Androgens And Androgen Receptor
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Androgens And Androgen Receptor
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Author : Chawnshang Chang
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Androgens And Androgen Receptor written by Chawnshang Chang and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Androgen Receptors is the most comprehensive and up to date volume on the topic, including discussions of the basic mechanisms of androgen-androgen receptor actions, their roles in the androgen-related diseases, and their potential clinical applications. Key topics covered include: -The discovery and cloning of the androgen receptor; -Androgen receptor coregulators; -Androgen related genes and their consensus DNA response elements; -Basic mechanism of action including functional analyses, cellular localization and phosphorylation studies; -Cross-talk to other signal transduction systems; -The recent connections of androgens to women's diseases, such as osteoporosis and ovarian cancer. This book is of interest to students, basic scientists, and clinicians as both a study guide and reference of research in the androgen field. It could also be used as an advanced level text in endocrinology, urology, OBGYN, or oncology.
The Mechanism Of Action Of Androgens
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Author : W.I.P. Mainwaring
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
The Mechanism Of Action Of Androgens written by W.I.P. Mainwaring and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
My introduction to androgens was neither auspicious nor impressive. I was sitting my viva voce examination for a degree in physiology and had haltingly intimated to my examiner (name decorously withheld) that I intended to pursue a career in re search. "On what topic?" was the reply. I had been deeply impressed by the work of C. Huggins and C. V. Hodges (Cancer Res. 1, 293, 1941) on the dramatic arrest of canine prostatic hyperplasia by the administration of stilboestrol. With some en thusiasm, I responded, "On steroid hormones, because I am struck by the profound effects that may be achieved by relatively small numbers of molecules. " The examiner sank into deep contemplation before replying, "Young man, have you considered go ing into teaching?" Suitably chastened, I finally began my research career investigating the effects of steroids on the nucleic acid metabolism of experimental tumours and on the process cells. Reaching an impasse in this work, I mentioned one of senescence in animal day to Dr. G. F. Marrian that, somewhat surprisingly, we had no understanding of the fundamental mechanism of action of steroid hormones, especially the androgens. me to tackle this problem, particularly since exciting new insights He encouraged were then being made into the interaction of radioactively labelled oestradiol-l?,8 with such tissues as rat uterus.
Androgen Receptors
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Author : Silvia Socorro
language : en
Publisher: Nova Science Publishers
Release Date : 2014
Androgen Receptors written by Silvia Socorro and has been published by Nova Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with Androgens categories.
The androgen receptor (AR) mediates a wide range of physiological actions of androgens in cells and tissues. Contributions to this volume cover distinct topics of AR signalling, extending from the structural aspects of AR to its role in androgen-associated diseases and potential clinical applications. Some key issues covered include an overview of structural aspects of AR genes and proteins in mammalian and non-mammalian vertebrate species and a description of the identified AR splice variants in pathological and non-pathological conditions. The structural and functional analysis of coding and untranslated regions of AR are discussed in the context of diseases such as androgen insensitivity syndrome, spinal and bulbar muscular atrophy, polycystic ovarian syndrome and breast, ovary and prostate cancers. The role of AR regulated genes implicated in prostate cancer progression is also explored. This book is a comprehensive conceptual review of the recent findings on AR genes and protein structure, molecular variants, ligands, target genes and signalling mechanisms. Graduate students, scientists and professionals can use it as both a study text and a reference for research purposes.
Androgens In Health And Disease
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Author : Carrie Bagatell
language : en
Publisher: Springer Science & Business Media
Release Date : 2003-05-27
Androgens In Health And Disease written by Carrie Bagatell and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-05-27 with Medical categories.
Authoritative researchers and clinicians review our latest understanding of andrology in both basic science and clinical medicine. Topics range from explaining the biology of androgens-from several different perspectives-to illuminating their role in the development and modulation of physiologic systems. Authors demonstrate in a number of cases that testosterone can be a useful adjunct to the treatment of a variety of disease states. Other chapters consider important topics such as androgens use in athletes, the potential of androgens to improve physical function and quality of life in older men, and androgens as potential male contraceptives.
Androgen Action In Prostate Cancer
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Author : Donald Tindall
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-04-20
Androgen Action In Prostate Cancer written by Donald Tindall and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-04-20 with Medical categories.
Androgens are critical regulators of prostate differentiation and function, as well as prostate cancer growth and survival. Therefore, androgen ablation is the preferred systemic treatment for disseminated prostate cancer. Androgen action is exerted in target tissues via binding the androgen receptor (AR), a nuclear receptor transcription factor. Historically, the gene expression program mediated by the AR has been poorly understood. However, recent gene expression profiling and more traditional single-gene characterization studies have revealed many androgen-regulated genes that are important mediators of androgen action in both normal and malignant prostate tissue. This book will focus on the androgen-regulated gene expression program, and examine how recently identified androgen-regulated genes are likely to contribute to the development and progression of prostate cancer. Recent studies that have attempted to unravel how these genes are deregulated in androgen depletion independent prostate cancer will be included
Androgen Action
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Author : Fahri Saatcioglu
language : en
Publisher: Humana Press
Release Date : 2011-08-04
Androgen Action written by Fahri Saatcioglu and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-08-04 with Science categories.
Androgens play a critical role in the development and maintenance of the male reproductive system and affect important physiological processes and pathological conditions, including the homeostasis of the normal prostate and prostate cancer. Androgen Action: Methods and Protocols is designed to provide a tool box to study various phases of androgen action, from its entry to the cell to the phenotypic response that the cell mounts, with up-to-date techniques for biochemists, molecular biologists, cell biologists, geneticists, and pathologists. The volume opens with a brief review of the research history on androgen action and prostate carcinogenesis, followed by chapters that cover state-of-the-art methods to determine androgen levels in biological tissues and fluids, experimental procedures to study the various aspects of androgen receptor activity, and methodology to study salient examples of interactions between androgen signalling and other major signalling pathways in cells. Written in the successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Androgen Action: Methods and Protocols provides a comprehensive overview of, and practical guidance on, the diverse methodologies that are propelling androgen action research forward, both for normal physiology as well as in disease states.
Pharmacology Biology And Clinical Applications Of Androgens
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Author : Chuck Kelly
language : en
Publisher: John Wiley & Sons
Release Date : 1996-02-13
Pharmacology Biology And Clinical Applications Of Androgens written by Chuck Kelly and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-02-13 with Medical categories.
Pharmacology, Biology, and Clinical Applications of AndrogensCurrent Status and Future Prospects Edited by Shalender Bhasin, Henry L. Gabelnick, Jeffrey M. Spieler,Ronald S. Swerdloff, Christina Wang, and Chuck Kelly As agents that affect the male primary and accessory sex organs,androgens--particularly the hormones testosterone andandrosterone--play a critical role in the development,functionality, and overall health of the male reproductive system.However, since androgens also have far-ranging effects onmetabolism, neurological activity, and behavior, scientistsexploring the contraceptive or therapeutic potential of androgensneed reliable, up-to-date information on the complex biologicalactivities of these agents. Pharmacology, Biology, and Clinical Applications of Androgens:Current Status and Future Prospects presents contributions fromleading investigators around the world, offering a focused,state-of-the-art summary of the central issues and controversies inandrogen research. The book is arranged into sections coveringandrogen physiology, androgens and the prostate, and theneurobehavioral and metabolic effects of androgens--as well astheir role in disease therapy and male contraception, and thevarious delivery systems for each application. Every chapter in thetext provides an expert opinion on a cutting-edge topic in thefield while highlighting the key points of dissent and disagreementwithin the scientific community. This approach is intended tofoster a deeper understanding of the status of androgen researchand lay the groundwork for future investigations in eacharea. This book explores such current topics as: * Androgen regulation of Sertoli cell function * Testosterone and spermatogenesis * Androgen effects on benign prostatic hyperplasia (BPH) andprostate cancer * Androgen effects on cognitive processes, sexual function, andaggressive behavior * Contraceptive efficacy of hormonal suppression of spermatogenesis * The latest transdermal and implantation delivery systems forandrogens Offering multifaceted coverage of the field, Pharmacology, Biology,and Clinical Applications of Androgens is an indispensable aid toall basic scientists and clinical investigators interested in thebiological actions of either natural or synthetic androgens.
Characterization And Intracellular Action Of The Androgen Receptor Microform
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Author : Elizabeth Jean Golsteyn
language : en
Publisher: National Library of Canada
Release Date : 1989
Characterization And Intracellular Action Of The Androgen Receptor Microform written by Elizabeth Jean Golsteyn and has been published by National Library of Canada this book supported file pdf, txt, epub, kindle and other format this book has been release on 1989 with Androgens categories.
Characterization Of Testosterone And Androgen Receptor Action In Human And Rhesus Macaque Heart Muscle Cells
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Author : Yuliia Tereshchenko
language : en
Publisher:
Release Date : 2024
Characterization Of Testosterone And Androgen Receptor Action In Human And Rhesus Macaque Heart Muscle Cells written by Yuliia Tereshchenko and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024 with categories.
Androgens are sex steroid hormones that influence various processes in reproductive tissues and peripheral organs. Their lipophilic nature enables free diffusion through the plasma membrane. In the cytoplasm, testosterone (T) binds to its receptor, the androgen receptor (AR), and the complex then translocates to the nucleus for activation or inhibition of gene expression. Although the effects of androgens are studied greatly in healthy and diseased reproductive tissues, little is known about their cellular and molecular action in the cardiovascular system. Clinical research reported the imp...
Androgen Action
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Author : Fahri Saatcioglu
language : en
Publisher: Humana Press
Release Date : 2011-08-09
Androgen Action written by Fahri Saatcioglu and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-08-09 with Science categories.
Androgens play a critical role in the development and maintenance of the male reproductive system and affect important physiological processes and pathological conditions, including the homeostasis of the normal prostate and prostate cancer. Androgen Action: Methods and Protocols is designed to provide a tool box to study various phases of androgen action, from its entry to the cell to the phenotypic response that the cell mounts, with up-to-date techniques for biochemists, molecular biologists, cell biologists, geneticists, and pathologists. The volume opens with a brief review of the research history on androgen action and prostate carcinogenesis, followed by chapters that cover state-of-the-art methods to determine androgen levels in biological tissues and fluids, experimental procedures to study the various aspects of androgen receptor activity, and methodology to study salient examples of interactions between androgen signalling and other major signalling pathways in cells. Written in the successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Androgen Action: Methods and Protocols provides a comprehensive overview of, and practical guidance on, the diverse methodologies that are propelling androgen action research forward, both for normal physiology as well as in disease states.