Amyotrophe Lateralsklerose Als
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Spectrums Of Amyotrophic Lateral Sclerosis
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Author : Christopher A. Shaw
language : en
Publisher: John Wiley & Sons
Release Date : 2021-05-04
Spectrums Of Amyotrophic Lateral Sclerosis written by Christopher A. Shaw and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-05-04 with Medical categories.
SPECTRUMS OF AMYOTROPHIC LATERAL SCLEROSIS Discover state-of-the-art research findings on ALS from leading authors and editors in the field In Spectrums of Amyotrophic Lateral Sclerosis: Heterogeneity, Pathogenesis & Therapeutic Directions, distinguished researchers and editors Dr. Christopher A. Shaw and Jessica R. Morrice deliver a practical and powerful perspective on Amyotrophic Lateral Sclerosis (ALS) as a heterogeneous spectrum of disorders. This increasingly accepted point-of-view allows researchers and medical professionals to develop better targeted interventions and more precise therapies. In the book, readers will find chapters on a wide variety of critical issues facing ALS researchers and healthcare practitioners treating ALS sufferers, including animal models of ALS, neuronal support cells known to have a pivotal role in ALS, and current challenges in ALS clinical trials, among others. The authors describe pathologic features common to all cases of ALS and why animal models, though crucial, should be interpreted with caution. Finally, multiple genetic and environmental etiologies of the disease are discussed. Readers will also benefit from the inclusion of: A thorough introduction to ALS as a spectrum disease and the implications for models, therapeutic development and clinical trial design Explorations of the genetic basis of ALS, prospective sALS etiologies, and the involvement of microbiome in ALS Discussions of ALS-PDC and environmental risk factors, protein aggregation in ALS, defects in RNA metabolism in ALS, and the non-cell autonomous nature of ALS and the involvement of glial cells Examinations of animal models of ALS and perspectives on previously failed ALS therapeutics and current therapeutic strategies Perfect for clinical neurologists, healthcare providers and caretakers, clinicians, and researchers studying motor neuron disease, Spectrums of Amyotrophic Lateral Sclerosis: Heterogeneity, Pathogenesis & Therapeutic Directions is also an indispensable resource for the neurodegenerative research community, neurology residents, and graduate-level neuroscience students.
Fast Facts Diagnosing Amyotrophic Lateral Sclerosis
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Author : Martin Turner
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2019-11-26
Fast Facts Diagnosing Amyotrophic Lateral Sclerosis written by Martin Turner and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-26 with Medical categories.
A diagnosis of amyotrophic lateral sclerosis (also known as Lou Gehrig's disease or motor neuron disease) is a progressive neurodegenerative disorder that exerts a notorious life-shortening physical toll. Understandably, clinicians are keen to avoid a wrong diagnosis when there are such serious consequences, but any delay in diagnosis can result in unnecessary, and sometimes harmful, interventions, and prevents prompt implementation of much-needed physical and emotional support. Starting from the premise that ALS is not one disease but a syndrome, with a spectrum of upper and lower motor neuron involvement, this highly readable resource examines the causes of diagnostic delay and how to avoid them. With no diagnostic test to confirm the disease, no mandatory investigations and very few plausible 'ALS mimics', the authors take a pragmatic approach to what must always be a clinical diagnosis. With case presentations and teaching points to aid understanding, 'Fast Facts: ALS' will give clinicians the confidence to confirm or exclude a diagnosis of ALS, so that individuals facing this most challenging of conditions can receive rapid multidisciplinary support to maximize the quality of their remaining life. Contents: • Defining the syndrome • Epidemiology and pathophysiology • The first symptoms • Differential diagnosis • Investigations • Emerging diagnostic biomarkers
Amyotrophic Lateral Sclerosis
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Author : Muralidhar L. Hegde
language : en
Publisher: BoD – Books on Demand
Release Date : 2020-08-26
Amyotrophic Lateral Sclerosis written by Muralidhar L. Hegde and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-08-26 with Medical categories.
A flurry of recent research on the role of the RNA/DNA-binding proteins TDP-43 and FUS as well as a dozen other factors (e.g., C9ORF72 and profilin) has led to a new paradigm in our understanding of the pathobiology of the motor neuron disease, Amyotrophic Lateral Sclerosis (ALS). How these factors trigger neuromuscular dysfunction is critical for developing more effective ALS therapeutics. The ‘gain-of-toxicity’ or ‘loss-of-function’ of these etiological factors is a key question. Recent studies on the imbalance in genome damage versus repair have opened avenues for potential DNA repair-based therapeutics. This book highlights emerging science in the area of ALS and discusses key approaches and mechanisms essential for developing a cure for ALS.
Amyotrophic Lateral Sclerosis
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Author : Christine A. Murray
language : en
Publisher: Nova Publishers
Release Date : 2006
Amyotrophic Lateral Sclerosis written by Christine A. Murray and has been published by Nova Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with Amyotrophic lateral sclerosis categories.
ALS, also known as Lou Gehrig's Disease, is the most common of the motor neuron diseases that cause muscle atrophy. ALS is a chronic, progressively debilitating disease characterised by progressive muscle atrophy starting in the limbs and spreading to the rest of the body, often accompanied by overactive reflexes. It usually manifests itself after the age of 40. The exact cause of ALS is unknown and there is no cure at this time. ALS may be fatal in one year or continue for 10 or more years. This new book includes leading edge research from around the world and covers the aetiology, pathogenesis, symptoms, diagnosis, and treatment of amyotrophic lateral sclerosis (ALS).
Amyotrophic Lateral Sclerosis Als Patient And Caregiver Resource Guide
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Author :
language : en
Publisher:
Release Date : 1996
Amyotrophic Lateral Sclerosis Als Patient And Caregiver Resource Guide written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with categories.
Current Advances In Amyotrophic Lateral Sclerosis
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Author : Alvaro Estévez
language : en
Publisher: BoD – Books on Demand
Release Date : 2013-09-11
Current Advances In Amyotrophic Lateral Sclerosis written by Alvaro Estévez and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-09-11 with Medical categories.
Our understanding of the pathology of amyotrophic lateral sclerosis is a continuously changing field. New hypotheses are generated with each new discovery; they are abandoned to be reanalyzed after some time under the light of new observations. This book present a series of reviews from experts in different aspects of the disease focus on these hypotheses. There are also a few review chapters providing clear examples of these new observations that make the field to reanalyze previous conclusions.
Navigating Life With Amyotrophic Lateral Sclerosis
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Author : Mark B. Bromberg
language : en
Publisher: Oxford University Press
Release Date : 2017-04-03
Navigating Life With Amyotrophic Lateral Sclerosis written by Mark B. Bromberg and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-04-03 with Medical categories.
Navigating Life with Amyotrophic Lateral Sclerosis provides accessible, comprehensive, and up-to-date information about the challenges patients, family members, and caregivers face when confronted by ALS, a disease that affects approximately 5,600 Americans every year, with as many as 30,000 people managing the disease at any given time. ALS is a difficult disease for the patient and is also challenging for the caregiver and family as there are many questions, issues relating to care, and problems to manage. This guide covers all aspects of managing ALS, from the onset of symptoms, diagnosis, treatments, and coping strategies, to the use of home health care or hospice, and new research in the field. The book also sheds lights on difficult topics, such as end-of-life care and managing legal affairs. Navigating Life with Amyotrophic Lateral Sclerosis is unique because it covers two perspectives: one author is a neurologist with 30 years of experience treating ALS patients, and the other author experienced first-hand the issues in providing care for a parent with ALS. Formatted in a question-and-answer style, peppered throughout with patient stories, and with sections devoted to family members and caregivers, this compassionate resource provides guidance to those seeking to understand how to live with this disease.
Amyotrophic Lateral Sclerosis
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Author : V. Cosi
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-09
Amyotrophic Lateral Sclerosis written by V. Cosi and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-09 with Medical categories.
An International Conference on "Therapeutic. Psychological and Research Aspects of Amyotrophic Lateral Sclerosis" was held in Varese. Italy from the 27th to the 31st March 1985. Health care professionals. scientists. patients and their families from twenty countries around the world participated in this meeting. The objectives of the Varese conference were the following: a. To provide a forum for the proponents of the various paths of research into ALS. b. To correlate the useful therapies employed regionally. for the purpose of developing a common guide for patients, families, and supporting professionals. c. To encourage self-examination by the health care professionals into the psychological barriers imposed by a diagnosis of terminal illness for which there is no known cause or cure. Not surprisingly, there were no announcements of "breakthroughs" or "miracle cures", which are nonetheless hoped for in the confrontation of a disease such as ALS. It is fair to say, however, that Varese provided the context for a thorough review of what is known about ALS and we hope that the papers will renew some of the enthusiasm which has characterized this conference. The book contains six sections: Basic Research Aspects, Diagnostic Tools, Clinical Management, Therapeutic Trials, Psychological Aspects and the Epidemiology of ALS. Certain aspects, such as pathological studies and animal models, have not been covered; these subjects were partially treated during the informal sessions. Nevertheless, the large number of papers bears evidence to the growing interest in ALS and to the success of the Varese meeting.
Amyotrophic Lateral Sclerosis
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Author : Francesco Pagnini
language : en
Publisher: Oxford University Press
Release Date : 2018-02-22
Amyotrophic Lateral Sclerosis written by Francesco Pagnini and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-02-22 with Medical categories.
Amyotrophic lateral sclerosis: Understanding and optimizing quality of life and psychological well-being presents a comprehensive and up-to-date review of the enhancement of the lives of people with amyotrophic lateral sclerosis (ALS) and their caregivers. ALS is a progressive, fatal neurodegenerative disorder. No current medical therapy can reverse or stop its progression, and the promotion of quality of life and psychological well-being is a central component of ALS care. Health care professionals who work in this field should incorporate attention to psychological, emotional, and relational aspects of the disease into their approach to care. This book provides some of the knowledge and direction necessary for optimizing the quality of care for individuals with ALS and their caregivers. Topics discussed include an ALS-centred view of quality of life, depressive features, anxiety, resilience, cognitive impairment, complementary and alternative medicines, and psychological research.
Amyotrophic Lateral Sclerosis
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Author : Hiroshi Mitsumoto
language : en
Publisher: Contemporary Neurology
Release Date : 1998
Amyotrophic Lateral Sclerosis written by Hiroshi Mitsumoto and has been published by Contemporary Neurology this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with Medical categories.
This volume provides comprehensive background for understanding amyotrophic lateral sclerosis (ALS) and a critical review of research. It points out the distinguishing characteristics of the disease and testing procedures for reliable diagnosis.