Ancestral Sequence Reconstruction
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Ancestral Sequence Reconstruction
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Author : David A Liberles
language : en
Publisher: OUP Oxford
Release Date : 2007-05-31
Ancestral Sequence Reconstruction written by David A Liberles and has been published by OUP Oxford this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-05-31 with Science categories.
Ancestral sequence reconstruction is a technique of growing importance in molecular evolutionary biology and comparative genomics. As a powerful tool for testing evolutionary and ecological hypotheses, as well as uncovering the link between sequence and molecular phenotype, there are potential applications in a range of fields. Ancestral Sequence Reconstruction starts with a historical overview of the field, before discussing the potential applications in drug discovery and the pharmaceutical industry. This is followed by a section on computational methodology, which provides a detailed discussion of the available methods for reconstructing ancestral sequences (including their advantages, disadvantages, and potential pitfalls). Purely computational applications of the technique are then covered, including whole proteome reconstruction. Further chapters provide a detailed discussion on taking computationally reconstructed sequences and synthesizing them in the laboratory. The book concludes with a description of the scientific questions where experimental ancestral sequence reconstruction has been utilized to provide insights and inform future research. This research level text provides a first synthesis of the theories, methodologies and applications associated with ancestral sequence recognition, while simultaneously addressing many of the hot topics in the field. It will be of interest and use to both graduate students and researchers in the fields of molecular biology, molecular evolution, and evolutionary bioinformatics.
Ancestral Sequence Reconstruction
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Author : Kristina Straub
language : en
Publisher:
Release Date : 2018
Ancestral Sequence Reconstruction written by Kristina Straub and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with categories.
Ancestral Sequence Reconstruction
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Author : David A Liberles
language : en
Publisher: Oxford University Press
Release Date : 2007-05-31
Ancestral Sequence Reconstruction written by David A Liberles and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-05-31 with Science categories.
Ancestral sequence reconstruction is a technique of growing importance in molecular evolutionary biology and comparative genomics. As a powerful tool for testing evolutionary and ecological hypotheses, as well as uncovering the link between sequence and molecular phenotype, there are potential applications in a range of fields.Ancestral Sequence Reconstruction starts with a historical overview of the field, before discussing the potential applications in drug discovery and the pharmaceutical industry. This is followed by a section on computational methodology, which provides a detailed discussion of the available methods for reconstructing ancestral sequences (including their advantages, disadvantages, and potential pitfalls). Purely computational applications of the technique are then covered, including wholeproteome reconstruction. Further chapters provide a detailed discussion on taking computationally reconstructed sequences and synthesizing them in the laboratory. The book concludes with a description of the scientific questions where experimental ancestral sequence reconstruction has been utilized toprovide insights and inform future research.This research level text provides a first synthesis of the theories, methodologies and applications associated with ancestral sequence recognition, while simultaneously addressing many of the hot topics in the field. It will be of interest and use to both graduate students and researchers in the fields of molecular biology, molecular evolution, and evolutionary bioinformatics.
Ancestral Sequence Reconstruction
DOWNLOAD
Author : David A Liberles
language : en
Publisher: OUP Oxford
Release Date : 2007-05-31
Ancestral Sequence Reconstruction written by David A Liberles and has been published by OUP Oxford this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-05-31 with Science categories.
Ancestral sequence reconstruction is a technique of growing importance in molecular evolutionary biology and comparative genomics. As a powerful tool for testing evolutionary and ecological hypotheses, as well as uncovering the link between sequence and molecular phenotype, there are potential applications in a range of fields.Ancestral Sequence Reconstruction starts with a historical overview of the field, before discussing the potential applications in drug discovery and the pharmaceutical industry. This is followed by a section on computational methodology, which provides a detailed discussion of the available methods for reconstructing ancestral sequences (including their advantages, disadvantages, and potential pitfalls). Purely computational applications of the technique are then covered, including wholeproteome reconstruction. Further chapters provide a detailed discussion on taking computationally reconstructed sequences and synthesizing them in the laboratory. The book concludes with a description of the scientific questions where experimental ancestral sequence reconstruction has been utilized toprovide insights and inform future research.This research level text provides a first synthesis of the theories, methodologies and applications associated with ancestral sequence recognition, while simultaneously addressing many of the hot topics in the field. It will be of interest and use to both graduate students and researchers in the fields of molecular biology, molecular evolution, and evolutionary bioinformatics.
Experimental Phylogenetics
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Author : Ryan Nicole Randall
language : en
Publisher:
Release Date : 2012
Experimental Phylogenetics written by Ryan Nicole Randall and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Evolution (Biology) categories.
The field of molecular evolution has benefited greatly from the use of ancestral sequence reconstruction as a methodology to better understand the molecular mechanisms associated with functional divergence. The method of ancestral sequence reconstruction has never been experimentally validated despite the method being exploited to generate high profile publications and gaining wider use in many laboratories. The failure to validate such a method is a consequence of 1) our inability to travel back in time to document evolutionary transitions and 2) the slow pace of natural evolutionary processes that prevent biologists from 'witnessing' evolution in action (pace viruses). In this thesis research, we have generated an experimentally known phylogeny of fluorescent proteins in order to benchmark ancestral sequence reconstruction methods. The tips/leaves of the fluorescent protein experimental phylogeny are used to determine the performances of various ASR methods. This is the first example of combining experimental phylogenetics and ancestral sequence reconstruction.
Ancestral Sequence Reconstruction As An Accessible Tool For The Engineering Of Biocatalyst Stability
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Author : A. Thomas
language : en
Publisher:
Release Date : 2019
Ancestral Sequence Reconstruction As An Accessible Tool For The Engineering Of Biocatalyst Stability written by A. Thomas and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with categories.
Ancestral Sequence Reconstruction With Maximum Parsimony And Its Accuracy In Mathematical Phylogenetics
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Author : Lina Herbst
language : de
Publisher:
Release Date : 2019
Ancestral Sequence Reconstruction With Maximum Parsimony And Its Accuracy In Mathematical Phylogenetics written by Lina Herbst and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with categories.
Computational Methods In Protein Evolution
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Author : Tobias Sikosek
language : en
Publisher: Humana
Release Date : 2018-10-09
Computational Methods In Protein Evolution written by Tobias Sikosek and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-10-09 with Science categories.
This volume presents a diverse collection of methodologies used to study various problems at the protein sequence and structure level. The chapters in this book look at issues ranging from broad concepts like protein space to specifics like antibody modeling. Topics include point mutations, gene duplication, de novo emergence of new genes, pairwise correlated mutations, ancestral protein reconstruction, homology modelling, protein stability and dynamics, and protein-protein interactions. The book also covers a wide range of computational approaches, including sequence and structure alignments, phylogenies, physics-based and mathematical approaches, machine learning, and more. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and prerequisites, step-by-step, readily reproducible computational protocols (using command line or graphical user interfaces, sometimes including computer code), and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and authoritative, Computational Methods in Protein Evolution is a valuable resource that offers useful workflows and techniques that will help both novice and expert researchers working with proteins computationally.
Codon Evolution
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Author : Gina M. Cannarozzi
language : en
Publisher: Oxford University Press
Release Date : 2012-02-23
Codon Evolution written by Gina M. Cannarozzi and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-02-23 with Mathematics categories.
The second part of the book focuses on codon usage bias.
Evolution By Gene Duplication
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Author : Susumu Ohno
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-12-11
Evolution By Gene Duplication written by Susumu Ohno and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-12-11 with Medical categories.
It is said that "necessity is the mother of invention". To be sure, wheels and pulleys were invented out of necessity by the tenacious minds of upright citi zens. Looking at the history of mankind, however, one has to add that "Ieisure is the mother of cultural improvement". Man's creative genius flourished only when his mind, freed from the worry of daily toils, was permitted to entertain apparently useless thoughts. In the same manner, one might say with regard to evolution that "natural selection mere(y tnodifted, while redundanry created". Natural selection has been extremely effective in policing alleHe mutations which arise in already existing gene loci. Because of natural selection, organisms have been able to adapt to changing environments, and by adaptive radiation many new species were created from a common ancestral form. Y et, being an effective policeman, natural selection is extremely conservative by nature. Had evolution been entirely dependent upon natural selection, from a bacterium only numerous forms of bacteria would have emerged. The creation of metazoans, vertebrates and finally mammals from unicellular organisms would have been quite impos sible, for such big leaps in evolution required the creation of new gene loci with previously nonexistent functions. Only the cistron which became redun dant was able to escape from the relentless pressure of natural selection, and by escaping, it accumulated formerly forbidden mutations to emerge as a new gene locus.
