Animal Models In Cardiovascular Research
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Animal Models In Cardiovascular Research
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Author : D.R. Gross
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-04-17
Animal Models In Cardiovascular Research written by D.R. Gross and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-17 with Medical categories.
Interest in the humane and scientifically justifiable use of research animals has intensified since the publication of the first edition of this textbook. This completely revised and updated text provides information essential to any researcher interested in using animal models for cardiovascular research, or any research which requires normal cardiovascular function. The format and presentation have been changed to make the text more easy to read and use. An introductory chapter offers general principles of animal selection, pre and post-operative care, preanesthesia, chemical restraint, analgesia, and the recognition of pain. The number of references cited has been almost doubled over the previous text and the chapter tabulating normal cardiovascular parameters from intact, awake animals, of those species commonly used in research, has been greatly expanded. Other chapters providing comprehensive data on the cardiovascular effects of opioids, tranquilizers, anesthetic agents and other drugs commonly used in cardiovascular research have been expanded with special emphasis on species variability to drug effects. The chapters on both naturally occurring and iatrogenic models of cardiovascular disease have also been expanded and updated.
Animal Models In Cardiovascular Research
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Author : David Gross
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-06-26
Animal Models In Cardiovascular Research written by David Gross and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-06-26 with Science categories.
Interest in the humane and scientifically justifiable use of research animals has intensified since the publication of the 2nd edition of Animal Models in Cardiovascular Research. This completely revised and updated edition will provide information essential to any researcher interested in using animal models for cardiovascular research, or any research which requires normal cardiovascular function. The format and presentation will be changed to make the text more easy to read and use: (1) This edition is in outline format, for ease and utility. (2) The opening chapter includes more information on the cardiovascular effects of post-operative analgesia and will address the recognition of pain behavior in species commonly used in research settings, particularly rats and mice. (3) New edition includes reference material more useful to researchers using transgenic and naturally occurring animal models to dissect these mechanisms.
Large Animal Models In Cardiovascular Research
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Author : Hidetoshi Masumoto
language : en
Publisher:
Release Date : 2020
Large Animal Models In Cardiovascular Research written by Hidetoshi Masumoto and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with Electronic books categories.
Studies of not only preclinical cardiovascular research but also those of life science, medical, and pharmacological fields commonly utilize small animal models. However, for the advancement of cardiovascular medicine, researches using large animal models are important step for preclinical validation of therapeutic efficacy and safety by virtue of having models with a body and heart size comparable with that of a human, providing clinically relevant experiments without the concern of over- or under-estimating therapeutic effects and risks. In particular, pigs are considered as a suitable animal model for research in cardiovascular medicine because of the similarities in physiology, metabolism, genomics, and proteomics to those in humans. Another advantage of pigs is the availability of various heart disease models such as myocardial infarction and genetically established cardiomyopathy. The present review updates the contributions of large animal model-based research to the development of cardiovascular medicine, especially focusing on the utility of pig models.
Animal Models For The Study Of Human Disease
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Author : Li Chen
language : en
Publisher: Elsevier Inc. Chapters
Release Date : 2013-05-29
Animal Models For The Study Of Human Disease written by Li Chen and has been published by Elsevier Inc. Chapters this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-05-29 with Medical categories.
With advances in molecular and genomic research offering novel insights into cardiovascular diseases, many transgenic animal models have been recently developed and characterized. Currently, more than 90 percent of all laboratory animal experiments are conducted in mice and rats. Although there are many scientific advantages to using small animal models, it has been recently recognized that many exciting therapeutic targets identified in small animals are not validated in clinical trials in patients. Thus, suitable large animal models, particularly under conscious state with appropriate direct measurements of cardiovascular function, are needed to serve as a better translational bridge between preclinical and clinical studies. In this chapter, we primarily focus on surgically instrumented large animal models of common cardiovascular disease studied in the conscious state. In addition, several important physiological factors that influence the characteristics of the models, as well as the importance of proper data interpretation, will also be discussed.
Animal Models In Biomedical Research
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Author : Cynthia Petrie Smith
language : en
Publisher:
Release Date : 1991
Animal Models In Biomedical Research written by Cynthia Petrie Smith and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with Animal models in research categories.
Heart Research On Animals
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Author : Brandon Kuker-Reines
language : en
Publisher:
Release Date : 1985
Heart Research On Animals written by Brandon Kuker-Reines and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1985 with Alternative toxicity testing categories.
A Handbook Of Mouse Models Of Cardiovascular Disease
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Author : Qinbo Xu
language : en
Publisher: John Wiley & Sons
Release Date : 2006
A Handbook Of Mouse Models Of Cardiovascular Disease written by Qinbo Xu and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with Medical categories.
Accompanying CD-ROM illustrates clearly each technique so that researchers can observe the operational procedures directly. The CD-ROM also features color versions of figures from the book for increased clarity.
A Handbook Of Mouse Models Of Cardiovascular Disease
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Author : Qingbo Xu
language : en
Publisher:
Release Date : 2006-10-28
A Handbook Of Mouse Models Of Cardiovascular Disease written by Qingbo Xu and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-10-28 with Science categories.
The availability of well-defined genetic strains and the ability to create transgenic and knockout mice makes mouse models extremely valuable biomedical tools. Their suitability as an experimental system for cardiovascular research depends on the individual investigator’s ability to manipulate the mice surgically. Many mouse models require microsurgical techniques, which hitherto could not be performed without practical training. This comprehensive handbook will enable scientists to develop these models in their own laboratories. It contains detailed advice on the issues that investigators need to consider before starting their experiments. It then provides essential information about experimental procedures, specific instruments and technical knowledge and will prove an indispensable guide to all scientists planning to work with these mouse models. This book includes a brief introduction to each disease, followed by a detailed description of the methods and materials used to establish the relevant mouse model. Each chapter has been written by an expert familiar with that system, who provides helpful discussion of the problems that may be encountered and examples of applications of the model. Importantly, each technique is clearly illustrated on the accompanying CD, so that researchers can observe the operational procedures directly. With coverage of all the major mouse models of cardiovascular disease, this book may be used to obtain a broad overview of commonly used methods and, more importantly, as a comprehensive source of detailed information on the development and study of such models. It will prove essential reading to all those working on experimental animal models of cardiovascular disease, from students to independent investigators.
Spotlight On Animal Models And Human Cardiovascular Disease
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Author : W. Schaper
language : en
Publisher:
Release Date : 1998
Spotlight On Animal Models And Human Cardiovascular Disease written by W. Schaper and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with categories.
Animal Models For The Study Of Human Disease
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Author : P. Michael Conn
language : en
Publisher: Academic Press
Release Date : 2013-05-29
Animal Models For The Study Of Human Disease written by P. Michael Conn and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-05-29 with Science categories.
Animal Models for the Study of Human Disease identifies important animal models and assesses the advantages and disadvantages of each model for the study of human disease. The first section addresses how to locate resources, animal alternatives, animal ethics and related issues, much needed information for researchers across the biological sciences and biomedicine.The next sections of the work offers models for disease-oriented topics, including cardiac and pulmonary diseases, aging, infectious diseases, obesity, diabetes, neurological diseases, joint diseases, visual disorders, cancer, hypertension, genetic diseases, and diseases of abuse. Organized by disease orientation for ease of searchability Provides information on locating resources, animal alternatives and animal ethics Covers a broad range of animal models used in research for human disease