Ancistrocladus Naphthylisoquinoline Alkaloids
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Ancistrocladus Naphthylisoquinoline Alkaloids
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Author : A. Douglas Kinghorn
language : en
Publisher: Springer Nature
Release Date : 2023-01-01
Ancistrocladus Naphthylisoquinoline Alkaloids written by A. Douglas Kinghorn and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-01-01 with Science categories.
This book describes a unique class of secondary metabolites, the mono- and dimeric-naphthylisoquinoline alkaloids. They exclusively occur in lianas of the palaeotropical Ancistrocladaceae and Dioncophyllaceae plant families. Their unprecedented structures include stereogenic centers and rotationally hindered, and therefore stereogenic, axes. Extended recent investigations on six Ancistrocladus species from Asia, as reported in this contribution, shed light on their fascinating phytochemical productivity, with over 100 intriguing natural products. This high chemodiversity arises from a similarly unique biosynthesis from acetate-malonate units, following a novel polyketidic pathway to plant-derived isoquinoline alkaloids. Some of the compounds show most promising anti-parasitic activities. Additionally, strategies for the regio- and stereoselective total synthesis of the alkaloids, including the directed construction of the chiral axis, are also presented.
Ancistrocladus Naphthylisoquinoline Alkaloids
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Author : A. Douglas Kinghorn
language : en
Publisher: Springer
Release Date : 2022-11-22
Ancistrocladus Naphthylisoquinoline Alkaloids written by A. Douglas Kinghorn and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-22 with Science categories.
This book describes a unique class of secondary metabolites, the mono- and dimeric-naphthylisoquinoline alkaloids. They exclusively occur in lianas of the palaeotropical Ancistrocladaceae and Dioncophyllaceae plant families. Their unprecedented structures include stereogenic centers and rotationally hindered, and therefore stereogenic, axes. Extended recent investigations on six Ancistrocladus species from Asia, as reported in this contribution, shed light on their fascinating phytochemical productivity, with over 100 intriguing natural products. This high chemodiversity arises from a similarly unique biosynthesis from acetate-malonate units, following a novel polyketidic pathway to plant-derived isoquinoline alkaloids. Some of the compounds show most promising anti-parasitic activities. Additionally, strategies for the regio- and stereoselective total synthesis of the alkaloids, including the directed construction of the chiral axis, are also presented.
Isolation Of Antiplasmodial Naphthylisoquinoline Alkaloids From Ancistrocladus Sp Through Bioassay Guided Fractionation
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Author : Mutombo Sephora Mianda
language : en
Publisher:
Release Date : 2019
Isolation Of Antiplasmodial Naphthylisoquinoline Alkaloids From Ancistrocladus Sp Through Bioassay Guided Fractionation written by Mutombo Sephora Mianda and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with categories.
Ancistrocladus is the only genus in the Ancistrocladaceae family and together with the closely related Dioncophyllaceae, they produce naphthylisoquinoline (NIQ) alkaloids. This class of compounds exhibits a very interesting large spectrum of bioactivities. Some of these compounds have shown very promising antiplasmodial activity. Leaves of an as yet unidentified Ancistrocladus sp collected in the region of Bonsolerive (Northwestern part of DRC), were investigated for their antiplasmodial activity. They were air dried at room temperature and ground. The ground plant material was extracted sequentially with n-hexane, dichloromethane, ethyl acetate, methanol, and water. Five extracts were obtained and all, except for the n-hexane extract, were assayed for their antiplasmodial activity using the Malaria SYBR Green I based assay. The results of the antiplasmodial screening of extracts showed that the methanol extract was the most active one (100 % inhibition at 10 and 20 IÌ2℗ơg/mL) and was thus chosen for further research. UPLC QTOF MS was used to chemically profile the sequentially extracted material and to identify naphthylisoquinoline alkaloids in the extracts. The methanol extract was fractionated using silica gel column chromatography to produce 18 fractions. TLC and UPLC QTOF MS were used to target fractions mainly containing naphthylisoquinoline alkaloids and based on this, five fractions were selected for screening against Plasmodium falciparum NF54 strains. They all exhibited good antiplasmodial activity (EÌ8¡2 95 % inhibition at 5 and 10 IÌ2℗ơg/mL). One fraction was further fractionated using preparative HPLC and four sub-fractions collected. They were screened against P. falciparum NF54 strains. One sub-fraction showed an excellent activity with more than 82 % inhibition at 1 IÌ2℗ơg/mL. Three compounds were isolated from the active fractions and one compound from a non-screened fraction using preparative HPLC and LC-MS-SPE-NMR. Through NMR and ECD, the structures of three compounds were fully elucidated as ealamine A (43), ancistrocladinium A (44) and ancistrocyclinone A (45). The structure of one compound was elucidated with only the relative configuration determined (compound 46). The presence of ealamine A (43), which is a 7,8'-coupled hybrid-type NIQ (R configured at C-3 with oxygen function at C-6), in this plant material has a geo- and chemotaxonomic importance. Such NIQs are mostly present in Ancistrocladus plants from the Northwestern Congo Basin. The results of antiplasmodial screening of compounds revealed that ancistrocladinium A (44) and ealamine A (43) showed good activity (IC50 EÌ80́( 10 IÌ2℗ơM) against the chloroquine-sensitive (NF54) and chloroquine-resistant (K1 and Indochina clones W2) strains with no cross-resistance towards drug resistant P. falciparum parasites (RI values
Isolation Structural Elucidation And Biological Evaluation Of Naphthylisoquinoline Alkaloids From Two African Ancistrocladus Species
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Author : Shaimaa Fayez Ali Mohammed Seaf
language : en
Publisher:
Release Date : 2019
Isolation Structural Elucidation And Biological Evaluation Of Naphthylisoquinoline Alkaloids From Two African Ancistrocladus Species written by Shaimaa Fayez Ali Mohammed Seaf and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with categories.
Isolation And Structural Elucidation Of Novel Anti Infective Naphthylisoquinoline Alkaloids From Ancistrocladus Ealaensis And Phytochemical Analysis Of Two Congolese Medicinal Plants
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Author : Dieudonné Tshitenge Tshitenge
language : en
Publisher:
Release Date : 2019
Isolation And Structural Elucidation Of Novel Anti Infective Naphthylisoquinoline Alkaloids From Ancistrocladus Ealaensis And Phytochemical Analysis Of Two Congolese Medicinal Plants written by Dieudonné Tshitenge Tshitenge and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with categories.
Novel Type Dimeric Naphthylisoquinoline Alkaloids From Congolese Ancistrocladus Lianas
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Author : Blaise Kimbadi Lombe
language : en
Publisher:
Release Date : 2019
Novel Type Dimeric Naphthylisoquinoline Alkaloids From Congolese Ancistrocladus Lianas written by Blaise Kimbadi Lombe and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with categories.
The Alkaloids
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Author :
language : en
Publisher: Elsevier
Release Date : 2024-05-27
The Alkaloids written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-05-27 with Science categories.
The Alkaloids: Chemistry and Biology, Volume 91, the newest release in a series that has covered the topic for more than 60 years, discusses key aspects of alkaloid chemistry, biology and pharmacology. Sections in this release include chapters on Recent Progress in the Chemistry of Naphthylisoquinoline Alkaloids. Provides the latest information on the study of alkaloids Covers alkaloid chemistry, biology, pharmacology, and medical applications Contains more than 80 published volumes in this interesting field of study
Phytochemical Research On Two Ancistrocladus Species Semi Synthesis Of Dimeric Naphthylisoquinoline Alkaloids And Structure Optimization Of Antitumoral Naphthoquinones
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Author : Guoliang Zhang
language : en
Publisher:
Release Date : 2012
Phytochemical Research On Two Ancistrocladus Species Semi Synthesis Of Dimeric Naphthylisoquinoline Alkaloids And Structure Optimization Of Antitumoral Naphthoquinones written by Guoliang Zhang and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with categories.
Isolation And Structural Elucidation Of Novel Anti Infective Naphthylisoquinoline Alkaloids From Ancistrocladus Ealaensis And Phytochemical Analysis Of Two Congolese Medicinal Plants
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Author : Dieudonné Tshitenge Tshitenge
language : en
Publisher:
Release Date : 2017
Isolation And Structural Elucidation Of Novel Anti Infective Naphthylisoquinoline Alkaloids From Ancistrocladus Ealaensis And Phytochemical Analysis Of Two Congolese Medicinal Plants written by Dieudonné Tshitenge Tshitenge and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with categories.
The Alkaloids
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Author : Richard Helmuth Fred Manske
language : en
Publisher:
Release Date : 1995
The Alkaloids written by Richard Helmuth Fred Manske and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995 with Alkaloids categories.