An Introduction To Toxicogenomics
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An Introduction To Toxicogenomics
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Author : Michael E. Burczynski
language : en
Publisher: CRC Press
Release Date : 2003-03-26
An Introduction To Toxicogenomics written by Michael E. Burczynski and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-03-26 with Medical categories.
Since the advent of cDNA microarrays, oligonucleotide array technology, and gene chip analysis, genomics has revolutionized the entire field of biomedical research. A byproduct of this revolution, toxicogenomics is a fast-rising star within toxicological analysis. Gathering together leading authors and scientists at the forefront of the field, An Introduction to Toxicogenomics provides a comprehensive overview of this new discipline. With a focus on toxicology, it introduces the basic principles of microarray/oligonucleotide array-based genomic analysis and explains how it fits into the field of biomedical research. These discussions provide an overview to the actual mechanics of the analyses themselves and offer insights on handling and quality control. Then the book features an important section on the basics of data analysis and clustering methods such as genetic algorithms. Finally, it covers the application of expression profiling in the field of toxicology and addresses the two fundamental types of analysis in detail, with sections dedicated to both mechanistic and predictive studies. Although toxicogenomics promises fast, efficient techniques and information-rich data, much of its potential remains untapped. An Introduction to Toxicogenomics consolidates the concepts underlying the field to provide a solid foundation from which to begin your research endeavors.
Applications Of Toxicogenomics In Safety Evaluation And Risk Assessment
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Author : Darrell R. Boverhof
language : en
Publisher: John Wiley & Sons
Release Date : 2011-10-11
Applications Of Toxicogenomics In Safety Evaluation And Risk Assessment written by Darrell R. Boverhof and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-10-11 with Science categories.
This book provides a timely overview of toxicogenomics, with special emphasis on the practical applications of this technology to the risk assessment process. Introductory sections are followed by a series of chapters highlighting practical and systematic applications of toxicogenomics in informing the risk assessment process – including the areas of mutagenicity, carcinogenicity, endocrine toxicity, organ-specific toxicity, population monitoring, and ecotoxicology. The book concludes with approaches for the integration of this technology in safety evaluation studies, and an outlook on how toxicogenomics and complementary technologies can reframe the current risk assessment paradigm.
Toxicogenomics
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Author : Hisham K. Hamadeh
language : en
Publisher: John Wiley & Sons
Release Date : 2004-09-06
Toxicogenomics written by Hisham K. Hamadeh and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-09-06 with Science categories.
Toxicogenomics: Principles and Applications fills the need for a single, thorough text on the key breakthrough technologies in genomics, proteomics, metabolomics, and bioinformatics, and their applications to toxicology research. The first section following a general introduction is on genomics and toxicogenomics, and qPCR. The next sections are toxicoproteomics and metabolomics. The final section covers bioinformatics aspects, from databases to data integration strategies. A practical resource for specialists and non-specialists alike, this book includes numerous illustrations that support the textual explanations. It offers practical guidance to investigators wishing to pursue this line of research, and lists key relevant software and Internet resources.
Handbook Of Toxicogenomics
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Author : Jürgen Borlak
language : en
Publisher: John Wiley & Sons
Release Date : 2006-03-06
Handbook Of Toxicogenomics written by Jürgen Borlak and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-03-06 with Science categories.
Toxicogenomics is a new, dynamic and very promising field that can help optimize toxicity analyses and streamline research into active substances. It is of interest not only for basic research and development, but also from a legal and ethical perspective. Here, experts from all the fields mentioned will find solid information provided by an international team of experienced authors. With its approach as an interdisciplinary overview, it will prove particularly useful for all those needing to develop appropriate research strategies. The authors work for major research institutions, such as the Fraunhofer Institute of Toxicology and Experimental Medicine (Germany), the German Cancer Research Center, the National Institute of Environmental Health Science (USA), the National Institute of Health Science (Japan) or for companies like Affymetrix, Altana Pharma, Bayer, Boehringer Ingelheim, Bruker, Merck, Nimblegen, Novartis, and Syngenta. Coverage ranges from the technology platforms applied, including DNA arrays or proteomics, via the bioinformatics tools required, right up to applications of toxicogenomics presented in numerous case studies, while also including an overview of national programs and initiatives as well as regulatory perspectives. Walter Rosenthal, Director of the Research Institute for Molecular Pharmacology in Berlin, praises the book thus: "I would like to congratulate the publishers of this handbook, one that deals with a extremely hot topic. They have succeeded in gaining as authors leading representatives from this field. The Handbook impressively shows how modern genomic research is leading to rapid advances and new insights within toxicology."
Toxicogenomics
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Author : Mohamed A. Selmy
language : en
Publisher: Delve Publishing
Release Date : 2017-11
Toxicogenomics written by Mohamed A. Selmy and has been published by Delve Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-11 with Bioinformatics categories.
Toxicological research targets the identification of risk factors that trigger harmful effects as a result of exposure, which may leads to acute illnesses, chronic disease or even immediate death. It is clear that exposing people intentionally to chemicals is limited both scientifically and ethically. Therefore, the assessment of chemical safety is predominantly based on animal testing as a substitute to study toxic effects of environmental chemicals in humans. A broad range of animal models have been developed to test different types and levels of toxicity, comprising tests for immunotoxicty, carcinogenicity and reproduction toxicity. In this regard, regulations and policies have been adopted to enhance the protection of human health and the environment from the risks that may develop through chemical exposures. One of the consequences of this regulation is an enormous increase in the number of laboratory animals needed to perform such safety evaluations. With this increase, regulations have been developed with regard to the ethical acceptability of such tests, leading to a demand for a development of animal free alternatives.In relation, the completion of the human genome project and sequencing of the genomes of many other organisms have opened new tracks in the biological area. Analysis of gene expression and proteomics have made it mandatory to combine mathematics, biology and information technology in one bioinformatics framework, which has been a growing field in recent years.Applying this technology to toxicology, known as toxicogenomics, has provided new potentials to the field, including compound screening for hazards, dose-response assessment, prediction of sensitivity to toxic agent and assessment of cellular response to different agents. However, despite the potential capability of the combination of genomic technologies with toxicology to improve risk assessment and the predictive capabilities, still many challenge ahead of the growing field. This book sheds light on the tools, benefits and applications of this newly developed field. In addition, an emphasis will be put on toxicogenomic databases and how they have improved throughout the last decade. This book discusses: an introduction to toxicogenomics in Chapter 1 followed by an illustration of the technologies encompassed in toxicogenomics as described in Chapter 2. This is followed by a description of study design and data analysis in Chapter 3. Chapter 4 discusses the current databases of toxicogenomics in terms of organization, methods of analysis and pitfalls. Chapter 5 discusses the common applications of toxicogenomic technologies. Chapter 6 addresses ethical considerations in the implementation of toxicogenomics and finally chapter 7 discusses the future directions of toxicogenomics.
Genomic Biomarkers For Pharmaceutical Development
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Author : Yuping Wang
language : en
Publisher: Elsevier Inc. Chapters
Release Date : 2013-07-16
Genomic Biomarkers For Pharmaceutical Development written by Yuping Wang and has been published by Elsevier Inc. Chapters this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-07-16 with Medical categories.
Although we have seen increased spending on drug research and development, the submission of new drug applications to the US Food and Drug Administration (FDA) has steadily decreased over the past 15 years. Meanwhile, toxicology is celebrating the ten-year anniversary of the introduction of toxicogenomics, a field that was anticipated to change our way of conducting toxicology with enhanced safety assessment. Despite the excitement, and a decade of further technical advancement, the anticipated benefits have been slow to reach the clinical bedside. The failure to translate toxicogenomics to drug development faster, illustrates the need for further innovations in its methodology as well as in its technology. This review introduces the concept of toxicogenomics, summarizes the prominent applications of this relatively young discipline in drug development, and provides a future perspective of advancement in this field.
Toxicogenomics
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Author : Hamadeh
language : en
Publisher:
Release Date : 2004
Toxicogenomics written by Hamadeh and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with categories.
Toxicogenomics: Principles and Applications fills the need for a single, thorough text on the key breakthrough technologies in genomics, proteomics, metabolomics, and bioinformatics, and their applications to toxicology research. The first section following a general introduction is on genomics and toxicogenomics, and qPCR. The next sections are toxicoproteomics and metabolomics. The final section covers bioinformatics aspects, from databases to data integration strategies.; A practical resource for specialists and non-specialists alike, this book includes numerous illustrations that support t.
Toxicogenomics
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Author : Saura C. Sahu
language : en
Publisher: John Wiley & Sons
Release Date : 2008-11-20
Toxicogenomics written by Saura C. Sahu and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-11-20 with Science categories.
Toxicogenomics is the integration of genomics to toxicology. This technology is a powerful tool for collecting information from a large number of biological samples simultaneously and thus it is very useful for large-scale screening of potential toxicants. Toxicogenomics: A Powerful Tool For Toxicity Assessment provides up-to-date state-of-the-art information presented by the recognized experts, and is therefore an authoritative source of current knowledge in this field of research. The potential link between toxicology, genetics and human diseases makes this book very useful to investigators in many and varied disciplines of science and toxicology. Topics covered include: mechanistic toxicogenomics analysis and interpretation of toxicogenomic data principles of data mining in toxicogenomics design issues in toxicogenomics studies sources of variability in toxicogenomic assays Escherichia coli stress response as a tool for detection of toxicity toxicogenomics as a tool to assess immunotoxicity toxicogenomics and ecogenomics for studying endocrine disruption and basic biology use of toxicogenomics as an early predictive tool for hepatotoxicity nutrigenomics: the application of genomic signatures in nutrition-related research application of toxicogenomics in drug discovery potential uses of toxicogenomic biomarkers in occupational health and risk assessment usefulness of toxicogenomics in the regulatory environment perspectives on toxicogenomics at the US Environmental Protection Agency Toxicogenomics: A Powerful Tool For Toxicity Assessment is an essential resource for research scientists currently engaged in toxicogenomics, and will also be of interest to researchers working in toxicology, genetics, medicine, pharmacology, and food sciences, and to regulators and risk assessors of drug, food, environmental and agricultural products.
Application Of Toxicogenomics To Cross Species Extrapolation
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Author : National Research Council
language : en
Publisher: National Academies Press
Release Date : 2006-04-24
Application Of Toxicogenomics To Cross Species Extrapolation written by National Research Council and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-04-24 with Science categories.
Some of what we know about the health effects of exposure to chemicals from food, drugs, and the environment come from studies of occupational, inadvertent, or accident-related exposures. When there is not enough human data, scientists rely on animal data to assess risk from chemical exposure and make health and safety decisions. However, humans and animals can respond differently to chemicals, including the types of adverse effects experienced and the dosages at which they occur. Scientists in the field of toxicogenomics are using new technologies to study the effects of chemicals. For example, in response to a particular chemical exposure, they can study gene expression ("transcriptomics"), proteins ("proteomics") and metabolites ("metabolomics"), and they can also look at how individual and species differences in the underlying DNA sequence itself can result in different responses to the environment. Based on a workshop held in August 2004, this report explores how toxicogenomics could enhance scientists' ability to make connections between data from experimental animal studies and human health.
Applications Of Toxicogenomic Technologies To Predictive Toxicology And Risk Assessment
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Author : National Research Council
language : en
Publisher: National Academies Press
Release Date : 2007-11-19
Applications Of Toxicogenomic Technologies To Predictive Toxicology And Risk Assessment written by National Research Council and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-11-19 with Science categories.
The new field of toxicogenomics presents a potentially powerful set of tools to better understand the health effects of exposures to toxicants in the environment. At the request of the National Institute of Environmental Health Sciences, the National Research Council assembled a committee to identify the benefits of toxicogenomics, the challenges to achieving them, and potential approaches to overcoming such challenges. The report concludes that realizing the potential of toxicogenomics to improve public health decisions will require a concerted effort to generate data, make use of existing data, and study data in new waysâ€"an effort requiring funding, interagency coordination, and data management strategies.