Animal Models In Cancer Research And Human Disease
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Animal Models In Cancer Research And Human Disease
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Author : Sean A. Murray
language : en
Publisher: Nova Science Publishers
Release Date : 2013
Animal Models In Cancer Research And Human Disease written by Sean A. Murray and has been published by Nova Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with Animal models in research categories.
This book discusses the applications, outcomes and controversies of using animal models in cancer research and human disease. Topics include murine models of sporadic and inflammation-related colon carcinogenesis with particular focus on the AOM/DSS chemically induced colorectal cancer model; large animal models of human cardiovascular disease; developments of cell therapeutic strategies for Alzheimer's disease using animal models; the techniques and limitations of murine models of human colorectal cancer; animal models for antineoplastic chemotherapy-induced alopecia; and development of columnar-lined oesophagus with or without goblet cells in rate duodengastroesophageal reflux models through gut regenerative cell lineage (GRCL).
Animal Models In Cancer Research And Human Disease
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Author : Sean A. Murray
language : en
Publisher: Nova Biomedical Books
Release Date : 2014-05-14
Animal Models In Cancer Research And Human Disease written by Sean A. Murray and has been published by Nova Biomedical Books this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-05-14 with Medical categories.
This book discusses the applications, outcomes and controversies of using animal models in cancer research and human disease. Topics include murine models of sporadic and inflammation-related colon carcinogenesis with particular focus on the AOM/DSS chemically induced colorectal cancer model; large animal models of human cardiovascular disease; developments of cell therapeutic strategies for Alzheimer's disease using animal models; the techniques and limitations of murine models of human colorectal cancer; animal models for antineoplastic chemotherapy-induced alopecia; and development of columnar-lined esophagus with or without goblet cells in rate duodengastroesophageal reflux models through gut regenerative cell lineage (GRCL).
Animal Models For The Study Of Human Disease
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Author : P. Michael Conn
language : en
Publisher: Academic Press
Release Date : 2013-05-29
Animal Models For The Study Of Human Disease written by P. Michael Conn and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-05-29 with Science categories.
Animal Models for the Study of Human Disease identifies important animal models and assesses the advantages and disadvantages of each model for the study of human disease. The first section addresses how to locate resources, animal alternatives, animal ethics and related issues, much needed information for researchers across the biological sciences and biomedicine.The next sections of the work offers models for disease-oriented topics, including cardiac and pulmonary diseases, aging, infectious diseases, obesity, diabetes, neurological diseases, joint diseases, visual disorders, cancer, hypertension, genetic diseases, and diseases of abuse. Organized by disease orientation for ease of searchability Provides information on locating resources, animal alternatives and animal ethics Covers a broad range of animal models used in research for human disease
Animal Models For The Study Of Human Disease
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Author : JoEllen Welsh
language : en
Publisher: Elsevier Inc. Chapters
Release Date : 2013-05-29
Animal Models For The Study Of Human Disease written by JoEllen Welsh and has been published by Elsevier Inc. Chapters this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-05-29 with Medical categories.
Breast cancer is one of the most frequently diagnosed malignancies, and despite extensive molecular and cellular research, the mortality rate remains high. Preclinical testing of new strategies to prevent the emergence of invasive disease and to effectively treat existing disease is dependent on appropriate in vivo models. The challenges with modeling breast cancer in animals include species differences in mammary gland development and sensitivity to carcinogens as well as the molecular heterogeneity of human breast cancer. This chapter focuses on the plethora of animal models that have been developed in rodents, including chemically induced protocols, transplantable and graft models, and transgenic and knockout approaches. Although no single model is suitable for all research purposes, genomic profiling has enabled the identification of rodent tumors that display molecular similarity to specific subtypes of human breast cancer. Practical aspects and key issues involved in choosing an animal model are discussed, along with the advantages and limitations of the most commonly utilized rodent models of breast cancer.
Animal Models For Human Cancer
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Author : Marianne I. Martic-Kehl
language : en
Publisher: John Wiley & Sons
Release Date : 2016-05-18
Animal Models For Human Cancer written by Marianne I. Martic-Kehl and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-05-18 with Medical categories.
Based on results from the past ten years, this ready reference systematically describes how to prepare, carry out, and evaluate animal studies for cancer therapies, addressing the widely recognized lack of reliable and reproducible results. Following a short historical introduction and a discussion of the ethics surrounding animal experiments, the book describes correct study design as well as the handling and housing of animals. It then goes on to describe the animal models available for different cancer types, from natural cancer models in mice and dogs to humanized animals. An evaluation of previously unpublished long-term data from the Swiss canine and feline cancer registry is also included. The final part of the book reviews the lessons learned over the last decade on how to interpret data from animal studies for improving human therapy and gives recommendations for future drug development.
Mouse Models Of Human Blood Cancers
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Author : Shaoguang Li
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-12-19
Mouse Models Of Human Blood Cancers written by Shaoguang Li and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-12-19 with Medical categories.
In this book, Dr. Li and his author team plan to emphasize why mouse models are useful in vivo systems for understanding disease mechanisms and developing therapeutic strategies in blood cancers. The authors do not intend to cover all types of blood cancers; instead, they will focus on some major ones such as leukemias and lymphomas. However, the authors will try to cover as much as they can the cancer types and point out that many blood cancers need to be studied in mouse disease models although they are still not available at present. A major focus in the book will be to show what we can or cannot learn from mouse disease models and to also show the critical contributions of mouse models in therapeutic drug development.
Tumor Models In Cancer Research
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Author : Beverly A. Teicher
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-12-01
Tumor Models In Cancer Research written by Beverly A. Teicher and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-12-01 with Medical categories.
The past 6 years since the first edition of this book have seen great progress in the development of genetically engineered mouse (GEM) models of cancer. These models are finding an important role in furthering our understanding of the biology of malignant disease. A comfortable position for GEM models in the routine conduct of screening for potential new therapeutics is coming more slowly but is coming. Increasing numbers of genetically engineered mice are available, some with conditional activation of oncogenes, some with multiple genetic changes providing mouse models that are moving closer to the human disease.
Animal Models Of Cancer Predisposition Syndromes
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Author : Hiroshi Hiai
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 1999
Animal Models Of Cancer Predisposition Syndromes written by Hiroshi Hiai and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with Medical categories.
This book brings together some of the most recent advances made in the genetic analysis of cancer susceptibility using animal models. Leading investigators in the field present model systems for studying cancers including liver and stomach cancer, breast cancer, myeloid leukemia, retrovirus-induced lymphoma, pulmonary adenoma and familial adenomatous polyposis. An overview of transgenic and gene knockout mice is given, and in several chapters the implications of these findings for human cancers are discussed. The book is recommended reading for all scientists and graduate students in experimental cancer research and cancer genomics.
Genetically Engineered Mice For Cancer Research
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Author : Jeffrey E. Green
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-12-09
Genetically Engineered Mice For Cancer Research written by Jeffrey E. Green and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-12-09 with Medical categories.
Genetically-engineered mouse models for cancer research have become invaluable tools for studying cancer biology and evaluating novel therapeutic approaches. This volume focuses on state-of-the-art methods for generating, analyzing and validating such models for studying aspects of human cancer biology. Additionally, these models are emerging as important pre-clinical systems in which to test cancer prevention and therapeutic strategies in order to select compounds for testing in clinical trials.
Animal Models Of Human Disease
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Author : Sara Green
language : en
Publisher: Cambridge University Press
Release Date : 2024-04-30
Animal Models Of Human Disease written by Sara Green and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-04-30 with Philosophy categories.
The crucial role of animal models in biomedical research calls for philosophical investigation of how and whether knowledge about human diseases can be gained by studying other species. This Element delves into the selection and construction of animal models to serve as preclinical substitutes for human patients. It explores the multifaceted roles animal models fulfil in translational research and how the boundaries between humans and animals are negotiated in this process. The book also covers persistent translational challenges that have sparked debates across scientific, philosophical, and public arenas regarding the limitations and future of animal models. Among the are persistent tensions between standardization and variation in medicine, as well as between strategies aiming to reduce and recapitulate biological complexity. Finally, the book examines the prospects of replacing animal models with animal-free methods. The Element demonstrates why animal modeling should be of interest to philosophers, social scientists, and scientists alike.