledge. Experienced authors who are scientifically active in their fields of study have been selected as contributors to this book, in an attempt to present a reasonably complete survey of the field. Inevitably, some exciting topics for one reason or another have not been included, for which we can only apologize. Standardization of terminology is often a problem in science, not least in the Alzheimer field; editorial effort has been made to achieve standardization between the Chapters, but some minor yet acceptable personal / author variation is still present, i. e. P-amyloid/amyloid-P; Ap42/Apl-42/APi. 42! The book commences with a broad survey of the contribution that the range of available microscopical techniques has made to the study of Alzheimer's amyloid plaques and amyloid fibrillogenesis. This chapter also serves as an Introduction to the book, since several of the topics introduced here are expanded upon in later chapters. Also, it is significant to the presence of this chapter that the initial discovery of brain plaques, by Alois Alzheimer, utilized light microscopy, a technique that continues to be extremely valuable in present-day AD research.
Ageing And Dementia
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Author : Kurt Jellinger
language : en
Publisher: Springer Science & Business Media
Release Date : 2002-08-20
Ageing And Dementia written by Kurt Jellinger and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-08-20 with Medical categories.
Epidemiological studies, modern clinical, neuroimaging, neuropsychological, molecular biological, and genetic studies have considerably enhanced our knowledge about ageing processes of the human brain, its sequelae, diagnostic, and therapeutic possibilities and limits. In addition to Alzheimer's disease and other degenerative dementias, the impact of cerebrovascular lesions and their risk factors in the pathogenesis of cognitive disorders of the aged are increasingly acknowledged, and the recognition of mild cognitive impairment as a frequent initial stage of developing dementia is becoming an increasingly important diagnostic and therapeutic problem. The included papers were presented at the 7th International Symposium in Graz, Sept. 2001 and give a timely overview of the current and future concepts of pathogenesis, diagnosis, and treatment strategies of pathological brain ageing and dementias, early recognition of mild cognitive impairment and future possiblities of prevention of dementing processes.
Amyloid Cholinergic Transmission And Cerebrovascular System A Developmental Study In A Transgenic Mouse Model Of Alzheimer S Disease
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Author : Elena Kuznetsova
language : en
Publisher:
Release Date : 2013
Amyloid Cholinergic Transmission And Cerebrovascular System A Developmental Study In A Transgenic Mouse Model Of Alzheimer S Disease written by Elena Kuznetsova and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with Amyloid categories.