Animal Friendly Methods For Rodent Behavioral Testing In Neuroscience Research
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Animal Friendly Methods For Rodent Behavioral Testing In Neuroscience Research
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Author : Raffaele d’Isa
language : en
Publisher: Frontiers Media SA
Release Date : 2024-07-03
Animal Friendly Methods For Rodent Behavioral Testing In Neuroscience Research written by Raffaele d’Isa and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-07-03 with Science categories.
Rodent behavioral testing has been used to study brain functions since the 1890s and has become a gold-standard model in modern neuroscience. Up to the 1950s, most behavioral tests on laboratory rodent models were based on punishments and rewards. Both approaches can lead to a certain degree of animal pain or suffering. Punishments involved the employment of painful stimuli, typically electric shocks. Passive avoidance and fear conditioning tests, among the most widely used behavioral paradigms used to evaluate learning and memory in rodents, can be performed using only a single brief shock. Other tests, such as the active avoidance, might require up to tens or hundreds of shocks, strongly challenging the psychological welfare of the model animals. On the other hand, tests based on rewards, which apparently may seem more ethical, actually still induce suffering in the animals, as food rewards are almost always associated with a food restriction protocol, in order to motivate food-seeking behavior. Rodents are starved for days before starting the test and kept under food restriction for the whole duration of the test. The distress during the testing session is only a minimal part compared to the stress lived outside of the testing session, which is prolonged and continuous. Analogously, liquid rewards commonly rely on a previous water restriction protocol to use thirst as motivation. Animal stress is not only an ethical issue per se, but also an important factor potentially impacting on the reliability and reproducibility of experimental results.
Handbook Of Molecular Genetic Techniques For Brain And Behavior Research
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Author : Wim E. Crusio
language : en
Publisher: Elsevier
Release Date : 1999-10-18
Handbook Of Molecular Genetic Techniques For Brain And Behavior Research written by Wim E. Crusio and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-10-18 with Psychology categories.
The book gives a broad overview of recombinant DNA techniques for the behavioral neuroscientist, with illustrative examples of applications. Species covered include rodents (mainly mice), Drosophila melanogaster, Caenorhabditis elegans and Danio rerio. Experimental techniques required to characterize the behavioral phenotypes of mutant animals is provided. Several aspects of novel molecular-genetic techniques are overviewed and possible research strategies are explained. The sections of the book start with general descriptions of techniques followed by illustrative examples. It is divided into six sections. Section 1, bioinformatics and genomics research. Section 2, top-down strategies, where the researcher starts with the phenotype and then analyzes the associated genes; bottom-up strategies, where the physiological chain leading to a phenotype is analyzed starting from the gene product. Section 3, transgenic approaches in rodents including overexpressing foreign genes and gene-targeting; systemic manipulation approaches directly targeting the central nervous system and methods used with invertebrates. Section 4, methods used to evaluate relevant behavioral phenotypes, including learning and aggression. Section 5, examples on molecular brain research in man. Section 6, ethical aspects of research in this field.
Nature And Nurture Two Sides Of The Coins Where We Are In The Neuropsychiatric Disorder Research
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Author : Bing Lang
language : en
Publisher: Frontiers Media SA
Release Date : 2021-07-21
Nature And Nurture Two Sides Of The Coins Where We Are In The Neuropsychiatric Disorder Research written by Bing Lang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-07-21 with Medical categories.
Behavioral Genetics Of The Mouse Volume 1 Genetics Of Behavioral Phenotypes
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Author : Wim E. Crusio
language : en
Publisher: Cambridge University Press
Release Date : 2013-04-25
Behavioral Genetics Of The Mouse Volume 1 Genetics Of Behavioral Phenotypes written by Wim E. Crusio and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-25 with Science categories.
The first volume in the new Cambridge Handbooks in Behavioral Genetics series, Behavioral Genetics of the Mouse provides baseline information on normal behaviors, essential in both the design of experiments using genetically modified or pharmacologically treated animals and in the interpretation and analyses of the results obtained. The book offers a comprehensive overview of the genetics of naturally occurring variation in mouse behavior, from perception and spontaneous behaviors such as exploration, aggression, social interactions and motor behaviors, to reinforced behaviors such as the different types of learning. Also included are numerous examples of potential experimental problems, which will aid and guide researchers trying to troubleshoot their own studies. A lasting reference, the thorough and comprehensive reviews offer an easy entrance into the extensive literature in this field, and will prove invaluable to students and specialists alike.
Neuroscience Fundamentals For Communication Sciences And Disorders
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Author : Richard D. Andreatta
language : en
Publisher: Plural Publishing
Release Date : 2018-12-14
Neuroscience Fundamentals For Communication Sciences And Disorders written by Richard D. Andreatta and has been published by Plural Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-12-14 with Medical categories.
Neuroscience Fundamentals for Communication Sciences and Disorders is a comprehensive textbook designed for undergraduate neural bases or graduate neuroscience courses in communication sciences and disorders programs (CSD). Written with a fresh user-friendly conversational style and complemented by more than 350 visually rich and beautifully drawn full-color illustrations, this book emphasizes brain and behavior relationships while also ensuring coverage of essential neuroanatomy in an integrative fashion. With a comprehensive background in neuroscience fundamentals, students will be able to better understand and apply brain-behavior relationships to make appropriate clinical assessments and treatment decisions. Neuroscience Fundamentals for Communication Sciences and Disorders is designed to provide CSD students with a broad overview of the principles, processes, and structures underlying the workings of the human nervous system. Extending well beyond traditional neuroanatomy-based textbooks, this publication is designed to satisfy three major goals: Provide neuroanatomical and neurophysiological detail that meets the real-world needs of the contemporary CSD student, as they move forward toward clinical practice, and into the future where advancements in the field of health and brain sciences are accelerating and contributing more and more to rehabilitation.Provide clear, understandable explanations and intuitive material that explains how and why neuroanatomical systems, processes, and mechanisms of the nervous system operate as they do during human behavior.Provide a depth and scope of material that will allow students to read, better understand, and appreciate a wide range of evidence-based literature related to behavior, cognition, emotion, language, and sensory perception--areas that directly impact treatment decisions. Key Features: An emphasis on fundamental information on neuroanatomy, neurophysiology, and functional processes using an analogy-driven and relaxed conversational writing style.More than 350 new and beautifully illustrated full-color neuroanatomical and neurophysiological figures that work to bring the written material to life.Content is divided into four major sections that build upon each other to foster a comprehensive understanding of the nervous system from the cellular to systems.Three summary chapters on the neural bases of speech, language, and hearing that help integrate the basic information from earlier chapters with content specific to CSD.Each chapter begins with an introduction and learning objectives and ends with a top ten summary list of key take-home concepts and study review questions.Bolded key terms throughout with a comprehensive glossary of definitions.Clinical Importance boxes highlight clinically relevant disorders and syndromes that compliment topic coverage.Further Interest boxes highlight interesting and exciting facts about the nervous system's structure, physiology, and functionality.Disclaimer: Please note that ancillary content (such as documents, audio, and video, etc.) may not be included as published in the original print version of this book.
Basic And Translation Research In Learning And Memory
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Author : Adebobola Imeh-Nathaniel
language : en
Publisher: Frontiers Media SA
Release Date : 2023-05-17
Basic And Translation Research In Learning And Memory written by Adebobola Imeh-Nathaniel and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-05-17 with Science categories.
Home Cage Based Phenotyping In Rodents Innovation Standardization Reproducibility And Translational Improvement
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Author : Stefano Gaburro
language : en
Publisher: Frontiers Media SA
Release Date : 2022-07-25
Home Cage Based Phenotyping In Rodents Innovation Standardization Reproducibility And Translational Improvement written by Stefano Gaburro and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-07-25 with Science categories.
Social Decision Making In Animals
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Author : Rui F. Oliveira
language : en
Publisher: Frontiers Media SA
Release Date : 2020-08-10
Social Decision Making In Animals written by Rui F. Oliveira and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-08-10 with categories.
Hayes Principles And Methods Of Toxicology
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Author : A. Wallace Hayes
language : en
Publisher: CRC Press
Release Date : 2023-07-03
Hayes Principles And Methods Of Toxicology written by A. Wallace Hayes and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-07-03 with Medical categories.
Hayes’ Principles and Methods of Toxicology has long been established as a reliable and informative reference for the concepts, methodologies, and assessments integral to toxicology. The new edition contains updated and new chapters with the addition of new authors while maintaining the same high standards that have made this book a benchmark resource in the field. Key Features: The comprehensive yet concise coverage of various aspects of fundamental and applied toxicology makes this book a valuable resource for educators, students, and professionals. Questions provided at the end of each chapter allow readers to test their knowledge and understanding of the material covered. All chapters have been updated and over 60 new authors have been added to reflect the dynamic nature of toxicological sciences New topics in this edition include Safety Assessment of Cosmetics and Personal Care Products, The Importance of the Dose/Rate Response, Novel Approaches and Alternative Models, Epigenetic Toxicology, and an Expanded Glossary. The volume is divided into 4 major sections, addressing fundamental principles of toxicology (Section I. "Principles of Toxicology"), major classes of established chemical hazards (Section II. "Agents"), current methods used for the assessment of various endpoints indicative of chemical toxicity (Section III. "Methods"), as well as toxicology of specific target systems and organs (Section IV. "Organ- and System-Specific Toxicology"). This volume will be a valuable tool for the audience that wishes to broaden their understanding of hazards and mechanisms of toxicity and to stay on top of the emerging methods and concepts of the rapidly advancing field of toxicology and risk assessment.
Therapeutic Agents And Targets To Minimize Ischemic Brain Injury
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Author : Bruno Meloni
language : en
Publisher: Frontiers Media SA
Release Date : 2021-11-30
Therapeutic Agents And Targets To Minimize Ischemic Brain Injury written by Bruno Meloni and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-30 with Medical categories.
BM would like to declare that he has filed patents for the application of arginine-rich peptide as neuroprotective agents for stroke and other neurological disorders. RRR patents licensed by Neuronasal Inc., a company that he also consults for and has equity interest in. All other Topic Editors declare no competing interests with regards to the Research Topic subject.