An Innovative Approach To Understanding And Treating Cancer Targeting Ph
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An Innovative Approach To Understanding And Treating Cancer Targeting Ph
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Author : Tomas Koltai
language : en
Publisher: Academic Press
Release Date : 2020-01-16
An Innovative Approach To Understanding And Treating Cancer Targeting Ph written by Tomas Koltai and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-16 with Science categories.
An Innovative Approach to Studying and Treating Cancer: Targeting pH describes one of the few characteristics of cancer that is not shared by normal tissues: the reversal or inversion of the pH gradient when intracellular pH becomes alkaline and extracellular pH becomes acid. This is now recognized as one of the most selective and differential hallmarks of all cancer cells and tissues, being the opposite of the condition found in normal tissues and a potential target in order to achieve either a stable disease or even regression with no toxicity. The book discusses topics such as lactic acid and its transport system in the pH paradigm, mechanisms to decrease extra cellular pH and increase intracellular pH, NHE-1 activity in cancer, carbonic anhydrases, vacuolar ATPase proton pump, and the sodium-bicarbonate cotransporter system. Additionally, it discusses complementary pharmacological interventions, cellular acidification and extracellular alkalinization as a new and integral approach to cancer treatment. - Analyzes the mechanisms that lead to the inversion of pH gradient in cancer tissues - Summarizes almost 100 years of research on pH inversion in cancer in one single source, discussing the most relevant and updated researches in the field - Proposes new efficient treatments against cancer using pH inversion mechanisms, either with new drugs like proton transport inhibitors and proton pump inhibitors (PTIs and PPIs) or with repurposed drugs
Ph Deregulation As The Eleventh Hallmark Of Cancer
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Author : Tomas Koltai
language : en
Publisher: Elsevier
Release Date : 2023-07-03
Ph Deregulation As The Eleventh Hallmark Of Cancer written by Tomas Koltai and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-07-03 with Computers categories.
pH Deregulation as the Eleventh Hallmark of Cancer presents key concepts about pH deregulation in a concise and straight-forward manner. The book discusses topics such as pH regulation and metabolism, sodium hydrogen exchanger, monocarboxylate transporter, V-ATPase proton pump, carbonic anhydrases, and voltage gated sodium channels. In addition, it covers clinical and therapeutic implications and future perspectives. This is a valuable resource for researchers, oncologists, students and members of the biomedical and medical fields who want to learn more about the role of pH deregulation in cancer treatment. pH deregulation can improve the outcome of classical treatments without adding toxicity to them, and the book shows that treating the pH peculiarities of cancer is simple and can be performed with existing drugs. Based on the classification of tumor malignancy in ten hallmarks, the authors put pH deregulation at the spotlight and separated from metabolic reprogramming due to its impact on all other hallmarks, proposing it as an additional characteristic to evaluate and fight cancer. - Proposes that pH deregulation should be considered as an independent hallmark of cancer from metabolic reprogramming due to its impact on all other hallmarks (based on seminal work of Hanahan and Weinberg) - Explains basic issues of cancer pH deregulation and its consequences in a simple and concise manner - Discusses the subject from the start with very elementary concepts on pH and pH regulation to help readers understand key concepts without proper background - Presents key concepts through original illustrations and table for easy comprehension
Cuproptosis And Tumor
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Author : Lin-Lin Bu
language : en
Publisher: Frontiers Media SA
Release Date : 2023-12-18
Cuproptosis And Tumor written by Lin-Lin Bu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-12-18 with Science categories.
Cuproptosis is a new type of cell death induced by copper that differs from other types of programmed cell death. Copper ions were discovered to bind to lipoacyl proteins during the tricarboxylic acid (TCA) cycle, resulting in abnormal lipoacyl protein oligomerization. Moreover, copper ions can also reduce the level of iron-sulfur cluster proteins, thereby causing the toxic stress response in proteins and ultimately leading to cell death. So far, cuproptosis‘s role in tumors, as well as the underlying mechanisms, are still unclear and require further investigation. Recent research suggests that inducing programmed death of abnormal cells could be one of the future methods for disease treatment and prevention. It can slow the progression of the disease and, eventually, cure it by causing tumor cell cuproptosis. Currently, the drug delivery system has received a lot of attention. It is also a novel idea to treat tumors by developing a drug delivery system to induce abnormal cell cuproptosis, which will effectively reduce treatment complications and improve patients’ life quality.
Functional Materials From Lipids And Proteins
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Author : Nandika Bandara
language : en
Publisher: Royal Society of Chemistry
Release Date : 2024-08-23
Functional Materials From Lipids And Proteins written by Nandika Bandara and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-08-23 with Technology & Engineering categories.
In recent years, the use of renewable raw materials and natural biopolymers has increased significantly to overcome the issues associated with environmental pollution and dwindling fossil fuel resources. Lipids and proteins are inexpensive, renewable raw materials, which are considered ideal feedstock for the development of a variety of functional materials. This book provides an international viewpoint on recent developments in the utilisation of lipids and proteins together, for the development of functional materials in food engineering, environmental and industry applications. This book presents the cutting-edge research in the utilization of lipids and proteins in food, cosmetics, therapeutics, food packaging, water remediation, biofuels, lubricants, biomaterials, and composite preparations. Researchers, scientists, engineers and students working on lipids and proteins derived materials will benefit from this book, which is highly application oriented. Focusing on the latest developments in the field, this will be the first book to describe lipids and proteins together, allowing it to act as a single reference for researchers working in this area.
Antiangiogenic Drugs As Chemosensitizers In Cancer Therapy
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Author :
language : en
Publisher: Academic Press
Release Date : 2022-01-14
Antiangiogenic Drugs As Chemosensitizers In Cancer Therapy written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-14 with Science categories.
Anti-angiogenic Drugs as Chemosensitizers in Cancer Therapy, Volume 19 focuses on the use of anti-angiogenic drugs as sensitizers of tumor cells to the inhibitory activity of antitumor agents. Conventional and novel anti-neoplastic agents (cytotoxic molecules, hormones/antihormones, immunotherapies) are taken into consideration, along with advances made in combination therapies. The book encompasses examples of studies on the use of antiangiogenic compounds—molecules that inhibit the growth of vessels inside a tumor—together with antineoplastic drugs in order to sensitize the resistant tumor to their cytotoxic effects, thus reducing adverse side reactions and resistance and improving the therapeutic response of cancer patients. In addition, the book discusses clinical applications in various types of cancer, such as colorectal, lung, breast, renal, genitourinary, skin and brain and circulating tumors. It is a valuable resource for cancer researchers, clinicians and members of the biomedical field who wants to be up-to-date on the most recent and promising developments in the field. - Provides the most updated reviews on anti-angiogenic drugs as chemosensitizers by leaders in the field - Encompasses summarized tables and schematic diagrams in each chapter to give a clear overview on recent findings in a didactic manner - Brings not only relevant information of current research but also new ideas and suggestions for further investigations to help advance the field
Prostate Cancer Metabolism
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Author : Tomas Koltai
language : en
Publisher: Academic Press
Release Date : 2021-06-25
Prostate Cancer Metabolism written by Tomas Koltai and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-06-25 with Science categories.
Prostate Cancer Metabolism: From Biochemistry to Therapeutics shows the peculiarities of prostate cancer metabolism, emphasizing the targetable aspects – that have not been considered in conventional treatment protocols. The book specifically addresses treatment of the castration-resistant stage of prostate cancer proposing many repurposed drugs and nutraceuticals to complement, not replace, standard therapies. The large body of evidence supporting these concepts makes them deserving of further research and well-designed clinical trials. It discusses lipid, cholesterol, glutamine, and glucose metabolisms and their impact on prostate cancer. Additionally, it explains how current established drugs can be repurposed to improve treatment outcomes. The concepts set out in the book, that deal with cancer at the cellular/molecular level, help identify new avenues of research and treatments to pursue that do not affect well-being whilst offer consistent benefits. Since most practicing physicians have not studied basic biochemistry since medical school, each chapter begins with a brief review of the topic to facilitate an understanding of the metabolically-oriented approach to targeting prostate cancer. Conventional treatments are not discussed here since they are covered in textbooks and specialized updates that abound in the medical literature. It is a valuable resource for cancer researchers, oncologists, clinicians and members of biomedical field who want to learn more about prostate cancer metabolism and how to apply recent findings in the field to bedside. - Explains the basic aspects of prostate cancer metabolism, including its biochemistry which has a pivotal role in clinical practice - Discusses new drugs and nutraceuticals with a metabolism-centered approach - Offers practical bedside approach in combination with molecular and biochemical fundamentals to help readers identify and provide the best treatment to their patients
Gold Nanoparticles Nanomaterials And Nanocomposites
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Author : S. K. Khadheer Pasha
language : en
Publisher: Elsevier
Release Date : 2024-11-30
Gold Nanoparticles Nanomaterials And Nanocomposites written by S. K. Khadheer Pasha and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-11-30 with Technology & Engineering categories.
Gold Nanoparticles, Nanomaterials and Nanocomposites: Science, Technology and Applications provides a comprehensive review of recent research developments in the synthesis, processing, functionalization, characterization, and properties of gold nanoparticles (Au NPs) for a broad range of different applications. Emphasis is placed on the fundamental chemistry, different synthesis approaches, strategies for stabilization and control of shape size and morphology, surface chemistry and physicochemical characteristics, as well as surface functionalization and applications of Au NPs. The book also covers important topics such as biocompatibility, biodegradability, cytotoxicity and the health and environmental impact of Au NPs. The book will be a valuable reference resource for academic and industrial researchers working in the fields of materials science and engineering, nanomaterials, polymer composites, and biomedical engineering. It will help them to find solutions to both fundamental and applied problems associated with this important research field and it will also enable new researchers to become acquainted with this field within a short period. - Covers current and emerging research trends in the synthesis, processing, functionalization, characterization, and performance of gold nanoparticles (Au NPs) - Includes comprehensive coverage of a broad range of applications such as sensing and biosensing, electronic devices, electro and photocatalysis, solar cells, supercapacitors, point of care diagnostic tools and devices, drug delivery and controlled drug release, antimicrobial, antifungal and antiviral applications, cancer diagnostics and therapy, tissue engineering, bioimaging, as well as for bioremediation and pharmaceutical applications - Contains contributions from leading researchers across the globe from academic, industrial, government, and private research institutions
Innovative Approaches To Overcome Resistance And Toxicities Of Anti Cancer Drugs
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Author : Awanish Mishra
language : en
Publisher: Frontiers Media SA
Release Date : 2025-08-18
Innovative Approaches To Overcome Resistance And Toxicities Of Anti Cancer Drugs written by Awanish Mishra and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-08-18 with Science categories.
Although diagnosis and treatment of various cancer types have made significant strides recently, drug resistance is a major challenge faced in the cancer clinic. Cancer cells evolve continuously through a combination of genetic mutations, epigenetic changes, support from cellular and acellular tumour microenvironment. The chemoresistant tumour cells expand and become the dominant population and, at this point, it becomes difficult to treat. The cancer cell heterogeneity is also a major contributing factor to chemoresistance. The other challenge faced is the development of adverse events due to drug toxicity which is overwhelming especially for immunocompromised patients. Collectively, these factors reduce the treatment response and overall survival. Current neoadjuvant chemotherapy (NACT) and targeted therapies aim at drug efficacy with minimal toxicity along with employment of adjuvant immunotherapy. Potential exploits include novel drug delivery platforms such as antibody-drug conjugates, combination therapies that target addicted signalling pathways, transcription factors, utilization of long noncoding RNAs including siRNA and miRNA using nanocarriers, reprogramming the tumour immune microenvironment (TIME), employment of in silico approaches from docking drug-like molecules to crystal structures of novel targets, bioinformatics, and machine learning approaches. These approaches hold immense potential to enhance cancer therapeutics while minimizing toxicities. These strategies aim to amplify therapy impact while minimizing toxicity leading to better patient outcome. This research topic welcomes data and review articles on the following sub-topics but are not limited to: 1. Novel molecular targets, targeting of signalling pathways, transcription, and epigenetic factors, proteomic, metabolomic and single-cell analyses of therapy-naïve and chemoresistant tumour cell populations. 2. Role of non-coding RNAs and microRNAs in chemoresistance. 3. Advancements in tumour immune microenvironment (TIME) and therapies taking advantage of reprogramming the TIME. 3. Novel synthetic and natural-derived compounds for targeted therapy to improve anti-cancer efficacy, overcoming resistance and minimizing toxicities. 4. Cancer stem or stem-like cells in creation of minimal residual disease and induction of drug resistance, cancer stemness factors that induce and orchestrate chemoresistance. 5. Bioinformatics, in silico studies and machine learning in design for the study of novel molecules to enhance efficacy and overcome resistance to anticancer drugs and toxicities. In silico results should be validated through the exploitation of experimental methodologies.
Innovative Approaches For Nanobiotechnology In Healthcare Systems
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Author : Amna, Touseef
language : en
Publisher: IGI Global
Release Date : 2021-09-17
Innovative Approaches For Nanobiotechnology In Healthcare Systems written by Amna, Touseef and has been published by IGI Global this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-09-17 with Technology & Engineering categories.
Innovative and fusion technologies have shown an incredible ability to improve various aspects of society, such as healthcare systems. Nanobiotechnology is one such technology that is being applied to medical equipment and treatment approaches. Many pharmaceutical and medical companies have begun to count on medical nanotechnology due to its abundant applications and practical uses. Innovative Approaches for Nanobiotechnology in Healthcare Systems is a pivotal reference source that provides insights into a comprehensive collection of novel techniques used for the development of safe drugs using the available resources for diverse deadly diseases. This book discusses the various platforms of nanobiotechnology that are utilized in various fields. It is expected that bionanosytems will play a crucial role in the treatment of human diseases and the improvement of existing healthcare systems. This book is ideal for scientists, biotechnologists, microbiologists, medical professionals, entrepreneurs, policymakers, researchers, academicians, and students.
Oncogenic Pi3kt Akt Mtor Pathway Alterations Ros Homeostasis Targeted Cancer Therapy And Drug Resistance
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Author : Rozangela Curi Pedrosa
language : en
Publisher: Frontiers Media SA
Release Date : 2025-01-22
Oncogenic Pi3kt Akt Mtor Pathway Alterations Ros Homeostasis Targeted Cancer Therapy And Drug Resistance written by Rozangela Curi Pedrosa and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-01-22 with Medical categories.
The phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway is an important signaling route that regulates several cell functions. PI3K/AKT/mTOR pathway is a crossroad of cell death and survival, playing a pivotal role in multiple interconnected cell signaling mechanisms implicated in cell metabolism, growth and proliferation, apoptosis, and angiogenesis. Disruptions in the Akt‑regulated pathways and alterations in PTEN expression are associated to Reactive oxygen species (ROS) homeostasis and different types of cancer. Genomic studies have shown that activating mutations in oncogenes as well as inactivating mutations in tumor suppressor genes are present across a variety of malignancies, including constitutive activation of the PI3K/AKT/mTOR pathway. The regulation of the Akt signaling pathway renders multiple challenges and valuable therapeutic targets. The discovery process of Akt, PDK1 and mTOR synthetic and natural products as inhibitors or immune checkpoint inhibitors using various strategies, could led to the identification of small molecule inhibitors with great selectivity, low side‑effects and also low toxicity regarding drug development.