An Innovative Approach To Understanding And Treating Cancer Targeting Ph
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An Innovative Approach To Understanding And Treating Cancer Targeting Ph
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Author : Tomas Koltai
language : en
Publisher: Academic Press
Release Date : 2020-01-16
An Innovative Approach To Understanding And Treating Cancer Targeting Ph written by Tomas Koltai and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-16 with Science categories.
An Innovative Approach to Studying and Treating Cancer: Targeting pH describes one of the few characteristics of cancer that is not shared by normal tissues: the reversal or inversion of the pH gradient when intracellular pH becomes alkaline and extracellular pH becomes acid. This is now recognized as one of the most selective and differential hallmarks of all cancer cells and tissues, being the opposite of the condition found in normal tissues and a potential target in order to achieve either a stable disease or even regression with no toxicity. The book discusses topics such as lactic acid and its transport system in the pH paradigm, mechanisms to decrease extra cellular pH and increase intracellular pH, NHE-1 activity in cancer, carbonic anhydrases, vacuolar ATPase proton pump, and the sodium-bicarbonate cotransporter system. Additionally, it discusses complementary pharmacological interventions, cellular acidification and extracellular alkalinization as a new and integral approach to cancer treatment. Analyzes the mechanisms that lead to the inversion of pH gradient in cancer tissues Summarizes almost 100 years of research on pH inversion in cancer in one single source, discussing the most relevant and updated researches in the field Proposes new efficient treatments against cancer using pH inversion mechanisms, either with new drugs like proton transport inhibitors and proton pump inhibitors (PTIs and PPIs) or with repurposed drugs
Ph Deregulation As The Eleventh Hallmark Of Cancer
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Author : Tomas Koltai
language : en
Publisher: Elsevier
Release Date : 2023-07-03
Ph Deregulation As The Eleventh Hallmark Of Cancer written by Tomas Koltai and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-07-03 with Computers categories.
pH Deregulation as the Eleventh Hallmark of Cancer presents key concepts about pH deregulation in a concise and straight-forward manner. The book discusses topics such as pH regulation and metabolism, sodium hydrogen exchanger, monocarboxylate transporter, V-ATPase proton pump, carbonic anhydrases, and voltage gated sodium channels. In addition, it covers clinical and therapeutic implications and future perspectives. This is a valuable resource for researchers, oncologists, students and members of the biomedical and medical fields who want to learn more about the role of pH deregulation in cancer treatment. pH deregulation can improve the outcome of classical treatments without adding toxicity to them, and the book shows that treating the pH peculiarities of cancer is simple and can be performed with existing drugs. Based on the classification of tumor malignancy in ten hallmarks, the authors put pH deregulation at the spotlight and separated from metabolic reprogramming due to its impact on all other hallmarks, proposing it as an additional characteristic to evaluate and fight cancer. Proposes that pH deregulation should be considered as an independent hallmark of cancer from metabolic reprogramming due to its impact on all other hallmarks (based on seminal work of Hanahan and Weinberg) Explains basic issues of cancer pH deregulation and its consequences in a simple and concise manner Discusses the subject from the start with very elementary concepts on pH and pH regulation to help readers understand key concepts without proper background Presents key concepts through original illustrations and table for easy comprehension
Prostate Cancer Metabolism
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Author : Tomas Koltai
language : en
Publisher: Academic Press
Release Date : 2021-06-25
Prostate Cancer Metabolism written by Tomas Koltai and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-06-25 with Science categories.
Prostate Cancer Metabolism: From Biochemistry to Therapeutics shows the peculiarities of prostate cancer metabolism, emphasizing the targetable aspects – that have not been considered in conventional treatment protocols. The book specifically addresses treatment of the castration-resistant stage of prostate cancer proposing many repurposed drugs and nutraceuticals to complement, not replace, standard therapies. The large body of evidence supporting these concepts makes them deserving of further research and well-designed clinical trials. It discusses lipid, cholesterol, glutamine, and glucose metabolisms and their impact on prostate cancer. Additionally, it explains how current established drugs can be repurposed to improve treatment outcomes. The concepts set out in the book, that deal with cancer at the cellular/molecular level, help identify new avenues of research and treatments to pursue that do not affect well-being whilst offer consistent benefits. Since most practicing physicians have not studied basic biochemistry since medical school, each chapter begins with a brief review of the topic to facilitate an understanding of the metabolically-oriented approach to targeting prostate cancer. Conventional treatments are not discussed here since they are covered in textbooks and specialized updates that abound in the medical literature. It is a valuable resource for cancer researchers, oncologists, clinicians and members of biomedical field who want to learn more about prostate cancer metabolism and how to apply recent findings in the field to bedside. Explains the basic aspects of prostate cancer metabolism, including its biochemistry which has a pivotal role in clinical practice Discusses new drugs and nutraceuticals with a metabolism-centered approach Offers practical bedside approach in combination with molecular and biochemical fundamentals to help readers identify and provide the best treatment to their patients
Advanced Drug Delivery Systems In The Management Of Cancer
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Author : Kamal Dua
language : en
Publisher: Elsevier
Release Date : 2021-06-24
Advanced Drug Delivery Systems In The Management Of Cancer written by Kamal Dua and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-06-24 with Business & Economics categories.
Advanced Drug Delivery Systems in the Management of Cancer discusses recent developments in nanomedicine and nano-based drug delivery systems used in the treatment of cancers affecting the blood, lungs, brain, and kidneys. The research presented in this book includes international collaborations in the area of novel drug delivery for the treatment of cancer. Cancer therapy remains one of the greatest challenges in modern medicine, as successful treatment requires the elimination of malignant cells that are closely related to normal cells within the body. Advanced drug delivery systems are carriers for a wide range of pharmacotherapies used in many applications, including cancer treatment. The use of such carrier systems in cancer treatment is growing rapidly as they help overcome the limitations associated with conventional drug delivery systems. Some of the conventional limitations that these advanced drug delivery systems help overcome include nonspecific targeting, systemic toxicity, poor oral bioavailability, reduced efficacy, and low therapeutic index. This book begins with a brief introduction to cancer biology. This is followed by an overview of the current landscape in pharmacotherapy for the cancer management. The need for advanced drug delivery systems in oncology and cancer treatment is established, and the systems that can be used for several specific cancers are discussed. Several chapters of the book are devoted to discussing the latest technologies and advances in nanotechnology. These include practical solutions on how to design a more effective nanocarrier for the drugs used in cancer therapeutics. Each chapter is written with the goal of informing readers about the latest advancements in drug delivery system technologies while reinforcing understanding through various detailed tables, figures, and illustrations. Advanced Drug Delivery Systems in the Management of Cancer is a valuable resource for anyone working in the fields of cancer biology and drug delivery, whether in academia, research, or industry. The book will be especially useful for researchers in drug formulation and drug delivery as well as for biological and translational researchers working in the field of cancer. Presents an overview of the recent perspectives and challenges within the management and diagnosis of cancer Provides insights into how advanced drug delivery systems can effectively be used in the management of a wide range of cancers Includes up-to-date information on diagnostic methods and treatment strategies using controlled drug delivery systems
Cuproptosis And Tumor
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Author : Lin-Lin Bu
language : en
Publisher: Frontiers Media SA
Release Date : 2023-12-18
Cuproptosis And Tumor written by Lin-Lin Bu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-12-18 with Science categories.
Cuproptosis is a new type of cell death induced by copper that differs from other types of programmed cell death. Copper ions were discovered to bind to lipoacyl proteins during the tricarboxylic acid (TCA) cycle, resulting in abnormal lipoacyl protein oligomerization. Moreover, copper ions can also reduce the level of iron-sulfur cluster proteins, thereby causing the toxic stress response in proteins and ultimately leading to cell death. So far, cuproptosis‘s role in tumors, as well as the underlying mechanisms, are still unclear and require further investigation. Recent research suggests that inducing programmed death of abnormal cells could be one of the future methods for disease treatment and prevention. It can slow the progression of the disease and, eventually, cure it by causing tumor cell cuproptosis. Currently, the drug delivery system has received a lot of attention. It is also a novel idea to treat tumors by developing a drug delivery system to induce abnormal cell cuproptosis, which will effectively reduce treatment complications and improve patients’ life quality.
Antiangiogenic Drugs As Chemosensitizers In Cancer Therapy
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Author :
language : en
Publisher: Academic Press
Release Date : 2022-01-14
Antiangiogenic Drugs As Chemosensitizers In Cancer Therapy written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-14 with Science categories.
Anti-angiogenic Drugs as Chemosensitizers in Cancer Therapy, Volume 19 focuses on the use of anti-angiogenic drugs as sensitizers of tumor cells to the inhibitory activity of antitumor agents. Conventional and novel anti-neoplastic agents (cytotoxic molecules, hormones/antihormones, immunotherapies) are taken into consideration, along with advances made in combination therapies. The book encompasses examples of studies on the use of antiangiogenic compounds—molecules that inhibit the growth of vessels inside a tumor—together with antineoplastic drugs in order to sensitize the resistant tumor to their cytotoxic effects, thus reducing adverse side reactions and resistance and improving the therapeutic response of cancer patients. In addition, the book discusses clinical applications in various types of cancer, such as colorectal, lung, breast, renal, genitourinary, skin and brain and circulating tumors. It is a valuable resource for cancer researchers, clinicians and members of the biomedical field who wants to be up-to-date on the most recent and promising developments in the field. Provides the most updated reviews on anti-angiogenic drugs as chemosensitizers by leaders in the field Encompasses summarized tables and schematic diagrams in each chapter to give a clear overview on recent findings in a didactic manner Brings not only relevant information of current research but also new ideas and suggestions for further investigations to help advance the field
Life Over Cancer
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Author : Keith Block
language : en
Publisher: Bantam
Release Date : 2009-04-21
Life Over Cancer written by Keith Block and has been published by Bantam this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-04-21 with Health & Fitness categories.
Dr. Keith Block is at the global vanguard of innovative cancer care. As medical director of the Block Center for Integrative Cancer Treatment in Evanston, Illinois, he has treated thousands of patients who have lived long, full lives beyond their original prognoses. Now he has distilled almost thirty years of experience into the first book that gives patients a systematic, research-based plan for developing the physical and emotional vitality they need to meet the demands of treatment and recovery. Based on a profound understanding of how body and mind can work together to defeat disease, this groundbreaking book offers: • Innovative approaches to conventional treatments, such as “chronotherapy”–chemotherapy timed to patients’ unique circadian rhythms for enhanced effectiveness and reduced toxicity • Dietary choices that make the biochemical environment hostile to cancer growth and recurrence, and strengthen the immune system’s ability to attack remaining cancer cells • Precise supplement protocols to tame treatment side effects, relieve disease-related symptoms, and modify processes like inflammation and glycemia that can fuel cancer if left untreated • A new paradigm for exercise and stress reduction that restores your strength, reduces anxiety and depression, and supports the body’s own ability to heal • A complete program for remission maintenance–a proactive plan to make sure the cancer never returns Also included are “quick-start” maps to help you find the information you need right now and many case histories that will support and inspire you. Encouraging, compassionate, and authoritative, Life over Cancer is the guide patients everywhere have been waiting for.
Targeted Radionuclide Therapy
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Author : Tod W. Speer
language : en
Publisher: Lippincott Williams & Wilkins
Release Date : 2012-03-28
Targeted Radionuclide Therapy written by Tod W. Speer and has been published by Lippincott Williams & Wilkins this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-03-28 with Medical categories.
Radioimmunotherapy, also known as systemic targeted radiation therapy, uses antibodies, antibody fragments, or compounds as carriers to guide radiation to the targets. It is a topic rapidly increasing in importance and success in treatment of cancer patients. This book represents a comprehensive amalgamation of the radiation physics, chemistry, radiobiology, tumor models, and clinical data for targeted radionuclide therapy. It outlines the current challenges and provides a glimpse at future directions. With significant advances in cell biology and molecular engineering, many targeting constructs are now available that will safely deliver these highly cytotoxic radionuclides in a targeted fashion. A companion website includes the full text and an image bank.
Theory At A Glance
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Author : Karen Glanz
language : en
Publisher:
Release Date : 1997
Theory At A Glance written by Karen Glanz and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with Health behavior categories.
Theranostic Approach For Pancreatic Cancer
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Author : Ganji Purnachandra Nagaraju
language : en
Publisher: Academic Press
Release Date : 2020-01-15
Theranostic Approach For Pancreatic Cancer written by Ganji Purnachandra Nagaraju and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-15 with categories.
Theranostic Approach for Pancreatic Cancer modulates the biologic properties of stroma in pancreatic cancer by targeting the several chemotherapy resistance mechanisms to impede their malignant property through introducing new strategies and drugs for tackling the disease. It brings information about ongoing research as well as clinical data about pancreatic cancer and provides detailed descriptions about diagnostic and therapeutic options for easy understanding. This book discusses several topics related to pancreatic cancer such as stem cells, drug resistance and pancreatic tumor microenvironment, the latest developments in chemotherapy for metastatic cancer and chemoprevention, and epigenome as a therapeutic strategy. Additionally, it encompasses a discussion on theranostic clinical applications for personalized treatment and management of pancreatic cancer. The book is a valuable resource for cancer researchers, oncologists, and several members of the biomedical field who need to understand more about the diagnosis and treatment of pancreatic cancer. Provides information on the roadblocks of chemotherapy in patients with newly diagnosed and metastatic pancreatic cancer Discusses treatment options available currently as well as prospective options for the future Focuses especially on stroma, tumor microenvironment, stem cells, stellate cells, transcription factors, growth factors, and important signaling pathways as already tested types of treatment