Analysis Of Environmental Endocrine Disruptors
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Analysis Of Environmental Endocrine Disruptors
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Author : Lawrence H. Keith
language : en
Publisher:
Release Date : 1999
Analysis Of Environmental Endocrine Disruptors written by Lawrence H. Keith and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with MEDICAL categories.
Environmental Endocrine Disruptors
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Author : A Crain
language : en
Publisher: CRC Press
Release Date : 2000-08-17
Environmental Endocrine Disruptors written by A Crain and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-08-17 with Medical categories.
Addresses many aspects of endocrine disruption by environmental encountered toxic substances. Initial chapters provide essential background information whilst later chapters address specific aspects of endocrine disrupting contaminants (EDC)
Special Report On Environmental Endocrine Disruption An Effects Assessment And Analysis Prepared For The Risk Assessment Forum U S Environmental Protection Agency
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Author :
language : en
Publisher: DIANE Publishing
Release Date : 1997
Special Report On Environmental Endocrine Disruption An Effects Assessment And Analysis Prepared For The Risk Assessment Forum U S Environmental Protection Agency written by and has been published by DIANE Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with Electronic government information categories.
Review Of The Environmental Protection Agency S State Of The Science Evaluation Of Nonmonotonic Dose Response Relationships As They Apply To Endocrine Disruptors
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Author : National Research Council
language : en
Publisher: National Academies Press
Release Date : 2014-05-27
Review Of The Environmental Protection Agency S State Of The Science Evaluation Of Nonmonotonic Dose Response Relationships As They Apply To Endocrine Disruptors written by National Research Council and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-05-27 with Nature categories.
Potential health effects from chemicals that disrupt endocrine function pose an environmental health concern because of their ability to interfere with normal hormone function in human and wildlife populations. The endocrine system regulates biological processes throughout the body and is sensitive to small changes in hormone concentrations. Endocrine-disruptor research has focused primarily on chemicals that affect three hormone pathways that play important roles in reproduction and development - the estrogen, androgen, and thyroid hormone pathways. Some of this research has identified dose-response relationships that have nonmonotonic curves. Nonmonotonic dose-response curves (NMDRs) are of concern because they do not follow the usual assumption made in toxicology that as dose decreases the response also decreases. The existence of NMDRs has been a controversial topic for decades, and there has been considerable debate about their implications for how chemicals are tested and for how risks from such chemicals are assessed. Toxicity tests are designed to identify hazards and to characterize dose-response relationships, so tests are aimed at finding a (high) dose that elicits a response, and dose-response is explored by testing lower doses spaced to identify statistically a no- or lowest-observed-adverse-effect level. The concern for NMDRs is that such studies, as currently designed, might not detect the inflection of the dose-response curve if only a few doses are tested or if the change in inflection occurs below the range of doses tested. Another concern is that some NMDRs are found for biological effects that are not usually evaluated in toxicity tests. If current testing strategies are inadequate to account for NMDRs, changes to risk assessment practices might be necessary. To help address these issues, the U.S. Environmental Protection Agency (EPA) developed a draft State-of-the-Science Evaluation: Nonmonotonic Dose Responses as they Apply to Estrogen, Androgen, and Thyroid Pathways and EPA Testing and Assessment Procedures. EPA asked the National Research Council to conduct an independent review of this evaluation to ensure that it is scientifically sound and of high quality. Review of Environmental Protection Agency's State-of-the-Science Evaluation of Nonmonotonic Dose-Response as they Apply to Endocrine Disrupters evaluates whether EPA's evaluation presents a scientifically sound and high-quality analysis of the literature on NMDRs. This report reviews how well the EPA evaluation described how the assessment was performed, whether consistent methods and criteria were applied in the analysis of different evidence streams, and whether appropriate methods were applied to evaluating the evidence. The report makes recommendations to improve EPA's process and strengthen the evaluation.
Special Report On Environmental Endocrine Disruption An Effects Assessment And Analysis
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Author : Environmental Protection Agency EPA : Office of Research and Development
language : en
Publisher:
Release Date : 1997
Special Report On Environmental Endocrine Disruption An Effects Assessment And Analysis written by Environmental Protection Agency EPA : Office of Research and Development and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with categories.
Special Report On Environmental Endocrine Disruption
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Author : Thomas M. Crisp
language : en
Publisher:
Release Date : 1997
Special Report On Environmental Endocrine Disruption written by Thomas M. Crisp and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with categories.
Special Report On Environmental Endocrine Disruption An Effects Assessment And Analysis U S Environmental Protection Agency Februar
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Author :
language : en
Publisher:
Release Date : 1998*
Special Report On Environmental Endocrine Disruption An Effects Assessment And Analysis U S Environmental Protection Agency Februar written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998* with categories.
Environmental Endocrinology And Endocrine Disruptors
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Author : Rosario Pivonello
language : en
Publisher: Springer Nature
Release Date : 2023-04-20
Environmental Endocrinology And Endocrine Disruptors written by Rosario Pivonello and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-04-20 with Medical categories.
This book describes how exposure to various classes of endocrine disruptors, as well as other environmental chemicals targeting the endocrine system by alternative non-endocrine mechanisms, impact on endocrinological and endocrinological-related diseases. It includes comprehensive reviews of all aspects of environmental endocrinology, ranging from sources and patterns of exposure and identification of endocrine targets to direct endocrine disruptive mechanisms and indirect actions on the endocrine system, the latter including endocrine cell-directed cytotoxicity, oxidative damage, and genetic and epigenetic aberrations resulting in endocrine damage. It also examines the causal pathways and offers an extensive overview of downstream endocrinological and endocrinological-related disorders. In addition, several chapters focus on transgenerational actions, which are a topic of particular interest. Lastly, evidence from preclinical and clinical studies provides the basis for an in-depth, critical discussion of each topic. The book is part of the SpringerReference program, which provides access to ‘living editions’ that are constantly updated using a dynamic peer-review publishing process.
Environmental Endocrinology
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Author : I. Assenmacher
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-07
Environmental Endocrinology written by I. Assenmacher and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-07 with Medical categories.
From 11 to 15 July 1977 about 60 physiologists, endo crinologists, ecologists and other biologists from 14 countries convened at the University Montpellier for a symposium on Environmental Endocrinology. This meet ing was organized as a Satellite Symposium of the 27th International Congress of Physiological Sciences, Paris, 18-23 July 1977. This volume is a record of the com munications presented at the symposium. The objectives of the program were to examine the role of the endocrine system in a wide spectrum of adjustments and adaptations to changes in environmental conditions by various spe cies of animals, including man, and to promote an ex change of ideas among investigators who have approached these functions from diverse aspects. The diversity of the information and ideas communicated is great. Of necessity, they represent only an extremely modest se lection of the many facets of endocrine function in the interaction of animals with their environments. Be yond the usefulness of the communications individually, we hope that they collectively demonstrate the substan tial heuristic value of the concept of environmental endocrinology as it was perceived by the participants. We acknowledge gratefully the kindness and sympathy of Professor Jaques ROUZAUD, President of the University of Montpellier II, for his generous extension of the hospitality of the University to the Symposium. We are most grateful to Mrs. Monique VIEU who effected so well the secretarial organization of the Sympos.
Environmental Analysis Of Endocrine Disrupting Effects From Hydrocarbon Contaminants In The Ecosystem
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Author :
language : en
Publisher:
Release Date : 2000
Environmental Analysis Of Endocrine Disrupting Effects From Hydrocarbon Contaminants In The Ecosystem written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with categories.
This annual report summarizes the progress of three years of a three-year grant awarded to the Center for Bioenvironmental Research (CBR) at Tulane and Xavier Universities. The objective of this project is to determine how environmental contaminants, namely hydrocarbons, can act as hormones or anti-hormones in different species present in aquatic ecosystems. The three major areas of research include (1) a biotechnology based screening system to identify potential hormone mimics and antagonists; (2) an animal screening system to identify biomarkers of endocrine effects; and (3) a literature review to identify compounds at various DOE sites that are potential endocrine disruptors. Species of particular focus in this study are those which can serve as sentinel species (e.g., amphibians) and, thus, provide early warning signals for more widespread impacts on an ecosystem and its wildlife and human inhabitants. The focus of the literature research was to provide an analysis of the contaminants located on or around various Department of Energy (DOE) sites that are or have the potential to function as endocrine disruptors and to correlate the need for studying endocrine disruptors to DOE's programmatic needs. Previous research within the Center for Bioenvironmental Research at Tulane and Xavier Universities has focused on understanding the effects of environmental agents on the human and wildlife health and disease. In particular this research has focused on how exogenous agents can function to mimic or disrupt normal endocrine signaling, i.e. estrogen, thyroid within various systems from whole animal studies with fish, amphibians and insects to human cancer cell lines. Significant work has focused on the estrogenic and anti-estrogenic action of both synthetic organochlorine chemicals and naturally produced phytochemicals. Recent projects have extended these research objectives to examination of these environmental agents on the symbiotic relationship between nitrogen fixing rhizobial bacteria and leguminous plants. This research will form the foundation for future experiments into the genetic manipulation of plants to potentially promote greater or more specific symbiotic relationships between plant and Rhizobium allowing this biological phenomenon to be used in a greater number of crop types. Future technology developments could include the genetic engineering of crops suitable for in situ vadose zone 2 bioremediation (via microbes) and phytoremediation (through the crop, itself) in contaminated DOE sites.