An Investigation Of Microrna Target Regulation Mechanisms Using An Integrative Approach
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An Investigation Of Microrna Target Regulation Mechanisms Using An Integrative Approach
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Author : Ulf Schmitz
language : en
Publisher: Logos Verlag Berlin GmbH
Release Date : 2015-06-29
An Investigation Of Microrna Target Regulation Mechanisms Using An Integrative Approach written by Ulf Schmitz and has been published by Logos Verlag Berlin GmbH this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-06-29 with MicroRNA. categories.
This work is a showcase for the integration of systems biology and bioinformatics tools, algorithms and models for deciphering biological phenomena. More specifically, it integrates (i) prediction algorithms for identifying and characterizing molecular interactions, (ii) structural modelling of molecule complexes, (iii) network analysis approaches, and (iv) mathematical modelling and simulation. Two comprehensive workflows are implemented for the analysis of collective target gene regulation by microRNAs and for the prediction of cooperating microRNA pairs and their mutual target genes. In two case studies mechanisms of fine-tuned target gene regulation are revealed for different cellular processes and the phenomenon of cooperative target regulation is identified as frequent mechanism of gene regulation in humans.
Microrna Cancer Regulation
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Author : Ulf Schmitz
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-02-03
Microrna Cancer Regulation written by Ulf Schmitz and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-02-03 with Medical categories.
This edited reflects the current state of knowledge about the role of microRNAs in the formation and progression of solid tumours. The main focus lies on computational methods and applications, together with cutting edge experimental techniques that are used to approach all aspects of microRNA regulation in cancer. We are sure that the emergence of high-throughput quantitative techniques will make this integrative approach absolutely necessary in the near future. This book will be a resource for researchers starting out with cancer microRNA research, but is also intended for the experienced researcher who wants to incorporate concepts and tools from systems biology and bioinformatics into his work. Bioinformaticians and modellers are provided with a general perspective on microRNA biology in cancer, and the state-of-the-art in computational microRNA biology.
Handbook Of Computational Molecular Biology
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Author : Srinivas Aluru
language : en
Publisher: CRC Press
Release Date : 2005-12-21
Handbook Of Computational Molecular Biology written by Srinivas Aluru and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-12-21 with Computers categories.
The enormous complexity of biological systems at the molecular level must be answered with powerful computational methods. Computational biology is a young field, but has seen rapid growth and advancement over the past few decades. Surveying the progress made in this multidisciplinary field, the Handbook of Computational Molecular Biology of
Plant Micrornas
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Author : Stefan de Folter
language : en
Publisher: Humana Press
Release Date : 2019-01-31
Plant Micrornas written by Stefan de Folter and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-01-31 with Science categories.
This detailed volume provides a collection of protocols for the study of miRNA functions in plants. Beginning with coverage of miRNA function, biogenesis, activity, and evolution in plants, the book continues by guiding readers through methods on the identification and detection of plant miRNAs, bioinformatic analyses, and strategies for functional analyses of miRNAs. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Plant MicroRNAs: Method and Protocols aims to ensure successful results in the further study of this vital area of plant science.
Activity Based Protein Profiling
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Author : Benjamin F. Cravatt
language : en
Publisher: Springer
Release Date : 2019-01-25
Activity Based Protein Profiling written by Benjamin F. Cravatt and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-01-25 with Medical categories.
This volume provides a collection of contemporary perspectives on using activity-based protein profiling (ABPP) for biological discoveries in protein science, microbiology, and immunology. A common theme throughout is the special utility of ABPP to interrogate protein function and small-molecule interactions on a global scale in native biological systems. Each chapter showcases distinct advantages of ABPP applied to diverse protein classes and biological systems. As such, the book offers readers valuable insights into the basic principles of ABPP technology and how to apply this approach to biological questions ranging from the study of post-translational modifications to targeting bacterial effectors in host-pathogen interactions.
The Development And Application Of Multi Omics Integration Approaches To Dissecting Complex Traits In Plants
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Author : Shang-Qian Xie
language : en
Publisher: Frontiers Media SA
Release Date : 2022-05-06
The Development And Application Of Multi Omics Integration Approaches To Dissecting Complex Traits In Plants written by Shang-Qian Xie and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-05-06 with Science categories.
Rna Infrastructure And Networks
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Author : Lesley J. Collins
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-09-15
Rna Infrastructure And Networks written by Lesley J. Collins and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-15 with Medical categories.
RNAs form complexes with proteins and other RNAs. The RNA‐infrastructure represents the spatiotemporal interaction of these proteins and RNAs in a cell‐wide network. RNA Infrastructure and Networks brings together these ideas to illustrate the scope of RNA‐based biology, and how connecting RNA mechanisms is a powerful tool to investigate regulatory pathways. This book is but a taste of the wide range of RNA‐based mechanisms that connect in the RNA infrastructure.
Computational Epigenetics And Diseases
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Author :
language : en
Publisher: Academic Press
Release Date : 2019-02-06
Computational Epigenetics And Diseases written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-02-06 with Business & Economics categories.
Computational Epigenetics and Diseases, written by leading scientists in this evolving field, provides a comprehensive and cutting-edge knowledge of computational epigenetics in human diseases. In particular, the major computational tools, databases, and strategies for computational epigenetics analysis, for example, DNA methylation, histone modifications, microRNA, noncoding RNA, and ceRNA, are summarized, in the context of human diseases. This book discusses bioinformatics methods for epigenetic analysis specifically applied to human conditions such as aging, atherosclerosis, diabetes mellitus, schizophrenia, bipolar disorder, Alzheimer disease, Parkinson disease, liver and autoimmune disorders, and reproductive and respiratory diseases. Additionally, different organ cancers, such as breast, lung, and colon, are discussed. This book is a valuable source for graduate students and researchers in genetics and bioinformatics, and several biomedical field members interested in applying computational epigenetics in their research. Provides a comprehensive and cutting-edge knowledge of computational epigenetics in human diseases Summarizes the major computational tools, databases, and strategies for computational epigenetics analysis, such as DNA methylation, histone modifications, microRNA, noncoding RNA, and ceRNA Covers the major milestones and future directions of computational epigenetics in various kinds of human diseases such as aging, atherosclerosis, diabetes, heart disease, neurological disorders, cancers, blood disorders, liver diseases, reproductive diseases, respiratory diseases, autoimmune diseases, human imprinting disorders, and infectious diseases
Systems Biology And Omics Approaches To Understand Complex Diseases Biology
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Author : Amit Kumar Yadav
language : en
Publisher: Frontiers Media SA
Release Date : 2022-05-03
Systems Biology And Omics Approaches To Understand Complex Diseases Biology written by Amit Kumar Yadav and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-05-03 with Science categories.
Regulation Of Micrornas
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Author : Helge Großhans
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-12-10
Regulation Of Micrornas written by Helge Großhans and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-12-10 with Science categories.
Given this pervasiveness and importance of miRNA-mediated gene regulation, it should come as little surprise that miRNAs themselves are also highly regulated. However, the recent explosion of knowledge on this topic has been remarkable, providing a primary motivation for publication of this book. As miRNAs are transcribed by RNA polymerase II, the enzyme that also generates mRNAs, it was perhaps not unexpected that miRNA transcription would be subject to regulation, and we have willfully mitted this aspect from this monograph. However, what has been unexpected is the extent of post-transcriptional regulation of miRNAs that is illustrated in this book.