Animal Friendly Methods For Rodent Behavioral Testing In Neuroscience Research
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Animal Friendly Methods For Rodent Behavioral Testing In Neuroscience Research
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Author : Raffaele d’Isa
language : en
Publisher: Frontiers Media SA
Release Date : 2024-07-03
Animal Friendly Methods For Rodent Behavioral Testing In Neuroscience Research written by Raffaele d’Isa and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-07-03 with Science categories.
Rodent behavioral testing has been used to study brain functions since the 1890s and has become a gold-standard model in modern neuroscience. Up to the 1950s, most behavioral tests on laboratory rodent models were based on punishments and rewards. Both approaches can lead to a certain degree of animal pain or suffering. Punishments involved the employment of painful stimuli, typically electric shocks. Passive avoidance and fear conditioning tests, among the most widely used behavioral paradigms used to evaluate learning and memory in rodents, can be performed using only a single brief shock. Other tests, such as the active avoidance, might require up to tens or hundreds of shocks, strongly challenging the psychological welfare of the model animals. On the other hand, tests based on rewards, which apparently may seem more ethical, actually still induce suffering in the animals, as food rewards are almost always associated with a food restriction protocol, in order to motivate food-seeking behavior. Rodents are starved for days before starting the test and kept under food restriction for the whole duration of the test. The distress during the testing session is only a minimal part compared to the stress lived outside of the testing session, which is prolonged and continuous. Analogously, liquid rewards commonly rely on a previous water restriction protocol to use thirst as motivation. Animal stress is not only an ethical issue per se, but also an important factor potentially impacting on the reliability and reproducibility of experimental results.
Mouse Behavioral Testing
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Author : Douglas Wahlsten
language : en
Publisher: Academic Press
Release Date : 2010-11-25
Mouse Behavioral Testing written by Douglas Wahlsten and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-11-25 with Nature categories.
Mouse Behavioral Testing: How to Use Mice in Behavioral Neuroscience provides detailed explanations of how to conduct an experiment on mouse behavior from the initial planning of the research design through every step of the process until the data analysis phase. The book discusses the practical matters that need to be considered carefully when working with any species of animal, such as how many animals need to be tested. It describes the tests and techniques devised specifically for work with mice. Every step of the research process is illustrated with real situations encountered in previous studies. All examples are based on real experiments, and extensive details of several published experiments are provided. The essential features of a behavioral test protocol are outlined, and several complete protocols are provided. Methods to balance the order of tests and determine throughput are described, then a completely balanced order of tests in a complex experiment is presented. The book will be useful for those already familiar with the general principles of research but are new to the realm of behavioral testing of live mice. It will also serve as a text for a formal course, most likely at the graduate level. A guide to running a behavioral testing lab, including the many aspects of mouse research beyond the confines of the specific test Diagrams and photographs are shown for many kinds of apparatus and test situations with sufficient details such as dimensions to enable building of replicas Provides step-by-step instructions on planning and executing behavioral experiments in order to run them successfully
A Researcher S Guide To Rodent Behavior
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Author : Robert M.J. Deacon
language : en
Publisher: Academic Press
Release Date : 2024-03-01
A Researcher S Guide To Rodent Behavior written by Robert M.J. Deacon and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-03-01 with Science categories.
A Researcher's Guide to Rodent Behavior: Experimental Designs, Methods and Protocols, Volume 32 provides a comprehensive guide to all forms of behavioral processes found in mice, rats and other rodents used in behavioral and cognitive research. Sections discuss basic skills necessary for successful rodent behavior research, including experimental design, animal selection, building any necessary apparatus, ethical considerations and interpretation of results. The book provides useful guidance for researchers at all stages of their careers, including a detailed description of how to perform stereotaxic surgery on the rat or mouse brain, advice on how to non-appetitively motivate rodents, and more. Most significantly, the book contains 35 proven, clearly defined protocols to aid readers in their research, making it one of the few books available that provides a collection of such protocols in a single publication. The cognitive, motor, sensory, affective, and species-typical protocols are profusely illustrated with full-color photographs from the author's own research, to help readers more fully understand the studies and methods discussed in the text and provide further instruction on the ideal ways to re-create research projects themselves.
The Behavior Of The Laboratory Rat
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Author : Ian Q. Whishaw
language : en
Publisher: Oxford University Press
Release Date : 2004-09-02
The Behavior Of The Laboratory Rat written by Ian Q. Whishaw and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-09-02 with Medical categories.
Both seasoned and beginning investigators will be amazed at the range and complexity of rat behavior as described in the 43 chapters of this volume. The behavioral descriptions are closely tied to the laboratory methods from which they were derived, thus allowing the investigator to exploit both the behavior and the methods for their own research. It will also serve as an indispensable reference for other neuroscientists, psychologist, pharmacologists, geneticists, molecular biologists, zoologists, and their students and trainees.
Guidelines For The Care And Use Of Mammals In Neuroscience And Behavioral Research
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Author : National Research Council
language : en
Publisher: National Academies Press
Release Date : 2003-08-22
Guidelines For The Care And Use Of Mammals In Neuroscience And Behavioral Research written by National Research Council and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-08-22 with Science categories.
Expanding on the National Research Council's Guide for the Care and Use of Laboratory Animals, this book deals specifically with mammals in neuroscience and behavioral research laboratories. It offers flexible guidelines for the care of these animals, and guidance on adapting these guidelines to various situations without hindering the research process. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research offers a more in-depth treatment of concerns specific to these disciplines than any previous guide on animal care and use. It treats on such important subjects as: The important role that the researcher and veterinarian play in developing animal protocols. Methods for assessing and ensuring an animal's well-being. General animal-care elements as they apply to neuroscience and behavioral research, and common animal welfare challenges this research can pose. The use of professional judgment and careful interpretation of regulations and guidelines to develop performance standards ensuring animal well-being and high-quality research. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research treats the development and evaluation of animal-use protocols as a decision-making process, not just a decision. To this end, it presents the most current, in-depth information about the best practices for animal care and use, as they pertain to the intricacies of neuroscience and behavioral research.
Guidelines For The Care And Use Of Mammals In Neuroscience And Behavioral Research
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Author : Institute for Laboratory Animal Research
language : en
Publisher: National Academy Press
Release Date : 2003
Guidelines For The Care And Use Of Mammals In Neuroscience And Behavioral Research written by Institute for Laboratory Animal Research and has been published by National Academy Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with Medical categories.
Provides advice for common situations in neuroscience and behavioral research that can pose difficulties. It treats the development, evaluation, and implementation of animal-use protocols as a decision-making process, not just a decision. It encourages the use of professional judgement and careful interpretation of regulations and guidelines to develop performance standards that ensure animal well-being and high-quality research. This book will be an indispensable resource for researchers, veterinarians, and institutional animal care and use committees.
Methods Of Behavior Analysis In Neuroscience
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Author : Jerry J. Buccafusco
language : en
Publisher: CRC Press
Release Date : 2000-08-29
Methods Of Behavior Analysis In Neuroscience written by Jerry J. Buccafusco and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-08-29 with Medical categories.
Using the most well-studied behavioral analyses of animal subjects to promote a better understanding of the effects of disease and the effects of new therapeutic treatments on human cognition, Methods of Behavior Analysis in Neuroscience provides a reference manual for molecular and cellular research scientists in both academia and the pharmaceutic
Rodent Model As Tools In Ethical Biomedical Research
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Author : Monica Levy Andersen
language : en
Publisher: Springer
Release Date : 2015-09-14
Rodent Model As Tools In Ethical Biomedical Research written by Monica Levy Andersen and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-09-14 with Medical categories.
The objective of this book is to concisely present information with respect to appropriate use of experimental rodents in research. The principles elaborated seek to provide knowledge of the techniques involved in both management and scientific research to all who use laboratory animals, with a focus on the well-being and ethics regarding rodents and also to fortify the awareness of the importance of the animal as a study object and to offer orientation and assistance in conducting laboratory research, education or tests.
Use Of Laboratory Animals In Biomedical And Behavioral Research
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Author : National Research Council
language : en
Publisher: National Academies Press
Release Date : 1988-02-01
Use Of Laboratory Animals In Biomedical And Behavioral Research written by National Research Council and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1988-02-01 with Science categories.
Scientific experiments using animals have contributed significantly to the improvement of human health. Animal experiments were crucial to the conquest of polio, for example, and they will undoubtedly be one of the keystones in AIDS research. However, some persons believe that the cost to the animals is often high. Authored by a committee of experts from various fields, this book discusses the benefits that have resulted from animal research, the scope of animal research today, the concerns of advocates of animal welfare, and the prospects for finding alternatives to animal use. The authors conclude with specific recommendations for more consistent government action.
Mood And Anxiety Related Phenotypes In Mice
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Author : Todd D Gould
language : en
Publisher: Humana Press
Release Date : 2012-03-07
Mood And Anxiety Related Phenotypes In Mice written by Todd D Gould and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-03-07 with Medical categories.
Affecting approximately twenty percent of the world population, mood and anxiety disorders have been the subject of ever-increasing research. This increased research parallels a remarkable growth in the use of the laboratory mouse as a tool to understand the biological and genetic basis of mood and anxiety disorders as well as to develop improved treatments. In Mood and Anxiety Related Phenotypes in Mice: Characterization Using Behavioral Tests, world-renowned researchers provide an overview of behavioral approaches utilized in the characterization of mood and anxiety related behaviors in mice as well as commonly used behavioral assays to assess the potential antidepressant and anxiolytic efficacy of novel compounds. As a volume in the successful NeuromethodsTM series, the chapters provide authoritative reviews including up-to-date detailed protocols of the most commonly used approaches in the field. Mood and Anxiety Related Phenotypes in Mice: Characterization Using Behavioral Tests is an ideal resource for scientists actively pursuing or interested in establishing behavioral protocols in their laboratories, while also serving as a reference for those students, scientists, and practitioners who have an interest in better understanding the preclinical behavioral methods used in mood and anxiety research.